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Cat. No. | Product Name | ||
---|---|---|---|
L5500 | 毒性化合物库 | 262 compounds | |
262 个细胞毒性化合物的特有集合,可用于高通量、高内涵筛选。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38272 |
Thiacloprid
|
AChR; Parasite | Microbiology/Virology; Neuroscience |
Thiacloprid 属于氯烟碱类杀虫剂,主要用于防治蔬菜和果园中的蚜虫。它会破坏 DNA 的稳定性,通过疏水或氢相互作用,结合到小沟槽中,改变 DNA 的结构和稳定性。 | |||
T40588 |
Acifluorfen
|
Others | Others |
Acifluorfen 是一种除草剂。Acifluorfen 是一种原卟啉原氧化酶抑制剂,可促进原卟啉 IX 的积累,并诱导啮齿动物肝脏发生肿瘤。它会引起敏感植物物种中的色素和脂质强烈的光氧化破坏。 | |||
T12189 |
NBDHEX
|
Apoptosis; Glutathione Peroxidase; Autophagy | Apoptosis; Autophagy; Metabolism |
NBDHEX 是一种谷胱甘肽 S-转移酶 P1-1 抑制剂,也是晚期自噬抑制剂。它诱导肿瘤细胞凋亡,通过抑制 GST 的催化活性,避免抑制剂被特异性泵从细胞中排出,以及破坏 GSTP1-1和关键信号传导因子之间的相互作用,从而起到抗癌的作用。 | |||
T15588 |
Iobenguane sulfate
MIBG sulfate |
Others | Others |
Iobenguane sulfate (MIBG sulfate) 是一种具有抗肿瘤活性的神经递质去甲肾上腺素的类似物。Iobenguane sulfate 是一种高亲和力的霍乱毒素底物,干扰细胞单核(ADP-核糖基化)。放射性碘代 Iobenguane sulfate 可用于肾上腺肿瘤诊断和肿瘤靶向药物的研究。 | |||
T9014 |
SKI-178
|
Apoptosis; S1P Receptor | Apoptosis; GPCR/G Protein |
SKI-178 是一种鞘氨醇激酶-1(SphK1)和 SphK2抑制剂,以 CDK1 依赖性方式诱导人急性髓性白血病细胞凋亡。 | |||
T13780 |
MS1943
|
Apoptosis; Histone Methyltransferase | Apoptosis; Chromatin/Epigenetic |
MS1943 是一种具有口服生物活性的 EZH2选择性降解剂,IC50为 120 nM。它显著降低了许多三阴性乳腺癌和其他癌及非癌细胞系中的 EZH2蛋白水平,能有效阻止多个三阴性乳腺癌和其他癌细胞系的增殖。 | |||
T6683 |
STF-62247
STF 62247 |
Estrogen/progestogen Receptor; Autophagy | Autophagy; Endocrinology/Hormones |
STF-62247 是一种自噬诱导剂,在 RCC4 和 RCC4/VHL 细胞中的IC50分别为 0.625 μM 和 16 μM。它对 VHL 缺陷型肾细胞癌有选择性的细胞毒性。 | |||
T21859 |
ARM1
|
Aminopeptidase; Epoxide Hydrolase | Metabolism |
ARM1 是氨基肽酶和环氧化物水解酶抑制剂,IC50分别为为7.61 µM 和12.4 µM。 | |||
T38562 |
AKN-028
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
AKN-028 是酪氨酸激酶 FLT3的抑制剂,可剂量依赖性的诱导 FLT3的自磷酸化。 | |||
T21854 |
Proteasome inhibitor IX
PS-IX,AM114 |
Proteasome | Proteases/Proteasome; Ubiquitination |
Proteasome inhibitor IX (PS-IX) 是 Chalcone 的一种衍生物,对20S 蛋白酶体的胰凝乳蛋白酶样活性有抑制作用,IC50约为 1 μM。它抑制 HCT116 p53+/+细胞生长,IC50为 1.49 μM,显示出有效的抗癌活性。 | |||
T12134 |
MYCMI-6
NSC354961 |
Apoptosis; c-Myc | Apoptosis; Cell Cycle/Checkpoint |
MYCMI-6 (NSC-354961) 是一种内源性MYC:MAX 蛋白相互作用抑制剂,选择性结合 MYC bHLHZip 域,Kd 值为 1.6 μM。它阻断 MYC 驱动的转录,以 MYC 依赖性的方式抑制肿瘤细胞的生长 ,诱导细胞凋亡。 | |||
T7739 |
L-Leucyl-L-Leucine methyl ester hydrochloride
Leu-Leu-ome hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) 是一种人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物,能够选择性消除具有细胞毒性潜能的淋巴细胞,也能够诱导溶酶体途径应激。 | |||
T0223 |
Tetrahydroxyquinone
4-benzoquinone,四羟基苯醌,Tetrahydroxybenzoquinone,Tetrahydroxy-1,Tetrahydroxy-1,4-benzoquinone,Tetroquinone |
Apoptosis; Antioxidant; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Tetrahydroxyquinone (Tetroquinone) 是一种苯醌,是一种抗白内障剂,具有氧化还原活性。它可与半醌自由基一起参与氧化还原循环,导致活性氧形成。 | |||
T3184 |
Kevetrin hydrochloride
Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride |
Mdm2; p53 | Apoptosis |
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) 是一种小分子,是肿瘤抑制蛋白 p53 的激活剂,具有潜在的抗肿瘤活性。 | |||
T19712 |
Levoglucosenone
|
Others | Others |
Levoglucosenone 具有细胞毒性。它对抗人肝癌细胞系。 | |||
TP1758L |
LCMV gp33-41 acetate
LCMV gp33-41 acetate(151705-84-9 Free base) |
Others | Others |
LCMV gp33-41 acetate 是淋巴细胞性脉络丛脑膜炎病毒的序列,受主要组织相容性复合体 I 类 H-2Db 限制,呈递给细胞毒性 T 淋巴细胞。 | |||
T4434 |
Tirapazamine
Tirazone,Win59075,SR4233,替拉扎明,SR259075 |
Others | Others |
Tirapazamine (Win59075) 是抗癌剂,对实体瘤中的缺氧细胞具有选择性细胞毒性,促使 DNA 中的单链和双链断裂,碱基损伤和细胞死亡。 | |||
T14858 |
Calicheamicin
Calicheamicin γ1,卡奇霉素 |
Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
Calicheamicin (Calicheamicin γ1) 是肿瘤抗生素,可引起DNA 双链断裂,抑制DNA 合成。 | |||
T0651 |
N-Phenylbenzylamine
Benzylaniline,Benzenemethanamine,N-苄基苯胺 |
Microtubule Associated | Cytoskeletal Signaling |
N-Phenylbenzylamine (Benzenemethanamine) 作为潜在的细胞毒性和抗有丝分裂剂,通过抑制微管蛋白聚合起作用。 | |||
T68061 |
Elinafide
|
Others | Others |
Elinafide 是一种双萘酰亚胺细胞毒性剂,是 DNA 靶向抗癌剂,在体内体外实验中显示出抗肿瘤活性。 | |||
T62525 |
TP-16
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
TP-16是一种新型高效且具有选择性的 EP4 拮抗剂,可阻断IMCs的功能,增强细胞毒性T细胞介导的体内肿瘤消除。 | |||
T16699 |
PYZD-4409
|
Others; E1/E2/E3 Enzyme | Others; Ubiquitination |
