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Search Results for " daf "

Targets Recommended: Others

21

抑制剂 & 化合物

3

天然产物

6

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T18966	DAF-2DA DAF2DA,DAF 2DA,5,6-Diaminofluorescein diacetat	Others	Others
	DAF 2DA is widely used as a probe for NO measurement.
T18965	DAF-FM DA Diaminofluorescein-FM diacetate	Others	Others
	DAF-FM DA (Diaminofluorescein-FM diacetate) 是一种用于检测一氧化氮 (NO)和活性氮（RNS）水平的活性染料，可用于生物成像 (Ex/Em=495/515 nm)。
T10953	Dafadine-A	P450	Metabolism
	Dafadine-A 是dafadine 的类似物，是C. elegans DAF-9 细胞色素P450抑制剂，同时对哺乳动物的CYP27A1具有抑制作用。
T4986	Imidafenacin 咪达那新,KRP-197,ONO-8025	AChR	Neuroscience
	Imidafenacin (KRP-197) 是一种有效的和选择性的 M3受体抑制剂，Kb 值为0.317nM。
T3726	Erdafitinib 厄达替尼,JNJ-42756493	Apoptosis; FGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Erdafitinib (JNJ-42756493) 是一种广谱的 FGFR 抑制剂，可以抑制 FGFR1/2/3/4 (IC50=1.2/2.5/3.0/5.7 nM)。Erdafitinib 具有抗肿瘤活性，可以诱导细胞凋亡。
T27808	Lefradafiban BIBU 104,BIBU104,BIBU-104	Others	Others
	Lefradafiban（BIBU-104）是一种口服血小板糖蛋白 IIb/IIIa 受体拮抗剂，可用于研究心绞痛和急性冠状动脉综合症。
T67787	Adafosbuvir PM AL-335 PM	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Adafosbuvir PM (AL-335 PM) 是一种具有抗病毒活性的化合物。
T6334	Ridaforolimus AP23573,Deforolimus,MK-8669	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物，具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。
T4262	BisfluoroModafinil	Dopamine Receptor	GPCR/G Protein; Neuroscience
	BisfluoroModafinil 是一种莫达非的常见替代品，具有增强认知能力的潜力。其中莫达非尼通常用于研究性嗜睡症。
T26370	(25S)-delta7-Dafachronic acid	Others	Others
	(25S)-delta7-Dafachronic acid, an orphan nuclear receptor DAF-12 ligand, inhibits the dauer-promoting activity of DAF-12.
T11322	Fradafiban BIBU-52	Others	Others
	Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.
T80597	Dafsolimab SPV-T3a
	Dafsolimab (SPV-T3a)为IgG2a型小鼠单克隆抗体，主要针对CD3。通过调节及激活CD3/T细胞受体复合物，Dafsolimab能够诱导细胞凋亡，常用于移植物抗宿主病（GVHD）的研究领域。
T29638	Adafenoxate Adafenoxato	Others	Others
	Adafenoxate is an intelligent compound related to centrophenoxine.
T36662	Imidafenacin Metabolite M4 Imidafenacin Metabolite M4	Others	Others
	Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. 1.Kanayama, N., Kanari, C., Masuda, Y., et al.Drug-drug interactions in the metabolism of imidafenacin: Role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymesXenobiotica37(2)139-154(2007)
T26560	Adafosbuvir	Others	Others
	Adafosbuvir has antiviral activity.
T73638	Fradafiban hydrochloride	Others	Others
	Fradafiban (BIBU-52) hydrochloride 是一种非肽血小板糖蛋白 IIb/IIIa 复合体拮抗剂，其与人血小板 GP IIb/IIIa 复合体结合，Kd 值为 148 nM。
T78297	Aldafermin NGM282
	Aldafermin (NGM282)，一种成纤维细胞生长因子19的类似物，主要用于非酒精性脂肪性肝炎（NASH）的研究。
T63818	Omesdafexor	Others	Others
	Omesdafexor 是 FXR 激动剂，能够用于研究肝病或代谢性炎症引起的疾病。
T20806	Pyridafenthion	Others	Others
	Pyridafenthion is an agricultural chemical which is suitable for rice.
T31190	Dafphedyn	Others	Others
	Dafphedyn, [D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN) is an effective analog of strong endorphin 1-13 and produces diuretic and deep analgesia when administered intravenously in rats.
T85140	27-hydroxy Cholestenone	Others	Others
	27-Hydroxy Cholestenone, an oxysterol, exhibits elevated levels in Cyp46a-/- mouse brain. It serves as an intermediate in synthesizing dafachronic acid ligands, targeting the DAF-12 nuclear hormone receptor.

