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Search Results for " d 13 "

Targets Recommended: Others

30

抑制剂 & 化合物

7

天然产物

6

重组蛋白

63

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T36054	D13	Others	Others
	D13 is an acylhydrazone antifungal.1 It is active against C. neoformans in vitro (MIC80 = 0.06 μg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infection. \|1. Lazzarini, C., Haranahalli, K., Rieger, R., et al. Acylhydrazones as antifungal agents targeting the synthesis of fungal sphingolipids. Antimicrob. Agents Chemother. 62(5), e00156-00118 (2018).
T37985	D-Fructose-6-phosphate (sodium salt hydrate) D-Fructose-6-phosphate (sodium salt hydrate) (643-13-0 free base)
	D-Fructose-6-phosphate (sodium salt hydrate) 是由磷酸葡萄糖异构酶将 6-磷酸葡萄糖异构化产生的糖酵解途径的糖中间体，可用于研究癌症。
T9310	mTOR inhibitor 13	PI3K; mTOR	PI3K/Akt/mTOR signaling
	mTOR inhibitor 13是一种选择性的mTOR 抑制剂，对mTOR 和PI3Kα的IC50分别为0.29nM 和119nM。
T10944	D13-9001	Others	Others
	The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effective AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor.
T24968	13-Deoxycarminomycin R20X,R-20X,Antibiotic D 788-11,R 20X	Others	Others
	13-Deoxycarminomycin is an antitumor antibiotic.
T14589	Biotin-PEG3-acid 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸	Others; PROTAC Linker	Others; PROTAC
	Biotin-PEG3-acid 是一种属于 PEG 类的、生物素标记的 PROTAC linker，可用于 PROTAC 分子的合成。
T38936	KRAS G13D peptide, 25 mer KRAS G13D peptide, 25 mer
	KRAS G13D peptide, a 25-mer sequence, is derived from the KRAS activating oncogene mutation and serves as an immune potentiator. This peptide possesses immunogenic properties and can be utilized for the development of a KRAS vaccine.
T35683	2-deoxy-D-Glucose-13C6 2-deoxy-D-Glucose-13C6	Others	Others
	2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B oste...
T37257	13,14-dihydro-15-keto Prostaglandin D1 13,14-dihydro-15-keto Prostaglandin D1	Others	Others
	Prostaglandin D1 (PGD1) is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2. 13,14-dihydro-15-keto Prostaglandin D1 (13,14-dihydro-15-keto PGD1) is the theoretical metabolite of PGD1 via the 15-hydroxy PG dehydrogenase metabolic pathway. No biological studies for this compound have been repo...
T64178	KRAS G12D inhibitor 13	Others	Others
	KRAS G12D inhibitor 13 是一种 KRAS G12D 的有效抑制剂。其中 Ras 蛋白家族是一种重要的细胞内信号分子，在生长发育中发挥着重要作用。KRAS G12D inhibitor 13 对 KRAS G12D 介导的癌症表现出研究潜力。
T83776	Dopamine D3 Receptor Agonist 13a
	Dopamine D3 受体激动剂13a是一种Dopamine D3 受体激动剂。该化合物选择性地与Dopamine D3 受体结合，相较于Dopamine D1、D2和D4受体(Kis = 0.14、4,600、2.85和756 nM，分别)具有更高的亲和力，并且还能与血清素(5-HT)受体亚型5-HT1A、5-HT2A、5-HT2B和5-HT2C(Kis = 6、54、1.47和252 nM，分别)结合；然而，它是Dopamine D2受体的部分激动剂(EC50 = 2.26 nM，在G蛋白招募分析中)并且作为Dopamine D3受体的拮抗剂(IC50 = 4.62 nM)。在大鼠身上，当剂量为3 mg/kg时，Dopamine D3 受体激动剂13a能减少可卡因自我给药。
T78271	Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)
	Anti-Mouse TCR gamma/delta Antibody为针对小鼠TCR gamma/delta的IgG类免疫抑制抗体，其宿主为亚美尼亚仓鼠。
T76601	(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14)
	'(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin(6-14)是一种蛙皮素(bombesin)拮抗剂，主要应用于癌症研究领域。'
T2664	Timapiprant OC000459	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Timapiprant (OC000459) 是一种有效的选择性 D 前列腺素受体 2(DP2) 拮抗剂，IC50为 13 nM。它抑制肥大细胞激活 Th2 淋巴细胞和嗜酸性粒细胞，有效地置换来自人重组 DP2、大鼠重组 DP2 和人天然 DP2 的 [3H] PGD2。
T14943	CGP60474	VEGFR; CDK; PKC	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CGP60474 是一种高效的抗内毒素药物，抑制细胞周期蛋白依赖激酶(CDK) ，抑制 CDK1/B、CDK2/E、CDK2/a、CDK4/D、CDK5/p25、CDK7/H 和 CDK9/T 的IC50分别为 26、3、4、216、10、200 和 13 nM。它是选择性和 ATP 竞争性PKC 抑制剂。
