首页工具

登录

搜索结果

Search Results for " dna double-strand "

Targets Recommended: Others

34

抑制剂 & 化合物

3

天然产物

20

重组蛋白

1

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T12019	Methylproamine	Others	Others
	Methylproamine是一种与DNA结合的辐射保护剂，可以修复辐射诱导的短暂活性氧。
T9168	NSC 617145 NSC617145,NSC-617145	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NSC 617145 (NSC617145) 是一种 WRN 解旋酶抑制剂，IC50值为 230 nM。它以浓度依赖性方式抑制 WRN 解旋酶的 ATP 酶，并诱导双链断裂和染色体异常。
T24925	UNC-2170 UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate	Others	Others
	UNC-2170 (UNC2170 Maleate) 是53BP1(IC50=29 µM;Kd=22 µM) 选择性的、功能活性的片段状配体，对 53BP1 的选择性比其他九种甲基赖氨酸读取器蛋白质高出至少17倍。53BP1 是 Kme 结合蛋白，在 DNA 损伤修复途径中起核心作用，并被招募到双链断裂位点。
T14858	Calicheamicin Calicheamicin γ1,卡奇霉素	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Calicheamicin (Calicheamicin γ1) 是肿瘤抗生素，可引起DNA 双链断裂，抑制DNA 合成。
T11600	IBR2 Isoquinoline	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	IBR2（Isoquinoline）是一种针对RAD51的强效特异性抑制剂，通过干预RAD51多聚体形成，加速蛋白酶体介导的RAD51蛋白降解，抑制癌细胞生长并诱导凋亡。实验证明在抑制RAD51介导的DNA双链断裂修复方面有效。
T84810	Cu(II)-Elesclomol	Others	Others
	Cu(II)-Elesclomol为Elesclomol的Cu2+络合物。该化合物可诱导K562细胞凋亡并引起G1期细胞周期阻滞，同时诱发DNA双链断裂。此外，Cu(II)-Elesclomol对DNA拓扑异构酶I有轻微的抑制作用。因其上述作用，Cu(II)-Elesclomol展现出抗癌活性。
T9760	IC 86621	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	IC 86621 是一种选择性和可逆的 ATP 竞争性 DNA-PK 抑制剂，IC50 为 120 nM。 IC 86621 增加 DNA 双链断裂 (DSB) 诱导的抗肿瘤活性，其 EC50 为 68 µM，用于 DNA-PK 介导的细胞 DSB 修复。
T63228	Simmiparib SMOCL-9112	Apoptosis; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Simmiparib (SMOCL-9112) 是一种新型有效的 PARP1 和 PARP2 抑制剂，是一种Olaparib 衍生物。Simmiparib 在同源重组修复 (HR) 缺陷细胞中诱导 DNA 双链断裂 (DSB) 和细胞周期阻滞，从而促使细胞凋亡 (apoptosis)。Simmiparib 可用于研究帕金森病、阿尔茨海默病、乳腺癌和黑色素瘤。
T3157	COH29 RNR Inhibitor COH29	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑，是人类核糖核苷酸还原酶 (RNR) 的抑制剂，具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。
T21303	Etoposide Phosphate Eposin Etopophos Vepesid VP16,磷酸依托泊苷	Others	Others
	Etoposide phosphate is a phosphate salt of Etoposide, which binds to the enzyme topoisomerase II, then induces double-strand DNA breaks and inhibits DNA repair, leading to decreased DNA synthesis and tumor cell proliferation.
T68985	Amonafide L-malate	Others	Others
	Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis.
T16283	Neocarzinostatin	5-HT Receptor	GPCR/G Protein; Neuroscience
	Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potential for EpCAM-positive cancer treatment.
T19149	5-BrdUTP sodium salt 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt	Others	Others
	5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks.
T76109	Nuclease S1	Others	Others
	Nuclease S1 是一种特异性的核酸内切酶，可降解单链 DNA (ssDNA) 和 RNA。Nuclease S1 还可以去除双链 DNA 中突出的单链末端。
T68671	Amsacrine Isothionate	Others	Others
	Amsacrine Isothionate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death.
T23654	Afeletecan free base BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan	Others	Others
	Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps are inhibited and subsequent collis
TD0003L	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO
	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO is a fluorescent dye with a unique involvement that binds to all dsDNA double helix sulcus regions.In the free state, the side strand and CelGreen emit weak fluorescence, but the fluorescence is greatly enhanced once they are combined with the double-stranded DNA. Therefore, the fluorescence signal strength of CelGreen is related to the amount of double-stranded DNA, and the amount of double-stranded DNA in the PCR system can be detec...
