490
260
2
1
64
1
Cat. No. | Product Name | ||
---|---|---|---|
L6720 | 抗COVID-19中药单体库 | 1147 compounds | |
根据抗新冠肺炎疫情过程中应用于临床治疗的中药方剂,收集了1147 种相关中药来源的单体化合物,可用于高通量和高内涵筛选,是抗新冠病毒药物研发的良好工具; | |||
L6200 | 瑶药化合物库 | 221 compounds | |
221 种瑶药来源的天然产物分子集合,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0005 |
Cell Counting Kit-8 (CCK-8)
Cell Counting Kit-8 (CCK-8) |
Solution in bottle |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9925 |
Ofatumumab
|
Others | Others |
Ofatumumab 是一种人源化靶向抗 CD20单克隆抗体。它作用于表达 CD20 的 B 淋巴细胞,能够诱导产生抗体依赖性细胞介导的细胞毒性和补体依赖性细胞毒性的作用。 | |||
T7057 |
Methylstat
|
Histone Demethylase; Others | Chromatin/Epigenetic; Others |
Methylstat 是一种含有 Jumonji C 结构域的组蛋白去甲基化酶 (JMJD) 抑制剂的甲酯前药,具有良好的细胞渗透性。在体外试验中,methylstat 的游离酸可抑制 JMJD2A、JMJD2C、JMJD2E、PHF8 和 JMJD3,IC50 值分别约为 4.3、3.4、5.9、10 和 43 µM。 Methylstat 抑制 JMJD2C 敏感的食管癌细胞系 KYSE150 的生长,GI50 为 5.1 µM,而 methylstat 的游离酸在高达 100 µM 时不抑制细胞生长。 Methylstat 以浓度依赖性方式在多个位点诱导组蛋白高甲基化(KYSE150 细胞中 H3K4me3 和 H3K9me3 的 EC50 = 10.3 和 8.6 µM,MCF-7 细胞中的 EC50 分别为 6.7 和 6.3 µM)。 | |||
T0840 |
Methimazole
Tapazole,Thiamazole,甲巯咪唑 |
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
Methimazole (Thiamazole) 是抗甲状腺化合物,具有显著的肝毒性,常用于研究甲亢。 | |||
T9918 |
Daratumumab
达妥木单抗 |
Others; ADC Antibody | Antibody-drug Conjugate/ADC Related; Others |
Daratumumab 是一种首创的特异性抗CD38单克隆抗体。它损伤了 MM 细胞的粘附,从而增加了 MM 对蛋白酶体抑制的敏感性。它具有抗多发性骨髓瘤(MM) 的作用。 | |||
T3594 |
ML346
|
HSP | Cytoskeletal Signaling; Metabolism |
ML346是 Hsp70和 HSF-1活性的激活剂,针对 Hsp70 的 EC50为 4.6 μM。它诱导热休克反应 (HSR) 的基因和蛋白质效应子的特异性增加,如 Hsp70、Hsp40 和 Hsp27。 | |||
T2496 |
(Z)-Semaxinib
SU5416 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
(Z)-Semaxinib (SU5416) 是一种有效的选择性 VEGFR(Flk-1/KDR) 抑制剂 (IC50: 1.23 μM),对 VEGFR 的选择性是 PDGFRβ 的 20 倍,对 FGFR、InsR 和 EGFR 没有抑制作用。 Semaxanib 是一种具有潜在抗肿瘤活性的喹诺酮衍生物。 | |||
T1753 |
D-64131
|
Microtubule Associated | Cytoskeletal Signaling |
D64131 是一种微管蛋白聚合抑制剂,IC50 值为 0.53 μM。它具有抗丝分裂活性,可用于癌症研究。 | |||
T5399 |
GeA-69
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
GeA-69 是一种选择性变构 PARP14 大结构域 2 (MD2) 抑制剂,Kd 值为 2.1 µM。 | |||
T8235 |
L-732138
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
L-732138 是选择性有效和竞争性神经激肽-1受体拮抗剂,IC50为 2.3 nM,可减轻痛觉过敏并具有抗肿瘤作用。它在克隆的人 NK-1受体中的效力比在克隆大鼠 NK-1受体中高 200 倍,比人类 NK-2 和 NK-3 受体高 1000 倍以上。 | |||
TP1444 |
Magainin 2
蛙皮素 2 |
Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Magainin 2是从非洲爪蟾皮肤中分离得到的一种抗菌肽。它对许多革兰氏阴性和革兰氏阳性细菌显示出抗生素活性,对原生动物也有活性。它通过优先与细菌膜中丰富的阴离子磷脂相互作用而发挥细胞毒性作用。 | |||
T8320 |
J14
J-14 |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
J14 是一种可逆的 sulfiredoxin 抑制剂,IC50=8.1 μM。它能够抑制sulfiredoxin 诱导氧化应激,使细胞内ROS 积累,导致细胞毒性和癌细胞死亡。 | |||
T4337 |
PCI 29732
PCI29732,PCI-29732 |
Others; BCRP; BTK | Angiogenesis; Membrane transporter/Ion channel; Others; Tyrosine Kinase/Adaptors |
PCI 29732 是一种有效的可逆BTK 抑制剂,对 BTK、Lck 和 Lyn 的Kiapp 值分别为 8.2、4.6 和 2.5 nM。它通过竞争性结合ABCG2 的 ATP 结合位点来抑制ABCG2的功能。 | |||
T6612 |
NU6027
|
ATM/ATR; DNA-PK; CDK | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
NU6027 是一种有效的 ATR/CDK 抑制剂,抑制 CDK1/2、ATR 和 DNA-PK,Ki 为 2.5 μM/1.3 μM、0.4 μM 和 2.2 μM。它以 ATR 依赖性方式增强羟基脲和顺铂的细胞毒性。 | |||
T13951 |
UCB-9260
|
TNF | Apoptosis |
UCB-9260 是口服活性小分子,通过稳定三聚体的不对称形式抑制肿瘤坏死因子信号传导。它对肿瘤坏死因子的选择性高于其他超家族成员,并与肿瘤坏死因子结合,其Kd 值为 13 nM。 | |||
T4517 |
L189
|
DNA; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
L189 是一种人类 DNA 连接酶抑制剂,抑制 hLigI/III/IV,IC50值分别为5、9 和 5 μM。 | |||
T12871 |
Talmapimod
他匹莫德,SCIO-469 |
p38 MAPK | MAPK |
Talmapimod (SCIO-469) 是 选择性的,具有口服活性的,ATP 竞争性的 p38α抑制剂,对 p38α和 p38β的 IC50 值分别是 9 nM 和90 nM。Talmapimod 在 20 个其他激酶 (包括其他 MAPKs) 上显示出至少 2000 倍的选择性。 | |||
T6912 |
NU1025
NSC 696807 |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
NU1025 (NSC-696807) 是一种PARP 的有效抑制剂,IC50为 400 nM,Ki 为 48 nM。它可增强电离辐射和抗癌药物的细胞毒性,有抗癌和神经保护的作用。 | |||
T8492 |
BO-264
|
Apoptosis; FGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
BO-264 是一种有口服活性的转化酸性卷曲螺旋 3 抑制剂,可特异性阻断 FGFR3-TACC3融合蛋白的功能。它诱导纺锤体检查点依赖的有丝分裂阻滞,DNA 损伤和细胞凋亡,具有广谱抗肿瘤活性。 | |||
T2324 |
Darunavir
地瑞那韦,达芦那韦,TMC114 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Darunavir (TMC114) 是一种 HIV 蛋白酶抑制剂,用于治疗艾滋病和 HIV 感染。 由于单独使用时会出现抗病毒药物耐药性,因此与其他抗 HIV 药物联合使用。 | |||
T5363 |
Tempo
2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy |
