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Search Results for " dna gyrase "

Targets Recommended: DNA gyrase DNA gyrase Topoisomerase

66

抑制剂 & 化合物

8

天然产物

2

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8747	Levofloxacin hydrochloride	DNA gyrase; Topoisomerase	DNA Damage/DNA Repair
	Levofloxacin hydrochloride 是一种广谱的第三代氟喹诺酮类抗生素，是氧氟沙星的光学活性 L-异构体，具有抗菌活性。左氧氟沙星通过细菌细胞壁扩散并通过抑制 DNA 促旋酶（细菌拓扑异构酶 II）起作用，这是一种 DNA 复制、RNA 转录和细菌 DNA 修复所需的酶。 DNA 促旋酶活性的抑制导致细菌细胞生长受阻。
T13231L	Trovafloxacin mesylate	Others; DNA/RNA Synthesis; Topoisomerase; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Trovafloxacin是一种广谱氟喹诺酮类抗生素，可阻断 DNA 促旋酶 (DNA gyrase) 和拓扑异构酶 IV (topoisomerase IV) 的活性，也是一种有效的特异性 pannexin 1 通道抑制剂 (PANX1, IC50 = 4 μM)。
T63442	DNA Gyrase-IN-2	Others	Others
	DNA Gyrase-IN-2 是细菌 DNA 促旋酶 B 抑制剂，能作用于大肠杆菌 DNA 促旋酶(IC50: 3.29-10.49 μM)和结核分枝杆菌 DNA 促旋酶(IC50: 4.41-5.61 μM)，表现出抗菌和抗结核作用。
T78866	DNA Gyrase-IN-9	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA Gyrase-IN-9 (compound 4j) 是一款抗细菌剂，作用于 DNA gyrase。该化合物对抑制革兰氏阳性菌的最小抑菌浓度（MIC）范围为 0.5-2 μg/mL，最小杀菌浓度（MBC）为 2-8 μg/mL。在金黄色葡萄球菌中，DNA Gyrase-IN-9 的 DNA gyrase 抑制半数有效浓度（IC50）为 6.29 μg/mL。
T63681	DNA Gyrase-IN-1	Others	Others
	DNA Gyrase-IN-1 是有效的、选择性的 DNA 促旋酶抑制剂 (IC50: 2.6 μM)。DNA Gyrase-IN-1 能够较好的抑制结核分枝杆菌 (Mtb) 的活性 (MIC: 0.49 μM)。DNA Gyrase-IN-1 能够用于研究结核病。
T74848	DNA Gyrase-IN-6	Others	Others
	Antibacterial agent 138 是细菌 DNA 促旋酶和拓扑异构酶 IV 的苯并噻唑抑制剂。Antibacterial agent 138 表现出良好的溶解度和血浆蛋白结合。Antibacterial agent 138 对革兰氏阳性和革兰氏阴性菌株具有抗菌活性。Antibacterial agent 138 是一种双重 GyrB 和 ParE 抑制剂。
T79240	DNA gyrase B-IN-2	Others	Others
	DNA gyrase B-IN-2 (Compound E) 是一款基于2-aminobenzothiazole的DNA gyrase B抑制剂，针对ESKAPE病原体显示出强效活性。该化合物在低纳摩尔浓度下表现出优异的DNA gyrase B抑制能力(IC50< 10 nM)，具备对多种ESKAPE病原体的广谱抗菌作用。对于大部分革兰氏阳性菌，最低抑菌浓度(MIC)低于0.03 μg/mL；针对革兰氏阴性病原体如E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa和Klebsiella pneumoniae，MIC为4 - 16 μg/mL。此化合物适用于感染性疾病的研究应用。
T7865	Danofloxacin 达氟沙星,达诺沙星,Danofloxacino,Danofloxacin free base,Danofloxacine	Others; DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Danofloxacin (Danofloxacin free base) free base 是一种具有口服活性第三代氟喹诺酮抗菌剂，对大多数革兰氏阴性和革兰氏阳性细菌，支原体和衣原体物种具有广谱的活性，并通过抑制细菌的 DNA 回转酶发挥抗菌作用。它可用于牛，猪和鸡呼吸道疾病的研究。
T78712	DNA Gyrase-IN-8	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA Gyrase-IN-8是一种高效的DNA gyrase抑制剂，其IC50为8.45 µM，同时展现出了抗菌活性。
T63395	DNA Gyrase-IN-5	Others	Others
	DNA Gyrase-IN-5 是 DNA gyrase 的有效抑制剂 (IC50: 0.10 μM)，对野生型和耐药株均有抗细菌（antibacterial）作用。
T62895	DNA Gyrase-IN-4	Others	Others
	DNA Gyrase-IN-4 (compound 8p) 是一种 DNA 促旋酶的有效抑制剂 (IC50: 0.13 μM)。DNA Gyrase-IN-4 对金黄色葡萄球菌 (MIC: 0.05 μg/ml)、单核增生李斯特菌 (MIC: 0.05 μg/ml)、沙门氏菌 (MIC: 0.05 μg/ml) 和大肠杆菌 (MIC: 8 μg/ml) 具有较好的抗菌作用。
T61937	DNA Gyrase-IN-3	Others	Others
	DNA Gyrase-IN-3 (Compound 28) 是细菌DNA 旋转酶 B (bacterial DNA gyrase B) 抑制剂。DNA Gyrase-IN-3抑制大肠杆菌DNA 旋转酶的 IC50为5.41-15.64 μM。DNA Gyrase-IN-3显示出抗结核和抗菌活性。
T64012	DNA gyrase B-IN-1	Others	Others
	DNA gyrase B-IN-1 是 DNA gyrase B 的有效抑制剂，表现出良好的结合亲和力和稳定性。DNA gyrase B-IN-1 能够抑制 P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM)。
T78776	DNA gyrase B-IN-3	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA gyrase B-IN-3（Compound A），作为一种细菌DNA gyrase B抑制剂（IC50: <10 nM），针对革兰氏阳性菌株表现出抗菌活性。
T62389	14α-Demethylase/DNA Gyrase-IN-2	Others	Others
	14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) 是一种 14α-Demethylase/DNA Gyrase 的有效抑制剂，具有抗菌作用。
