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Search Results for " dna-pk "

Targets Recommended: DNA-PK Apoptosis ATM/ATR DNA-PK PI3K

68

抑制剂 & 化合物

5

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T2433	NU 7026 NU7026,DNA-PK Inhibitor II,LY293646	Apoptosis; ATM/ATR; DNA-PK; PI3K	Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	NU 7026 (DNA-PK Inhibitor II) 是一种新型特异性的DNA-PK 抑制剂，IC50为 0.23 μM，也抑制PI3K，IC50为 13 μM。
T15789	LTURM34	DNA-PK; PI3K; PI4K	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	LTURM34 是一种 DNA-PK 抑制剂，IC50 为 34 nM。它在广泛的肿瘤细胞系中显示出有效的抗增殖活性，对 DNA-PK 的选择性比 PI3K 高 170 倍。
T4339	YU238259	DNA-PK; Others	DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling
	YU238259 是一种新型的同源依赖性 DNA 修复 (HDR) 抑制剂，在基于细胞的 GFP 报告基因检测中不抑制非同源末端连接 (NHEJ)，可研究癌症。
T2461	PIK-90	DNA-PK; PI3K	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PIK90 PIK-90 是一种 DNA-PK 和 PI3K 抑制剂，抑制 p110α、p110γ和DNA-PK，IC50分别为 11、18 和 13 nM。
T6100	Torin 2	Apoptosis; ATM/ATR; DNA-PK; mTOR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Torin 2 是一种特异性 mTOR 抑制剂，IC50值为0.25 nM，并改善了药代动力学特性。它抑制 ATM/ATR/DNA-PK 的 EC50 分别为 28 nM/35 nM/118 nM。
T3541	CC-115 CC 115	DNA-PK; PI3K; mTOR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	CC-115 是一种双重 mTOR/DNA-PK 的抑制剂，IC50分别为 21 nM 和 13 nM，可阻断mTORC1和mTORC2信号通路。
T3986	SF2523	DNA-PK; Epigenetic Reader Domain; PI3K; mTOR	Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	SF2523 是一种选择性PI3K 抑制剂，抑制DNA-PK、PI3Kα、PI3Kγ、BRD4 和 mTOR，IC50分别为 9 nM、34 nM、158 nM、241 nM 和 280 nM。
T4459	PK11000	DNA Alkylator/Crosslinker	DNA Damage/DNA Repair
	PK11000 是一种烷化剂，可通过共价半胱氨酸修饰来稳定野生型和突变型p53的 DNA 结合结构域。
T9760	IC 86621	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	IC 86621 是一种选择性和可逆的 ATP 竞争性 DNA-PK 抑制剂，IC50 为 120 nM。 IC 86621 增加 DNA 双链断裂 (DSB) 诱导的抗肿瘤活性，其 EC50 为 68 µM，用于 DNA-PK 介导的细胞 DSB 修复。
T6557	KU-0060648 KU0060648	DNA-PK; PI3K; mTOR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	KU-0060648 是一种 PI3K 和 DNA-PK 的双重抑制剂，对 PI3Kα、PI3Kβ、PI3Kδ、PI3Kγ 和 DNA-PK 的 IC50值分别为 4 nM、0.5 nM、0.1 nM、0.59 nM 和 8.6 nM。
T6143	PI-103 PI103,PI 103	Apoptosis; DNA-PK; PI3K; mTOR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PI-103 是一种 PI3K 和 mTOR 抑制剂，抑制 p110α、p110β、p110δ、p110γ、mTORC1和 mTORC2，IC50分别为 8 nM、88 nM、48 nM、150 nM、20 nM 和 83 nM。它可诱导自噬，还抑制 DNA-PK，IC50为 2 nM。
T2667	PIK-75	Apoptosis; DNA-PK; PI3K	Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PIK75 是一种可逆的DNA-PK 和p110α-选择性的抑制剂，抑制 DNA-PK、p110α 和 p110γ，IC50分别为 2、5.8 和 76 nM。它诱导凋亡，抑制 p110α 效果比抑制 p110β 高 200 多倍，p110β的IC50为 1.3 μM。
T25399	ETP-45658 ETP45658,ETP 45658	DNA-PK; PI3K; mTOR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	ETP-45658 (ETP45658) 是一种PI3K 抑制剂，抑制PI3Kα、PI3Kδ、PI3Kβ和PI3Kγ的IC50值分别为 22.0、39.8、129.0 和 717.3 nM。它可研究癌症，还抑制DNA-PK 和mTOR，IC50分别为70.6 和 152 nM。
T7122	AZD-7648	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	AZD-7648 是一种 DNA 依赖性蛋白激酶 (DNA-PK) 抑制剂，在酶试验中 IC50 为 0.63 nM，具有抗肿瘤活性。
T6276	KU-57788 NU7441	DNA-PK; CRISPR/Cas9	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	KU-57788 (NU7441) 是一种 NHEJ 通路抑制剂，抑制 PI3K 和 mTOR，IC50分别为 5.0 和 1.7 μM。它是高效的选择性DNA-PK 抑制剂，IC50为 14 nM。
T6883	Samotolisib GTPL8918,LY3023414	DNA-PK; PI3K; mTOR; Autophagy	Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Samotolisib (LY3023414) 在低纳摩尔浓度下，有效抑制mTORC1/2。它选择性地有效抑制PI3Kα、PI3Kβ、PI3Kδ、PI3Kγ、DNA-PK 和mTOR，IC50分别为 6.07 nM、77.6 nM、38 nM、23.8 nM、4.24 nM 和 165 nM。它可用于多种肿瘤和癌症的试验。
T3586	Compound 401 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) 是一种可靶向 mTOR 的合成 DNA-PK 抑制剂，IC50为0.28 μM。
T85267	DNA-PK Inhibitor IV	Others	Others