PYZD-4409 是一种特异性 UBA1 抑制剂,IC50 为 20 μM。 PYZD-4409 在恶性细胞中诱导细胞死亡,并且对恶性细胞的细胞毒性优于对正常造血细胞的细胞毒性。 | |||
T60812 |
Cathepsin X-IN-1
|
Cysteine Protease | Proteases/Proteasome |
Cathepsin X-IN-1 (compound 25) 降低人前列腺癌细胞 PC-3 的迁移且具有较低的细胞毒性,它是组织蛋白酶 X 的有效抑制剂 (IC50 = 7.13 μM)。 | |||
T39027 |
PKH 26
PKH26,PKH-26 |
||
PKH 26 是一种有红荧光的膜染料,Ex/Em=551/567 nm。PKH 26 常用于流式细胞术,可测定 T 细胞介导的细胞毒性活性。 | |||
T27612 |
INI-43
INI 43,INI43 |
Others | Others |
INI-43 是Nuclear Import-43 的抑制剂,通过靶向 Kpnβ1 对各种宫颈和食管癌细胞系显示出显着的细胞毒性作用,并干扰 Kpnβ1 和已知的 Kpnβ1 cargo 蛋白、NFAT、NFκB、AP-1和NFY 的核定位。 | |||
T19766 |
Captan
Amercide,Buvisild K,Agrosol S,Bangton,AI3-26538,Aacaptan |
Antibacterial | Microbiology/Virology |
Captan (Aacaptan) 是一种邻苯二甲酰亚胺类杀菌剂,可破坏卵母细胞的发育。Captan 对哺乳动物细胞具有细胞毒性作用,可提高过氧化氢的细胞毒性。Captan 在果园中降低了 BFR 和 AFR 发生率。 | |||
T5872 |
Faltan
灭菌丹,Folpet |
Antifungal | Microbiology/Virology |
Faltan (Folpet) 是一种广泛使用的二甲酰亚胺类杀菌剂,可诱发小鼠胃肠道肿瘤,主要发生在十二指肠,对人支气管上皮细胞也有细胞毒作用。 | |||
T12360 |
para-Nitroblebbistatin
p-Nitroblebbistatin |
Myosin | Cytoskeletal Signaling |
para-Nitroblebbistatin (p-Nitroblebbistatin) 是无细胞毒性、无荧光、光稳定、特异性的肌球蛋白 II (Myosin II) 抑制剂。para-Nitroblebbistatin 可用于肌球蛋白 II 在生理学、发育和细胞生物学中特殊作用的相关研究。 | |||
T1478 |
Ondansetron hydrochloride dihydrate
盐酸昂丹司琼,SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ondansetron hydrochloride dihydrate (GR 38032) 是5- HT3受体拮抗剂,可治疗化疗后的恶心和呕吐,有抗焦虑和抗精神病作用。 | |||
T68122 |
Oxmetidine
SKF 92994,Oxmetidina,Oxmetidinum |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Oxmetidine (SKF 92994) 是一种新型 H2 受体拮抗剂,具有细胞毒性。 Oxmetidine 抑制心脏和血管组织中跨膜钙通量,可用于治疗活动性十二指肠溃疡。 | |||
T77466 |
Tremelimumab
Ticilimumab,CP-675206 |
Others | Others |
Tremelimumab 是一种细胞毒性T淋巴细胞相关抗原-4(CTLA-4)阻断抗体.Tremelimumab 常与 Durvalumab 联合使用来治疗肝癌、肺癌等实体癌。 | |||
T17946 |
Fmoc-Ala-Ala-Asn(Trt)-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Fmoc-Ala-Ala-Asn(Trt)-OH 是一种可切割的 ADC 接头,用于抗体-药物偶联物。 | |||
T19051 |
Reactive Blue 4
活性艳蓝X-ARL,活性蓝4 |
Others | Others |
Reactive Blue 4 是蒽醌类染料,具有植物毒性、细胞毒性和基因毒性。它可作为单一的比色化学传感器,用于在水介质中连续测定具有不同光学响应的多种分析物。 | |||
T19841 |
Tribenoside
Glyvenol,Glyvenal,Ba 2140,BG-356,Glivenol,三苄糖苷,TBGF |
Others | Others |
Tribenoside (BG-356) 是血管保护剂,能够温和的镇痛、抗炎及伤口愈合,可用研究痔疮。 | |||
T68896 |
Daniquidone
NSC 320846,BAY-H 2049 |
Topoisomerase | DNA Damage/DNA Repair |
Daniquidone (Batracylin) 是一种有效的 DNA 拓扑异构酶 I 和 DNA 拓扑异构酶 II 双重抑制剂, 具有细胞毒性和抗增殖活性,可诱导 DNA 断裂,可用于研究肿瘤、免疫系统疾病和淋巴系统疾病。 | |||
TQ0141 |
Taltobulin
HTI-286,SPA-110 |
Apoptosis; Microtubule Associated; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Apoptosis; Cytoskeletal Signaling |
Taltobulin (HTI-286) 是一种三肽半胱氨酸的合成类似物,是一种微管蛋白抑制剂,在体外抑制肝肿瘤细胞增殖和体内肿瘤生长。Taltobulin 具有细胞毒性,诱导有丝分裂停滞以及凋亡 (apoptosis),可用于研究乳腺癌和与微管组织相关的疾病。 | |||
T13298 |
Verubulin hydrochloride
MPC-6827 hydrochloride,N-(4-甲氧基苯基)-N,2-二甲基-4-喹唑啉胺盐酸盐 |
Microtubule Associated | Cytoskeletal Signaling |
Verubulin hydrochloride (MPC-6827 hydrochloride) 是一种血脑屏障渗透性微管破坏剂,具有强效和广谱的细胞毒活性,在人 MX-1 乳腺癌和其他小鼠异种移植癌模型中具有有效的抗癌活性。 | |||
T6798 |
Tretazicar
5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829 |
DNA Alkylator/Crosslinker; DNA Alkylation | DNA Damage/DNA Repair |
Tretazicar (NSC-115829) 是一种抗肿瘤前药,由 NAD(P)H 醌氧化还原酶 2 激活。它在酶促活化后生成细胞毒性双功能烷基剂,可以形成 DNA-DNA 链间交联。 | |||
T83627 |
Pim-1 kinase inhibitor 8
|
Pim; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling |
Pim-1 kinase inhibitor 8 是一种高效的 Pim-1 kinase 抑制剂,具有抗癌活性,可有效抑制细胞迁移。Pim-1 kinase inhibitor 8 对 MCF-7 和 HepG2 细胞有细胞毒性,是研究乳腺癌的候选化合物。 | |||
T18870 |
Vc-MMAD
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
Vc-MMAD 由 linker (Val-Cit) 和微管抑制剂 MMAD 组成。Vc-MMAD 可用于偶联抗体。 | |||
T77567 |
BCPA
|
Others | Others |
BCPA 是一种无细胞毒性的 Pin1 调节剂。BCPA 可调节破骨细胞活化,减弱 Pin1 蛋白的减少,从而抑制 RANKL 诱导的破骨细胞发生的受体激活物。BCPA 用于研究骨质疏松。 | |||
T11728 |
JR-AB2-011
|
mTOR | PI3K/Akt/mTOR signaling |
JR-AB2-011 是一种选择性 mTORC2抑制剂,IC50值为 0.36 μM。JR-AB2-011 通过阻断 Rictor-mTOR 联合体 (Ki: 0.19 μM) 抑制 mTORC2 活性,并且具有抗多形性胶质母细胞瘤 (GBM) 的活性。 | |||
T20067 |
WST-1
WST 1 |
||
WST-1 是一种具有细胞毒性的水溶性四唑盐,诱导细胞内线粒体脱氢酶进行 NADH 依赖性酶解反应,释放出水溶性甲基苯产物。WST-1 可通过检测吸收值来检测细胞增殖和细胞活性,可用于WST-1平板测定法测定超氧化物歧化酶活性。 | |||
T21314 |
Amsilarotene
TAC-101,TAC 101,TAC101 |