T78747	DiPT-4	Topoisomerase	DNA Damage/DNA Repair
	DiPT-4为一种TOP1/PARP1双重抑制剂，可引发癌细胞大量DNA双链断裂(DSB)、细胞周期阻滞及凋亡。DiPT-4具有研究癌症耐药性克服潜力。
T68673	Amsacrine gluconate	Others	Others
	Amsacrine gluconate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death.
T68672	Amsacrine lactate	Others	Others
	Amsacrine lactate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death.
T60621	PFM03	Others	Others
	PFM03 是MRE11 核酸内切酶抑制剂，可通过非同源末端连接 (NHEJ) 调节 DNA 双链断裂修复 (DSBR) [1]。
T69862	Afeletecan HCl	Others	Others
	Afeletecan, also known as BAY 56-3722, is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA repli...
T61664	Benzoquinoquinoxaline	Others	Others
	Benzoquinoquinoxaline (BQQ) is a heterocyclic compound featuring an aminoalkyl side chain. BQQ exhibits preferential binding to DNA triplex structures, intercalating between the bases to stabilize the triplex conformation. Additionally, conjugation of BQQ to 1,10-phenanthroline enables specific binding and cleavage of double-strand DNA at the site where a triplex structure forms [1].
T79330	PARP-1-IN-13	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP-1-IN-13 (Compound 19c) 为一种高效PARP-1抑制剂，其IC50值为26 nM。该化合物能够抑制DNA单链断裂修复并增强DNA双链断裂效应。此外，PARP-1-IN-13通过激活线粒体凋亡(apoptosis)途径来促进癌细胞死亡。
T68870	SU-11752	Others	Others
	SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.
T79925	T4 UvsX Recombinase	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	T4 UvsX Recombinase 促进双链DNA模板上DNA复制的启动，通过催化模板DNA与同源单链DNA引物间的突触形成。此酶显著增强了T4 DNA聚合酶全酶在线性单链DNA模板上进行的回跳（发夹引物）DNA合成反应。
TD0003	CelGreen nucleic acid gel stain (10,000×, water)	Others	Others
	CelGreen 是一种具有独特参与性的荧光染料，可与所有 dsDNA 双螺旋沟区域结合。在游离状态下，侧链和 CelGreen 发出微弱的荧光，但一旦与双链DNA 结合，荧光就会大大增强。因此，CelGreen 的荧光信号强度与双链DNA 的量有关，可以根据荧光信号检测PCR 系统中双链DNA 的量。
T78581	Selenocystine	Others	Others
	Selenocystine为一种广谱抗癌剂，能诱导HepG2细胞发生DNA损伤，尤其是 DNA 双链断裂(DSBs)。Selenocystine在靶向DNA修复领域，作为癌症治疗的潜在治疗或辅助剂，展现出显著的应用前景。
T85298	T2AA hydrochloride T2-amino Alcohol	Others	Others
	T2AA, a proliferating cell nuclear antigen (PCNA) inhibitor, disrupts protein-protein interactions between PCNA and both a PIP-box-containing peptide (IC50= 1 μM) and full-length p21, reducing cellular colocalization of PCNA with DNA polymerase δ. This compound effectively inhibits DNA replication and cell proliferation in U2OS and HeLa cells in a concentration-dependent manner, additionally inducing S phase cell cycle arrest at a 20 μM concentration. Furthermore, T2AA enhances DNA double strand...
T73023	PARP1-IN-12	Others	Others
	PARP1-IN-12 是一种有效的PARP1抑制剂，其IC50值为 2.99 nM。PARP1-IN-12 具有较好的抗癌细胞增殖活性，可诱导细胞凋亡并使细胞周期停滞在 G2/M 期。PARP1-IN-12 能在BRCA 缺陷的细胞中诱导 DNA 双链断裂 (DSBs)。
T80899	UNC3474	Others	Others
	UNC3474为小分子配体，与53BP1相结合。该化合物针对53BP1TT的芳香族甲基赖氨酸结合笼展现出1.0 ± 0.3μM的解离常数（Kd）。UNC3474抑制53BP1募集至DSB，其机制为稳定细胞内预存的53BP1自抑制状态。
T61017	Topoisomerase II inhibitor 6	Others	Others
	Topoisomerase II inhibitor 6 (Compound 5) 是色胺酮的衍生物。它是一种有效的拓扑异构酶的选择性抑制剂。Topoisomerase II inhibitor 6 在 G2 期阻断 CCRF-CEM 的细胞周期并诱导 DNA 双链断裂。Topoisomerase II inhibitor 6 对不同的肿瘤细胞系具有抗增殖活性，在癌症疾病研究中具有潜力。
T61369	p53 Activator 2	Others	Others
	p53 Activator 2 (compound 10ah) 插入DNA，导致显著的DNA双链断裂。该化合物通过增加p53、p-p53、CDK4、p21的表达，使细胞周期在G2/M期停滞，诱导细胞凋亡，并显著降低抗凋亡蛋白Bcl-2、Bcl-xL和cyclin B1的水平。此外，p53 Activator 2表现出对MGC-803细胞的抗增殖效果，其IC50为1.73 μM，且在MGC-803异种移植肿瘤模型中展示出有效的抗癌活性。
T79405	PARP1-IN-15	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-15（Compound 6）是一款针对PARP1的抑制剂，能够抑制坦聚合酶(TNKS)并促进DNA双链断裂损伤。该化合物在诱导肿瘤细胞凋亡(apoptosis)方面具有显著作用，且在三阴性乳腺癌(TNBC)细胞及来源于TNBC患者的类器官中显示出抗癌活性，适用于探究BRCA1突变状态下的TNBC研究。