T13017	STL127705 Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione	DNA-PK; Others	DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling
	STL127705 (Compound L) 是一种有效的 Ku 70/80 异二聚体蛋白抑制剂，抑制 Ku70/80-DNA 相互作用，IC50 为 3.5 μM。它抑制 Ku 依赖性 DNA-PKCS 激酶的激活，IC50 为 2.5 μM。
T25069	AMA-37 DNA-PK Inhibitor V,ArylMorpholine Analog 37,AMA 37	Others	Others
	AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor.
T61828	DNA-PK-IN-8	Others	Others
	DNA-PK-IN-8（化合物DK1）是一种高效、选择性且口服活性的DNA依赖蛋白激酶 (DNA-PK) 抑制剂，其IC50值为0.8 nM。与Doxorubicin联合应用时，该化合物能在多种癌细胞中展现出协同的抗增殖效应，并能显著地抑制HL-60肿瘤生长。
T2008	LY294002 LY 294002,NSC 697286,SF 1101	Apoptosis; DNA-PK; Casein Kinase; PI3K; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	LY294002 (SF 1101) 是一种 PI3K 的广谱抑制剂，抑制 PI3Kα、PI3Kδ 和 PI3Kβ (IC50=0.5/0.57/0.97 μM)。LY294002 也是 DNA-PK 抑制剂 (IC50=1.4 μM) 和 CK2 抑制剂 (IC50=98 nM)。LY294002 可以激活凋亡和自噬。
T62034	DNA-PK-IN-7	Others	Others
	DNA-PK-IN-7 是有效的 DNA-PK 抑制剂，IC50为 1 nM (WO2021104277A1, compound 5)。
T62191	DNA-PK-IN-5	Others	Others
	DNA-PK-IN-5 是一种 DNA-PK 的有效抑制剂。DNA-PK-IN-5 能够抑制 DNA-PKcs 活性，明显降低肿瘤 DNA 修复，并诱导细胞凋亡。DNA-PK-IN-5 能够提高肿瘤组织对放疗的敏感性，克服耐药问题，提高对多种实体瘤和血液肿瘤的抑制效果。
T62648	DNA-PK-IN-1	Others	Others
	DNA-PK-IN-1 是一种 DNA-PK 的有效抑制剂。DNA 依赖性蛋白激酶 (DNA-PK) 是一种由 Ku70/Ku80 异二聚体和 DNA 依赖性蛋白激酶催化亚基 (DNA-PKcs) 组成的 DNA-PK 酶复合物。DNA-PK-IN-1 具有潜力进行癌症疾病的研究。
T61633	DNA-PK-IN-2	Others	Others
	DNA-PK-IN-2 is a highly effective inhibitor of DNA-dependent protein kinase (DNA-PK), which is a complex enzyme composed of Ku70/Ku80 heterodimer and DNA-PK catalytic subunit (DNA-PKcs). With its potential applications in cancer research, DNA-PK-IN-2 demonstrates promise as a valuable tool for studying cancer diseases [1].
T61751	DNA-PK-IN-3	Others	Others
	DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tumor growth. Furthermore, DNA-PK-IN-3 demonstrates remarkable efficacy in reducing damage to normal cells, effectively minimizing adverse side effects. Due to these compelling properties, DNA-PK-IN-3 holds great potential for cancer research applications[1].
T61533	DNA-PK-IN-9	Others	Others
	DNA-PK-IN-9 (also known as compound YK6) is a highly potent inhibitor of DNA-dependent protein kinase (DNA-PK), displaying an IC50 value of 10.47 nM. DNA-PK-IN-9 holds significant potential in anticancer research [1].
T79165	DNA-PK-IN-10	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	DNA-PK-IN-10是一种DNA-PK抑制剂, 主要应用于乳腺癌与非小细胞肺癌的研究。
T61857	DNA-PK-IN-4	Others	Others
	DNA-PK-IN-4 (WO2021209055A1, compound 27), an imidazolinone derivative compound, is a highly effective inhibitor of DNA-PK, specifically targeting DNA-PKcs activity. By inhibiting DNA-PKcs, the compound significantly impairs tumor DNA repair mechanisms and triggers apoptosis in cells. With its potential application in cancer research, DNA-PK-IN-4 holds promise for further investigation [1].
T61370	DNA-PK-IN-6	Others	Others
	DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 amplifies the responsiveness of tumor tissues to radiotherapy, overcomes the challenge of drug resistance, and augments its inhibitory impact on a diverse range of solid and hematological tumors[1].
T2287	PIK-75 hydrochloride PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75	Apoptosis; DNA-PK; PI3K	Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PIK-75 hydrochloride (PIK-75 HCl) 是一种可逆的 DNA-PK 和 p110α-选择性抑制剂，抑制 DNA-PK，p110α和 p110γ，可诱导凋亡。
T4079	LY-294002 hydrochloride SF 1101,LY 294002,NSC 697286	PI3K	PI3K/Akt/mTOR signaling