T31190	Dafphedyn	Others	Others
	Dafphedyn, [D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN) is an effective analog of strong endorphin 1-13 and produces diuretic and deep analgesia when administered intravenously in rats.
T38695	2-Acetamido-2,4-dideoxy-4-fluoro-α-D-glucopyranose	Others	Others
	2-Acetamido-2,4-dideoxy-4-fluoro-α-D-glucopyranose (compound 13) functions as a potent hepatic glycosaminoglycan biosynthesis inhibitor.
T3407	Rapastinel GLYX-13,雷帕替奈,Thr-Pro-Pro-Thr-NH2,TPPT-amide	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Rapastinel (TPPT-amide) 是 N-甲基-D-天冬氨酸受体 (NMDAR) 调节剂，也有部分激动剂特性。
TP1023	NT 13 TPPT
	NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.
T125682	Schisanchinin D	Others	Others
	Schisanchinin D 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125682，CAS号为 1614245-13-4。
T17099	Timapiprant sodium OC000459 sodium	Others	Others
	Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), ra
T37056	D-erythro-MAPP	Others	Others
	D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 μM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 μM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.
T37565	C6 D-threo Ceramide (d18:1/6:0) C6 D-threo Ceramide (d18:1/6:0)	Others	Others
	C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater...
T36396	D-Homoserine lactone	Others	Others
	D-homoserine lactone is an enantiomer of L-homoserine lactone and an inhibitor of serine hydroxymethyltransferase (SHMT; Ki= 11 mM for the rabbit enzyme).1 1.Wang, E.A., Kallen, R., and Walsh, C.Mechanism-based inactivation of serine transhydroxymethylases by D-fluoroalanine and related amino acidsJ. Biol. Chem.256(13)6917-6926(1981)
T81451	PKCd (8-17)
	PKCd (8-17) 是源自蛋白激酶 C (PKC)d V1 结构域的生物活性肽。它能抑制由佛波醇 12-肉豆蔻酸酯 13-乙酸酯 (PMA) 诱导的 PKCd 易位和激活。此外，PKCd (8-17) 在降低心脏和脑细胞缺血损伤、促进成纤维细胞增殖、以及抑制小鼠移植冠状动脉疾病方面具有潜在应用。
T36281	VH 032 amide-alkylC5-amine VH 032 amide-alkylC5-amine	Others	Others
	Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 13 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
T36917	Ethynyl Estradiol 3-β-D-Glucuronide (hydrate)	Others	Others
	Ethynyl estradiol 3-β-D-glucuronide is a metabolite of ethynyl estradiol that can be detected in urine.1,2It is used as a marker of estrogen contamination in fresh and saltwater.2 1.Hadd, H.E., Slikker, W., Jr., and Helton, E.D.The synthesis and characterization of the glucopyranosiduronic acids of 17a-ethynylestradiol-17bJ. Steroid Biochem.13(9)1107-1114(1980) 2.Griffith, D.R., Soule, M.C.K., Eglinton, T.I., et al.Steroidal estrogen sources in a sewage-impacted coastal oceanEnviron. Sci.: Proce...
T37874	Feglymycin
	Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities. It is active against Gram-positive bacteria (MICs = 32-64 μg/ml) and inhibits HIV viral replication in H9 cells (IC50 = ~5 μM). Feglymycin is also active against clinical isolates of HIV-1 from clades A-D, A/E, and G (EC50s = 0.5-6.7 μM). It interacts with gp120 and inhibits HIV-1 NL4.3 binding to human soluble CD4 (EC50 = 4.4 μM) and to CD4+ SupT1 T cells by 74.5% when us...
T37860	T 26c disodium salt	Others	Others
	Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable. Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1 binding site. Bioorg.Med.Chem. 22 5487 PMID:25192810"
T36176	AMK (hydrochloride)	Others	Others
	AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7...