Free radical scavengers; Reactive Oxygen Species; DNA/RNA Synthesis; Mitochondrial Metabolism | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Tempo (2,2,6,6-Tetramethylpiperidinooxy) 可用作自由基清除剂、有机合成中的试剂和电子自旋共振光谱中的结构探针。它可在催化循环中使超氧化物歧化,也可诱导DNA 链断裂。 | |||
T8756 |
KRAS inhibitor-9
DUN09716 |
Apoptosis; Ras | Apoptosis; GPCR/G Protein; MAPK |
KRAS inhibitor-9 (DUN09716) 是一种 KRAS 抑制剂,阻止 GTP-KRAS 的形成和 KRAS 下游激活。它以中等的结合亲和力与 KRAS G12D、KRAS G12C 和 KRAS Q61H 蛋白结合,选择性抑制具有 KRAS 突变的 NSC-LC 细胞的增殖。它可导致 G2/M 细胞周期停滞并诱导凋亡。 | |||
T20038 |
2-Fluoroadenine
NSC-27364,NSC 27364,NSC27364,2-氟腺嘌呤 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
2-Fluoroadenine (NSC-27364) 对非增殖性和增殖性肿瘤细胞具有毒性。2-Fluoroadenine 可用于抗癌症的相关研究。 | |||
T7055 |
Bz-RS-ISer(3-Ph)-Ome
Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) 是紫杉醇衍生物,在低细胞毒性下抑制 HSV 复制周期,阻断 Vero 细胞的有丝分裂,影响 M-MSV 诱导的肿瘤大小,并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。 | |||
T6120 |
Pralatrexate
Folotyn,10-炔丙基-10-去氮杂氨基蝶呤,10-Propargyl-10-deazaaminopterin,普拉曲沙 |
Apoptosis; DHFR; Antifolate; TAM Receptor | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Tyrosine Kinase/Adaptors |
Pralatrexate (10-Propargyl-10-deazaaminopterin) 是一种抗叶酸剂,也是二氢叶酸还原酶抑制剂,Ki 值为 13.4 pM。它具有抗肿瘤活性,可研究复发/难治性 T 细胞淋巴瘤。它是叶酰聚谷氨酸合成酶的底物,具有改善的细胞摄取和保留能力。 | |||
T9150 |
SCR130
1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- |
Apoptosis; Others; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) 是基于 SCR7 的 DNA 非同源末端连接抑制剂,可诱导细胞凋亡并,具有抗癌活性。 它特异性依赖连接酶 IV,抑制 DNA 的末端连接。 | |||
T22381 |
Antimalarial agent 14
4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone |
Others | Others |
Antimalarial agent 14 (NSC-102533) 是一种生物活性化学品。 | |||
T13238 |
Tyrphostin AG1433
SU1433,AG1433 |
VEGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Tyrphostin AG1433 (AG1433) 是选择性的PDGFRβ和VEGFR-2 (Flk-1/KDR)抑制剂,IC50分别为 5.0 μM 和 9.3 μM。Tyrphostin AG1433有防止血管形成的活性。 | |||
T2241 |
Alisertib
MLN 8237,4-[[9-氯-7-(2-氟-6-甲氧基苯基)-5H-嘧啶并[5,4-D][2]苯并氮杂卓-2-基]氨基]-2-甲氧基苯甲酸 |
Apoptosis; Aurora Kinase; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Alisertib (MLN 8237) 是一种 Aurora A 激酶抑制剂 (IC50=1.2 nM),具有口服活性和选择性。Alisertib 具有抗肿瘤活性,可以诱导细胞凋亡和自噬,诱导细胞周期阻滞。 | |||
T4297 |
Flibanserin
BIMT-17BS,氟立班丝氨,Girosa,BIMT-17 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Flibanserin (Girosa) 一种具有口服活性的 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂,Ki 值分别为 1 和 49 nM。它与多巴胺 D4 受体结合,Ki 值在 4 到 24 nM 之间。它是一种血清素能抗抑郁药,用于治疗性欲减退症。 | |||
T2514 |
Linifanib
利尼伐尼,ABT-869,RG3635,AL-39324 |
Apoptosis; c-Fms; VEGFR; FLT; CSF-1R; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; Tyrosine Kinase/Adaptors |
Linifanib (AL-39324) 是一种高效口服的VEGFR 和PDGFR 家族多靶点抑制剂,具有显著的抗肿瘤活性。它对无关 RTKs、可溶性酪氨酸激酶或丝氨酸/苏氨酸激酶的活性要低得多。它是特异性 miR-10b 抑制剂,阻断miR-10b 的生物合成。 | |||
T14848 |
C 87
|
Others; TNF | Apoptosis; Others |
C 87 是一种小分子 TNF-α 抑制剂。 C 87 直接与 TNFα 结合,有效抑制 TNF-α 诱导的细胞毒性 (IC50 = 8.73 μM),并有效阻断 TNF-α 触发的信号传导活动。 | |||
T16557 |
PNU-159682
|
Topoisomerase; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; DNA Damage/DNA Repair |
PNU-159682 是蒽环类新霉素的代谢产物,是一种 DNA 拓扑异构酶 II 抑制剂,具有出色的细胞毒性。 | |||
T7969 |
Dipyrithione
|
Others | Others |
Dipyrithione 似乎具有新的细胞毒性和强大的广谱抗肿瘤活性。 | |||
T7082 |
HDAC8-IN-1
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HDAC8-IN-1 是一种 HDAC8 抑制剂,在癌细胞系中的 IC50 为 27.2 nM,有抗增殖作用。 | |||
T6256 |
YYA-021
YYA 021 |
gp120/CD4; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
YYA-021具有高抗HIV 活性和低细胞毒性,是一种抑制HIV 进入的小分子CD4模拟物,。 | |||
T7293 |
EC330
|
Others | Others |
EC330 是一种白血病抑制因子抑制剂。 | |||
T9903 |
Avelumab
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
Avelumab 是人 IgG1 抗PD-L1单克隆抗体,具有潜在的抗体依赖性细胞介导的细胞毒性作用。 | |||
T73588 |
8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY
|
||
8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY 是一种新型的 BODIPY 荧光染料,可用于治疗细胞毒性研究。 | |||
T8622 |
ETHYL 5-HYDROXY-2-METHYLINDOLE-3-CARBOXYLATE
|
Others | Others |
ETHYL 5-HYDROXY-2-METHYLINDOLE-3-CARBOXYLATE 可用于制备和研究吲哚醌抗肿瘤剂的缺氧选择性细胞毒性。 | |||
T79468 |
Antimicrobial agent-22
THI 6c |
Antibacterial | Microbiology/Virology |
Antimicrobial agent-22 (THI 6c) 是一种抗菌剂,具有低细胞毒性、抗生物膜活性和快速杀菌的作用。 | |||
T83643 |
4-Methylumbelliferyl heptanoate
4-Methylumbelliferyl enanthate |
||
4-Methylumbelliferyl heptanoate (4-Methylumbelliferyl enanthate) 是一种脂肪酶荧光底物,可检测细胞介导的细胞毒性和细胞增殖。 | |||
T7323 |
BCI-215
|
