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Search Results for " d-13 "

23

抑制剂 & 化合物

7

天然产物

6

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T37985	D-Fructose-6-phosphate (sodium salt hydrate) D-Fructose-6-phosphate (sodium salt hydrate) (643-13-0 free base)
	D-Fructose-6-phosphate (sodium salt hydrate) 是由磷酸葡萄糖异构酶将 6-磷酸葡萄糖异构化产生的糖酵解途径的糖中间体，可用于研究癌症。
T36054	D13	Others	Others
	D13 is an acylhydrazone antifungal.1 It is active against C. neoformans in vitro (MIC80 = 0.06 μg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infection. \|1. Lazzarini, C., Haranahalli, K., Rieger, R., et al. Acylhydrazones as antifungal agents targeting the synthesis of fungal sphingolipids. Antimicrob. Agents Chemother. 62(5), e00156-00118 (2018).
T9310	mTOR inhibitor 13	PI3K; mTOR	PI3K/Akt/mTOR signaling
	mTOR inhibitor 13是一种选择性的mTOR 抑制剂，对mTOR 和PI3Kα的IC50分别为0.29nM 和119nM。
T10944	D13-9001	Others	Others
	The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effective AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor.
T24968	13-Deoxycarminomycin R20X,R-20X,Antibiotic D 788-11,R 20X	Others	Others
	13-Deoxycarminomycin is an antitumor antibiotic.
T14589	Biotin-PEG3-acid 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸	Others; PROTAC Linker	Others; PROTAC
	Biotin-PEG3-acid 是一种属于 PEG 类的、生物素标记的 PROTAC linker，可用于 PROTAC 分子的合成。
T2664	Timapiprant OC000459	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Timapiprant (OC000459) 是一种有效的选择性 D 前列腺素受体 2(DP2) 拮抗剂，IC50为 13 nM。它抑制肥大细胞激活 Th2 淋巴细胞和嗜酸性粒细胞，有效地置换来自人重组 DP2、大鼠重组 DP2 和人天然 DP2 的 [3H] PGD2。
T14943	CGP60474	VEGFR; CDK; PKC	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CGP60474 是一种高效的抗内毒素药物，抑制细胞周期蛋白依赖激酶(CDK) ，抑制 CDK1/B、CDK2/E、CDK2/a、CDK4/D、CDK5/p25、CDK7/H 和 CDK9/T 的IC50分别为 26、3、4、216、10、200 和 13 nM。它是选择性和 ATP 竞争性PKC 抑制剂。
T31190	Dafphedyn	Others	Others
	Dafphedyn, [D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN) is an effective analog of strong endorphin 1-13 and produces diuretic and deep analgesia when administered intravenously in rats.
T38695	2-Acetamido-2,4-dideoxy-4-fluoro-α-D-glucopyranose	Others	Others
	2-Acetamido-2,4-dideoxy-4-fluoro-α-D-glucopyranose (compound 13) functions as a potent hepatic glycosaminoglycan biosynthesis inhibitor.
T3407	Rapastinel GLYX-13,雷帕替奈,Thr-Pro-Pro-Thr-NH2,TPPT-amide	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Rapastinel (TPPT-amide) 是 N-甲基-D-天冬氨酸受体 (NMDAR) 调节剂，也有部分激动剂特性。
TP1023	NT 13 TPPT
	NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.
T125682	Schisanchinin D	Others	Others
	Schisanchinin D 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125682，CAS号为 1614245-13-4。
T17099	Timapiprant sodium OC000459 sodium	Others	Others
	Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), ra
T37056	D-erythro-MAPP	Others	Others
	D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 μM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 μM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.
T37565	C6 D-threo Ceramide (d18:1/6:0) C6 D-threo Ceramide (d18:1/6:0)	Others	Others
	C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater...
T36396	D-Homoserine lactone	Others	Others
	D-homoserine lactone is an enantiomer of L-homoserine lactone and an inhibitor of serine hydroxymethyltransferase (SHMT; Ki= 11 mM for the rabbit enzyme).1 1.Wang, E.A., Kallen, R., and Walsh, C.Mechanism-based inactivation of serine transhydroxymethylases by D-fluoroalanine and related amino acidsJ. Biol. Chem.256(13)6917-6926(1981)
T81451	PKCd (8-17)
	PKCd (8-17) 是源自蛋白激酶 C (PKC)d V1 结构域的生物活性肽。它能抑制由佛波醇 12-肉豆蔻酸酯 13-乙酸酯 (PMA) 诱导的 PKCd 易位和激活。此外，PKCd (8-17) 在降低心脏和脑细胞缺血损伤、促进成纤维细胞增殖、以及抑制小鼠移植冠状动脉疾病方面具有潜在应用。
T36281	VH 032 amide-alkylC5-amine VH 032 amide-alkylC5-amine	Others	Others
	Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 13 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
T36917	Ethynyl Estradiol 3-β-D-Glucuronide (hydrate)	Others	Others
	Ethynyl estradiol 3-β-D-glucuronide is a metabolite of ethynyl estradiol that can be detected in urine.1,2It is used as a marker of estrogen contamination in fresh and saltwater.2 1.Hadd, H.E., Slikker, W., Jr., and Helton, E.D.The synthesis and characterization of the glucopyranosiduronic acids of 17a-ethynylestradiol-17bJ. Steroid Biochem.13(9)1107-1114(1980) 2.Griffith, D.R., Soule, M.C.K., Eglinton, T.I., et al.Steroidal estrogen sources in a sewage-impacted coastal oceanEnviron. Sci.: Proce...
T37874	Feglymycin
	Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities. It is active against Gram-positive bacteria (MICs = 32-64 μg/ml) and inhibits HIV viral replication in H9 cells (IC50 = ~5 μM). Feglymycin is also active against clinical isolates of HIV-1 from clades A-D, A/E, and G (EC50s = 0.5-6.7 μM). It interacts with gp120 and inhibits HIV-1 NL4.3 binding to human soluble CD4 (EC50 = 4.4 μM) and to CD4+ SupT1 T cells by 74.5% when us...
T37860	T 26c disodium salt	Others	Others
	Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable. Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1 binding site. Bioorg.Med.Chem. 22 5487 PMID:25192810"
T36176	AMK (hydrochloride)	Others	Others
	AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7...