化合物

Cat.No: T36054

Target: Others

D-Fructose-6-phosphate (sodium salt hydrate)

Cat.No: T37985

Synonym: D-Fructose-6-phosphate (sodium salt hydrate) (643-13-0 free base)

mTOR inhibitor 13

Cat.No: T9310

Target: PI3K, mTOR

Cat.No: T10944

Target: Others

13-Deoxycarminomycin

Cat.No: T24968

Synonym: R20X,R-20X,Antibiotic D 788-11,R 20X

Target: Others

Biotin-PEG3-acid

Cat.No: T14589

Synonym: 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸

Target: Others, PROTAC Linker

KRAS G13D peptide, 25 mer

Cat.No: T38936

Synonym: KRAS G13D peptide, 25 mer

2-deoxy-D-Glucose-13C6

Cat.No: T35683

Synonym: 2-deoxy-D-Glucose-13C6

Target: Others

13,14-dihydro-15-keto Prostaglandin D1

Cat.No: T37257

Synonym: 13,14-dihydro-15-keto Prostaglandin D1

Target: Others

KRAS G12D inhibitor 13

Cat.No: T64178

Target: Others

Dopamine D3 Receptor Agonist 13a

Cat.No: T83776

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)

Cat.No: T78271

(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14)

Cat.No: T76601

Cat.No: T2664

Synonym: OC000459

Target: GPR, Prostaglandin Receptor

Cat.No: T14943

Target: VEGFR, CDK, PKC

Cat.No: T31190

Target: Others

2-Acetamido-2,4-dideoxy-4-fluoro-α-D-glucopyranose

Cat.No: T38695

Target: Others

Cat.No: T3407

Synonym: GLYX-13,雷帕替奈,Thr-Pro-Pro-Thr-NH2,TPPT-amide

Target: NMDAR, iGluR

Cat.No: TP1023

Synonym: TPPT

Schisanchinin D

Cat.No: T125682

Target: Others

Timapiprant sodium

Cat.No: T17099

Synonym: OC000459 sodium

Target: Others

Cat.No: T37056

Target: Others

C6 D-threo Ceramide (d18:1/6:0)

Cat.No: T37565

Synonym: C6 D-threo Ceramide (d18:1/6:0)

Target: Others

D-Homoserine lactone

Cat.No: T36396

Target: Others

Cat.No: T81451

VH 032 amide-alkylC5-amine

Cat.No: T36281

Synonym: VH 032 amide-alkylC5-amine

Target: Others

Ethynyl Estradiol 3-β-D-Glucuronide (hydrate)

Cat.No: T36917

Target: Others

Cat.No: T37874

T 26c disodium salt

Cat.No: T37860

Target: Others

AMK (hydrochloride)

Cat.No: T36176

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN6271	11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester
	11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6271，CAS号为 75911-16-9。
TN6498	Stevia impurity (13-[(2-O-6-deoxy-Î²-D-glucopyranosyl-3-O-Î²-D-glucopyranosyl-Î²-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid Î²-D-glucopyranosyl ester)
	Stevia impurity (13-[(2-O-6-deoxy-Î²-D-glucopyranosyl-3-O-Î²-D-glucopyranosyl-Î²-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid Î²-D-glucopyranosyl ester) 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6498，CAS号为 1309929-72-3。
TN2661	19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide	Others	Others
	19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2661，CAS号为 919120-78-8。
T3889	Platycodin D	Prostaglandin Receptor; AMPK	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物，是AMPKα的激活剂，具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。
TN6432	Bergaptol O-β-D-glucopyranoside Bergaptol-beta-glucopyranoside
	Bergaptol O-β-D-glucopyranoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6432，CAS号为 131623-13-7。
T75567	Cabenoside D	Others	Others
	Cabenoside D（化合物 8）是从苔藓根的甲醇提取物中分离的一种三萜苷，显示出对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的小鼠炎症的抗炎活性，并能抑制TPA促使的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）激活。
T37272	9(S),12(S),13(S)-TriHOME	Others	Others
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...

天然产物

11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester

Cat.No: TN6271

Stevia impurity (13-[(2-O-6-deoxy-Î²-D-glucopyranosyl-3-O-Î²-D-glucopyranosyl-Î²-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid Î²-D-glucopyranosyl ester)