T62792	14α-Demethylase/DNA Gyrase-IN-1	Others	Others
	14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) 是一种 14α-Demethylase/DNA Gyrase 的有效抑制剂，具有抗菌作用。
T1451	Levofloxacin hydrate 左氧氟沙星半水合物,Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate	DNA gyrase; Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Levofloxacin hydrate (Cravit hydrate) 是抗生素化合物，抑制细菌DNA 旋转酶活性。
T0909L	Nalidixic acid sodium salt 萘啶酮酸,萘啶酮酸钠,Baktogram,Sodium nalidixate	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Nalidixic acid sodium salt (Baktogram) 是一种喹诺酮类抗生素，对革兰氏阳性和革兰氏阴性细菌均有效。它在较低浓度下有抑菌作用，在较高浓度下有杀菌作用。它抑制 DNA 促旋酶和拓扑异构酶IV 的亚基，并可逆地阻止易感细菌中的 DNA 复制。
T0717L	Enoxacin 依诺沙星,NSC 629661,AT 2266,Pd107779,CI 919	DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Enoxacin (NSC-629661) 是一种可干扰DNA 复制的氟喹诺酮，抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。它是特异性癌症生长抑制剂，可有效抑制革兰氏阳性和阴性细菌。
T7804	Garenoxacin mesylate hydrate Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate)	Antibacterial	Microbiology/Virology
	Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) 是一种新型口服 des-fluoro(6) 喹诺酮，具有强抗菌活性，抗呼吸道病原体。
T0717	Enoxacin hydrate CI-919 hydrate,Enoxacin Sesquihydrate,依诺沙星半水合物,AT-2266 hydrate,依诺沙星倍半水合物	DNA gyrase; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Enoxacin hydrate (AT-2266 hydrate) 是氟喹诺酮，可干扰DNA 复制，抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。它是特异性癌症生长抑制剂，抑制革兰氏阳性和阴性细菌。
T13231	Trovafloxacin	DNA gyrase; Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Trovafloxacin 是广谱喹诺酮类抗生素，对革兰氏阳性，革兰氏阴性和厌氧菌有活性。它可阻断 DNA 促旋酶和拓扑异构酶 IV 的活性。它也是口服活性的 Pannexin 1通道选择性抑制剂，对 PANX1内向电流的 IC50为 4 μM。
T7179	Garenoxacin BMS284756,加雷沙星	Antibacterial	Microbiology/Virology
	Garenoxacin (BMS284756) 是一种新型的口服 des-fluoro(6) 喹诺酮，有抗菌活性，可抑制呼吸道病原体。
T2353	BRD7116 BRD7716	DNA gyrase; Antibacterial	DNA Damage/DNA Repair; Microbiology/Virology
	BRD7116 与细菌 DNA 促旋酶竞争性结合，作用于LSCe 细胞，EC50值为200 nM。它具有细胞非自主抗白血病活性。
T0425L	Pefloxacin Mesylate Dihydrate Pefloxacinium mesylate dihydrate,1589 RB,甲磺酸培氟沙星二水合物	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Pefloxacin Mesylate Dihydrate (1589 RB) 是一种抗菌素，能通过抑制DNA 旋转酶阻断细菌DNA 复制。
T1095	Sparfloxacin AT-4140,PD 131501,Zagam,司帕沙星,CI-978	DNA gyrase; Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Sparfloxacin (CI-978) 是一种氟喹诺酮类抗菌素。
T1640	Ciprofloxacin Ciproxan,环丙沙星,Ciprobay,Bay o 9867,Bay-09867	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Ciprofloxacin (Bay-09867) 是一种有高抗菌活性的氟喹诺酮类抗生素。
T1294	Fleroxacin AM-833,氟罗沙星,RO 23-6240	DNA gyrase; Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Fleroxacin (RO 23-6240) 是一种广谱氟喹诺酮类抗菌素。
T20510	Novobiocin U-6391,U 6391,U6391,Cathomycin,Albamycin	Apoptosis; Virus Protease; HSP; DNA gyrase; Antibacterial; Antibiotic	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Novobiocin 是一种具有口服活性和有效性的的抗生素。Novobiocin 是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂，对促旋酶和Hsp90 具有抑制作用。 Novobiocin 具有抗正痘活性，可用于研究高度耐药性肺炎球菌感染。
T0902	Ofloxacin DL8280,菲宁达,Hoe-280,氧氟沙星,Floxin,Tarivid,Oxaldin	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Ofloxacin (Oxaldin) 是可抑制细菌DNA 旋转酶的一种氟喹诺酮类抗生素。
T8835	Tosufloxacin hydrochloride A-61827 hydrochloride,盐酸妥舒沙星,T-3262 hydrochloride	Antibacterial	Microbiology/Virology
	Tosufloxacin hydrochloride 是一种氟喹诺酮类抗菌剂，用于治疗细菌感染。 Tosufloxacin hydrochloride 也是一种细菌 Topo（DNA 促旋酶，拓扑异构酶）抑制剂。