CDK | Cell Cycle/Checkpoint |
Amsilarotene (TAC101) 是口服有活性的合成类视黄醇,对视黄酸受体 α (RAR-α) 具有选择性亲和力,对 RAR-α 和 RAR-β 的 Ki=为 2.4 nM 和 400 nM。它可造成人胃癌、卵巢癌细胞及肝细胞癌的凋亡,可用于研究癌症。 | |||
T16277 |
NCT-502
N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide |
Dehydrogenase | Metabolism |
NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) 是磷酸甘油酸脱氢酶 (PHGDH) 抑制剂(IC50:3.7 μM),对 PHGDH 依赖性癌细胞具有细胞毒性,能够减少葡萄糖衍生的丝氨酸的产生,。 | |||
T38271 |
TH1217
TH 1217 |
Others | Others |
TH1217 是一种有效的、选择性的 dCTPase pyrophosphatase 1 (dCTPase) 抑制剂,IC50 值为 47 nM。TH1217 可增强胞苷类似物在白血病细胞中的细胞毒性作用。TH1217 还可以调节 SARS-Cov-2 相互作用体,因此它具有抗 COVID-19 的活性。 | |||
T36879L |
H-Leu-Leu-OMe . HBr
H-Leu-Leu-OMe . HBr (16689-14-8 Free base) |
Others | Others |
H-Leu-Leu-OMe . HBr 是由人单核细胞或多形核白细胞产生的L-亮氨酸甲酯的二肽缩合产物。 H-Leu-Leu-OMe . HBr 诱导内溶酶体途径应激并选择性地消除具有细胞毒性潜力的淋巴细胞。 | |||
T8591 |
RNase L-IN-2
5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one |
Others | Others |
RNase L-IN-2 是 RNase L 的激活剂,EC50 为 22 uM;对多种类型的 RNA 病毒(包括人类病原体人类副流感病毒 3 型)具有广谱抗病毒活性,在有效浓度下没有细胞毒性。 | |||
T14348 |
Auristatin E
|
Microtubule Associated; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling |
Auristatin E 通过阻断微管蛋白的聚合来抑制细胞分裂。它是一种细胞毒性微管蛋白修饰剂,具有强效和选择性抗肿瘤活性。它是一种 MMAE 类似物,是抗体-药物偶联物中的细胞毒素。 | |||
T15713 |
Larotaxel
XRP9881 |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Larotaxel (XRP9881) 是一种紫杉烷类似物,具有抗癌活性,通过促进微管蛋白装配和稳定微管发挥其细胞毒性作用,并通过细胞凋亡诱导细胞死亡。Larotaxel (XRP9881) 是一种可穿过血脑屏障的化合物,对 Docetaxel 的亲和力比 P-糖蛋白 1 高,可用于研究乳腺癌和膀胱癌。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN7043 |
Neolancerin
|
Others | Others |
Neolancerin 是一种对 HL-60 细胞具有弱细胞毒作用的天然产物。 | |||
T32291 |
Jineol
NSC694081,3,8-Quinolinediol,NSC 694081,NSC-694081 |
Others | Others |
Jineol (NSC-694081) 是一种来自蜈蚣 Scolopendra subspinipes 的喹啉生物碱。Jineol 在体外对人类肿瘤细胞系的生长具有细胞毒活性。 | |||
TN6512 |
Tectol
|
Transferase; Parasite | Metabolism; Microbiology/Virology |
Tectol 是从Lippia sidoides 中分离的,对人白血病细胞株 HL60 和 CEM 具有显著的抑制作用。它是法尼基转移酶抑制剂,在人和布氏锥虫的IC50分别为 2.09 和 1.73 μM。它具有抗疟原虫活性,是一种中等活性的生长抑制剂,IC50 为 3.44±0.20μM。 | |||
TN2182 |
Sarracenin
脱水莫诺苷元,金银花 |
Others | Others |
Sarracenin 是一种的环烯醚萜,分离自鸢尾草的根和根茎中。它对肿瘤细胞显示出细胞毒作用。 | |||
TN1722 |
Hamamelitannin
|
Antifection | Microbiology/Virology |
Hamamelitannin 是分离自 Hamamelis virginiana 树皮的一种多酚,是群体感应抑制剂。它通过影响肽聚糖生物合成和 eDNA 释放增加金黄色葡萄球菌生物膜的抗生素敏感性。 | |||
T21165 |
Pellitorine
AI3-19560,墙草碱,Pellitorin |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pellitorine (Pellitorin) 是提取自 Piper nigrum 的根的一种化合物。它对 HL60 和 MCT-7 细胞系表现出显著的细胞毒活性。它可用于癌症疾病的研究。 | |||
TN6720 |
Acetylalkannin
Acetyl alkannin,Alkannin acetate |
Antibacterial | Microbiology/Virology |
Acetylalkannin (Alkannin acetate) 是一种从 Arnebia euchroma 中分离出来的异己烯基萘色素,具有抗菌和细胞毒性作用。 | |||
T5808 |
(-)-Oxypeucedanin hydrate
水合氧化前胡素,OXYPEUCEDANIN HYDRATE |
Others | Others |
(-)-Oxypeucedanin hydrate 是一种呋喃香豆素衍生物,分离自Ducrosia anethifolia 中。 | |||
T13741 |
Isoviolanthin
异佛莱心苷,异佛来心苷 |
Others | Others |
Isoviolanthin 是一种黄酮类苷类化合物,提取自铁皮石斛叶中。它能减少 TGF-β1 处理的 HCC 细胞的迁移和入侵能力,对正常细胞没有毒性影响,对转移性肝癌晚期具有潜在的研究价值。 | |||
T3933 |
Jatrorrhizine
Yatrorizine,neprotin,药根碱 |
MAO; 5-HT Receptor; Antibacterial; AChE | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Jatrorrhizine (neprotin) 是一种从黄连中分离得到的生物碱,具有抗菌、抗氧化、抗疟原虫和神经保护活性。它通过抑制 uptake-2 transporter 的活性减少血清素和去甲肾上腺素的摄取。它是一种有口服活性的乙酰胆碱酯酶制剂。 | |||
T4912 |
Jatrorrhizine chloride
盐酸药根碱,Yatrorhizine chloride,Neprotine chloride |
Others; 5-HT Receptor; OCT; Antibacterial; AChE | GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others |
Jatrorrhizine chloride (Neprotine chloride) 是从黄连中分离得到的生物碱,具有神经保护、抗菌、抗氧化和抗疟原虫活性。它通过抑制摄取2转运蛋白的活性减少血清素和去甲肾上腺素的摄取。它是具有口服活性的乙酰胆碱酯酶抑制剂。 | |||
TN1915 |
Matairesinol 4′-O-β-D-glucopyranoside
Matairesinol 4'-O-beta-gentiobioside,罗汉松树脂酚-4'-O-Β-龙胆二糖苷,(3R-反式)-3-[[4-[(6-O-BETA-D-吡喃葡萄糖基-BETA-D-吡喃葡萄糖基)氧基]-3-甲氧基苯基]甲基]二氢-4-[(4-羟基-3-甲氧基苯基)甲基]-2(3H)-呋喃酮 |
Others | Others |
Matairesinol 4′-O-β-D-glucopyranoside 对 HeLa 细胞具有细胞毒活性(IC50:47.1 μM)。 | |||
TN2546 |
1-Isomangostin
|
NF-κB | NF-κB |
1-Isomangostin 具有细胞毒性和抗补体活性。 | |||
T25664 |
Lepidiline A
Macaline A |
Others | Others |