Cat.No: TN6498

19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide

Cat.No: TN2661

Target: Others

Cat.No: T3889

Target: Prostaglandin Receptor, AMPK

Bergaptol O-β-D-glucopyranoside

Cat.No: TN6432

Synonym: Bergaptol-beta-glucopyranoside

Cat.No: T75567

Target: Others

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00074	IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) IFN-α-1/13,IFN alpha1,干扰素,Interferon α-1/13	Mouse	HEK293 Cells
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.88 kDa and the accession number is P01572.
TMPK-00075	IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc) IFN-α-1/13,IFN α1,IFN alpha1,干扰素,IFNA1,IFN α 1,IFNa...	Human	HEK293 Cells
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.14 kDa and the accession number is P01562.
TMPH-01632	MRC1 Protein, Human, Recombinant (His) Human mannose receptor,C-type lectin domain family ...	Human	E. coli
	Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.; (Microbial infection) Interacts with Hepatitis B virus envelope protein. MRC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 69.9...
TMPY-03391	ESD Protein, Human, Recombinant (His) esterase D,FGH	Human	E. coli
	Esterase D, also known as ESD, is a serine hydrolase that belongs to the esterase D family. Esterase D is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. Esterase D gene is used as a genetic marker and a diagnostic tool for retinoblastoma, Wilson's disease and other hereditary or acquired diseases controlled by genes located at the 13 chromosome 13q14 region.
TMPK-01373	Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc) FINC,LETS,GFND,SMDCF,GFND2,ED...	Human	HEK293 Cells
	Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicte...
TMPK-01391	Fibronectin Protein, Human, Recombinant (aa 1266-1356, His) FN1,LETS,GFND,MSF,FNZ,CIG,ED-B,FN,SMD<...	Human	HEK293 Cells
	Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 1266-1356, His) is expressed in HEK293 mammalian cells with C-His tag. The predicte...

重组蛋白

IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00074

Species: Mouse

Expression System: HEK293 Cells

IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00075

Species: Human

Expression System: HEK293 Cells

MRC1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01632

Species: Human

Expression System: E. coli

ESD Protein, Human, Recombinant (His)

Cat.No: TMPY-03391

Species: Human

Expression System: E. coli

Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc)

Cat.No: TMPK-01373

Species: Human

Expression System: HEK293 Cells

Fibronectin Protein, Human, Recombinant (aa 1266-1356, His)