T0116	Balofloxacin	DNA gyrase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Balofloxacin 是一种具有口服活性的氟喹诺酮类抗生素，可通过干扰 DNA 促旋酶来抑制细菌 DNA 的合成，对革兰氏阴性，革兰氏阳性和厌氧菌具有广谱抗菌活性。它可研究呼吸道，肠道和泌尿道感染。
T1293	Gatifloxacin BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155,加替沙星	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Gatifloxacin (CG5501) 是一种具有广谱抗菌活性的氟喹诺酮类抗生素。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml) 和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml)。在动物模型中，它有抗细菌性结膜炎作用。
T67826	Alalevonadifloxacin	DNA gyrase; Topoisomerase; Antibacterial	DNA Damage/DNA Repair; Microbiology/Virology
	Alalevonadifloxacin 是一种DNA 回旋酶和DNA 拓扑异构酶抑制剂，是一种喹诺酮类针对Mrsa 的新型抗菌化合物。Alalevonadifloxacin 对治疗细菌性革兰氏阳性、革兰氏阴性和厌氧性感染有潜在作用。
T1060	Flumequine Flumigal,氟甲喹,R-802	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Flumequine (R-802) 是一种喹诺酮类抗生素，对革兰氏阳性菌和革兰氏阴性菌均有效。它是拓扑异构酶 II 抑制剂，抑制细胞分裂，IC50值为 15 μM (3.92 μg/mL)。
TQ0063	Zoliflodacin ETX0914,AZD0914	DNA gyrase; DNA/RNA Synthesis; Topoisomerase; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Zoliflodacin (ETX0914) 是一种新型螺旋嘧啶三酮，对革兰氏阳性和阴性生物有抗菌活性，对金黄色葡萄球菌的b>MIC90值为0.25 μg/mL。他也是细菌DNA 促旋酶/拓扑异构酶的抑制剂。
T1625	Lomefloxacin hydrochloride Lomefloxacin HCl,盐酸洛美沙星,Okacyn,Maxaquin	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Lomefloxacin hydrochloride (Okacyn) 是一种广谱喹诺酮类抗生素，具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。
T1492	Gemifloxacin mesylate LB-20304a,甲磺酸吉米沙星,SB-265805S,Gemifloxacin mesylate	DNA gyrase; Topoisomerase; Antibacterial	DNA Damage/DNA Repair; Microbiology/Virology
	Gemifloxacin mesylate (Gemifloxacin mesylate) 是一种喹诺酮类口服广谱抗菌剂，可研究轻中度肺炎和慢性支气管炎的急性细菌性发作。
T1451L	Levofloxacin sodium	Others	Others
	Levofloxacin sodium is a synthetic fluoroquinolones antibacterial. It inhibits the supercoiling activity of bacterial DNA gyrase, so that halting DNA replication.
T23924	Cyclothialidine Ro 09-1437	Others	Others
	Cyclothialidine is an inhibitor of DNA gyrase.
T24126	Gyramide A Gyramide-A	Others	Others
	Gyramide A is an inhibitor of bacterial DNA gyrase. It shows antimicrobial activity and inhibits bacterial cell division.
T26588	Albicidin	Others	Others
	Albicidin is a DNA gyrase inhibitor produced by Xanthomonas albilineans.
T22797	Gatifloxacin mesylate	Others	Others
	Gatifloxacin (mesylate) is an antibiotic of the fourth-generation fluoroquinolone family. It also inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
T25265	Clorobiocin RP18631,RP 18631,RP-18631	Others	Others
	Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase.
T26717	AZD-5099 AZD5099	Others	Others
	AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection.
T1293L	Gatifloxacin sesquihydrate Gatifloxacin	Others	Others
	Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia.
T71982	Ofloxacin HCl	Others	Others
	Ofloxacin HCl is a synthetic fluoroquinolone ( FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
T62866	844-TFM	Others	Others
	844-TFM 是一种 NBTI (新型细菌拓扑异构酶抑制剂) DNA gyrase 抑制剂 (IC50: 1.5 μM)。844-TFM 对脓肿分枝杆菌的表现出杀菌作用。
T23578	(S)-Gyramide A (S)-Gyramide-A,(S)-534F6,(S)534F6,(S) 534F6	Others	Others
	(S)-Gyramide A is a bacterial DNA gyrase inhibitor that acts by exhibiting antimicrobial activity and inhibiting bacterial cell division.
T71459	PD 163449	Others	Others
	PD 163449 is a bioactive molecule of 4-pyridone group that inhibits bacterial type IIA topoisomerase (DNA gyrase and topoisomerase IV).