Lepidiline A (Macaline A) 是一种具有抗炎症活性的黄酮木质素。Lepidiline A 对HL-60细胞具有细胞毒活性,IC50值为 32.3 μM。它是从芸苔科植物Lepidium meyenii Walpers 的活性成分,可改善小鼠内源性性激素的平衡,提高果蝇的繁殖力。Lepidiline A 靶向HSD17B1基因的机制来增强酶的活性,提高性激素的生物转化效率,提高生殖能力。Lepidiline A 具有抗癌活性。 | |||
TN5922 |
3,4-Dimethoxycinnamyl alcohol
(E)-3-(3,4-dimethoxyphenyl)prop-2-en-1-ol,3,4-二甲氧基肉桂醇 |
Others | Others |
3,4-Dimethoxycinnamyl alcohol ((E)-3-(3,4-dimethoxyphenyl)prop-2-en-1-ol) 显示出显着的抗菌和细胞毒性活性。 | |||
T2S2018 |
7beta-Hydroxylathyrol
7β-Hydroxylathyrol,7-Hydroxylathyrol,7-beta-Hydroxylathyrol,7-羟基千金子二萜醇 |
P-gp | Membrane transporter/Ion channel; Neuroscience |
7β-Hydroxylathyrol 是天然萜类化合物的一种。 | |||
T31866 |
FR901464
FR 901464,FR-901464,WB 2663B |
Others | Others |
FR901464 (WB 2663B)是具有强细胞毒性的天然产物,共享一个含胺的四氢吡喃环。 | |||
T22857 |
Illudin S
|
Apoptosis; DNA Alkylator/Crosslinker; Antifungal | Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology |
Illudin S (ILS)是一种真菌倍半萜次生代谢物,具有很强的遗传毒性和细胞毒性 | |||
T4S1999 |
Valepotriate
戊曲酯/缬草素,Valtrate |
Apoptosis; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Valepotriate (Valtrate) 是从蜘蛛香分离而来的一种天然产物,是一类新的细胞毒剂和抗肿瘤剂,对 HTC 肝癌细胞是非常有效的细胞毒剂。 它可能对焦虑的精神症状具有潜在的抗焦虑作用。 | |||
TN3029 |
4-(Ethoxymethyl)phenol
p-Hydroxybenzyl Et ether |
Antioxidant | oxidation-reduction |
4-(Ethoxymethyl)phenol (p-Hydroxybenzyl Et ether) 是一种从 Amburana cearensis 中提取的小分子化合物,具有细胞毒性和抗氧化会活性。 | |||
T2S0029 |
4'-Demethylpodophyllotoxin
4'-去甲鬼臼毒素,4'-去甲基鬼臼毒素 |
Others | Others |
4'-Demethylpodophyllotoxin 是一种木脂素类化合物,存在于Podophyllum hexandrum 根和P. peltatum 中,对多种癌细胞系具有潜在的细胞毒性。 | |||
TN1656 |
Ganoderenic acid A
灵芝烯酸A,灵芝烯酸 A |
Others | Others |
Ganoderenic acid A 是三萜类化合物。它对 CCl4 诱导的肝损伤具有保护作用。它是β-葡萄糖醛酸酶抑制剂。 | |||
T4S1024 |
Picfeltarraenin IB
苦玄参苷IB,苦玄参苷 IB |
Others; AChE | Neuroscience; Others |
Picfeltarraenin IB 是一种Picriafel-terraeLour (P.fel-terrae) 中提取的三萜类化合物,是一种乙酰胆碱酯酶抑制剂。它可用于感染,癌症和炎症的研究。 | |||
TN3231 |
Pratol
7-Hydroxy-4'-methoxyflavone,三叶草,车轴草醇 |
Others | Others |
Pratol (7-Hydroxy-4'-methoxyflavone) 显着增加细胞中的黑色素含量和酪氨酸酶活性,而没有细胞毒性。 | |||
T41288 |
Myristoleic acid
cis-9-tetradecenoic acid,肉豆蔻酸,9-Tetradecenoic acid,(Z)-Tetradec-9-enoic acid |
Apoptosis | Apoptosis |
Myristoleic acid (9-Tetradecenoic acid) 是 Serenoa repens 提取物中的一种细胞毒性成分。Myristoleic acid 诱导人前列腺 LNCaP 细胞凋亡和坏死。 | |||
T8206 |
Cycleanine
|
Others | Others |
Cycleanine 是一种高效血管选择性Ca- 拮抗剂,具有缓解疼痛、肌肉松弛和抗炎作用。它还具有有效的抗菌、抗真菌、抗疟原虫和细胞毒活性。 | |||
TN2430 |
Glucodigifucoside
洋地黄毒苷元葡萄糖基岩藻糖苷,洋地黄 |
||
Glucodigifucoside 是可从洋地黄种子中分离得到的强心苷,对人肾腺癌细胞有特异性细胞毒性。 | |||
T5S0168 |
Atractylenolide II
2-Atractylenolide,Asterolide,苍术内酯II |
Apoptosis; ERK; p38 MAPK; Akt; STAT | Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells |
Atractylenolide II (2-Atractylenolide) 是一种从白术干燥根茎分离的倍半萜类天然产物,具有抗增殖活性。 | |||
TN1018 |
Angeloylgomisin H
当归酰戈米辛 H,当归酰戈米辛H |
PPAR | DNA Damage/DNA Repair; Metabolism |
Angeloylgomisin H 是从五味子中提取的一种木脂素类天然产物。它通过激活PPAR-γ来改善胰岛素刺激的葡萄糖摄取潜力。 | |||
T5744 |
7-Prenyloxycoumarin
7-(异戊烯基氧基)香豆素,Nsc267697,7-O-Prenylumbelliferone,7-异戊烯氧基香豆素 |
Antifungal | Microbiology/Virology |
7-Prenyloxycoumarin (Nsc267697) 是一种 Heracleum dissectum 的天然产物,对乳腺癌具有预防和治疗作用。 | |||
T2S1593 |
Gypenoside XLVI
|
Others | Others |
Gypenoside XLVI 是一种来源于绞股蓝的主要达玛烷型三萜皂苷。它具有四环三萜结构,能够有效抑制非小细胞肺癌 A549 细胞的活性。 | |||
TMA2394 |
DL-alpha-Tocopherol
DL-α-生育酚,消旋-α-生育酚,DL-α-Tocopherol,Alpha-Tochopherol,Ephanyl |
Antioxidant; Ferroptosis | Apoptosis; oxidation-reduction |
DL-alpha-Tocopherol (Ephanyl) 是一种合成维生素 E,能保护皮肤成纤维细胞免受紫外线的细胞毒性作用,具有抗氧化作用。 | |||
TN4375 |
Kamebanin
|
Antifection | Microbiology/Virology |
Kamebanin 是一种天然二萜类化合物,具有抗菌活性。它对 HeLa 和 HL-60 细胞显示出有效的细胞毒活性。 | |||
T13815 |
Penicillic acid
|
Apoptosis; Caspase; Antibacterial; Antibiotic | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Penicillic acid,一种由多种Aspergillus和Penicillium物种合成的polyketide mycotoxin,通过阻碍caspase-8的自我处理作用,抑制Fas ligand引发的apoptosis。此外,体外研究表明,Penicillic acid在rat alveolar macrophages中显示出cytotoxic特性。 | |||
T3386 |
Kaempferitrin
Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷 |
cell cycle arrest; Glucokinase; IGF-1R | Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors |
Kaempferitrin (Lespenephryl) 是天然黄酮苷类化合物,具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用,可激活胰岛素信号传导。 | |||