化合物

D-Fructose-6-phosphate (sodium salt hydrate)

Cat.No: T37985

Synonym: D-Fructose-6-phosphate (sodium salt hydrate) (643-13-0 free base)

Cat.No: T36054

Target: Others

mTOR inhibitor 13

Cat.No: T9310

Target: PI3K, mTOR

Cat.No: T10944

Target: Others

13-Deoxycarminomycin

Cat.No: T24968

Synonym: R20X,R-20X,Antibiotic D 788-11,R 20X

Target: Others

Biotin-PEG3-acid

Cat.No: T14589

Synonym: 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸

Target: Others, PROTAC Linker

Cat.No: T2664

Synonym: OC000459

Target: GPR, Prostaglandin Receptor

Cat.No: T14943

Target: VEGFR, CDK, PKC

Cat.No: T31190

Target: Others

2-Acetamido-2,4-dideoxy-4-fluoro-α-D-glucopyranose

Cat.No: T38695

Target: Others

Cat.No: T3407

Synonym: GLYX-13,雷帕替奈,Thr-Pro-Pro-Thr-NH2,TPPT-amide

Target: NMDAR, iGluR

Cat.No: TP1023

Synonym: TPPT

Schisanchinin D

Cat.No: T125682

Target: Others

Timapiprant sodium

Cat.No: T17099

Synonym: OC000459 sodium

Target: Others

Cat.No: T37056

Target: Others

C6 D-threo Ceramide (d18:1/6:0)

Cat.No: T37565

Synonym: C6 D-threo Ceramide (d18:1/6:0)

Target: Others

D-Homoserine lactone

Cat.No: T36396

Target: Others

Cat.No: T81451

VH 032 amide-alkylC5-amine

Cat.No: T36281

Synonym: VH 032 amide-alkylC5-amine

Target: Others

Ethynyl Estradiol 3-β-D-Glucuronide (hydrate)

Cat.No: T36917

Target: Others

Cat.No: T37874

T 26c disodium salt

Cat.No: T37860

Target: Others

AMK (hydrochloride)