化合物

Levofloxacin hydrochloride

Cat.No: T8747

Target: DNA gyrase, Topoisomerase

Trovafloxacin mesylate

Cat.No: T13231L

Target: Others, DNA/RNA Synthesis, Topoisomerase, Antibacterial

DNA Gyrase-IN-2

Cat.No: T63442

Target: Others

DNA Gyrase-IN-9

Cat.No: T78866

Target: DNA/RNA Synthesis

DNA Gyrase-IN-1

Cat.No: T63681

Target: Others

DNA Gyrase-IN-6

Cat.No: T74848

Target: Others

DNA gyrase B-IN-2

Cat.No: T79240

Target: Others

Cat.No: T7865

Synonym: 达氟沙星,达诺沙星,Danofloxacino,Danofloxacin free base,Danofloxacine

Target: Others, DNA/RNA Synthesis, Antibacterial, Antibiotic

DNA Gyrase-IN-8

Cat.No: T78712

Target: DNA/RNA Synthesis

DNA Gyrase-IN-5

Cat.No: T63395

Target: Others

DNA Gyrase-IN-4

Cat.No: T62895

Target: Others

DNA Gyrase-IN-3

Cat.No: T61937

Target: Others

DNA gyrase B-IN-1

Cat.No: T64012

Target: Others

DNA gyrase B-IN-3

Cat.No: T78776

Target: DNA/RNA Synthesis

14α-Demethylase/DNA Gyrase-IN-2

Cat.No: T62389

Target: Others

14α-Demethylase/DNA Gyrase-IN-1

Cat.No: T62792

Target: Others

Levofloxacin hydrate

Cat.No: T1451

Synonym: 左氧氟沙星半水合物,Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Nalidixic acid sodium salt

Cat.No: T0909L

Synonym: 萘啶酮酸,萘啶酮酸钠,Baktogram,Sodium nalidixate

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T0717L

Synonym: 依诺沙星,NSC 629661,AT 2266,Pd107779,CI 919

Target: DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic

Garenoxacin mesylate hydrate

Cat.No: T7804

Synonym: Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate)

