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Search Results for " d4-receptor "

Targets Recommended: Dopamine Receptor

82

抑制剂 & 化合物

1

天然产物

1

重组蛋白

38

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T22019	ABT 724 trihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	ABT 724 trihydrochloride 是一种有效的选择性 D4 受体激动剂（EC50 = 12.4 nM，14.3 nM 和 23.2 nM，分别对人、大鼠和雪貂）。 ABT-724 trihydrochloride 可用于勃起功能障碍研究。
T7834	ABT-724 2 - [(4-吡啶-2-基哌嗪-1-基)甲基]-1H-苯并咪唑	Dopamine Receptor	GPCR/G Protein; Neuroscience
	ABT-724 是高度选择性的多巴胺D4受体激动剂，对人多巴胺D4受体的EC50=12.4 nM。它是大鼠D4(EC50为 14.3 nM) 和雪貂D4受体 (EC50为 23.2 nM) 的有效部分激动剂，对多巴胺 D1，D2，D3或 D5受体没有影响。它可用于勃起功能障碍的研究，并具有较少的副作用。
T22904	L-745870 trihydrochloride L-745870三盐酸盐,L-745,870 trihydrochloride	Dopamine Receptor; Sigma receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	L-745870 trihydrochloride 是可透过血脑屏障的、选择性的、具有口服活性的多巴胺D4受体拮抗剂，Ki=0.43 nM，而对 D2(Ki 为 960 nM) 和 D3(Ki 为 2300 nM) 受体的亲和力相对较弱，对 5-HT2受体，sigma 位点和 α-肾上腺素受体表现出中等亲和力。
T60917	Dopamine D4 receptor antagonist-1	Others	Others
	Dopamine D4 receptor antagonist-1 可用于研究精神分裂症。Dopamine D4 receptor antagonist-1 是多巴胺D4受体 (DRD4) 的选择性拮抗剂。Dopamine D4 receptor antagonist-1 对Hd4.2的Ki 值为 9.0 nM。
T12761	Ro 10-5824 dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Ro 10-5824 dihydrochloride 是选择性的多巴胺D4 受体部分激动剂，Ki=5.2 nM。
T12383	PD 168568 dihydrochloride PD 168568 (dihydrochloride),二盐酸PD168568	Dopamine Receptor	GPCR/G Protein; Neuroscience
	PD 168568 dihydrochloride (PD 168568 (dihydrochloride)) 是一种口服有效的，选择性的 D4 受体拮抗剂，其 Ki 值为 8.8 nM。
T15270	Fananserin RP 62203,法南色林	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Fananserin 是一种有效的、特异性的、口服活性的 5-HT2 拮抗剂（大鼠 5-HT2A 的 Ki = 0.37 nM）。 Fananserin 是人 D4 受体的拮抗剂 (Ki = 2.93 nM)。
T10213	A-437203 ABT-925,A37203,Lu201640	Dopamine Receptor	GPCR/G Protein; Neuroscience
	A-437203 (Lu201640) 是一种基于1H-pyrimidin-2-one scaﬀold 的、具有选择性的、新型强效的d3受体拮抗剂，对 D2, D3, 和 D4 受体,的Ki 值分别为 71, 1.6 和 6220 nM。
T11799	L-745870 hydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	L-745870 hydrochloride 是可透过血脑屏障的、选择性的、具有口服活性的多巴胺 D4受体拮抗剂，Ki=0.43 nM。它对 D2(Ki 为 960 nM) 和 D3(Ki 为 2300 nM) 受体的亲和力相对较弱，对 5-HT2受体，sigma 位点和 α-肾上腺素受体表现出中等亲和力。
T23066	NGD 94-1	Dopamine Receptor	GPCR/G Protein; Neuroscience
	NGD 94-1 是一种选择性的 D4 受体拮抗剂，对D4受体的亲和力为3 nM，而对D1、D2、D3和D5受体的亲和力大于2 pM。NGD 94-1 可用研究认知障碍等精神性疾病。
T5047	PD-168077 maleate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	PD-168077 maleate 是多巴胺 D4受体选择性激动剂，其 Ki=9 nM。
T27979	Masilukast ICI-D-3523,ZD-3523,ICI D-3523,MCC-847,SA-09012,D-3523	Leukotriene Receptor	GPCR/G Protein
	Masilukast(MCC-847) 是一种口服的白三烯D4 (LTD4) 受体拮抗剂，可用于研究与炎症相关的疾病。
T12480	Pipamperone Floropipamide,McN-JR 3345,酰胺哌啶酮,R 3345	Others; Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience; Others
	Pipamperone (McN-JR 3345) 是5-HT2A 受体和D4受体的高亲和力拮抗剂，也是D2受体的低亲和力拮抗剂，pKi 分别为 8.2、8.0 和 6.7。
T27060	CP-226269 CP 226269,CP226269	Dopamine Receptor	GPCR/G Protein; Neuroscience
	CP-226269 是一种高效的多巴胺 D4 受体 (dopamine D4 receptor) 激动剂，可以调节钙通量，其 EC50 值为32.0 nM。CP 226269 可用于研究精神分裂症等神经系统疾病。
T5397	A-381393	Dopamine Receptor	GPCR/G Protein; Neuroscience