	LY-294002 hydrochloride (NSC 697286) 是一种合成的 PI3Kα/δ/β 分子抑制剂（IC50：0.5/0.57/0.97 μM，在无细胞试验中）；在溶液中比 Wortmannin 更稳定，也是自噬体形成的阻断剂。
T9498	BAY-8400	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	BAY-8400是一种具有口服活性、有效和选择性 DNA 依赖蛋白激酶 (DNA-PK) 抑制剂(IC50=81 nM)，与靶向α疗法联合使用显示协同疗效。BAY-8400 可用于癌症研究。
T1826	PI3K-IN-1 Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409	DNA-PK; PI3K	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PI3K-IN-1 (Voxtalisib Analogue) 是 PI3K 抑制剂，PI3K-IN-1(25 μM) 能够阻断 PI3K/Akt 信号通路。
T6612	NU6027	ATM/ATR; DNA-PK; CDK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	NU6027 是一种有效的 ATR/CDK 抑制剂，抑制 CDK1/2、ATR 和 DNA-PK，Ki 为 2.5 μM/1.3 μM、0.4 μM 和 2.2 μM。它以 ATR 依赖性方式增强羟基脲和顺铂的细胞毒性。
T7014	Voxtalisib XL765,SAR245409	DNA-PK; PI3K; mTOR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Voxtalisib (XL765) 是一种PI3K 抑制剂，抑制p110α，p110β，p110γ和p110δ。它抑制mTORC1和mTORC2，IC50s 分别为 160 和 910 nM。它也抑制 DNA-PK (其 IC50=150 nM) 和 mTOR (其 IC50=157 nM)。
T15673	KU 59403 KU-59403,KU59403	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	KU 59403 是一种具有选择性和高效性的 ATM 抑制剂，具有抗肿瘤和抗癌活性，抑制 ATM、DNA-PK 和 PI3K，常与PARP或ATR抑制剂的联合治疗来延缓癌症的进程。
T62083	Camonsertib ATR inhibitor 4,RP-3500	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Camonsertib (RP-3500) 是一种选择性的、口服具有活力的 ATR 激酶抑制剂 (ATRi)，在生化试验中的 IC50: 1.00 nM，表现出有效的抗肿瘤作用。RP-3500 对 ATR 的选择性是 mTOR 的 30 倍 (IC50: 120 nM)，是 ATM、DNA-PK 和 PI3Kα 激酶的 2,000 倍以上。
T8637	DMNB 6-Nitroveratraldehyde,6-硝基藜芦醛	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	DMNB (6-Nitroveratraldehyde) 可用于合成no-carrier-added 6-[18F]fluoro-L-DOPA (6-FDOPA)。它可用于研究多巴胺能系统的PET。
T8651	CAL-101 (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one,GS-1101,Idelalisib	PI3K	PI3K/Akt/mTOR signaling
	CAL-101 (Idelalisib) 是 p110δ 的选择性抑制剂（IC50：2.5 nM；在无细胞试验中）；显示对 p110δ 的选择性比 p110α/β/γ 高 40 到 300 倍，对 p110δ 的选择性比 C2β、hVPS34、DNA-PK 和 mTOR 高 400 到 4000 倍。
T6319	OSI-027 ASP4786,OSI027	DNA-PK; PI3K; mTOR; Autophagy	Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	OSI-027 (ASP4786) 是一种选择性、可口服和 ATP 竞争性的mTOR 激酶活性抑制剂，IC50为 4 nM。它抑制mTORC1和mTORC2，IC50分别为 22 nM 和 65 nM。
T2685	KU-55933 ATM Kinase Inhibitor	ATM/ATR; DNA-PK; PI3K; mTOR; Autophagy	Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	KU-55933 (ATM Kinase Inhibitor) 是一种 ATM 抑制剂，IC50和 Ki 值分别为 12.9 和 2.2 nM。它对 ATM 的选择性比对 PI3K/PI4K、 DNA-PK、ATR 和 mTOR 高。
T12672	(Rac)-Nedisertib (Rac)-M3814	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM).
T6283	Wortmannin SL-2052,渥曼青霉素,KY-12420	ATM/ATR; DNA-PK; Serine/threonin kinase; PLK; PI3K; Antibiotic; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Wortmannin (SL-2052) 是一种 PI3K 抑制剂 (IC50=3 nM)，具有共价性和不可逆性。Wortmannin 也是一种 PlK1 和 PlK3 的抑制剂 (IC50=5.8/48 nM)，可以阻断自噬。
T13444	(R)-Nedisertib (R)-M3814	Others	Others
	(R)-Nedisertib is a less active R-enantiomer of Nedisertib(IC50 in the range of 7-30 nM for DNA-PK).
T68192	OK-1035	Others	Others
	OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of consensus peptide as well as that of recombinant human wild type-p53. Kinetic studies indicated that OK-1035 inhibited DNA-PK activity in an ATP-competitive manner.
T68691	NU-7031	Others	Others
	NU-7031 is a potent DNA-PK inhibitor with potential anticancer activity.
T68978	KU-0058684	Others	Others
	KU-0058684 is a potent PARP and DNA-PK inhibitors.
T24559	NU-7163 NU 7163,NU7163	Others	Others
	NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.