T5S0777 |
Phellodendrine chloride
|
Others | Others |
Phellodendrine chloride 是一种Phellodendron amurense 中的生物碱。它通过巨胞饮抑制营养物质的吸收,进而抑制 KRAS 突变的胰腺癌细胞的增殖。 | |||
T3819 |
Ursolic acid acetate
熊果酸乙酸酯,Acetylursolic acid,3-Acetylursolic Acid |
AChE | Neuroscience |
Ursolic acid acetate (Acetylursolic acid) 分离于 Ficus microcarpa 的气根中,对 KB 细胞显示细胞毒性(IC50:8.4 μM)。 | |||
T20091 |
Stearamide
Stearic acid amide,NSC 66462,NSC66462,NSC-66462 |
||
Stearamide(Stearic acid amide)是一种初级脂肪酸酰胺,具有细胞毒性和鱼类毒性,可用于增加纳米颗粒的性能。 | |||
TN1252 |
3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone
|
Apoptosis | Apoptosis |
3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone 是一种来自桑叶的黄酮类化合物,具有细胞毒性,可诱导细胞凋亡。 | |||
T10164 |
5,6-Dihydroxyindole
Dopamine lutine |
Endogenous Metabolite | Metabolism |
5,6-Dihydroxyindole (Dopamine lutine) 是黑色素的前体,显示出广谱的抗菌,抗真菌,抗病毒,抗寄生虫活性。5,6-Dihydroxyindole 也显示出细胞毒性作用。 | |||
T67922 |
Lepidiline C
|
Others | Others |
Lepidiline C 是一种 从十字花科Lepidium meenii Walpers 根中提取的新型的咪唑类生物碱 ,对HL-60细胞表现出细胞毒活性(IC50为:27.7 μM)。 | |||
T0671 |
2-Naphthol
Betanaphthol,β-萘酚,乙萘酚 |
Others; Endogenous Metabolite | Metabolism; Others |
2-Naphthol 是一种 naphthalene 的代谢物,由细胞色素 P450 亚型 (CYP 1A1,CYP 1A2,CYP 2A1,CYP 2E1 和 CYP 2F2) 催化而成。2-Naphthol 具有细胞毒性。 | |||
T3020 |
Sclareol
|
Apoptosis; Others | Apoptosis; Others |
Sclareol 是一种从快乐鼠尾草中分离出来的拉丹型二萜,对多种人类 Y 细胞系具有生长抑制和细胞毒活性,诱导细胞凋亡。 | |||
T5S0229 |
Isosakuranetin
4'-Methylnaringenin,异野樱素,异樱花亭 |
Others | Others |
Isosakuranetin (4'-Methylnaringenin) 是一种黄烷酮黄酮类化合物,存在于 Citrus bergamia 果实中。 | |||
T6S0781 |
Phellodendrine
黄柏碱,Phallodendrin |
Others; NF-κB; Akt | Cytoskeletal Signaling; NF-κB; Others; PI3K/Akt/mTOR signaling |
Phellodendrine (Phallodendrin) 是异喹啉生物碱,是黄柏皮层中的重要特征成分之一。它具有良好的抗氧化,抗炎作用。它通过调节AKT/NF-κB 途径抵抗 AAPH 诱导的氧化应激。 | |||
T3S1692 |
Octahydrocurcumin
|
Anti-infection; NF-κB; Reactive Oxygen Species; ROS | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Octahydrocurcumin 是一种姜黄素的氢化衍生物,是姜黄素的代谢物。 | |||
T6S1485 |
Ginsenoside Rh4
人参皂苷Rh4 |
Others | Others |
Ginsenoside Rh4 可以安全地用作佐剂,具有低溶血作用或无溶血作用。它具有细胞毒活性,其苷元对癌细胞系具有杀伤作用。 | |||
T4601 |
9-Methoxycanthin-6-one
|
Others | Others |
9-Methoxycanthin-6-one 是存在于完整植株和不同外植体的愈伤组织中的 Canthin-6-one 生物碱,具有抗肿瘤作用。 | |||
T0501 |
Mequinol
4-Hydroxyanisole,Leucobasal,对苯二酚单甲醚,4-Methoxyphenol |
Others | Others |
Mequinol (Leucobasal) 是一种Mercurialis spp 的生物活性成分,常用于皮肤褪色。 | |||
T5S0506 |
Rotundic acid
Rutundic acid,铁冬青酸 |
Apoptosis; Others; p38 MAPK; Akt; mTOR | Apoptosis; Cytoskeletal Signaling; MAPK; Others; PI3K/Akt/mTOR signaling |
Rotundic acid (Rutundic acid) 是一种从圆形肠球菌中获得的三萜类天然产物,具有抗炎和保护心脏的能力。它可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01604 |
CTLA-4 Protein, Mouse, Recombinant (His)
Ly-56,Cd152,cytotoxic T-lymphocyte-associated prote... |
Mouse | HEK293 Cells |
CTLA-4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.46 kDa and the accession number is Q6GTR6. | |||
TMPH-03319 |
IL-17A Protein, Rat, Recombinant (His)
Cytotoxic T-lymphocyte-associated antigen 8,Interle... |
Rat | E. coli |
IL-17A Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.0 kDa and the accession number is Q61453. | |||
TMPY-04348 |
CTLA-4 Protein, Human, Recombinant (His)
ALPS5,CD152,GRD4,cytotoxic T-lymphocyte-associated ... |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is P16410-1. | |||
TMPY-05159 |
Granzyme A/GZMA Protein, Human, Recombinant (His)
CTLA3,granzyme A (granzyme 1, cytotoxic T-lymphocyt... |
Human | HEK293 Cells |
Granzyme A/GZMA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.5 kDa and the accession number is P12544-1. | |||
TMPJ-01172 |
IL-17 Protein, Mouse, Recombinant (His)
CTLA8,IL-17,IL-17A,Interleukin-17A,CTLA-8,Cytotoxic... |
Mouse | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumato... | |||
TMPY-04824 |
CTLA-4 Protein, Human, Recombinant
CTLA-4,GSE,IDDM12,CELIAC3,ALPS5,CD,GRD4,cytotoxic T... |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 13.5 kDa and the accession number is P16410-1. | |||
TMPY-02411 |
CTLA-4 Protein, Canine, Recombinant (His)
cytotoxic T-lymphocyte-associated protein 4 |