化合物

Cat.No: T12019

Target: Others

Cat.No: T9168

Synonym: NSC617145,NSC-617145

Target: DNA/RNA Synthesis

Cat.No: T24925

Synonym: UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate

Target: Others

Cat.No: T14858

Synonym: Calicheamicin γ1,卡奇霉素

Target: Others, ADC Cytotoxin

Cat.No: T11600

Synonym: Isoquinoline

Target: DNA/RNA Synthesis

Cu(II)-Elesclomol

Cat.No: T84810

Target: Others

Cat.No: T9760

Target: DNA-PK

Cat.No: T63228

Synonym: SMOCL-9112

Target: Apoptosis, PARP

Cat.No: T3157

Synonym: RNR Inhibitor COH29

Target: DNA/RNA Synthesis

Etoposide Phosphate

Cat.No: T21303

Synonym: Eposin Etopophos Vepesid VP16,磷酸依托泊苷

Target: Others

Amonafide L-malate

Cat.No: T68985

Target: Others

Neocarzinostatin

Cat.No: T16283

Target: 5-HT Receptor

5-BrdUTP sodium salt

Cat.No: T19149

Synonym: 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt

Target: Others

Cat.No: T76109

Target: Others

Amsacrine Isothionate

Cat.No: T68671

Target: Others

Afeletecan free base

Cat.No: T23654

Synonym: BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan

Target: Others

CelGreen nucleic acid gel stain *10,000× concentrate in DMSO*

Cat.No: TD0003L

Cat.No: T78747

Target: Topoisomerase

Amsacrine gluconate

Cat.No: T68673

Target: Others

Amsacrine lactate

Cat.No: T68672

Target: Others

Cat.No: T60621

Target: Others

Cat.No: T69862

Target: Others

Benzoquinoquinoxaline

Cat.No: T61664

Target: Others

Cat.No: T79330

Target: PARP

Cat.No: T68870

Target: Others

T4 UvsX Recombinase

Cat.No: T79925

Target: DNA/RNA Synthesis

CelGreen nucleic acid gel stain (10,000×, water)