Phosphatase | Metabolism |
BCI-215 是高效肿瘤细胞选择性的双重特异性磷酸酶DUSP-MKP 抑制剂。它对肿瘤细胞有细胞毒性,但对正常细胞无毒性。 | |||
TNU0031 |
5-Hydroxyuridine
OHUrd |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
5-Hydroxyuridine (OHUrd) 是一种嘌呤核苷类似物,具有潜在的抗肿瘤活性,对人结肠腺癌细胞系显示出细胞毒。 | |||
T29857 |
Alethine
β-Alethine |
TNF | Apoptosis |
Alethine (β-Alethine) 是一种小分子化合物,具有抗肿瘤活性,可用于治疗肿瘤和感染。 Alethine 诱导的TNFα上调增加T 细胞的细胞毒性。 | |||
T28607 |
Rocepafant
LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730 |
Platelet aggregation | Others |
Rocepafant (LAU8080) 是一种血小板活化因子(PAF)拮抗剂,可减轻新生大鼠缺氧缺血性脑损伤。Rocepafant 抑制肿瘤坏死因子-Afa 介导的小鼠 L929 肿瘤细胞的细胞毒性。 | |||
T40063 |
CBR-470-1
|
Nrf2 | Immunology/Inflammation |
CBR-470-1 是一种有效的糖酵解磷酸甘油酸激酶1 (PGK1) 抑制剂,通过增加甲基乙二醛的水平来激活 NRF2。 CBR-470-1 是一种非共价的 Nrf2 激活剂,具有神经保护活性,通过激活 Keap1-Nrf2 级联反应来保护 SH-SY5Y 神经元细胞免受 MPP+ 诱导的细胞毒性。 | |||
T84330 |
(±)-Indoxacarb
|
Apoptosis; Sodium Channel | Apoptosis; Membrane transporter/Ion channel |
(±)-Indoxacarb 是一种吡唑啉类杀虫剂,具有杀虫活性和细胞毒性,可阻断昆虫神经元钠通道,可诱导细胞凋亡。 | |||
T19766 |
Captan
Amercide,Buvisild K,Agrosol S,Bangton,AI3-26538,Aacaptan |
Antibacterial | Microbiology/Virology |
Captan (Aacaptan) 是一种邻苯二甲酰亚胺类杀菌剂,可破坏卵母细胞的发育。Captan 对哺乳动物细胞具有细胞毒性作用,可提高过氧化氢的细胞毒性。Captan 在果园中降低了 BFR 和 AFR 发生率。 | |||
T65309 |
S-Methyl methanesulfonothioate
|
Antibacterial | Microbiology/Virology |
S-Methyl methanesulfonothioate 是一种生物原料,具有细胞毒性和潜在的抗菌活性,可用于研究铜绿假单胞菌感染。 | |||
T23409 |
FM4-64
SynaptoRedTM C2 |
Others | Others |
FM4-64 (SynaptoRedTM C2) 是一种苯乙烯类染料,染色效果稳定,但在在水溶液中基本不发荧光。FM4-64与质膜双层结合后不能被动扩散进入细胞内部,必须通过主动运输的方式进行跨膜运输。FM4-64 可用于研究胞吞胞吐和囊泡运输。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1807 |
Isoverticine
泪杉醇,异浙贝甲素 |
BCL; Caspase | Apoptosis; Proteases/Proteasome |
Isoverticine 是一种具有生物活性的等甾体生物碱,从 Fritillaria pallidiflora 球茎中分离得到,具有显著的细胞毒性。 | |||
T37341 |
N-Acetyltyramine
|
Antibacterial | Microbiology/Virology |
N-Acetyltyramine 是一种群体感应抑制剂,由溶藻弧菌 M3-10 产生。N-Acetyltyramine 可以抑制C. violaceumATCC 12472 的群体感应。它可以逆转阿霉素耐药白血病 P388 细胞的耐药性。 | |||
T11685 |
Isolongifolene
异长叶烯,(-)-Isolongifolene |
Apoptosis; Others | Apoptosis; Others |
Isolongifolene ((-)-Isolongifolene) 是一种从调料九里香中分离的三环倍半萜烯,具有抗氧化,抗炎,抗癌和神经保护的特性。它通过调节 PI3K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激,线粒体功能障碍和细胞凋亡。 | |||
T8205 |
Norwogonin
5,7,8-Trihydroxyflavone,去甲汉黄芩素 |
Virus Protease | Microbiology/Virology |
Norwogonin (5,7,8-Trihydroxyflavone) 是从黄芩中分离出来的,对肠道病毒 71 具有抗病毒活性,IC50为 31.83 μg/ ml。 | |||
TN1103 |
Diphyllin
山荷叶素,二叶草素 |
ATPase; Proton pump; Influenza Virus; HIV Protease | Membrane transporter/Ion channel; Microbiology/Virology; Proteases/Proteasome |
Diphyllin 是一种从Justicia procumbens 中分离的芳基萘木脂素,是HIV-1的有效抑制剂,IC50 为 0.38 μM。它是V-ATPase 抑制剂,IC50值为 17 nM,可抑制人破骨细胞中的溶酶体酸化。它抑制NO 产生,IC50值为 50 μM ,具有抗癌和抗炎活性。 | |||
T0626 |
Uric Acid
尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate |
Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase | Immunology/Inflammation; Metabolism; NF-κB |
Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ,如单线态氧和过氧亚硝酸盐,抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。 | |||
T17155 |
Trabectedin
Ecteinascidin 743,曲贝替定,ET-743 |
Apoptosis; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱,有抗肿瘤的活性, 通过与 DNA 的小沟结合,阻断应激诱导的蛋白质的转录,诱导 DNA 骨架裂解和癌细胞凋亡,并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。 | |||
T4034 |
Solamargine
Solamargin,δ-Solanigrine,澳洲茄边碱 |
Apoptosis; p38 MAPK; P-gp; STAT | Apoptosis; JAK/STAT signaling; MAPK; Membrane transporter/Ion channel; Neuroscience; Stem Cells |
Solamargine (δ-Solanigrine) 是一种来源于茄属植物的类固醇 Solasodine 的衍生物,诱导非选择性细胞毒性和 P-gp 抑制作用。它通过下调 MMP-2 和 MMP-9 的表达和活性来显著抑制 HepG2 细胞的迁移和侵袭,在多种癌症中均表现出抗癌活性。 | |||
T4970 |
LANOSTEROL
羊毛甾醇,3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol |
Endogenous Metabolite | Metabolism |
Lanosterol (3β-Hydroxy-8,24-lanostadiene) 是胆固醇合成的中间产物,能够诱导胆固醇合成的速率控制酶 HMG-CoA 还原酶的泛素化和降解。Lanosterol 可以抑制神经退行性疾病相关错误折叠蛋白的聚集和细胞毒性。 | |||
TN6924 |
Anhydrosafflor yellow B
(2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,脱水红花黄色素B,AHSYB |
Others | Others |
Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1) 是从红花中分离出来的,可抑制 ADP 诱导的血小板聚集,在体外表现出显着的抗氧化作用,并对 H2O2 诱导的细胞毒性具有一定的活性。 | |||
TN4340 |
Ivangustin
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Ivangustin exhibits remarkable cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines. | |||