Target: Antibacterial

Enoxacin hydrate

Cat.No: T0717

Synonym: CI-919 hydrate,Enoxacin Sesquihydrate,依诺沙星半水合物,AT-2266 hydrate,依诺沙星倍半水合物

Target: DNA gyrase, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic

Cat.No: T13231

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Cat.No: T7179

Synonym: BMS284756,加雷沙星

Target: Antibacterial

Cat.No: T2353

Synonym: BRD7716

Target: DNA gyrase, Antibacterial

Pefloxacin Mesylate Dihydrate

Cat.No: T0425L

Synonym: Pefloxacinium mesylate dihydrate,1589 RB,甲磺酸培氟沙星二水合物

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T1095

Synonym: AT-4140,PD 131501,Zagam,司帕沙星,CI-978

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Cat.No: T1640

Synonym: Ciproxan,环丙沙星,Ciprobay,Bay o 9867,Bay-09867

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T1294

Synonym: AM-833,氟罗沙星,RO 23-6240

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Cat.No: T20510

Synonym: U-6391,U 6391,U6391,Cathomycin,Albamycin

Target: Apoptosis, Virus Protease, HSP, DNA gyrase, Antibacterial, Antibiotic

Cat.No: T0902

Synonym: DL8280,菲宁达,Hoe-280,氧氟沙星,Floxin,Tarivid,Oxaldin

Target: Topoisomerase, Antibacterial, Antibiotic

Tosufloxacin hydrochloride

Cat.No: T8835

Synonym: A-61827 hydrochloride,盐酸妥舒沙星,T-3262 hydrochloride

Target: Antibacterial

Cat.No: T0116

Target: DNA gyrase, Antibacterial, Antibiotic

Cat.No: T1293

Synonym: BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155,加替沙星

Target: Topoisomerase, Antibacterial, Antibiotic

Alalevonadifloxacin

Cat.No: T67826

Target: DNA gyrase, Topoisomerase, Antibacterial

Cat.No: T1060

Synonym: Flumigal,氟甲喹,R-802

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: TQ0063

Synonym: ETX0914,AZD0914

Target: DNA gyrase, DNA/RNA Synthesis, Topoisomerase, Antibacterial

Lomefloxacin hydrochloride

Cat.No: T1625

Synonym: Lomefloxacin HCl,盐酸洛美沙星,Okacyn,Maxaquin

Target: Topoisomerase, Antibacterial, Antibiotic

Gemifloxacin mesylate

Cat.No: T1492

Synonym: LB-20304a,甲磺酸吉米沙星,SB-265805S,Gemifloxacin mesylate

Target: DNA gyrase, Topoisomerase, Antibacterial

Levofloxacin sodium

Cat.No: T1451L

Target: Others

Cyclothialidine

Cat.No: T23924

Synonym: Ro 09-1437

Target: Others

Cat.No: T24126

Synonym: Gyramide-A

Target: Others

Cat.No: T26588

Target: Others

Gatifloxacin mesylate

Cat.No: T22797

Target: Others

Cat.No: T25265

Synonym: RP18631,RP 18631,RP-18631

Target: Others

Cat.No: T26717

Synonym: AZD5099

Target: Others

Gatifloxacin sesquihydrate

Cat.No: T1293L

Synonym: Gatifloxacin

Target: Others

Cat.No: T71982

Target: Others

Cat.No: T62866

Target: Others

Cat.No: T23578

Synonym: (S)-Gyramide-A,(S)-534F6,(S)534F6,(S) 534F6

Target: Others

Cat.No: T71459

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6567	Levofloxacin Levaquin,Cravit,Tavanic,Fluoroquinolone,左氧氟沙星,(-)-Ofloxacin	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Levofloxacin (Fluoroquinolone) 是合成的氟喹诺酮类抗生素，有抑制细菌DNA 旋转酶的超螺旋活性的作用，能阻止DNA 复制。
T0909	Nalidixic acid 萘啶酸,NSC-82174	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Nalidixic acid (NSC-82174) 是一种喹诺酮类抗生素，对革兰氏阳性和革兰氏阴性细菌有效。它在较低浓度下有抑菌作用，而在较高浓度下有杀菌作用。它抑制 DNA 促旋酶和拓扑异构酶 IV 的亚基，并可逆地阻止易感细菌中的 DNA 复制。
T7786	Tryptanthrin	DNA gyrase	DNA Damage/DNA Repair
	Tryptanthrin 是一种口服具有活性的细胞内Leukotriene (LT) biosynthesis 抑制剂。它能够降低大鼠胸膜炎模型中的 LTB4 水平，并抑制人全血中Leukotriene 的形成 (IC50= 10 µM)。
T1276	Danofloxacin mesylate 甲磺酸达氟沙星,CP 76136-27	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Danofloxacin mesylate (CP 76136-27) 是一种兽医用氟喹诺酮类抗菌素。
TQ0184	Chebulinic acid	ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells
	Chebulinic acid 是从诃子果中提取的一种天然产物，结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。
T0974	Novobiocin Sodium Albamycinsodium,新生霉素钠,Cathomycin,Albamycin	Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy	Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology
	Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。
T10838	Closthioamide	Antibacterial	Microbiology/Virology
	Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against MRSA, Ec, VRE, and Mv (MICs: 0.58 μM, 9.00 μM, 0.58 μM and 72.03 μM).
T36303	Psammaplin A	Others	Others
	Psammaplin A, a marine metabolite, functions as a robust inhibitor of HDAC and DNA methyltransferases, displaying notable potency and selectivity as a DAC1 inhibitor, with an IC50 value of 0.9 nM. It exhibits antimicrobial effects against Gram-positive bacteria and inhibits both DNA synthesis and DNA gyrase activity, also demonstrating antitumor activity[1][2].

天然产物

Cat.No: T6567

Synonym: Levaquin,Cravit,Tavanic,Fluoroquinolone,左氧氟沙星,(-)-Ofloxacin

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T0909

Synonym: 萘啶酸,NSC-82174

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T7786

Target: DNA gyrase

Danofloxacin mesylate

Cat.No: T1276

Synonym: 甲磺酸达氟沙星,CP 76136-27

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Chebulinic acid

Cat.No: TQ0184

Target: ATPase, Proton pump, DNA/RNA Synthesis, Antibacterial, TGF-beta/Smad

Novobiocin Sodium

Cat.No: T0974

Synonym: Albamycinsodium,新生霉素钠,Cathomycin,Albamycin

Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy

Cat.No: T10838

Target: Antibacterial

Cat.No: T36303

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00610	gyrA Protein, E. coli, Recombinant (His) DNA gyrase subunit A,gyrA	E. coli	E. coli
	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli. Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Relaxes negatively supercoiled DNA in an ATP-independent manner. E.coli gyrase has hig...
TMPH-03470	GyrB Protein, Salmonella typhi, Recombinant (His & Myc) gyrB,DNA gyrase subunit B	Salmonella typhi	E. coli
	GyrB Protein, Salmonella typhi, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 51.8 kDa and the accession number is P0A2I4.

重组蛋白

gyrA Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00610

Species: E. coli

Expression System: E. coli

GyrB Protein, Salmonella typhi, Recombinant (His & Myc)

Cat.No: TMPH-03470

Species: Salmonella typhi

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0154	Ciprofloxacin-d8
	Ciprofloxacin-d8 是 Ciprofloxacin 的氘代化合物。Ciprofloxacin 的 CAS 号为 85721-33-1。Ciprofloxacin是一种有高抗菌活性的氟喹诺酮类抗生素。
TMID-0194	Ofloxacin-d8
	Ofloxacin-d8 是 Ofloxacin 的氘代化合物。Ofloxacin 的 CAS 号为 82419-36-1。Ofloxacin是可抑制细菌DNA旋转酶的一种氟喹诺酮类抗生素。
T71984	Enrofloxacin-d5
	Enrofloxacin-d5 is intended for use as an internal standard for the quantification of enrofloxacin by GC- or LC-MS. Enrofloxacin is a fluoroquinolone antibiotic. It is active against panels of Campylobacter, E. coli, and Salmonella isolates (mean MIC50s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates of L. intracellularis (MICs = 0.125-0.5 µg/ml). Enrofloxacin inhibits bacterial DNA gyrase. In vivo, enrofloxacin (10 mg/kg) increases survival in a mouse model...
T36021	Flumequine-13C3 Flumequine-13C3
	Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl...

同位素标记化合物

Ciprofloxacin-d8

Cat.No: TMIH-0154

Cat.No: TMID-0194

Enrofloxacin-d5

Cat.No: T71984

Flumequine-13C3

Cat.No: T36021

Synonym: Flumequine-13C3

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