Cat.No: TMPK-01391

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T35618	D-Fructose-13C6 D-果糖 13C6	Others	Others
	D-Fructose-13C6 可用作通过 GC-或 LC-MS 定量 D-果糖的内标。
T19261	D-Glucose-13C6 D-(+)-Glucose-13C6,Glucose-13C6,Dextrose-13C6	Endogenous Metabolite	Metabolism
	D-Glucose-13C6 (Dextrose-13C6) 是一种 D-Glucose 的同位素标记物，可作为代谢示踪剂，可用于研究机体代谢相关疾病和部分物质的代谢过程。
T13432	β-Apo-13-carotenone D3 D'Orenone D3	Others	Others
	β-Apo-13-carotenone D3 is the deuterium labeled β-Apo-13-carotenone. β-Apo-13-carotenone is an antagonist of RXRα.
TMID-0199	Rifampicin-13C-d3
	Rifampicin-13C-d3 是 Rifampicin 的 13C 和氘代化合物。Rifampicin 的 CAS 号为 13292-46-1。Rifampicin是广谱抗生素，可抵抗细菌病原体以及具有抗流感病毒活性。
TMIJ-0477	Alachlo-d13 (2,6-diethylphenyl-d13)
	Alachlo-d13 (2,6-diethylphenyl-d13) 是 Alachlo 的氘代化合物。
TMIJ-0087	Mycophenolic acid-13C-d3
	Mycophenolic acid-13C-d3 是 Mycophenolic acid 的 13C 和氘代化合物。Mycophenolic acid 的 CAS 号为 24280-93-1。Mycophenolic acid 是一种有效的非竞争性肌苷单磷酸脱氢酶 (IMPDH) 抑制剂，EC50为 0.24 µM。它对多种 RNA 病毒具有抗病毒作用。它也是一种免疫抑制剂，具有抗血管生成和抗肿瘤作用。
TMIJ-0110	Clarithromycin-13C-d3
	Clarithromycin-13C-d3 是 Clarithromycin 的 13C 和氘代化合物。Clarithromycin 的 CAS 号为 81103-11-9。Clarithromycin 具有广谱的抗菌活性。它抑制CYP3A4催化的三唑仑 α-羟基化，IC50(Ki) 值为 56 (43) μM。它抑制 HERG 钾电流。它可削弱连接 hERG1 和 PI3K 的信号通路影响自噬流。
TMIJ-0250	Lusutrombopag-d13
	Lusutrombopag-d13 是 Lusutrombopag 的氘代化合物。Lusutrombopag 的 CAS 号为 1110766-97-6。Lusutrombopag 是一种口服生物可利用的小分子血小板生成素 (TPO) 受体激动剂，用于选择性侵入性手术前患有血小板减少症的慢性肝病的患者。
TMIJ-0340	Lincomycin-13C-d3
	Lincomycin-13C-d3 是 Lincomycin 的 13C 和氘代化合物。Lincomycin 的 CAS 号为 7179-49-9。Lincomycin hydrochloride monohydrate 是一种窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌的作用效果很好, 主要抑制细菌细胞蛋白质的合成。
TMIJ-0375	Levomefolic Acid-13C-d3
	Levomefolic Acid-13C-d3 是 Levomefolic Acid 的 13C 和氘代化合物。Levomefolic Acid 的 CAS 号为 31690-09-2。Levomefolic acid是一种具有口服活性、可穿过血脑屏障的天然活性叶酸，是广泛使用的叶酸食品补充剂。
TMIJ-0109	Erythromycin Ethylsuccinate-13C-d3
	Erythromycin Ethylsuccinate-13C-d3 是 Erythromycin Ethylsuccinate 的 13C 和氘代化合物。Erythromycin Ethylsuccinate 的 CAS 号为 1264-62-6。Erythromycin Ethylsuccinate是一种由红链霉菌产生的大环内酯类抗生素，有潜力用于多种细菌感染。它具有抗HIV-1病毒活性。
TMIJ-0186	Bromocriptine-13C-d3
	Bromocriptine-13C-d3 是 Bromocriptine 的 13C 和氘代化合物。Bromocriptine 的 CAS 号为 25614-03-3。
TMIJ-0181	Clindamycin-13C-d3
	Clindamycin-13C-d3 是 Clindamycin 的 13C 和氘代化合物。Clindamycin 的 CAS 号为 18323-44-9。Clindamycin 从细菌核糖体中解离肽基-tRNA，破坏细菌蛋白质合成。它是一种半合成广谱抗生素，由母体化合物林可霉素化学修饰而成。
TMIJ-0111	Azithromycin-13C-d3
	Azithromycin-13C-d3 是 Azithromycin 的 13C 和氘代化合物。Azithromycin 的 CAS 号为 83905-01-5。Azithromycin是一种常用于细菌感染研究的大环内酯抗生素。
TMIJ-0265	Homovanillic Acid-13C-d3
	Homovanillic Acid-13C-d3 是 Homovanillic Acid 的 13C 和氘代化合物。Homovanillic Acid 的 CAS 号为 306-08-1。Homovanillic acid 是一种多巴胺代谢物，它与乳糜泻、生长激素缺乏、芳香族氨基酸脱羧酶缺乏症以及脂联素还原酶缺乏症相关。
TMIJ-0251	Nicergoline-13C-d3
	Nicergoline-13C-d3 是 Nicergoline 的 13C 和氘代化合物。Nicergoline 的 CAS 号为 27848-84-6。Nicergoline 是一种有效的，选择性的、具有口服活性的α1A-肾上腺素能受体拮抗剂，是一种溴烟碱酸的麦角林衍生物。它具有血管舒张作用，可以改善阿尔茨海默症小鼠的认知功能。