T11354 |
Gambogellic acid
|
||
Gambogellic acid是从藤黄和加工甘博格中提取得到的氧杂蒽酮类化合物,是具有抗肿瘤活性和细胞毒性。 | |||
T5S0246 |
Pseudoprotodioscin
山药 |
Others; Fatty Acid Synthase | Metabolism; Others |
Pseudoprotodioscin 是一种呋喃葡糖苷,抑制SREBP1/2和microRNA 33a/b 水平,降低胆固醇和甘油三酯合成相关的基因表达。 | |||
T2907 |
Tanshinone I
丹参酮I,Tanshinone A |
Phospholipase | Metabolism |
Tanshinone I (Tanshinone A) 是IIA 型人重组sPLA2(IC50=11 μM)和兔重组cPLA2(IC50=82 μM)抑制剂。 | |||
TN6444 |
Cyclo(Tyr-Leu)
|
Antifungal | Microbiology/Virology |
Cyclo(Tyr-Leu) 是一种来自马齿苋 Portulaca oleracea Linn 的环状二肽,具有细胞毒性、抗真菌和抗凝血活性。 | |||
TN7032 |
4'-O-Methylpyridoxine
4-methoxymethylpyridoxine,Ginkgotoxin |
Antioxidant | oxidation-reduction |
4'-O-Methylpyridoxine(MPN)是从银杏叶中发现的维生素类化合物,具有抗氧化活性和细胞毒性。 | |||
TN4618 |
N-trans-Sinapoyltyramine
|
Others | Others |
N-trans-Sinapoyltyramine 对 HeLa 人癌细胞系表现出强烈的选择性细胞毒性,IC50 值为 9.77 ± 1.25 μm。 | |||
TN1856 |
Leachianone A
Isokurarinone,里查酮 A |
SGLT | GPCR/G Protein |
Leachianone A (Isokurarinone) 是从槐花中分离的一种天然产物,可诱导细胞凋亡,具有抗疟疾、抗炎和细胞毒性作用。 | |||
T3S1628 |
Vitexin-4''-O-glucoside
Vitexin -4''-O-glucoside,牡荆素-4''-O-葡萄糖苷 |
Others | Others |
Vitexin-4''-O-glucoside (Vitexin -4''-O-glucoside) 是一种从Crataegus pinnatifida 叶片中得到的类黄酮成分。 | |||
T5132 |
9-dihydro-13-acetylbaccatin III
13-乙酰基-9-羟基巴卡丁 III,13-Acetyl-9-dihydrobaccatin III,9-DHAB III |
Apoptosis | Apoptosis |
9-dihydro-13-acetylbaccatin III (9-DHAB III) 是一种制备紫杉醇类似物的中间体。 | |||
T30086 |
Anthragallol
Anthragallic acid,1,2,3-Trihydroxyanthraquinone |
Others | Others |
Anthragallol(1,2,3-Trihydroxyanthraquinone) 通过与 DNA 结合而显示出细胞毒性。Anthragallol 可作为分析试剂,可用于生产棕色酸洗色料。 | |||
TMS0879 |
Asiaticoside B
积雪草苷 B,积雪草苷B |
Others | Others |
Asiaticoside B 是一种从类叶升麻中分离得到的三萜糖苷,具有抗肿瘤作用。 它对 HepG2 和 MCF-7 癌细胞系具有显著的细胞毒性。 | |||
T3844 |
Deltonin
三角叶薯蓣皂苷 |
ERK; Others; Akt; Endogenous Metabolite | Cytoskeletal Signaling; MAPK; Metabolism; Others; PI3K/Akt/mTOR signaling |
Deltonin 是从盾叶薯蓣中得到的一种甾体皂苷,抑制ERK1/2和AKT 的活化,具有抗肿瘤活性。 | |||
T7441 |
Cuminaldehyde
Cuminic aldehyde,4-异丙基苯甲醛,Cuminal |
Endogenous Metabolite | Metabolism |
Cuminaldehyde (Cuminal) 是一种具有抑制 α-突触核蛋白纤颤和细胞毒性作用的天然醛,是一种 Cuminum cyminum 的主要成分。它显示抗癌特性。 | |||
TN1512 |
Clinopodiside A
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Clinopodiside A 是一种从 Clinopodium polycephalum 中分离出来的三萜皂苷,具有抗肿瘤活性,通过 T24 膀胱癌细胞中 BLK 和 RasGRP2 信号传导介导的自噬诱导细胞毒性。 | |||
T5746 |
Dictamine
Dictamnine,Dectamine,白鲜碱 |
Apoptosis; Anti-infection; Antibacterial; Antifungal | Apoptosis; Microbiology/Virology |
Dictamine (Dectamine) 显示抗胆碱酯酶、抗炎、致突变、抗菌和抗真菌活性。 它具有在人子宫颈、结肠和口腔癌细胞中发挥细胞毒性的能力。 | |||
TN1038 |
Galgravin
|
Apoptosis | Apoptosis |
Galgravin 是望春花中的一种天然产物,具有抗炎和体外细胞毒活性,能诱导白血病细胞凋亡。 | |||
T2S1120 |
Ganoderenic acid B
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Ganoderenic acid B 是一种从Ganoderma lucidum 中提取的天然产物,可以通过抑制ABCB1的转运功能,增强化疗药物对ABCB1介导的耐多药癌细胞的细胞毒性来发挥作用。 | |||
T3S0381 |
Chrysophanol 8-O-glucoside
|
Serine Protease | Proteases/Proteasome |
Chrysophanol 8-O-glucoside 来自Rumex acetosa 根部,具有中等的弹性蛋白酶抑制特性。它具有温和的细胞毒性和抗糖尿病特性,能够在胰岛素刺激的葡萄糖转运途径中发挥代谢作用。 | |||
T5826 |
Eupalinolide A
|
HSP | Cytoskeletal Signaling; Metabolism |
Eupalinolide A 是分离于林泽兰中的一种天然产物,通过抑制 HSF1 与 HSP90 的相互作用,激活 HSF1,诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。 | |||
T2S0357 |
6-Hydroxycoumarin
6-hydroxychromen-2-one,6-羟基香豆素 |
Others; Carbonic Anhydrase | Metabolism; Others |
6-Hydroxycoumarin (6-hydroxychromen-2-one) 是一种香豆素。其中香豆素具有抗炎,支气管扩张,解热,血管扩张,抗氧化,抗菌,抗真菌,抑菌和抗肿瘤作用。 | |||
TN3669 |
Cis-N-Feruloyltyramine
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Cis-N-Feruloyltyramine 是一种天然存在的化合物,存在于各种植物中,对 P-388癌细胞系具有细胞毒性。 Cis-N-Feruloyltyramine 是体外前列腺素(PG)合成的抑制剂。 | |||
T4036 |
Solasodine
Solancarpidine,Purapuridine,澳洲茄铵,Solasodin |
Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal | Apoptosis; Microbiology/Virology; Others; Ubiquitination |
Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。 | |||
T3795 |
Corilagin
|
Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology |
Corilagin 是一种鞣酸,有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长,MIC 为 25 μg/mL。它有抗肿瘤活性,可用于肝癌和卵巢癌。 | |||
TN2331 |
Eleutheroside B1
刺五加苷B1 |
Influenza Virus | Microbiology/Virology |
Eleutheroside B1是具有广谱抗人流感病毒的一种香豆素。它抑制多种趋化因子基因和流感病毒核蛋白基因的 mRNA 表达。它具有抗病毒、抗流感和抗炎活性,且细胞毒性小。 | |||