化合物

Cat.No: T2433

Synonym: NU7026,DNA-PK Inhibitor II,LY293646

Target: Apoptosis, ATM/ATR, DNA-PK, PI3K

Cat.No: T15789

Target: DNA-PK, PI3K, PI4K

Cat.No: T4339

Target: DNA-PK, Others

Cat.No: T2461

Target: DNA-PK, PI3K

Cat.No: T6100

Target: Apoptosis, ATM/ATR, DNA-PK, mTOR, Autophagy

Cat.No: T3541

Synonym: CC 115

Target: DNA-PK, PI3K, mTOR

Cat.No: T3986

Target: DNA-PK, Epigenetic Reader Domain, PI3K, mTOR

Cat.No: T4459

Target: DNA Alkylator/Crosslinker

Cat.No: T9760

Target: DNA-PK

Cat.No: T6557

Synonym: KU0060648

Target: DNA-PK, PI3K, mTOR

Cat.No: T6143

Synonym: PI103,PI 103

Target: Apoptosis, DNA-PK, PI3K, mTOR, Autophagy

Cat.No: T2667

Target: Apoptosis, DNA-PK, PI3K

Cat.No: T25399

Synonym: ETP45658,ETP 45658

Target: DNA-PK, PI3K, mTOR

Cat.No: T7122

Target: DNA-PK

Cat.No: T6276

Synonym: NU7441

Target: DNA-PK, CRISPR/Cas9

Cat.No: T6883

Synonym: GTPL8918,LY3023414

Target: DNA-PK, PI3K, mTOR, Autophagy

Cat.No: T3586

Synonym: 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one

Target: DNA-PK

DNA-PK Inhibitor IV

Cat.No: T85267

Target: Others

Cat.No: T13017

Synonym: Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Target: DNA-PK, Others