TMID-0285	Lamivudine-13C-d2
	Lamivudine-13C-d2 是 Lamivudine 的 13C 和氘代化合物。Lamivudine 的 CAS 号为 134678-17-4。Lamivudine 是一种核苷逆转录酶抑制剂，可抑制HIV逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。
TMID-0060	Methylcobalamin-13C-d3
	Methylcobalamin-13C-d3 是 Methylcobalamin 的 13C 和氘代化合物。Methylcobalamin 的 CAS 号为 13422-55-4。Methylcobalamin 是维生素B12的一种形式,可直接参与同型半胱氨酸代谢。
TMID-0281	Moxifloxacin-13C-d3
	Moxifloxacin-13C-d3 是 Moxifloxacin 的 13C 和氘代化合物。Moxifloxacin 的 CAS 号为 151096-09-2。Moxifloxacin 是一种8-甲氧基喹诺酮类口服有效抗菌药物，用于急性细菌性鼻窦炎，慢性支气管炎的急性细菌性加重和感染性肺炎的研究。
TMIH-0210	Eluxadoline-13C-d3
	Eluxadoline-13C-d3 是 Eluxadoline 的 13C 和氘代化合物。Eluxadoline 的 CAS 号为 864825-13-8。
TMIJ-0003	Dabigatran-13C-d3
	Dabigatran-13C-d3 是 Dabigatran 的 13C 和氘代化合物。Dabigatran 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
TMIH-0393	Nintedanib-13C-d3
	Nintedanib-13C-d3 是 Nintedanib 的 13C 和氘代化合物。Nintedanib 的 CAS 号为 656247-17-5。Nintedanib 是一种有效的三重血管激酶抑制剂，能够抑制VEGFR1 (IC50:34 nM)、VEGFR2 (IC50:13 nM)、VEGFR3 (IC50:13 nM)，FGFR1 (IC50:69 nM)、FGFR2 (IC50:37 nM)、FGFR3 (IC50:108 nM)，PDGFRα (IC50:59 nM)、PDGFRβ (IC50:65 nM)。
TMIH-0092	Apalutamide-13C-d3
	Apalutamide-13C-d3 是 Apalutamide 的 13C 和氘代化合物。Apalutamide 的 CAS 号为 956104-40-8。Apalutamide 是一种有效、竞争性的雄激素受体 (AR) 拮抗剂(IC50:16 nM)。
TMIJ-0143	Linagliptin-13C-d3
	Linagliptin-13C-d3 是 Linagliptin 的 13C 和氘代化合物。Linagliptin 的 CAS 号为 668270-12-0。Linagliptin 是一种有效的、可口服的、基于二氢嘌呤二酮的二肽基肽酶 4 抑制剂，具有降血糖活性。
TMIJ-0185	Telmisartan-13C-d3
	Telmisartan-13C-d3 是 Telmisartan 的 13C 和氘代化合物。Telmisartan 的 CAS 号为 144701-48-4。Telmisartan 是一种血管紧张素II 1型受体拮抗剂，能够抑制其活性，IC50值为 9.2 nM。
T37928	13C6 Glucosylsphingosine (d18:1)
	13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS. 1-β-D-Glucosylsphingosine is a lysolipid derivative of glucosylcerebroside that decreases activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner.
TMIJ-0124	Regorafenib-13C-d3
	Regorafenib-13C-d3 是 Regorafenib 的 13C 和氘代化合物。Regorafenib 的 CAS 号为 755037-03-7。Regorafenib 是一种多靶点受体酪氨酸激酶抑制剂，对 RET、C-RAF、VEGFR2、c-Kit、VEGFR1和PDGFRβ 的 IC50为1.5、2.5、4.2、7、13和22 nM。
TMIJ-0076	Ritonavir-13C-d3
	Ritonavir-13C-d3 是 Ritonavir 的 13C 和氘代化合物。Ritonavir 的 CAS 号为 155213-67-5。Ritonavir 是一种 HIV 蛋白酶抑制剂，可研究 HIV 感染和 AIDS 。它也是SARS-CoV 3CLpro的抑制剂，IC50为 1.61 μM。
TMIH-0524	Sofosbuvir-13C-d3
	Sofosbuvir-13C-d3 是 Sofosbuvir 的 13C 和氘代化合物。Sofosbuvir 的 CAS 号为 1190307-88-0。Sofosbuvir 是一种丙型肝炎病毒聚合酶 NS5B 的尿苷单磷酸类似物抑制剂，用作治疗慢性丙型肝炎的抗病毒剂。
TMIH-0497	Riociguat-13C-d6
	Riociguat-13C-d6 是 Riociguat 的 13C 和氘代化合物。Riociguat 的 CAS 号为 625115-55-1。Riociguat 是一种鸟苷酸环化酶的刺激剂，可导致血管平滑肌松弛，用于治疗严重的肺动脉高压。
TMIH-0550	Taltirelin-13C-d3
	Taltirelin-13C-d3 是 Taltirelin 的 13C 和氘代化合物。Taltirelin 的 CAS 号为 103300-74-9。Taltirelin 是促甲状腺激素释放激素受体(TRH-R)超激动剂(IC50:910 nM)，能够刺激细胞溶质Ca2+浓度增加 (Ca2+释放) (EC50:36 nM)。
TMIJ-0066	Alosetron-13C-d3
	Alosetron-13C-d3 是 Alosetron 的 13C 和氘代化合物。Alosetron 的 CAS 号为 122852-42-0。
TMIJ-0148	Avanafil-13C-d3