	A-381393 是选择性、可透过血脑屏障的多巴胺 D4受体拮抗剂，对人多巴胺 D4.4，D4.2和 D4.7受体的 Ki 分别为 1.5，1.9 和 1.6 nM，选择性是对 D1，D2，D3，D5多巴胺受体的 2700 多倍，对 5-HT2A 的选择性适中，Ki=370 nM。
T24055	FAUC 213 FAUC213,FAUC-213	Dopamine Receptor	GPCR/G Protein; Neuroscience
	FAUC 213 是一种具有口服活性的‘、高度选择性的、可透过血脑屏障的多巴胺 D4受体完全拮抗剂，对 hD4.4的 Ki=2.2 nM。它对 D2和 D3受体的活性较低，对于 hD2、hD3的 Ki 分别为 3.4 μM、5.3 μM。它表现出非典型的抗精神病活性。
T2631	WAY-100635 Monomaleate	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	WAY-100635 maleate 是一种选择性的5-hydroxytryptamine 1A 受体拮抗剂，IC50值为 0.91 nM，Ki 值为 0.39 nM。它也是多巴胺 D4受体激动剂，对于5-HT1A 和 α1-肾上腺素的 pIC50值分别为 8.9 和 6.6。
T5158	N-Desmethylclozapine N-去甲基氯氮平,Desmethylclozapine,Normethylclozapine,Norclozapine	Virus Protease; Dopamine Receptor; 5-HT Receptor; Opioid Receptor; AChR; Drug Metabolite	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	N-Desmethylclozapine (Desmethylclozapine) 是非典型抗精神病药 Clozapine 的主要活性代谢产物。它是血清素受体亚型 5-HT2C 的拮抗剂，IC50值为7.1 nM。它也是多巴胺 D4 受体的拮抗剂和δ-阿片受体的激动剂。
T30098	Aplindore Fumarate Aplindore,DAB-452 Fumarate,DAB-452	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Aplindore Fumarate （DAB-452）是一种小分子多巴胺 D2 受体部分激动剂，Aplindore Fumarate 对多巴胺D2 和D3 受体表现出高亲和力，对多巴胺D4、5-羟色胺（5-HT2）和α1-肾上腺素受体表现出低亲和力。Aplindore Fumarate 可用于研究帕金森和精神分裂症。
T28167	NGB 2904 NGB2904 HCl,NGB-2904,NGB2904	Others; Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience; Others
	NGB 2904 是一种具有口服活性的、选择性的多巴胺(DA) D3受体拮抗剂，可用于具可卡因成瘾。
T31602	Ecopipam Sch-39166,UNII-0X748O646K,Sch 39166	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Ecopipam (UNII-0X748O646K) 是一种有效的、选择性、具有口服活性的多巴胺 D1/D5 受体拮抗剂，Ki 值分别为 1.2 nM 和 2.0 nM。Ecopipam 对 D2、D4、5-HT 和 α2a 受体 (Ki=0.98，5.52，0.08 和 0.73 μM) 显示出超过 40 倍的选择性。Ecopipam 可用于精神分裂症、可卡因成瘾和肥胖症的研究。
T6736	Zafirlukast Vanticon,ICI 204219,Accolate,扎鲁司特	Leukotriene Receptor	GPCR/G Protein
	Zafirlukast (ICI 204219) 是一种可口服的白三烯 D4受体拮抗剂，具有平喘、抗炎和抗菌作用。
T1476	Pramipexole SND 919,普拉克索	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Pramipexole (SND 919) 是能够透过血脑屏障的 D2 型多巴胺受体的选择性激动剂，对 D2 型受体、D2、D3、D4亚型受体的Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM。它可用于研究帕金森综合症和腿多动综合征。
T14767	BP 897 hydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	BP 897 hydrochloride 是有效的部分多巴胺 D3受体激动剂和弱 D2受体拮抗剂，在多巴胺 D3 受体 (Ki=0.92 nM) 上显示出高亲和力，而在 D2 受体上显示出 70 倍的低亲和力 (Ki=61 nM)。它表现出对可卡因寻求行为的选择性抑制。
T9100	BP 897 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-	Dopamine Receptor	GPCR/G Protein; Neuroscience
	BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) 是一种有效的部分多巴胺D3受体激动剂和弱D2受体拮抗剂，在多巴胺 D3 受体(Ki=0.92 nM) 上显示出高亲和力，而在 D2 受体上显示出 70 倍的低亲和力 (Ki=61 nM)。它表现出对可卡因寻求行为的选择性抑制。
T11463	GR 103691	Dopamine Receptor	GPCR/G Protein; Neuroscience
	GR 103691 是选择性的多巴胺 D3受体拮抗剂，Ki=0.4 nM。它对人多巴胺 D3的选择性超过 D4和 D1的 100 倍以上。
T23380	Sonepiprazole	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Sonepiprazole 是D4多巴胺受体选择性拮抗剂，与rD4多巴胺受体，hD4.2多巴胺受体，rD2多巴胺受体和组胺H1受体结合的Ki 分别为 3.6、10.1、5147 和 7430 nM。
T1539	Iloperidone 伊潘立酮,HP 873	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Iloperidone (HP 873) 是一种D2/5-HT2受体拮抗剂，是非典型抗精神病药，可治疗精神分裂症。
T3148	MK-571 sodium L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	MK-571 sodium (L-660711 sodium salt) 是一种可口服的选择性白三烯 D4受体拮抗剂，在豚鼠和人肺膜的 Ki 分别为0.22 和 2.1 nM。