T4S0094 |
Hydroxygenkwanin
羟基芫花素,Luteolin 7-methylether,7-O-Methylluteolin |
Antioxidant | oxidation-reduction |
Hydroxygenkwanin (Luteolin 7-methylether) 是一种丁香达芙妮的主要成分,是一种天然的类黄酮化合物。它具有抗氧化,抗神经胶质瘤能力和抗癌作用。 | |||
T3S1873 |
Talatisamine
塔拉乌头胺,塔拉萨敏 |
Potassium Channel | Membrane transporter/Ion channel |
Talatisamine 是一种乌头生物碱,对K+通道有特异性阻滞作用。它能减弱 beta- 淀粉样低聚物对培养的皮层神经元的毒性。 | |||
TN6714 |
Geranylgeraniol
FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095 |
Apoptosis | Apoptosis |
Geranylgeraniol (FT0626663) 是一种类异戊二烯,存在于水果、蔬菜和谷物中,包括大米。 Geranylgeraniol (FT0626663) 抑制生长并诱导各种肿瘤细胞的凋亡。 Geranylgeraniol (FT0626663) 保护单核细胞免受他汀类药物诱导的细胞毒性并抑制分枝杆菌的生长。 | |||
TJP2872 |
Acevaltrate
Acevaltratum,乙酰缬草三酯,Acetoxyvaltrate |
ATPase; Others | Membrane transporter/Ion channel; Others |
Acevaltrate (Acevaltratum) 对人小细胞肺癌细胞系 GLC(4) 和人结肠直肠癌细胞系 COLO 320 具有高细胞毒性,IC50 值为 1-6 uM。它抑制大鼠肾和脑半球中 Na+/K+-ATP 酶活性,IC50分别为 22.8 和 42.3 μM。 | |||
T8724 |
6-Methoxydihydrosanguinarine
|
Others | Others |
6-Methoxydihydrosanguinarine 是一种从M. cordata 果实中分离出的生物碱,它对 MCF-7 细胞系(IC50:0.61 μM)和 SF-268 细胞系(IC50:0.54 μM)具有强的细胞毒性。 | |||
TN1674 |
Garcinone D
伽升沃 D |
Reactive Oxygen Species; Nrf2; STAT | Immunology/Inflammation; JAK/STAT signaling; Metabolism; NF-κB; Stem Cells |
Garcinone D 是来自山竹的一种呫吨酮,可促进 C17.2 神经干细胞的增殖。它以浓度和时间依赖的方式增加磷酸化信号转导和转录激活因子 3 (p-STAT3)、Cyclin D1 和核因子红细胞 2 相关因子 (Nrf2)、以及血红素加氧酶-1 (HO-1) 的蛋白质水平。 | |||
TN1216 |
2-O-Acetyl-20-hydroxyecdysone
20-Hydroxyeedysone 2-acetate |
Beta Amyloid; Others | Neuroscience; Others |
2-O-Acetyl-20-hydroxyecdysone 是存在于昆虫和陆生植物中的一种蜕皮激素,2-O-Acetyl-20-hydroxyecdysone 对 amyloid-β42 诱导的细胞毒性有抑制作用,能够通过促进纤维发生减少 Aβ 寡聚物的形成,将 Aβ 寡聚物转变为低毒性纤维。 | |||
T36528 |
Illudin M
|
Apoptosis; DNA Alkylator/Crosslinker | Apoptosis; DNA Damage/DNA Repair |
Illudin M是真菌O. illudens中的一种细胞毒性倍半萜,能使DNA烷基化。它对 HL-60 人类白血病细胞的细胞毒性为 6-100 nM。Illudin M 具有抗癌活性,是抗癌化合物的前药,可用于合成抗癌化合物。 | |||
T0194 |
Chloroquine phosphate
Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate |
SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Chloroquine phosphate (Aralen phosphate) 是广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。它是autophagy 和toll-like receptors 抑制剂,有效抑制SARS-CoV-2(COVID-19) 感染 (EC50=1.13 μM)。 | |||
TN1601 |
Effusol
灯心草菲酚,厄弗酚 |
Caspase | Apoptosis; Proteases/Proteasome |
Effusol 是一种从 Juncus effuses 中分离到的酚类物质,对 DPPH 自由基(IC50:79 μM) 及 ABTS 自由基(IC50:2.73 μM)具有较强的清除活性。它能挽救皮质酮减弱的 CA1 LTP,保护海马功能对抗应激诱导的认知能力下降。 | |||
T4S0181 |
Hinokiflavone
日本扁柏黄酮,扁柏双黄酮 |
MMP; BCL; E1/E2/E3 Enzyme | Apoptosis; Proteases/Proteasome; Ubiquitination |
Hinokiflavone 是pre-mRNA 剪接活性的新型调节剂,通过抑制剪接体装配来阻止pre-mRNA 底物的剪接,特别是阻止 B complex 的形成。它是SUMO protease 蛋白酶抑制剂,能够抑制前哨蛋白特异性蛋白酶 1 的活性。 | |||
T7028 |
Licochalcone C
LICOCHALCONEC,甘草查尔酮C |
Phosphatase; Antioxidant; Glucosidase | Metabolism; oxidation-reduction |
Licochalcone C (LICOCHALCONEC) 能够抑制 α-葡萄糖苷酶,其对 α-葡萄糖苷酶的 IC50 <100 nM,对蛋白酪氨酸磷酸酶 1B 的 IC50=92.43 μM 。 | |||
T2P2806 |
Hederacolchiside A1
黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13 |
Apoptosis; ERK; MEK; Akt; PI3K; Parasite; mTOR | Apoptosis; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Hederacolchiside A1 (Raddeanoside R13) 是从白头翁中分离的一种有抗利什曼原虫和抗肿瘤增殖活性的天然产物。 | |||
T1020 |
Doxorubicin hydrochloride
Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,DOX hydrochloride,盐酸阿霉素,NSC 123127 |
Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素,是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化,还可诱导凋亡和自噬。 | |||
T3390 |
Obacunone
|
Apoptosis; Aromatase; p38 MAPK | Apoptosis; Endocrinology/Hormones; MAPK |
Obacunone 是从沼泽白葡萄柚种子中分离得到的,通过诱导凋亡发挥抗癌作用。它在雄激素依赖性人前列腺 Y 细胞中具有细胞毒性。它对鼠伤寒沙门氏菌具有抗毒作用,可作为开发鼠伤寒沙门氏菌抗毒策略的先导化合物。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04616 |
NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His)
natural cytotoxicity triggering receptor 3 |
Cynomolgus,Rhesus | HEK293 Cells |
NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.3 kDa and the accession number is XP_005553604.1. | |||
TMPY-05511 |
NKp46/NCR1 Protein, Mouse, Recombinant (His)
NKp46,Ly94,natural cytotoxicity triggering receptor... |
Mouse | HEK293 Cells |
NKp46/NCR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the accession number is A0A0R4IZY7. | |||
TMPY-01807 |