Cat.No: T25069

Synonym: DNA-PK Inhibitor V,ArylMorpholine Analog 37,AMA 37

Target: Others

Cat.No: T61828

Target: Others

Cat.No: T2008

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

Cat.No: T62034

Target: Others

Cat.No: T62191

Target: Others

Cat.No: T62648

Target: Others

Cat.No: T61633

Target: Others

Cat.No: T61751

Target: Others

Cat.No: T61533

Target: Others

Cat.No: T79165

Target: DNA-PK

Cat.No: T61857

Target: Others

Cat.No: T61370

Target: Others

PIK-75 hydrochloride

Cat.No: T2287

Synonym: PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75

Target: Apoptosis, DNA-PK, PI3K

LY-294002 hydrochloride

Cat.No: T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: PI3K

Cat.No: T9498

Target: DNA-PK

Cat.No: T1826

Synonym: Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409

Target: DNA-PK, PI3K

Cat.No: T6612

Target: ATM/ATR, DNA-PK, CDK

Cat.No: T7014

Synonym: XL765,SAR245409

Target: DNA-PK, PI3K, mTOR

Cat.No: T15673

Synonym: KU-59403,KU59403

Target: ATM/ATR

Cat.No: T62083

Synonym: ATR inhibitor 4,RP-3500

Target: ATM/ATR

Cat.No: T8637

Synonym: 6-Nitroveratraldehyde,6-硝基藜芦醛

Target: DNA-PK

Cat.No: T8651

Synonym: (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one,GS-1101,Idelalisib

Target: PI3K

Cat.No: T6319

Synonym: ASP4786,OSI027

Target: DNA-PK, PI3K, mTOR, Autophagy

Cat.No: T2685

Synonym: ATM Kinase Inhibitor

Target: ATM/ATR, DNA-PK, PI3K, mTOR, Autophagy

(Rac)-Nedisertib

Cat.No: T12672

Synonym: (Rac)-M3814

Target: DNA-PK

Cat.No: T6283

Synonym: SL-2052,渥曼青霉素,KY-12420

Target: ATM/ATR, DNA-PK, Serine/threonin kinase, PLK, PI3K, Antibiotic, Autophagy

Cat.No: T13444

Synonym: (R)-M3814

Target: Others

Cat.No: T68192

Target: Others

Cat.No: T68691

Target: Others

Cat.No: T68978

Target: Others

Cat.No: T24559

Synonym: NU 7163,NU7163

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00476	DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc) DNA-PKcs,DNA-PK catalyti...	Dictyostelium discoideum	E. coli
	DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc) is expressed in E. coli.
TMPY-02287	Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His) KARP1,XRCC5 & XRCC6,KUB2,KU80,KARP-1,Ku86,NFIV	Human	Baculovirus Insect Cells
	X-ray repair cross-complementing protein 5, also known as 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 8 kDa subunit, CTC box-binding factor 85 kDa subunit, DNA repair protein XRCC5, Lupus Ku autoantigen protein p86, TLAA and XRCC5, is a nucleus and chromosome which belongs to the ku8 family. XRCC5 is a single-stranded DNA-dependent ATP-dependent helicase. XRCC5 has a role in chromosome translocation. X-ray repair cross-complementing protein...
TMPK-00972	PK-1/PROK1 Protein, Mouse, Recombinant (hFc) PROK1,Mambakine,Prokineticin-1,EG-VEGF	Mouse	HEK293 Cells
	PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in regulating viral propagation. Electron microscopy revealed that pk-1 deletion affected the formation of normal nucleocapsids.PK-1 appears to phosphorylate some viral or cellular proteins that are essential for DNA packaging to regulate nucleocapsid assembly.
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP) Nuclear factor IV,Lupus Ku autoantigen protein p86,ATP-depen...	Human	Baculovirus Insect Cells
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc) ATP-dependent DNA helicase 2 subunit 2,XRCC5,Ku86,N...	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...

重组蛋白

DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc)

Cat.No: TMPH-00476

Species: Dictyostelium discoideum

Expression System: E. coli

Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His)

Cat.No: TMPY-02287

Species: Human

Expression System: Baculovirus Insect Cells

PK-1/PROK1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00972

Species: Mouse

Expression System: HEK293 Cells

XRCC5 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPH-02314

Species: Human

Expression System: Baculovirus Insect Cells

XRCC5 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02315

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11067	VX-984 M9831	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用，可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。
T12648	(R)-VX-984 (R)-M9831	Others	Others
	(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.

同位素标记化合物

Cat.No: T11067

Synonym: M9831

Target: DNA-PK

Cat.No: T12648

Synonym: (R)-M9831

Target: Others

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