T12252	NRA-0160	Dopamine Receptor	GPCR/G Protein; Neuroscience
	NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
T7635L	Raclopride tartrate FLA 870,FLA-870,FLA870	Others	Others
	Raclopride is a selective antagonist on D2 dopamine receptor ( D2 Ki: 1.8 nm, D3 Ki: 3.5 nm, D4 Ki: 2400, D1 Ki: 18000 nM).
T6951	Pramipexole dihydrochloride hydrate Pramipexole 2HCl Monohydrate,普拉克索盐酸盐水合物,Mirapex,普拉克索	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Pramipexole dihydrochloride hydrate (Mirapex) 是选择性的，具有血脑屏障 (BBB) 渗透性的 D2 型多巴胺受体激动剂，对 D2 型受体、D2、D3、D4亚型受体的 Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM，可用于研究帕金森综合症和腿多动综合征。
T11799L	L-745870	Dopamine Receptor	GPCR/G Protein; Neuroscience
	L-745870 is a high-affinity and selective human dopamine D4 receptor antagonist (Ki: 0.43 nM). L-745870 has excellent brain penetration. It considerably weaker D2 (Ki: 960 nM) and D3 (Ki: 2300 nM) receptors affinity.
T25407	FAUC-113 FAUC113	Others	Others
	FAUC-113 is an antagonist of Dopamine D4 receptor.
T14088	ABT-670	Dopamine Receptor	GPCR/G Protein; Neuroscience
	ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.
T27893	LY 203647 LY203647,LY-203647	Others	Others
	LY 203647 is a antagonist of leukotriene D4 and E4 receptor.
T28505	RBI-257 Maleate RBI257 Maleate,p-Iodo-U-101958 Maleate,RBI 257 Maleate,p-Iodo U-101958 Maleate	Others	Others
	RBI-257 Maleate is a highly potent selective ligand of dopamine D4 receptor.
T11764	KP496	Others	Others
	KP496 is a selective, dual antagonist for Thromboxane A2 receptor and Leukotriene D4 receptor.
T69095	FAUC-179	Others	Others
	FAUC-179 is a selective dopamine D4 receptor partial agonist.
T23170	PNU-96415E PNU 96415E	Others	Others
	dopamine D4 and serotonergic 5-HT2A receptor antagonist
T24304	L 648051 4-Apsob,L48051,L-648051	Others	Others
	L 648051 is a leukotriene D4 receptor antagonist.
T24358	L 741742 (free base) L-741,742,L-741742,L 741742,L 741,742,L741742	Others	Others
	L 741742 is an effective and highly selective antagonist of the D4 dopamine receptor (Ki: 1700, 770, and 3.5 nM at cloned human D2, D3, and D4 receptors).
T19691	A412997	Others	Others
	A412997 is a selective agonist of dopamine D4 receptor.
T19666	PD168,077 PD-168,077,PD 168,077	Others	Others
	PD168,077 is an agonist of dopamine D4 receptor. It has a facilitatory effect on memory consolidation.
T27777	L-750,667 TriHydrochloride L 750,667,L750,667,L-750,667	Others	Others
	L-750,667 TriHydrochloride is a selective antagonist of D4 dopamine receptor.
T27063	CP-293019 CP293019	Others	Others
	CP-293019 is a potent, selective antagonist of dopamine D4 receptor.
T22903	L-741,742 hydrochloride	Others	Others
	highly potent and selective D4 dopamine receptor antagonist
T69466	FAUC-299	Others	Others
	FAUC-299 is a dopamine D4 receptor agonist.
T70662	UCSF924NC	Others	Others
	UCSF924NC is the recommended negative control compound for the high-affinity dopamine D4 receptor (DRD4) partial agonist UCSF924. UCSF924NC exhibits a 1/2500-fold reduced D4 affinity when compared with that of UCSF924.
T24056	FAUC-312 FAUC 312	Others	Others
	FAUC-312 is a potent and selective agonist of the dopamine D4 receptor.