	Avanafil-13C-d3 是 Avanafil 的 13C 和氘代化合物。Avanafil 的 CAS 号为 330784-47-9。Avanafil 是一种高活性PDE-5抑制剂，IC50=5.2 nM，对PDE1，PDE6和PDE11活性较低。
TMIJ-0191	Ondansetron-13C-d3
	Ondansetron-13C-d3 是 Ondansetron 的 13C 和氘代化合物。Ondansetron 的 CAS 号为 99614-02-5。Ondansetron 是一种血清素 5-HT3 受体拮抗剂，主要用作止吐剂。
TMIJ-0108	rac-Hesperetin-13C-d3 rac-Diosmin EP Impurity G-13C-d3
	rac-Hesperetin-13C-d3 是 rac-Hesperetin 的 13C 和氘代化合物。rac-Hesperetin 的 CAS 号为 69097-99-0。
TMIH-0221	Erythromycin-13C-d3
	Erythromycin-13C-d3 是 Erythromycin 的 13C 和氘代化合物。
TMIH-0117	Binimetinib-13C-d3
	Binimetinib-13C-d3 是 Binimetinib 的 13C 和氘代化合物。Binimetinib 的 CAS 号为 606143-89-9。Binimetinib 是一种可口服的选择性MEK1/2抑制剂，抑制MEK的IC50为 12 nM。
TMIH-0548	Tacrolimus-13C-d2
	Tacrolimus-13C-d2 是 Tacrolimus 的 13C 和氘代化合物。
TMIH-0461	Prucalopride-13C-d3
	Prucalopride-13C-d3 是 Prucalopride 的 13C 和氘代化合物。Prucalopride 的 CAS 号为 179474-81-8。Prucalopride 是一种选择性、高亲和力的 5-HT4A/4B 受体激动剂，Ki为2.5和 8 nM。它对 5-HT4A/4B 受体的选择性是其他 5-HT 受体亚型的 290 倍以上。
TMIJ-0058	Lamotrigine-13C-d3
	Lamotrigine-13C-d3 是 Lamotrigine 的 13C 和氘代化合物。Lamotrigine 的 CAS 号为 84057-84-1。Lamotrigine 是一种抗癫痫剂和情绪稳定剂，可研究癫痫、局灶性癫痫等。。它选择性地阻断电压门控钠离子通道，稳定突触前神经元膜，抑制谷氨酸释放。
TMIJ-0223	Exemestane-13C-d3
	Exemestane-13C-d3 是 Exemestane 的 13C 和氘代化合物。Exemestane 的 CAS 号为 107868-30-4。Exemestane 是一种选择性的、具有口服活性的、不可逆的甾体芳香酶抑制剂，能够作用于人胎盘芳香酶 (IC50:30 nM) 和大鼠卵巢芳香酶 (IC50:40 nM)，可用于研究激素依赖性乳腺癌。
TMID-0210	Sildenafil-13C-d3
	Sildenafil-13C-d3 是 Sildenafil 的 13C 和氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂，IC50为 5.22 nM。
TMIH-0583	Trelagliptin-13C-d3
	Trelagliptin-13C-d3 是 Trelagliptin 的 13C 和氘代化合物。Trelagliptin 的 CAS 号为 865759-25-7。Trelagliptin 是一种有效的，具有口服活性的DPP-4抑制剂，IC50=4 nM。它可以改善体内血糖控制，能够用于2 型糖尿病 (T2DM) 的研究。
TMID-0209	Tadalafil-13C-d3
	Tadalafil-13C-d3 是 Tadalafil 的 13C 和氘代化合物。Tadalafil 的 CAS 号为 171596-29-5。Tadalafil 是一种PDE5抑制剂，IC50为 1.8 nM。
TMIJ-0071	Oseltamivir-13C-d3 Acid
	Oseltamivir-13C-d3 Acid 是 Oseltamivir Acid 的 13C 和氘代化合物。Oseltamivir Acid 的 CAS 号为 187227-45-8。Oseltamivir acid是Oseltamivir phosphate 的活性代谢产物，是一种有效的流感病毒神经氨酸酶抑制剂和 GS4071 的前药。
TMIH-0025	13C-d3-AOH1996
	13C-d3-AOH1996 是 AOH1996 的 13C 和氘代化合物。AOH1996 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体，靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用，导致 DNA 复制应激，诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用，可抑制肿瘤细胞生长。
TMID-0283	Vancomycin-13C-d3
	Vancomycin-13C-d3 是 Vancomycin 的 13C 和氘代化合物。Vancomycin 的 CAS 号为 1404-90-6。Vancomycin 是一种抗生素，用于通过阻止细菌生长来治疗严重的细菌感染。它还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。
TMIH-0111	Berberine hydrochloride-13C-d3
	Berberine hydrochloride-13C-d3 是 Berberine hydrochloride 的 13C 和氘代化合物。
TMIJ-0113	Clevidipine Impurity 24-13C-d3
	Clevidipine Impurity 24-13C-d3 是 Clevidipine Impurity 24 的 13C 和氘代化合物。
TMIJ-0376	D-Glucose-1,2-13C2
	D-Glucose-1,2-13C2 是 D-Glucose 的 13C 的标记化合物。D-Glucose 的 CAS 号为 50-99-7。D-Glucose 是一种单糖。D-Glucose 是甜味剂，是一般代谢的关键组成部分，并作为与细胞代谢状态以及生物和非生物应激反应有关的关键信号分子。
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同位素标记化合物