NKp44/NCR2 Protein, Human, Recombinant (His)
RP1-149M18.2,LY95,dJ149M18.1,NK-p44,CD336,natural cytoto... |
Human | HEK293 Cells |
NKp44/NCR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is O95944-1. | |||
TMPY-01145 |
NKp30/NCR3 Protein, Human, Recombinant (His)
NCR3,natural cytotoxicity triggering receptor 3,CD3... |
Human | HEK293 Cells |
NKp30/NCR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.4 kDa and the accession number is O14931-1. | |||
TMPY-00334 |
NKp30/NCR3 Protein, Rat, Recombinant (His)
natural cytotoxicity triggering receptor 3,1c7 |
Rat | HEK293 Cells |
NKp30/NCR3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is CAD23066.1. | |||
TMPY-03233 |
NKp46/NCR1 Protein, Rat, Recombinant (hFc)
natural cytotoxicity triggering receptor 1,Kilr1,Ly... |
Rat | HEK293 Cells |
NKp46/NCR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is Q9Z0H5. | |||
TMPY-04618 |
B7-H6 Protein, Cynomolgus, Recombinant (His)
natural killer cell cytotoxicity receptor 3 ligand ... |
Cynomolgus | HEK293 Cells |
B7-H6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.9 kDa and the accession number is XP_005578557.1. | |||
TMPY-04495 |
B7-H6 Protein, Rat, Recombinant (His)
natural killer cell cytotoxicity receptor 3 ligand ... |
Rat | HEK293 Cells |
B7-H6 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.1 kDa and the accession number is XP_006223356.1. | |||
TMPY-04617 |
B7-H6 Protein, Cynomolgus, Recombinant (hFc)
natural killer cell cytotoxicity receptor 3 ligand ... |
Cynomolgus | HEK293 Cells |
B7-H6 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.2 kDa and the accession number is XP_005578557.1. | |||
TMPY-00327 |
B7-H6 Protein, Rat, Recombinant (hFc)
B7H6,natural killer cell cytotoxicity receptor 3 li... |
Rat | HEK293 Cells |
B7-H6 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 60.4 kDa and the accession number is XP_006223356.1. | |||
TMPY-06363 |
B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
B7H6,natural killer cell cytotoxicity receptor 3 li... |
Cynomolgus | HEK293 Cells |
B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 29.76 kDa and the accession number is XP_005578557.1. | |||
TMPY-04619 |
B7-H6 Protein, Human, Recombinant (His)
natural killer cell cytotoxicity receptor 3 ligand ... |
Human | HEK293 Cells |
B7-H6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.1 kDa and the accession number is Q68D85. | |||
TMPY-05383 |
NKp30/NCR3 Protein, Human, Recombinant (hFc)
DAAP-90L16.3,natural cytotoxicity triggering recept... |
Human | HEK293 Cells |
NKp30/NCR3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is O14931-3. | |||
TMPY-05367 |
NKp44/NCR2 Protein, Human, Recombinant (His), Biotinylated
RP1-149M18.2,CD336,natural cytotoxicity triggering ... |
Human | HEK293 Cells |
NKp44/NCR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is O95944-1. | |||
TMPY-06178 |
B7-H6 Protein, Human, Recombinant (His), Biotinylated
natural killer cell cytotoxicity receptor 3 ligand ... |
Human | HEK293 Cells |
B7-H6 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.1 kDa and the accession number is Q68D85. | |||
TMPY-00377 |
B7-H6 Protein, Human, Recombinant (hFc)
DKFZp686O24166,B7H6,B7-H6,natural killer cell cytotoxici... |
Human | HEK293 Cells |
B7-H6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.4 kDa and the accession number is Q68D85. | |||
TMPJ-00083 |
NCR3 Protein, Human, Recombinant (hFc)
Activating Natural Killer Receptor p30,CD337,NKp30,NCR3,Natu... |
Human | HEK293 Cells |
Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) matur... | |||
TMPJ-00567 |
NCR1 Protein, Human, Recombinant (hFc)
hNKp46,Natural cytotoxicity triggering receptor 1,N... |
Human | HEK293 Cells |
Natural cytotoxicity triggering receptor 1(NCR1) is a single-pass type I membrane protein .It contains 2 Ig-like (immunoglobulin-like) domains and belongs to the natural cytotoxicity receptor (NCR) family. The protein is a natural killer (NK) lymphocyte-activating receptor. It is involved in major aspects of NK immune function and shows a high degree of lineage specificity in blood and bone marrow. | |||
TMPY-01964 |
CD16a Protein, Human, Recombinant (F176V, His)
FCGRIII,Fc gamma RIIIa,FCR-10,FCRIII,FCRIIIA,FCGR3,CD16A,Fc... |
Human | HEK293 Cells |