化合物

ABT 724 trihydrochloride

Cat.No: T22019

Target: Dopamine Receptor

Cat.No: T7834

Synonym: 2 - [(4-吡啶-2-基哌嗪-1-基)甲基]-1H-苯并咪唑

Target: Dopamine Receptor

L-745870 trihydrochloride

Cat.No: T22904

Synonym: L-745870三盐酸盐,L-745,870 trihydrochloride

Target: Dopamine Receptor, Sigma receptor, 5-HT Receptor, Adrenergic Receptor

Dopamine D4 receptor antagonist-1

Cat.No: T60917

Target: Others

Ro 10-5824 dihydrochloride

Cat.No: T12761

Target: Dopamine Receptor

PD 168568 dihydrochloride

Cat.No: T12383

Synonym: PD 168568 (dihydrochloride),二盐酸PD168568

Target: Dopamine Receptor

Cat.No: T15270

Synonym: RP 62203,法南色林

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T10213

Synonym: ABT-925,A37203,Lu201640

Target: Dopamine Receptor

L-745870 hydrochloride

Cat.No: T11799

Target: Dopamine Receptor

Cat.No: T23066

Target: Dopamine Receptor

PD-168077 maleate

Cat.No: T5047

Target: Dopamine Receptor

Cat.No: T27979

Synonym: ICI-D-3523,ZD-3523,ICI D-3523,MCC-847,SA-09012,D-3523

Target: Leukotriene Receptor

Cat.No: T12480

Synonym: Floropipamide,McN-JR 3345,酰胺哌啶酮,R 3345

Target: Others, Dopamine Receptor, 5-HT Receptor

Cat.No: T27060

Synonym: CP 226269,CP226269

Target: Dopamine Receptor

Cat.No: T5397

Target: Dopamine Receptor

Cat.No: T24055

Synonym: FAUC213,FAUC-213

Target: Dopamine Receptor

WAY-100635 Monomaleate

Cat.No: T2631

Target: Dopamine Receptor, 5-HT Receptor

N-Desmethylclozapine

Cat.No: T5158

Synonym: N-去甲基氯氮平,Desmethylclozapine,Normethylclozapine,Norclozapine

Target: Virus Protease, Dopamine Receptor, 5-HT Receptor, Opioid Receptor, AChR, Drug Metabolite