化合物

Cat.No: T18966

Synonym: DAF2DA,DAF 2DA,5,6-Diaminofluorescein diacetat

Target: Others

Cat.No: T18965

Synonym: Diaminofluorescein-FM diacetate

Target: Others

Cat.No: T10953

Target: P450

Cat.No: T4986

Synonym: 咪达那新,KRP-197,ONO-8025

Target: AChR

Cat.No: T3726

Synonym: 厄达替尼,JNJ-42756493

Target: Apoptosis, FGFR

Cat.No: T27808

Synonym: BIBU 104,BIBU104,BIBU-104

Target: Others

Cat.No: T67787

Synonym: AL-335 PM

Target: HCV Protease

Cat.No: T6334

Synonym: AP23573,Deforolimus,MK-8669

Target: mTOR, Autophagy

BisfluoroModafinil

Cat.No: T4262

Target: Dopamine Receptor

(25S)-delta7-Dafachronic acid

Cat.No: T26370

Target: Others

Cat.No: T11322

Synonym: BIBU-52

Target: Others

Cat.No: T80597

Synonym: SPV-T3a

Cat.No: T29638

Synonym: Adafenoxato

Target: Others

Imidafenacin Metabolite M4

Cat.No: T36662

Synonym: Imidafenacin Metabolite M4

Target: Others

Cat.No: T26560

Target: Others

Fradafiban hydrochloride

Cat.No: T73638

Target: Others

Cat.No: T78297

Synonym: NGM282

Cat.No: T63818

Target: Others

Cat.No: T20806

Target: Others

Cat.No: T31190

Target: Others

27-hydroxy Cholestenone

Cat.No: T85140

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1072	Lappaol A	P-gp; JNK	MAPK; Membrane transporter/Ion channel; Neuroscience
	Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an
TN4410	Lappaol C	P-gp; JNK	MAPK; Membrane transporter/Ion channel; Neuroscience
	Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an
TN4411	Lappaol F	CDK; P-gp; JNK	Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience
	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju

天然产物

Cat.No: TN1072

Target: P-gp, JNK

Cat.No: TN4410

Target: P-gp, JNK

Cat.No: TN4411

Target: CDK, P-gp, JNK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06679	CD55/DAF Protein, Mouse, Recombinant (hFc) Daf,CD55 molecule, decay accelerating factor for co...	Mouse	HEK293 Cells
	CD55/DAF Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.48 kDa and the accession number is Q61475.
TMPY-02616	CD55/DAF Protein, Mouse, Recombinant (His) GPI-DAF,Daf-GPI,Daf,Daf1...	Mouse	HEK293 Cells
	CD55/DAF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is Q61475.
TMPK-00550	CD55/DAF Protein, Cynomolgus, Recombinant (His) TC,DAF-GPI,CR,CROM,Daf1,CD55,Cd55a,DAF...	Cynomolgus	HEK293 Cells
	Decay Accelerating Factor (or CD55) is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection.
TMPY-01292	CD55/DAF Protein, Human, Recombinant (His) CD55 molecule, decay accelerating factor for complement (Cro...	Human	HEK293 Cells
	CD55/DAF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P08174-1.
TMPY-00713	CD55/DAF Protein, Human, Recombinant (hFc) CR,CD55 molecule, decay accelerating factor for complement (...	Human	HEK293 Cells
	CD55/DAF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.7 kDa and the accession number is P08174-1.
TMPY-03004	CD55/DAF Protein, Rat, Recombinant (hFc) CD55 molecule, decay accelerating factor for complement (Cro...	Rat	HEK293 Cells
	CD55/DAF Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.5 kDa and the accession number is Q9Z0M0.

重组蛋白

CD55/DAF Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-06679

Species: Mouse

Expression System: HEK293 Cells

CD55/DAF Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02616

Species: Mouse

Expression System: HEK293 Cells

CD55/DAF Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00550

Species: Cynomolgus

Expression System: HEK293 Cells

CD55/DAF Protein, Human, Recombinant (His)

Cat.No: TMPY-01292

Species: Human

Expression System: HEK293 Cells

CD55/DAF Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00713

Species: Human

Expression System: HEK293 Cells

CD55/DAF Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03004

Species: Rat

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0353	Modafinil-d5
	Modafinil-d5 是 Modafinil 的氘代化合物。Modafinil 的 CAS 号为 68693-11-8。
TMIJ-0336	Imidafenacin-d10
	Imidafenacin-d10 是 Imidafenacin 的氘代化合物。Imidafenacin 的 CAS 号为 170105-16-5。Imidafenacin 是一种有效的和选择性的M3受体抑制剂，Kb值为0.317nM。

同位素标记化合物

Cat.No: TMIH-0353

Imidafenacin-d10

Cat.No: TMIJ-0336

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