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the... | |||
TMPK-00091 |
NKp30/NCR3 Protein, Human, Recombinant (His & Avi), Biotinylated
1C7,LY117,CD337,NKp30,MALS,NCR3 |
Human | HEK293 Cells |
NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. | |||
TMPK-00090 |
NKp30/NCR3 Protein, Human, Recombinant (His & Avi)
NKp30,1C7,MALS,CD337,LY117,NCR3 |
Human | HEK293 Cells |
NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature ph... | |||
TMPY-03623 |
NKp80/KLRF1 Protein, Cynomolgus, Recombinant (hFc)
killer cell lectin like receptor F1,KLRF1 |
Cynomolgus | HEK293 Cells |
NKp80, also known as KLRF1, is an activating homodimeric C-type lectin-like receptor that is expressed on nearly all-natural killer cells and stimulates their cytotoxicity and cytokine release. NKp80 stimulates cytotoxicity upon engagement of its genetically linked ligand: myeloid-specific CTLR activation-induced C-type lectin (AICL). NKp80, but not NKp80 mutated at tyrosine 7 (NKp80/Y7F), is tyrosine phosphorylated. Accordingly, NKp80/Y7F, but not NKp80/Y3F or NKp80/Y37F, failed to induce cytot... | |||
TMPK-00116 |
NKp80/KLRF1 Protein, Human, Recombinant (hFc)
NKp80,KLRF1,Lectin-like receptor F1,CLEC5C,ML |
Human | HEK293 Cells |
NKp80, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on essentially all human natural killer (NK) cells and stimulates their cytotoxicity and cytokine release. | |||
TMPK-00598 |
Fc gamma RIIIA/CD16a (V176) Protein, Human, Recombinant (His & Avi), Biotinylated
Fc gamma RIIIA,Fc γ RIIIA,FCGR3,FcRIII,FCG3,IGFR3,FCGR3A,FcR... |
Human | HEK293 Cells |
The Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. | |||
TMPK-01469 |
HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Monomer Protein, Human, MHC (His & Avi)
MLANA,SK29-AA,Melan-A,MART1,LB39-AA |
Human | HEK293 Cells |
Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for melanoma. | |||
TMPK-01468 |
HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Tetramer Protein, Human, MHC (His & Avi)
SK29-AA,MLANA,LB39-AA,Melan-A,MART1 |
Human | HEK293 Cells |
Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for melanoma. | |||
TMPK-00136 |
ULBP-2 Protein, Human, Recombinant (His & Avi)
ALCAN-α,RAET1L,NKG2D ligand 2,ALCAN-alpha,N2DL2,ULBP-2/5/6,R... |
Human | HEK293 Cells |
ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity. | |||
TMPK-00260 |
CD155/PVR Protein, Human, Recombinant (His & Avi)
NECL5,PVSFLJ25946,Necl-5,CD155,Tage4,PVR,HVED,FLJ25946,necti... |
Human | HEK293 Cells |
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR. | |||
TMPK-00597 |
Fc gamma RIIIA/CD16a (V176) Protein, Human, Recombinant (His & Avi)
CD16,FcRIII,IMD20,IGFR3,FCG3,Fc γ RIIIA,CD16A,FCGR3,FcRIIIa,... |
Human | HEK293 Cells |
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (V176) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is AAH17865. | |||
TMPY-05055 |
GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His)
GGH/Glutamyl hydrolase γ,γ-glutamyl hydrolase (conjugase, fo... |
Human | HEK293 Cells |
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer. | |||
TMPK-00599 |
Fc gamma RIIIA/CD16a (V176) Domain 2 Protein, Human, Recombinant (mFc)
FCGR3,IGFR3,FcR-10,Fc γ RIIIA/CD16a (V176) Domain 2 Protein,... |
Human | HEK293 Cells |
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (V176) Domain 2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 35.29 kDa and the accession number is AAH17865. | |||
TMPK-00792 |
Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi), Biotinylated
FCGR3A,FcRIII,FCGR3,Fc γ RIIIA,CD16A,FcgRIIIA,IGFR3,FCGRIII,... |
Human | HEK293 Cells |
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is P08637-1. | |||
TMPK-00791 |
Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi)
FCG3,IGFR3,FcgRIIIA,FCGR3,Fc γ RIIIA,FCGR3A,CD16,FcRIIIa,Fc ... |
Human | HEK293 Cells |
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is P08637-1. | |||
TMPK-00747 |
NKp46/NCR1 Protein, Human, Recombinant (mFc)
NKp46,NKP46FLJ99094,CD335,NCR1,MAR-1,Ly94 |
Human | HEK293 Cells |
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 52.9 kDa and the accession numb... | |||
TMPK-01134 |
NKp46/NCR1 Protein, Cynomolgus, Recombinant (His)
NKp46,NCR1,NKP46FLJ99094,MAR-1,CD335,Ly94 |