Aplindore Fumarate

Cat.No: T30098

Synonym: Aplindore,DAB-452 Fumarate,DAB-452

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T28167

Synonym: NGB2904 HCl,NGB-2904,NGB2904

Target: Others, Dopamine Receptor, 5-HT Receptor

Cat.No: T31602

Synonym: Sch-39166,UNII-0X748O646K,Sch 39166

Target: Dopamine Receptor

Cat.No: T6736

Synonym: Vanticon,ICI 204219,Accolate,扎鲁司特

Target: Leukotriene Receptor

Cat.No: T1476

Synonym: SND 919,普拉克索

Target: Dopamine Receptor

BP 897 hydrochloride

Cat.No: T14767

Target: Dopamine Receptor

Cat.No: T9100

Synonym: 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-

Target: Dopamine Receptor

Cat.No: T11463

Target: Dopamine Receptor

Cat.No: T23380

Target: Dopamine Receptor

Cat.No: T1539

Synonym: 伊潘立酮,HP 873

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T3148

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

Cat.No: T12252

Target: Dopamine Receptor

Raclopride tartrate

Cat.No: T7635L

Synonym: FLA 870,FLA-870,FLA870

Target: Others

Pramipexole dihydrochloride hydrate

Cat.No: T6951

Synonym: Pramipexole 2HCl Monohydrate,普拉克索盐酸盐水合物,Mirapex,普拉克索

Target: Dopamine Receptor

Cat.No: T11799L

Target: Dopamine Receptor

Cat.No: T25407

Synonym: FAUC113

Target: Others

Cat.No: T14088

Target: Dopamine Receptor

Cat.No: T27893

Synonym: LY203647,LY-203647

Target: Others

RBI-257 Maleate

Cat.No: T28505

Synonym: RBI257 Maleate,p-Iodo-U-101958 Maleate,RBI 257 Maleate,p-Iodo U-101958 Maleate

Target: Others

Cat.No: T11764

Target: Others

Cat.No: T69095

Target: Others

Cat.No: T23170

Synonym: PNU 96415E

Target: Others

Cat.No: T24304

Synonym: 4-Apsob,L48051,L-648051

Target: Others

L 741742 (free base)

Cat.No: T24358

Synonym: L-741,742,L-741742,L 741742,L 741,742,L741742

Target: Others

Cat.No: T19691

Target: Others

Cat.No: T19666

Synonym: PD-168,077,PD 168,077

Target: Others

L-750,667 TriHydrochloride

Cat.No: T27777

Synonym: L 750,667,L750,667,L-750,667

Target: Others

Cat.No: T27063

Synonym: CP293019

Target: Others

L-741,742 hydrochloride

Cat.No: T22903

Target: Others

Cat.No: T69466

Target: Others

Cat.No: T70662

Target: Others

Cat.No: T24056

Synonym: FAUC 312

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T15686	L-741626 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole	Dopamine Receptor	GPCR/G Protein; Neuroscience
	L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) 是D2多巴胺受体选择性拮抗剂，对人 D2、D3 和 D4 受体的Ki 分别为 2.4、100 和 220 nM。

天然产物

Cat.No: T15686

Synonym: 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole

Target: Dopamine Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03749	CYSLTR1 Protein, Human, Recombinant (His) Cysteinyl leukotriene receptor 1,G-protein coupled ...	Human	E. coli
	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

重组蛋白

CYSLTR1 Protein, Human, Recombinant (His)

