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Search Results for " dhea "

Targets Recommended: Others

7

抑制剂 & 化合物

4

天然产物

4

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T36921	16α-Hydroxyetiocholanolone	Others	Others
	16α-Hydroxyetiocholanolone is a metabolite of 16α-hydroxydehydroisoandrosterone (16α-DHEA) and androstenedione.1,2 1.Lai, E.Y., and Solomon, S.The in vivo metabolism of 16ɑ-hydroxydehydroisoandrosterone in manBiochemistry6(7)2040-2052(1967) 2.Christakoudi, S., Cowan, D.A., Christakudis, G., et al.21-hydroxylase deficiency in the neonate - trends in steroid anabolism and catabolism during the first weeks of lifeJ. Steroid Biochem. Mol. Biol.138334-347(2013)
T2195L	Epiandrosterone Sulfate Epiandrosterone 16-bromo,Epiandrosterone	Others	Others
	Epiandrosterone sulfate is a steroid hormone with weak androgenic activity. Epiandrosterone is naturally produced by the enzyme 5α-reductase of the adrenal hormone DHEA.
T38028	(R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide	Others	Others
	N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Docosahexaenoyl ethanolamide (DHEA) has potential signaling roles in cancer, inflammation, and neurological development and functioning. At least some of DHEA's effects are mediated through cannabinoid (CB) receptors, while some NAEs also act as vanilloid receptor agonists and voltage-gated K+ channel blockers. (R)-(+)-Docosahexaenyl-1'-hydroxy-2'-propylamide is a homolog of DHEA,...
T73779	5β-Androstan-3β-ol-17-one	Others	Others
	5β-Androstan-3β-ol-17-one（3β-Etiocholanolone；5β-Epiandrosterone），为5β还原型类固醇，主要是脱氢表雄酮（DHEA）的关键代谢物之一。在C57BL/KsJ基因型糖尿病（db/db）小鼠中，该化合物显示出显著的降糖效果，并且具有对神经元的抑制活性。
T84943	5-Androstenetriol Δ5-AT	Others	Others
	5-Androstenetriol, a steroid and active metabolite of dehydroepiandrosterone (DHEA), demonstrates significant therapeutic effects. Administered at 0.75 mg/25 g body weight, it mitigates radiation-induced mortality and facilitates hematopoietic recovery from surviving stem cells in mice. Moreover, a dosage of 40 mg/kg enhances survival rates in rats subjected to surgical trauma-induced sepsis. Additionally, elevated urinary levels of 5-androstenetriol are observed in women suffering from androgen...
T72213	Efonidipine hydrochloride NZ-105 hydrochloride	Others	Others
	Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。
T36920	16α-hydroxy Dehydroepiandrosterone	Others	Others
	16α-hydroxy Dehydroepiandrosterone is a metabolite of the endogenous steroid hormone dehydroepiandrosterone .116α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosteronevia16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol .2 1.Miller, K.K.M., Cai, J., Ripp, S.L., et al.Stereo- and regioselectivity account for the diversity of dehydro...

化合物

16α-Hydroxyetiocholanolone

Cat.No: T36921

Target: Others

Epiandrosterone Sulfate

Cat.No: T2195L

Synonym: Epiandrosterone 16-bromo,Epiandrosterone

Target: Others

(R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide

Cat.No: T38028

Target: Others

5β-Androstan-3β-ol-17-one

Cat.No: T73779

Target: Others

5-Androstenetriol

Cat.No: T84943

Synonym: Δ5-AT

Target: Others

Efonidipine hydrochloride

Cat.No: T72213

Synonym: NZ-105 hydrochloride

Target: Others

16α-hydroxy Dehydroepiandrosterone

Cat.No: T36920

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T26366	Dehydroepiandrosterone sulfate PB 005,PB005,Prasterone sulfate,DHEA sulfate,DHEAS,PB-005	Others	Others
	Dehydroepiandrosterone sulfate (PB-005) 影响神经元的迁移、树突的分枝和新突触的形成。
T0856	Dehydroisoandrosterone 3-acetate Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,醋酸去氢表雄酮,androstenolone acetate	Androgen Receptor	Endocrinology/Hormones
	Dehydroisoandrosterone 3-acetate (Prasterone acetate) 是一种雄性激素/雌性激素的前体物质，是一种由肾上腺皮质产生的主要 C19 类固醇，能够调节脊椎动物的攻击性行为。
TN7319	7-keto Dehydroepiandrosterone Acetate 7-keto DHEA Acetate	Others	Others