D-Fructose-13C6

Cat.No: T35618

Synonym: D-果糖 13C6

Target: Others

Cat.No: T19261

Synonym: D-(+)-Glucose-13C6,Glucose-13C6,Dextrose-13C6

Target: Endogenous Metabolite

β-Apo-13-carotenone D3

Cat.No: T13432

Synonym: D'Orenone D3

Target: Others

Rifampicin-13C-d3

Cat.No: TMID-0199

Alachlo-d13 (2,6-diethylphenyl-d13)

Cat.No: TMIJ-0477

Mycophenolic acid-13C-d3

Cat.No: TMIJ-0087

Clarithromycin-13C-d3

Cat.No: TMIJ-0110

Lusutrombopag-d13

Cat.No: TMIJ-0250

Lincomycin-13C-d3

Cat.No: TMIJ-0340

Levomefolic Acid-13C-d3

Cat.No: TMIJ-0375

Erythromycin Ethylsuccinate-13C-d3

Cat.No: TMIJ-0109

Bromocriptine-13C-d3

Cat.No: TMIJ-0186

Clindamycin-13C-d3

Cat.No: TMIJ-0181

Azithromycin-13C-d3

Cat.No: TMIJ-0111

Homovanillic Acid-13C-d3

Cat.No: TMIJ-0265

Nicergoline-13C-d3

Cat.No: TMIJ-0251

Lamivudine-13C-d2

Cat.No: TMID-0285

Methylcobalamin-13C-d3

Cat.No: TMID-0060

Moxifloxacin-13C-d3

Cat.No: TMID-0281

Eluxadoline-13C-d3

Cat.No: TMIH-0210

Dabigatran-13C-d3

Cat.No: TMIJ-0003

Nintedanib-13C-d3

Cat.No: TMIH-0393

Apalutamide-13C-d3

Cat.No: TMIH-0092

Linagliptin-13C-d3

Cat.No: TMIJ-0143

Telmisartan-13C-d3

Cat.No: TMIJ-0185

13C6 Glucosylsphingosine (d18:1)

Cat.No: T37928

Regorafenib-13C-d3

Cat.No: TMIJ-0124

Ritonavir-13C-d3

Cat.No: TMIJ-0076

Sofosbuvir-13C-d3

Cat.No: TMIH-0524

Riociguat-13C-d6

Cat.No: TMIH-0497

Taltirelin-13C-d3

Cat.No: TMIH-0550

Alosetron-13C-d3

Cat.No: TMIJ-0066

Avanafil-13C-d3

Cat.No: TMIJ-0148

Ondansetron-13C-d3

Cat.No: TMIJ-0191

rac-Hesperetin-13C-d3

Cat.No: TMIJ-0108

Synonym: rac-Diosmin EP Impurity G-13C-d3

Erythromycin-13C-d3

Cat.No: TMIH-0221

Binimetinib-13C-d3

Cat.No: TMIH-0117

Tacrolimus-13C-d2

Cat.No: TMIH-0548

Prucalopride-13C-d3

Cat.No: TMIH-0461

Lamotrigine-13C-d3

Cat.No: TMIJ-0058

Exemestane-13C-d3

Cat.No: TMIJ-0223

Sildenafil-13C-d3

Cat.No: TMID-0210

Trelagliptin-13C-d3

Cat.No: TMIH-0583

Tadalafil-13C-d3

Cat.No: TMID-0209

Oseltamivir-13C-d3 Acid

Cat.No: TMIJ-0071

Cat.No: TMIH-0025

Vancomycin-13C-d3

Cat.No: TMID-0283

Berberine hydrochloride-13C-d3

Cat.No: TMIH-0111

Clevidipine Impurity 24-13C-d3

Cat.No: TMIJ-0113

D-Glucose-1,2-13C2

Cat.No: TMIJ-0376

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