Cat.No: TMPH-03749

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11197	Enclomiphene D4 hydrochloride (E)-Clomiphene D4 hydrochloride,Enclomifene D4 hydrochloride,trans-Clomiphene D4 hydrochloride	Others	Others
	Enclomiphene D4 hydrochloride ((E)-Clomiphene D4 hydrochloride; trans-Clomiphene D4 hydrochloride; Enclomifene D4 hydrochloride) is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property.Enclomiphene D4 hydrochloride ((E)-Clomiphene D4 hydrochloride; trans-Clomiphene D4 hydrochloride; Enclomifene D4 hydrochloride) is a deuterium labeled Enclomiphene.
T11675	Irbesartan-d4 厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4	Others	Others
	Irbesartan D4, a deuterium-labeled variant of Irbesartan, is a highly potent and specific antagonist of the angiotensin II type 1 (AT1) receptor.
T12329	Ospemifene D4 FC-1271a D4	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
T11934	Macitentan-d4 Macitentan D4,ACT-064992 D4	Endothelin Receptor	GPCR/G Protein
	Macitentan-d4 (ACT-064992 D4) 是一种 Macitentan 氘代物，可被当作非多肽 ETA 和 ETB (内皮素受体)双拮抗剂。Macitentan-d4 比 Macitentan 毒性更低，半衰期更长，可用于研究由内皮素受体介导介导的疾病。
T11869	Losartan (D4 Carboxylic Acid) E-3174 D4,氯沙坦羧酸 D4,EXP-3174 D4	Others	Others
	Losartan D4 Carboxylic Acid is the deuterium labeled Losartan, which is an angiotensin II receptor antagonist.
T11591	Hydroxyzine D4 羟嗪 D4	Others	Others
	Hydroxyzine D4 is a deuterium-labeled variation of Hydroxyzine, a chemical compound known for its anticholinergic, anxiolytic, and analgesic properties. It is classified as a heterocyclic histamine H1-receptor antagonist.
T73713	Flupirtine-d4 hydrochloride
	Flupirtine-d4 (D 9998-d4) hydrochloride，Flupirtine (D 9998) hydrochloride的氘代物，为神经元钾通道开放剂，具有拮抗NMDA受体的作用。
T11536	Haloperidol (D4') Haloperidol D4',氟哌啶醇 (D4')	Others	Others
	Haloperidol D4' is deuterium-labeled haloperidol. Haloperidol is a dopamine D2 receptor antagonist.
T19233	Cetirizine D4 dihydrochloride Cetirizine D4 dihydrochloride (1219803-84-5 free base)	Others	Others
	Cetirizine D4 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
T12300	Olmesartan-d4 RNH-6270 D4,奥美沙坦 D4	Others	Others
	Olmesartan D4 is the deuterium labeled Olmesartan. Olmesartan is an antagonist of angiotensin II receptor (AT1R) used to treat high blood pressure.
T10670	Candesartan-d4 坎地沙坦 D4,CV-11974 D4	Others	Others
	Candesartan D4 is the deuterium labeled Candesartan. Candesartan is an antagonist of angiotensin II receptor.
T11870	Losartan D4 氯沙坦 D4,DuP-753 D4	Others	Others
	Losartan D4, the deuterium-labeled version of Losartan, functions as an angiotensin II receptor antagonist. It inhibits the interaction between angiotensin II and AT1 receptors by competing for binding, achieving an IC50 value of 20 nM.
T10769	Cetirizine D4	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cetirizine D4 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
T12618	Quetiapine-d4 fumarate Quetiapine D4 fumarate,富马酸奎硫平 D4	Others	Others
	Quetiapine D4 fumarate is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a agonist of 5-HT receptors and a antagonist of dopamine receptor,with antidepressant and anxiolytic.
T12618L	Quetiapine-d4 hemifumarate 半富马酸奎硫平 D4	Others	Others
	Quetiapine D4 hemifumarate is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a agonist of 5-HT receptors and a antagonist of dopamine receptor,with ntidepressant and anxiolytic.
TMIJ-0248	Stanolone-d4
	Stanolone-d4 是 Stanolone 的氘代化合物。Stanolone 的 CAS 号为 521-18-6。Dihydrotestosterone(DHT) 是睾酮的强效雄激素代谢物。它是雄激素受体的激动剂。
TMID-0064	Androsterone-d4
	Androsterone-d4 是 Androsterone 的氘代化合物。Androsterone 的 CAS 号为 53-41-8。Androsterone 是睾酮的代谢产物，可以激活法尼醇 X 受体。
T11295	Flibanserin-d4 BIMT-17BS D4,BIMT-17 D4,Flibanserin D4	Others	Others