Canine | HEK293 Cells |
CTLA-4 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is A0A8C0TW59. | |||
TMPY-02557 |
CTLA-4 Protein, Rat, Recombinant (His)
cytotoxic T-lymphocyte-associated protein 4 |
Rat | HEK293 Cells |
CTLA-4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q62859. | |||
TMPJ-00635 |
CTLA-4 Protein, Cynomolgus, Recombinant (hFc)
Cytotoxic T-lymphocyte-associated antigen 4,Cyt... |
Cynomolgus | HEK293 Cells |
CTLA-4 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 45-60 KDa and the accession number is G7PL88. | |||
TMPJ-00640 |
CTLA-4 Protein, Cavia porcellus, Recombinant (His)
Cytotoxic T-lymphocyte protein 4,CTLA4,Cytotoxi... |
Cavia porcellus | P. pastoris (Yeast) |
CTLA-4 Protein, Cavia porcellus, Recombinant (His) is expressed in P. pastoris yeast expression system with C-6xHis tag. The predicted molecular weight is 18-40 KDa and the accession number is H0VUB1. | |||
TMPY-00620 |
CTLA-4 Protein, Canine, Recombinant (hFc)
cytotoxic T-lymphocyte-associated protein 4 |
Canine | HEK293 Cells |
CTLA-4 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.1 kDa and the accession number is A0A8C0TW59. | |||
TMPY-01674 |
CRTAM Protein, Human, Recombinant (His)
cytotoxic and regulatory T cell molecule,CD355 |
Human | HEK293 Cells |
Cytotoxic and regulatory T-cell molecule, also known as Class-I MHC-restricted T-cell-associated molecule and CRTAM, is a single-pass type I membrane protein which belongs to thenectin family.CRTAM contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. In the immune system, the expression of CRTAM is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. It is strongly expressed in spleen, thymus, small inte... | |||
TMPY-00817 |
Granzyme B/GZMB Protein, Human, Recombinant (His)
CGL1,CTLA1,CSP-B,CTSGL1,HLP,SECT,CSPB,granzyme B (granzyme 2... |
Human | HEK293 Cells |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G... | |||
TMPJ-00636 |
CTLA-4 Protein, Cynomolgus, Recombinant (His)
Cytotoxic T-lymphocyte protein 4,CTLA-4,CD152,C... |
Cynomolgus | HEK293 Cells |
CTLA-4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 17-25 KDa and the accession number is G7PL88. | |||
TMPY-02492 |
CTLA-4 Protein, Rat, Recombinant (hFc)
cytotoxic T-lymphocyte-associated protein 4 |
Rat | HEK293 Cells |
CTLA-4 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.5 kDa and the accession number is Q62859. | |||
TMPY-03589 |
CTLA4 Protein, Cynomolgus/Rhesus, Recombinant (His)
cytotoxic T-lymphocyte-associated protein 4 |
Cynomolgus,Rhesus | HEK293 Cells |
CTLA4 Protein, Cynomolgus/Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is Q9BDC4. | |||
TMPY-03359 |
CTLA-4 Protein, Cynomolgus, Rhesus, Recombinant (hFc)
cytotoxic T-lymphocyte-associated protein 4 |
Cynomolgus,Rhesus | HEK293 Cells |
CTLA-4 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.4 kDa and the accession number is Q9BDC4. | |||
TMPJ-00420 |
CTLA-4 Protein, Mouse, Recombinant (Flag)
Cytotoxic T-lymphocyte protein 4, Cytotoxic |
Mouse | HEK293 Cells |
Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their fu... | |||
TMPJ-00108 |
CTLA-4 Protein, Human, Recombinant (GST)
Cytotoxic T-lymphocyte protein 4, Cytotoxic |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant (GST) is expressed in HEK293 mammalian cells with C-GST tag. The predicted molecular weight is 40-55 KDa and the accession number is P16410. | |||
TMPJ-00107 |
CTLA-4 Protein, Human, Recombinant (Flag)
Cytotoxic T-lymphocyte protein 4,CTLA-4,Cytotox... |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 20 KDa and the accession number is P16410. | |||
TMPY-04968 |
CTLA-4 Protein, Mouse, Recombinant (His), Biotinylated
cytotoxic T-lymphocyte-associated protein 4,Ctla-4,... |
Mouse | HEK293 Cells |
CTLA-4 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.3 kDa and the accession number is Q6GTR6. | |||
TMPH-02688 |
Granzyme C/GZMC Protein, Mouse, Recombinant (His & Myc)
Cytotoxic cell protease 2,B10,Gzmc,Granzyme C |
Mouse | E. coli |