Cat.No: T36176

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN6271	11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester
	11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6271，CAS号为 75911-16-9。
TN6498	Stevia impurity (13-[(2-O-6-deoxy-Î²-D-glucopyranosyl-3-O-Î²-D-glucopyranosyl-Î²-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid Î²-D-glucopyranosyl ester)
	Stevia impurity (13-[(2-O-6-deoxy-Î²-D-glucopyranosyl-3-O-Î²-D-glucopyranosyl-Î²-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid Î²-D-glucopyranosyl ester) 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6498，CAS号为 1309929-72-3。
TN2661	19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide	Others	Others
	19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2661，CAS号为 919120-78-8。
T3889	Platycodin D	Prostaglandin Receptor; AMPK	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物，是AMPKα的激活剂，具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。
TN6432	Bergaptol O-β-D-glucopyranoside Bergaptol-beta-glucopyranoside
	Bergaptol O-β-D-glucopyranoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6432，CAS号为 131623-13-7。
T75567	Cabenoside D	Others	Others
	Cabenoside D（化合物 8）是从苔藓根的甲醇提取物中分离的一种三萜苷，显示出对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的小鼠炎症的抗炎活性，并能抑制TPA促使的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）激活。
T37272	9(S),12(S),13(S)-TriHOME	Others	Others
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...

天然产物

11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester

Cat.No: TN6271

Stevia impurity (13-[(2-O-6-deoxy-Î²-D-glucopyranosyl-3-O-Î²-D-glucopyranosyl-Î²-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid Î²-D-glucopyranosyl ester)

Cat.No: TN6498

19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide

Cat.No: TN2661

Target: Others

Cat.No: T3889

Target: Prostaglandin Receptor, AMPK

Bergaptol O-β-D-glucopyranoside

Cat.No: TN6432

Synonym: Bergaptol-beta-glucopyranoside

Cat.No: T75567

Target: Others

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00074	IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) IFN-α-1/13,IFN alpha1,干扰素,Interferon α-1/13	Mouse	HEK293 Cells
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.88 kDa and the accession number is P01572.
TMPK-00075	IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc) IFN-α-1/13,IFN α1,IFN alpha1,干扰素,IFNA1,IFN α 1,IFNa...	Human	HEK293 Cells
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.14 kDa and the accession number is P01562.
TMPH-01632	MRC1 Protein, Human, Recombinant (His) Human mannose receptor,C-type lectin domain family ...	Human	E. coli
	Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.; (Microbial infection) Interacts with Hepatitis B virus envelope protein. MRC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 69.9...
TMPY-03391	ESD Protein, Human, Recombinant (His) esterase D,FGH	Human	E. coli
	Esterase D, also known as ESD, is a serine hydrolase that belongs to the esterase D family. Esterase D is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. Esterase D gene is used as a genetic marker and a diagnostic tool for retinoblastoma, Wilson's disease and other hereditary or acquired diseases controlled by genes located at the 13 chromosome 13q14 region.
TMPK-01373	Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc) FINC,LETS,GFND,SMDCF,GFND2,ED...	Human	HEK293 Cells
	Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicte...
TMPK-01391	Fibronectin Protein, Human, Recombinant (aa 1266-1356, His) FN1,LETS,GFND,MSF,FNZ,CIG,ED-B,FN,SMD<...	Human	HEK293 Cells
	Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 1266-1356, His) is expressed in HEK293 mammalian cells with C-His tag. The predicte...

重组蛋白

IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00074

Species: Mouse

Expression System: HEK293 Cells

IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00075

Species: Human

Expression System: HEK293 Cells

MRC1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01632

Species: Human

Expression System: E. coli

ESD Protein, Human, Recombinant (His)

Cat.No: TMPY-03391

Species: Human

Expression System: E. coli

Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc)

Cat.No: TMPK-01373

Species: Human

Expression System: HEK293 Cells

Fibronectin Protein, Human, Recombinant (aa 1266-1356, His)

Cat.No: TMPK-01391

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T13432	β-Apo-13-carotenone D3 D'Orenone D3	Others	Others
	β-Apo-13-carotenone D3 is the deuterium labeled β-Apo-13-carotenone. β-Apo-13-carotenone is an antagonist of RXRα.

同位素标记化合物

β-Apo-13-carotenone D3

Cat.No: T13432

Synonym: D'Orenone D3

Target: Others

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