	Flibanserin, a compound identified as BIMT-17, acts as a complete agonist at the serotonin 5-HT1A receptor, with a binding affinity (Ki) of 1 nM, while functioning as an antagonist at the 5-HT2A receptor with a 49 nM affinity. Flibanserin D4 represents a deuterium-labeled version of Flibanserin.
TMIJ-0057	5α-Dihydrotestosterone-d4
	5α-Dihydrotestosterone-d4 是 5α-Dihydrotestosterone 的氘代化合物。5α-Dihydrotestosterone 的 CAS 号为 521-18-6。Dihydrotestosterone(DHT) 是睾酮的强效雄激素代谢物。它是雄激素受体的激动剂。
TMIJ-0162	Dexamethasone-d4
	Dexamethasone-d4 是 Dexamethasone 的氘代化合物。Dexamethasone 的 CAS 号为 50-02-2。Dexamethasone是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。在脂多糖诱导的巨噬细胞炎症反应中，它抑制含有炎性 microRNA-155 的外泌体的产生。
TMIJ-0173	Calcipotriol-d4
	Calcipotriol-d4 是 Calcipotriol 的氘代化合物。Calcipotriol 的 CAS 号为 112965-21-6。Calcipotriol 是一种合成的 VitD3类似物，对维他命D受体具有高亲和力。
TMIJ-0260	Bilastine-d4
	Bilastine-d4 是 Bilastine 的氘代化合物。Bilastine 的 CAS 号为 202189-78-4。Bilastine是新型抗组胺药，对H1组胺受体具有高度选择性，起效快，作用时间长的特性，可用于变应性鼻结膜炎和荨麻疹。
TMIJ-0193	Hydrocortisone-d4
	Hydrocortisone-d4 是 Hydrocortisone 的氘代化合物。Hydrocortisone 的 CAS 号为 50-23-7。Hydrocortisone 是肾上腺皮质分泌的糖皮质激素。
TMID-0055	17β-estradiol-d4
	17β-estradiol-d4 是 17β-estradiol 的氘代化合物。17β-estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素，对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。
TMID-0200	rac-Clopidogrel-d4 Carboxylic Acid
	rac-Clopidogrel-d4 Carboxylic Acid 是 rac-Clopidogrel Carboxylic Acid 的氘代化合物。rac-Clopidogrel Carboxylic Acid 的 CAS 号为 113665-84-2。Clopidogrel 是一种 P2Y12 受体拮抗剂，可降低血小板聚集，用于抑制冠状动脉疾病、周围血管疾病和脑血管疾病中的血凝块。
TMIH-0124	Brivanib Alaninate-d4
	Brivanib Alaninate-d4 是 Brivanib Alaninate 的氘代化合物。Brivanib Alaninate 的 CAS 号为 649735-63-7。Brivanib alaninate 是一种血管内皮生长因子受体 2 (VEGFR2) 抑制剂的丙氨酸盐，IC50值为 25 nM，具有潜在的抗肿瘤活性。它对 VEGFR1 和 FGFR1 适度抑制，对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。
TMIH-0372	N-desmethyl Apalutamide-d4
	N-desmethyl Apalutamide-d4 是 N-desmethyl Apalutamide 的氘代化合物。N-desmethyl Apalutamide 的 CAS 号为 1332391-11-3。N-Desmethyl Apalutamide 是一种 Apalutamide 的活性代谢产物，主要由 CYP2C8 和 CYP3A4 介导形成。它是一种低活性的雄激素受体拮抗剂，其作用力是 Apalutamide 活性的三分之一。它是中等至强的CYP3A4和CYP2B6诱导剂，并具有优异的血浆蛋白结合浓度。
TMIJ-0154	Lenvatinib-d4
	Lenvatinib-d4 是 Lenvatinib 的氘代化合物。Lenvatinib 的 CAS 号为 417716-92-8。Lenvatinib 是一种口服具有活性的，多靶点酪氨酸激酶抑制剂，能够抑制血管内皮生长因子受体(VEGFR1-3)，成纤维细胞生长因子受体(FGFR1-4)，干细胞因子受体(KIT)，血小板衍生生长因子受体(PDGFR)，转染期间重排(RET)，具有效抗癌的作用。
TMIJ-0119	Pitavastatin-d4 Sodium Salt
	Pitavastatin-d4 Sodium Salt 是 Pitavastatin Sodium Salt 的氘代化合物。Pitavastatin Sodium Salt 的 CAS 号为 574705-92-3。
TMID-0013	Tiapride-d3
	Tiapride-d3 是 Tiapride 的氘代化合物。Tiapride 的 CAS 号为 51012-32-9。Tiapride 是一种非典型的抗精神病剂，不会引起强直性昏厥和镇静。Tiapride 是多巴胺 D2受体的选择性拮抗剂，其对 D1；D2；D3；D4 受体的 IC50值分别为 1440、45.8、<100 和 11.7 μM。
TMIH-0271	Hydroxyzine dihydrochloride-d4 (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy-1,1,2,2-d4)ethan-1-ol dihydrochloride
	Hydroxyzine dihydrochloride-d4 是 Hydroxyzine dihydrochloride 的氘代化合物。Hydroxyzine dihydrochloride 的 CAS 号为 2192-20-3。Hydroxyzine dihydrochloride是一种苯二氮卓抗组胺剂，是可口服的组胺 H1 受体和血清素拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它还可以作为止吐剂和镇静剂，有缓解焦虑和紧张的作用。
TMIJ-0099	Minodronic acid-d4
	Minodronic acid-d4 是 Minodronic acid 的氘代化合物。Minodronic acid 的 CAS 号为 180064-38-4。Minodronic acid(YM-529) 是一种 P2X2/3 受体拮抗剂，具有抗癌活性，可直接或间接的抑制癌细胞增殖，诱导细胞凋亡。Minodronic-acid 对各种类型的癌细胞的转移具有抑制作用。Minodronic-acid 可用于研究骨质疏松。
TMIJ-0519	Fosaprepitant-d4 Dimeglumine
	Fosaprepitant-d4 Dimeglumine 是 Fosaprepitant Dimeglumine 的氘代化合物。Fosaprepitant Dimeglumine 的 CAS 号为 265121-04-8。Fosaprepitant dimeglumine 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂，可用于预防化疗引起的恶心呕吐。
TMIH-0609	Zafirlukast-d7
	Zafirlukast-d7 是 Zafirlukast 的氘代化合物。Zafirlukast 的 CAS 号为 107753-78-6。Zafirlukast 是一种可口服的白三烯 D4受体拮抗剂，具有平喘、抗炎和抗菌作用。
T71305	Clofibric Acid-d4
	Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate. It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxal...
TMIH-0065	Acalabrutinib-d4
	Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...

