Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9707 |
DB2313
Carboximidamide |
Apoptosis | Apoptosis |
DB2313 (Carboximidamide) 是一种有效的转录因子 PU.1 抑制剂,IC50 为 14 nM。DB2313 破坏了 PU.1 与靶基因启动子的相互作用。DB2313 可诱导急性髓细胞性白血病 (AML) 细胞凋亡 (apoptosis),并具有抗癌作用。 | |||
T69841 |
GC813 sodium
|
Others | Others |
GC813 is a potent and permeable inhibitor of MERS coronavirus 3CL protease. GC813 is analogue of GC376. | |||
T69842 |
DB2313 HCl
|
Others | Others |
DB2313 is a first-in-class potent small-molecule inhibitor of PU.1. DB2313 disrupts the interaction of PU.1 with target gene promoters and leads to down-regulation of canonical PU.1 transcriptional targets. |