This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. Granzyme C/GZMC Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.6 kDa and the accession number is P08882. | |||
TMPJ-00770 |
Granzyme B/GZMB Protein, Mouse, Recombinant (His)
Gzmb,Cytotoxic cell protease 1,Fragmentin-2,CTLA-1,... |
Mouse | HEK293 Cells |
Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. | |||
TMPY-01721 |
CTLA-4 Protein, Mouse, Recombinant (hFc)
Ly-56,Ctla-4,Cd152,cytotoxic T-lymphocyte-associate... |
Mouse | HEK293 Cells |
CTLA-4 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41 kDa and the accession number is Q6GTR6. | |||
TMPY-06326 |
CTLA-4 Protein, Mouse, Recombinant (His & Avi), Biotinylated
cytotoxic T-lymphocyte-associated protein 4,Ctla-4,... |
Mouse | HEK293 Cells |
CTLA-4 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.27 kDa and the accession number is NP_033973.2. | |||
TMPJ-00429 |
CRTAM Protein, Cynomolgus, Recombinant (hFc)
CRTAM,CD355,Cytotoxic and Regulatory T-Cell Molecul... |
Cynomolgus | HEK293 Cells |
CRTAM Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 80-90 KDa and the accession number is A0A2K5TKL4. | |||
TMPY-06824 |
CTLA-4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD152,cytotoxic T-lymphocyte-associated protein 4,G... |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 42.89 kDa and the accession number is NP_005205.2. | |||
TMPY-05369 |
CTLA-4 Protein, Human, Recombinant (hFc), Biotinylated
IDDM12,cytotoxic T-lymphocyte-associated protein 4,... |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is P16410-1. | |||
TMPJ-01444 |
IL-17A Protein, Cynomolgus, Recombinant (His)
CTLA-8,CTLA8,IL17A,IL-17,IL-17A,Cytotoxic T-Lymphoc... |
Cynomolgus | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synt... | |||
TMPH-02456 |
IL-12B Protein, Mesocricetus auratus, Recombinant (His & Myc)
Cytotoxic lymphocyte maturation factor 40 kDa subun... |
Mesocricetus auratus | E. coli |
IL-12B Protein, Mesocricetus auratus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.8 kDa and the accession number is Q8CJE6. | |||
TMPJ-01422 |
CRTAM Protein, Cynomolgus, Recombinant (His)
Cytotoxic and Regulatory T-Cell Molecule,CD355,CRTA... |
Cynomolgus | HEK293 Cells |
CRTAM Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 50-60 KDa and the accession number is XP_005580021.1. | |||
TMPY-04948 |
CTLA-4 Protein, Human, Recombinant (His), Biotinylated
GSE,ALPS5,GRD4,IDDM12,cytotoxic T-lymphocyte-associ... |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is P16410-1. | |||
TMPY-04998 |
CTLA-4 Protein, Human, Recombinant (rFc)
GRD4,CELIAC3,ALPS5,CD,CTLA-4,CD152,cytotoxic T-lymp... |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 39.7 kDa and the accession number is P16410-1. | |||
TMPY-05002 |
CTLA-4 Protein, Human, Recombinant (hFc)
CD,cytotoxic T-lymphocyte-associated protein 4,IDDM... |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is P16410-1. | |||
TMPJ-00221 |
SLAMF7 Protein, Human, Recombinant (His & Avi), Biotinylated
Membrane Protein FOAP-12,Novel Ly9,CRACC,SLAMF7,SLAM Family ... |
Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 35-55 KDa and the accession number is Q9NQ25. | |||
TMPJ-00655 |
TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His)
TRAIL-R1,TNFRSF10A,cytotoxic TRAIL receptor,APO2,CD... |
Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF... | |||
TMPJ-00222 |
SLAMF7 Protein, Human, Recombinant (mFc)
CD2 Subset 1,CRACC,CD319,CS1,Membrane Protein FOAP-12,SLAMF7... |
Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60-90 KDa and the accession number is Q9NQ25. | |||
TMPJ-01442 |
SLAMF7 Protein, Rhesus macaque, Recombinant (His)
CD2 Subset 1,CD2-Like Receptor-Activating Cytotoxic... |
Rhesus | HEK293 Cells |
SLAMF7 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-50 KDa and the accession number is F7HQ72. | |||
TMPH-01412 |
Granzyme B Protein, Human, Recombinant (E. coli, His)
Cytotoxic T-lymphocyte proteinase 2,Granzyme B,SECT... |
Human | E. coli |
Granzyme B Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.0 kDa and the accession number is P10144. | |||
TMPJ-00216 |
IL-12B Protein, Human, Recombinant