同位素标记化合物

Enclomiphene D4 hydrochloride

Cat.No: T11197

Synonym: (E)-Clomiphene D4 hydrochloride,Enclomifene D4 hydrochloride,trans-Clomiphene D4 hydrochloride

Target: Others

Cat.No: T11675

Synonym: 厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4

Target: Others

Cat.No: T12329

Synonym: FC-1271a D4

Target: Estrogen/progestogen Receptor

Cat.No: T11934

Synonym: Macitentan D4,ACT-064992 D4

Target: Endothelin Receptor

Losartan (D4 Carboxylic Acid)

Cat.No: T11869

Synonym: E-3174 D4,氯沙坦羧酸 D4,EXP-3174 D4

Target: Others

Cat.No: T11591

Synonym: 羟嗪 D4

Target: Others

Flupirtine-d4 hydrochloride

Cat.No: T73713

Haloperidol (D4')

Cat.No: T11536

Synonym: Haloperidol D4',氟哌啶醇 (D4')

Target: Others

Cetirizine D4 dihydrochloride

Cat.No: T19233

Synonym: Cetirizine D4 dihydrochloride (1219803-84-5 free base)

Target: Others

Cat.No: T12300

Synonym: RNH-6270 D4,奥美沙坦 D4

Target: Others

Cat.No: T10670

Synonym: 坎地沙坦 D4,CV-11974 D4

Target: Others

Cat.No: T11870

Synonym: 氯沙坦 D4,DuP-753 D4

Target: Others

Cat.No: T10769

Target: Histamine Receptor

Quetiapine-d4 fumarate

Cat.No: T12618

Synonym: Quetiapine D4 fumarate,富马酸奎硫平 D4

Target: Others

Quetiapine-d4 hemifumarate

Cat.No: T12618L

Synonym: 半富马酸奎硫平 D4

Target: Others

Cat.No: TMIJ-0248

Androsterone-d4

Cat.No: TMID-0064

Cat.No: T11295

Synonym: BIMT-17BS D4,BIMT-17 D4,Flibanserin D4

Target: Others

5α-Dihydrotestosterone-d4

Cat.No: TMIJ-0057

Dexamethasone-d4

Cat.No: TMIJ-0162

Calcipotriol-d4

Cat.No: TMIJ-0173

Cat.No: TMIJ-0260

Hydrocortisone-d4

Cat.No: TMIJ-0193

17β-estradiol-d4

Cat.No: TMID-0055

rac-Clopidogrel-d4 Carboxylic Acid

Cat.No: TMID-0200

Brivanib Alaninate-d4

Cat.No: TMIH-0124

N-desmethyl Apalutamide-d4

Cat.No: TMIH-0372

Cat.No: TMIJ-0154

Pitavastatin-d4 Sodium Salt

Cat.No: TMIJ-0119

Cat.No: TMID-0013

Hydroxyzine dihydrochloride-d4

Cat.No: TMIH-0271

Synonym: (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy-1,1,2,2-d4)ethan-1-ol dihydrochloride

Minodronic acid-d4

Cat.No: TMIJ-0099

Fosaprepitant-d4 Dimeglumine

Cat.No: TMIJ-0519

Cat.No: TMIH-0609

Clofibric Acid-d4

Cat.No: T71305

Acalabrutinib-d4

Cat.No: TMIH-0065

Cat.No: T71402

Flufenamic Acid-d4

Cat.No: T71303

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