Cat.No: TD0003

Target: Others

Cat.No: T78581

Target: Others

T2AA hydrochloride

Cat.No: T85298

Synonym: T2-amino Alcohol

Target: Others

Cat.No: T73023

Target: Others

Cat.No: T80899

Target: Others

Topoisomerase II inhibitor 6

Cat.No: T61017

Target: Others

p53 Activator 2

Cat.No: T61369

Target: Others

Cat.No: T79405

Target: PARP

Cat. No.	Product Name	Target	Signaling Pathways
TN1637	Eurycomalactone	Anti-infection; NF-κB	Microbiology/Virology; NF-κB
	Eurycomalactone 是一种NF-κB 抑制剂，IC50=0.5 μM，是一种天然产物。它可抑制蛋白合成，降低 cyclin D1 蛋白水平，但对 TNFα 诱导的 IκBα 降解或 IKKα/β 和 IκBα 的磷酸化水平没有作用。
T6228	Irinotecan CPT-11,Topotecin,伊立替康,(+)-Irinotecan	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan (CPT-11) 是喜树碱的衍生物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂。Irinotecan 通过与 Topo I 复合物结合来阻止 DNA 链的重新连接，并导致双链 DNA 断裂和细胞死亡，具有抗肿瘤活性。
T35770	Cylindrospermopsin	Others	Others
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &...

天然产物

Eurycomalactone

Cat.No: TN1637

Target: Anti-infection, NF-κB

Cat.No: T6228

Synonym: CPT-11,Topotecin,伊立替康,(+)-Irinotecan

Target: Topoisomerase, Autophagy

Cylindrospermopsin

Cat.No: T35770

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc) ATP-dependent DNA helicase 2 subunit 2,XRCC5,Ku86,N...	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP) Nuclear factor IV,Lupus Ku autoantigen protein p86,ATP-depen...	Human	Baculovirus Insect Cells
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...
TMPH-03440	RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) RAD52,DNA repair and recombination protein RAD52	Saccharomyces cerevisiae	E. coli
	Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.1 kDa and the accession number is P06778.
TMPH-01244	POLM Protein, Human, Recombinant (His) DNA-directed DNA/RNA polymerase mu,Termina...	Human	E. coli
	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.8 kDa and the accession number is Q9NP87.
TMPH-00531	SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO) Single-stranded DNA-binding protein,Gene p...	Enterobacteria phage T7	E. coli
	Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions ...
TMPH-00039	Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc) Single-strand DNA-binding protein,63.5 kDa...	Agrobacterium fabrum	E. coli
	Involved in DNA transformation; mediates the nuclear uptake of single-stranded DNA copies of the transferred DNA (T-DNA) element. Binds single-stranded but not double-stranded DNA regardless of nucleotide sequence composition. Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 70.3 kDa and the accession number is P08062.
TMPH-01238	POLQ Protein, Human, Recombinant (His) DNA polymerase eta,POLQ,DNA polymerase the...	Human	Baculovirus Insect Cells
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...
TMPJ-00918	HMGB2 Protein, Human, Recombinant (His) High Mobility Group Protein B2,HMG2,High Mobility Group Prot...	Human	HEK293 Cells
	High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cells. HMGB2 contains 2 HMG box DNA-binding domains. It is associated with chromatin and has the ability to bend DNA, preferentially single-stranded DNA. It is shown that HMGB2 is able to efficiently bend DNA and form DNA circles. In addition, HMGB2 is involved in the final ligation ...
TMPH-01245	POLM Protein, Human, Recombinant (His & Myc) DNA-directed DNA/RNA polymerase mu,POLM,Te...	Human	Baculovirus Insect Cells
	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 58.8 kDa and the accession number is Q9NP87.
TMPH-00532	SSB Protein, Enterobacteria phage T7, Recombinant Gene product 2.5,Single-stranded DNA-bindi...	Enterobacteria phage T7	P. pastoris (Yeast)
	Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions ...
TMPH-01431	HELQ Protein, Human, Recombinant (His & Myc) Mus308-like helicase,POLQ-like helicase,HELQ,Helicase POLQ-l...	Human	E. coli
	Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links. HELQ Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 4...
TMPH-01237	POLQ Protein, Human, Recombinant (E. coli, His) DNA polymerase eta,POLQ,DNA polymerase the...	Human	E. coli
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...
TMPH-02681	GPX7 Protein, Mouse, Recombinant (His & Myc) Glutathione peroxidase 7,Gpx7	Mouse	E. coli
	It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. GPX7 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.7 kDa and the accession number is Q99LJ6.
TMPH-00533	T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc) T7 RNA polymerase,DNA-directed RNA polymerase	Escherichia phage T7	E. coli
	Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short transcripts are synthesized and released before proceeding to the processive transcription of long RNA chains. Unwinds the double-stranded DNA to expose the coding strand for templating. Participates in the initiation of viral DNA replication presumably by making primers accessible...
TMPH-01621	BRCC3 Protein, Human, Recombinant (His & SUMO) BRCC36,CXorf53,C6.1A,BRCC3,BRCA1/BRCA2-containing complex su...	Human	E. coli
	Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, anta...
TMPH-02649	FAN1 Protein, Mouse, Recombinant (His & Myc) Fanconi-associated nuclease 1,Myotubularin-related protein 1...	Mouse	E. coli
	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to e...
TMPY-02421	PARP3 Protein, Human, Recombinant (His & GST) ARTD3,IRT1,ADPRTL2,ADPRTL3,poly (ADP-ribose) polymerase fami...	Human	Baculovirus Insect Cells
	Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular response to DNA double-strand breaks (DSBs), plays an essential role in the maintenance of genome integrity. The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation...
TMPH-00610	gyrA Protein, E. coli, Recombinant (His) DNA gyrase subunit A,gyrA	E. coli	E. coli
	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli. Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Relaxes negatively supercoiled DNA in an ATP-independent manner. E.coli gyrase has hig...
TMPH-01239	XPC Protein, Human, Recombinant (His) Xeroderma pigmentosum group C-complementing protein,p125,XPC...	Human	E. coli
	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein i...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc) RING finger protein 8,RNF8,E3 ubiquitin-protein ligase RNF8,...	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...