TN7320	7-keto Dehydroepiandrosterone 7-keto DHEA	Others	Others

天然产物

Dehydroepiandrosterone sulfate

Cat.No: T26366

Synonym: PB 005,PB005,Prasterone sulfate,DHEA sulfate,DHEAS,PB-005

Target: Others

Dehydroisoandrosterone 3-acetate

Cat.No: T0856

Synonym: Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,醋酸去氢表雄酮,androstenolone acetate

Target: Androgen Receptor

7-keto Dehydroepiandrosterone Acetate

Cat.No: TN7319

Synonym: 7-keto DHEA Acetate

Target: Others

7-keto Dehydroepiandrosterone

Cat.No: TN7320

Synonym: 7-keto DHEA

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01587	SULT2A1 Protein, Human, Recombinant (His) hSTa,HST,ST2,ST2A1,STD,DHEAS,ST2A3,sulfotransferase...	Human	E. coli
	Hydroxysteroid sulfotransferase ( SULT2A1 ) is a key enzyme in the testicular and hepatic metabolism of 5alpha-androstenone, which is a major component of the off-odor and off-flavor in pork known as boar taint. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar amon...
TMPH-02139	CYP17A1 Protein, Human, Recombinant (GST) Cytochrome P450 17A1,CYPXVII,CYP17A1,CYP17,S17AH,Cytochrome ...	Human	E. coli
	A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, follow...
TMPH-01303	HSD17B11 Protein, Human, Recombinant (His & Myc) Estradiol 17-beta-dehydrogenase 11,HSD17B11,Retinal short-ch...	Human	E. coli
	Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. HSD17B11 Prot...
TMPY-01616	SULT2B1 Protein, Human, Recombinant (His) SULT2B1,sulfotransferase family 2B member 1,HSST2	Human	E. coli
	Sulfotransferase family cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2, is a cytoplasm protein that belongs to the sulfotransferase 1 family. The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies, SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta, prostate and trachea. A lesser expression of SULT1B1 was observed in the small intestine and lung. SULT2B1 ca...

重组蛋白

SULT2A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01587

Species: Human

Expression System: E. coli

CYP17A1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02139

Species: Human

Expression System: E. coli

HSD17B11 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01303

Species: Human

Expression System: E. coli

SULT2B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01616

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0115	Dehydroepiandrosterone-2,2,3,4,4,6-d6 DHEA-d6
	Dehydroepiandrosterone-2,2,3,4,4,6-d6 是 Dehydroepiandrosterone 的氘代化合物。Dehydroepiandrosterone 的 CAS 号为 53-43-0。Dehydroepiandrosterone 是一种类固醇激素。它通过多种信号传导途径介导其作用，并通过转化成雄激素和雌激素衍生物（例如，雄激素，雌激素，7α和7β DHEA (Prasterone)，以及7α和7β表雄甾酮衍生物）在特异性受体上起作用。
TMID-0147	17a-Hydroxypregnenolone-d3
	17a-Hydroxypregnenolone-d3 是 17a-Hydroxypregnenolone 的氘代化合物。17a-Hydroxypregnenolone 的 CAS 号为 387-79-1。17a-Hydroxypregnenolone 是一种孕烷类固醇, 是形成脱氢表雄酮的激素原。17a-Hydroxypregnenolone 是一种神经调节剂。

同位素标记化合物

Dehydroepiandrosterone-2,2,3,4,4,6-d6

Cat.No: TMID-0115

Synonym: DHEA-d6

17a-Hydroxypregnenolone-d3

Cat.No: TMID-0147

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