Cynomolgus | HEK293 Cells |
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 27.4 kDa and the accession... | |||
TMPH-03036 |
Cytotoxin 2 Protein, Naja atra, Recombinant (His & Myc)
Cardiotoxin 2,CTX A2,Cardiotoxin 1A,Cardiotoxin A2,Cardiotox... |
Naja atra | E. coli |
Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity. It may interact with sulfatides in the cell membrane which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induce mitochondrial swelling and fragmentation. | |||
TMPK-00237 |
2B4/CD244 Protein, Human, Recombinant (aa 22-221, His & Avi), Biotinylated
NAIL,CD244,SLAMF4,h2B4,NKR2B4,Nmrk,CD244 antigen,2B4 |
Human | HEK293 Cells |
2B4 (CD244) is expressed by memory-phenotype CD8() T cells and all natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 is conserved in humans and mice, and a number of reports have linked 2B4 with activation of lymphocytes.Engagement of 2B4 on NK cell surfaces with specific antibodies or CD48 can trigger cell mediated cytotoxicity, interferon γ secretion, phosphoinositol turnover and NK cell invasiveness. | |||
TMPK-00746 |
NKp46/NCR1 Protein, Human, Recombinant (hFc)
CD335,NKP46FLJ99094,MAR-1,NCR1,NKp46,Ly94 |
Human | HEK293 Cells |
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.2 kDa and the accession numb... | |||
TMPK-01133 |
NKp46/NCR1 Protein, Cynomolgus, Recombinant (hFc)
CD335,Ly94,MAR-1,NKP46FLJ99094,NCR1,NKp46 |
Cynomolgus | HEK293 Cells |
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.1 kDa and the accession... | |||
TMPK-00614 |
NKp46/NCR1 Protein, Human, Recombinant (His)
NKp46,MAR-1,Ly94,NCR1,NKP46FLJ99094,CD335 |
Human | HEK293 Cells |
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 27.5 kDa and the accession numb... | |||
TMPK-00615 |
NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
CD335,NCR1,NKp46,NKP46FLJ99094,Ly94,MAR-1 |
Human | HEK293 Cells |
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular we... | |||
TMPK-00460 |
Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi), Biotinylated
CD16B,FcgRIIIB,FCG3B,FCGR3,Fc γ RIIIB/CD16b (NA2),CD16,FCRII... |
Human | HEK293 Cells |
Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells wit... | |||
TMPK-00459 |
Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi)
FCGR3,FCGR3B,CD16B,Fc γ RIIIB/CD16b (NA2),CD16b (NA2),IGFR3,... |
Human | HEK293 Cells |
Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi ta... | |||
TMPY-01561 |
PIG3 Protein, Human, Recombinant (His)
TP53I3,PIG3,tumor protein p53 inducible protein 3 |
Human | E. coli |
Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of cancers, including acute myeloid leukemia (AML). The important role of TP53I3/PIG3 in mediating the apoptotic activity of Nutlin-3 was underlined by knock-down experiments with siRNA specific for TP53I3/PIG3, which resulted in a significant decrease in the pro-apoptotic activity of... | |||
TMPH-01207 |
DOCK8 Protein, Human, Recombinant (His)
DOCK8,Dedicator of cytokinesis protein 8 |
Human | P. pastoris (Yeast) |
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing c... | |||
TMPH-02623 |
DOCK8 Protein, Mouse, Recombinant (His)
Dedicator of cytokinesis protein 8,DOCK8 |
Mouse | P. pastoris (Yeast) |
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing cent... | |||
TMPH-02622 |
DOCK8 Protein, Mouse, Recombinant (E. coli, His)
DOCK8,Dedicator of cytokinesis protein 8 |
Mouse | E. coli |
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing cent... | |||
TMPJ-00175 |
B7-H4 Protein, Rhesus macaque, Recombinant (hFc)
V-set domain containing T cell activation inhibitor 1,B7x,B7... |
Rhesus | HEK293 Cells |
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the s... | |||
TMPJ-00604 |
KIR2DL4 Protein, Human, Recombinant (His)
CD158 Antigen-Like Family Member D,KIR2DL4,MHC Class I NK Ce... |
Human | HEK293 Cells |
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of ... | |||
TMPK-00971 |
CRTAM Protein, Mouse, Recombinant (His)
CRTAM,CD355,CD355 antigen |
Mouse | HEK293 Cells |
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Pr... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35775 |
HT-2 Toxin-13C22
HT-2 Toxin-13C22 |
||
HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human... |