重组蛋白

XRCC5 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02315

Species: Human

Expression System: E. coli

XRCC5 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPH-02314

Species: Human

Expression System: Baculovirus Insect Cells

RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO)

Cat.No: TMPH-03440

Species: Saccharomyces cerevisiae

Expression System: E. coli

POLM Protein, Human, Recombinant (His)

Cat.No: TMPH-01244

Species: Human

Expression System: E. coli

SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO)

Cat.No: TMPH-00531

Species: Enterobacteria phage T7

Expression System: E. coli

Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc)

Cat.No: TMPH-00039

Species: Agrobacterium fabrum

Expression System: E. coli

POLQ Protein, Human, Recombinant (His)

Cat.No: TMPH-01238

Species: Human

Expression System: Baculovirus Insect Cells

HMGB2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00918

Species: Human

Expression System: HEK293 Cells

POLM Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01245

Species: Human

Expression System: Baculovirus Insect Cells

SSB Protein, Enterobacteria phage T7, Recombinant

Cat.No: TMPH-00532

Species: Enterobacteria phage T7

Expression System: P. pastoris (Yeast)

HELQ Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01431

Species: Human

Expression System: E. coli

POLQ Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01237

Species: Human

Expression System: E. coli

GPX7 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02681

Species: Mouse

Expression System: E. coli

T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)

Cat.No: TMPH-00533

Species: Escherichia phage T7

Expression System: E. coli

BRCC3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01621

Species: Human

Expression System: E. coli

FAN1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02649

Species: Mouse

Expression System: E. coli

PARP3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02421

Species: Human

Expression System: Baculovirus Insect Cells

gyrA Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00610

Species: E. coli

Expression System: E. coli

XPC Protein, Human, Recombinant (His)

Cat.No: TMPH-01239

Species: Human

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11067	VX-984 M9831	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用，可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。

同位素标记化合物

Cat.No: T11067

Synonym: M9831

Target: DNA-PK

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