Interleukin-12 subunit beta,IL-12B,CLMF p40,NKSF2,Interleuki... |
Human | HEK293 Cells |
Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells develop... | |||
TMPJ-00779 |
TNF alpha Protein, Rabbit, Recombinant
TNF-a,Tumor Necrosis Factor,TNF-α,TNF α,Cachectin,肿瘤坏死因子,Tum... |
Rabbit | E. coli |
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other ... | |||
TMPY-03956 |
Fas Ligand Protein, Human, Recombinant (His)
TNLG1A,FASL,FASLG,CD178,CD95-L,APT1LG1,APTL,CD95L,Fas ligand... |
Human | P. pastoris (Yeast) |
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei... | |||
TMPY-02153 |
TNF beta Protein, Human, Recombinant
LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymphotoxin alpha,lymphotoxin α |
Human | E. coli |
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS... | |||
TMPH-03717 |
YopE Protein, Yersinia enterocolitica, Recombinant (His)
yopE,Outer membrane virulence protein YopE |
Yersinia enterocolitica | E. coli |
Essential virulence determinant; cytotoxic effector, involved in resistance to phagocytosis. | |||
TMPK-01494 |
HLA-A*01:01&B2M&CT83 (NTDNNLAVY) Tetramer Protein, Human, MHC (His & Avi)
HLA-A,HLA-A*0101,HLA class I,MHC,MHC HLA-A alpha,CT83,MHC cl... |
Human | HEK293 Cells |
Cancer/testis antigens 83 (CT83), also called KK-LC-1 or CXorf61, recognized by cytotoxic T lymphocytes (CTL), has become a promising target for immunotherapy. | |||
TMPK-01496 |
HLA-A*01:01&B2M&CT83 (NTDNNLAVY) Monomer Protein, Human, MHC (His & Avi)
HLA-A,CT83,HLA-A*0101,HLA class I,MHC class I,MHC,MHC HLA-A ... |
Human | HEK293 Cells |
Cancer/testis antigens 83 (CT83), also called KK-LC-1 or CXorf61, recognized by cytotoxic T lymphocytes (CTL), has become a promising target for immunotherapy. | |||
TMPK-01545 |
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
sHLA-E,MHC,MHC class I antigen E,HLAE,MHC HLA-E alpha-1,MHC ... |
Human | HEK293 Cells |
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ... | |||
TMPH-02628 |
Cathepsin C Protein, Mouse, Recombinant (His & Myc)
Dipeptidyl transferase,Dipeptidyl peptidase I,Cathepsin J,DP... |
Mouse | E. coli |
Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function. | |||
TMPK-01541 |
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi), Biotinylated
QA1,MHC HLA-E alpha-2.1,MHC,HLAE,MHC class I antigen E,MHC H... |
Human | HEK293 Cells |
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ... | |||
TMPK-01544 |
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi)
MHC class I antigen E,HLAE,sHLA-E,QA1,MHC HLA-E alpha-2.1,MH... |
Human | HEK293 Cells |
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T36895 |
5-Fluorouracil-13C,15N2
5-Fluorouracil-13C,15N2 |
||
5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. | |||
TMIJ-0470 |
Folpet-d4
|
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Folpet-d4 是 Folpet 的氘代化合物。Folpet 的 CAS 号为 133-07-3。Folpet 是一种广泛使用的二甲酰亚胺类杀菌剂,可诱发小鼠胃肠道肿瘤,主要发生在十二指肠,对人支气管上皮细胞也有细胞毒作用。 | |||
T69758 |
Flutamide-d7
|
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Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft mo... | |||
TMID-0076 |
Busulfan-d8
|
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Busulfan-d8 是 Busulfan 的氘代化合物。Busulfan 的 CAS 号为 55-98-1。Busulfan 是二甲磺酸盐的合成衍生物,具有抗肿瘤和细胞毒特性。是一种烷化剂,对骨髓具有选择性免疫抑制作用。 | |||
T71401 |
Oxaliplatin-d10
|
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Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.... | |||
TMID-0242 |
Capecitabine-d11
|
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Capecitabine-d11 是 Capecitabine 的氘代化合物。Capecitabine 的 CAS 号为 154361-50-9。Capecitabine 是一种可口服的前药,可由胸苷磷酸化酶催化转变为其活性代谢物 Fluorouracil。 | |||
TMID-0078 |
Irinotecan-d10 Hydrochloride
|
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Irinotecan-d10 Hydrochloride 是 Irinotecan Hydrochloride 的氘代化合物。Irinotecan Hydrochloride 的 CAS 号为 100286-90-6。Irinotecan Hydrochloride 是喜树碱半合成衍生物的盐酸盐,是一种拓扑异构酶 I 抑制剂,可研究结肠癌和直肠癌。 | |||
T71142 |
Tebuconazole-d9
|
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Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per... |