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Search Results for " cytolysin "

Targets Recommended: Others

4

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36324	C8 L-threo Ceramide (d18:1/8:0) C8 L-threo Ceramide (d18:1/8:0)	Others	Others
	C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide , induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 L-erythro ceramide . C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~30 μg/ml.
T77863	TAM558	Others; Drug-Linker Conjugates for ADC	Antibody-drug Conjugate/ADC Related; Others
	TAM558为OMTX705合成中的有效载荷组分。OMTX705是人源化抗FAP（成纤维细胞活化蛋白）抗体，与TAM470结合后展示出抗肿瘤活性。
T74648	TAM470	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	TAM470 是一种新型的细胞溶素，可抑制微管蛋白聚集和微管解聚。TAM470 可作为有效载荷分子用于合成 OMTX705，OMTX705 是一种具有抗肿瘤活性的FAP 靶向抗体偶联活性分子 (ADCs)。
T36322	C8 D-threo Ceramide (d18:1/8:0) C8 D-threo Ceramide (d18:1/8:0)	Others	Others
	C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein r...

化合物

C8 L-threo Ceramide (d18:1/8:0)

Cat.No: T36324

Synonym: C8 L-threo Ceramide (d18:1/8:0)

Target: Others

Cat.No: T77863

Target: Others, Drug-Linker Conjugates for ADC

Cat.No: T74648

Target: Others, ADC Cytotoxin

C8 D-threo Ceramide (d18:1/8:0)

Cat.No: T36322

Synonym: C8 D-threo Ceramide (d18:1/8:0)

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03704	Cytolysin Protein, Vibrio vulnificus, Recombinant (His & Myc) Cytolysin,vvhA	Vibrio vulnificus	E. coli
	Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined. Cytolysin Protein, Vibrio vulnificus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 55.8 kDa and the accession number is P19247.
TMPH-03592	Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (His) Thiol-activated cytolysin,ply,Pneumolysin	Streptococcus pneumoniae	P. pastoris (Yeast)
	A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. Pneum...
TMPH-03593	Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (Avi & His) Thiol-activated cytolysin,Pneumolysin,ply	Streptococcus pneumoniae	E. coli
	A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. Pneum...
TMPH-02824	Perforin-1/PRF1 Protein, Mouse, Recombinant (His) Lymphocyte pore-forming protein,Cytolysin,Perforin-...	Mouse	E. coli
	Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
TMPH-03349	Perforin-1/PRF1 Protein, Rat, Recombinant (His) Cytolysin,Perforin-1,Prf1,Lymphocyte pore-forming p...	Rat	E. coli
	Perforin-1/PRF1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 62.9 kDa and the accession number is P35763.
TMPH-00420	Perfringolysin O Protein, Clostridium perfringens, Recombinant (His & SUMO) Perfringolysin O,Thiol-activated cytolysin,pfo,Thet...	C.perfringens	E. coli
	Perfringolysin O Protein, Clostridium perfringens, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 68.7 kDa and the accession number is P0C2E9.
TMPH-01854	Perforin-1/PRF1 Protein, Human, Recombinant (His & SUMO) PRF1,Cytolysin,Perforin-1,Lymphocyte pore-forming p...	Human	E. coli
	Perforin-1/PRF1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 75.2 kDa and the accession number is P14222.
TMPH-01853	Perforin-1/PRF1 Protein, Human, Recombinant (His & MBP) Perforin-1,PRF1,Lymphocyte pore-forming protein,Cytolysi...	Human	Baculovirus Insect Cells
	Perforin-1/PRF1 Protein, Human, Recombinant (His & MBP) is expressed in Baculovirus insect cells with N-MBP and C-6xHis tag. The predicted molecular weight is 103.2 kDa and the accession number is P14222.
TMPH-00511	Lysenin Protein, Eisenia fetida, Recombinant (His) Beta-barrel pore-forming toxin,Invertebrate cytolysin	Eisenia fetida	E. coli
	Lysenin Protein, Eisenia fetida, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 40.4 kDa and the accession number is O18423.

重组蛋白

Cytolysin Protein, Vibrio vulnificus, Recombinant (His & Myc)

Cat.No: TMPH-03704

Species: Vibrio vulnificus

Expression System: E. coli

Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (His)

Cat.No: TMPH-03592

Species: Streptococcus pneumoniae

Expression System: P. pastoris (Yeast)

Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (Avi & His)

Cat.No: TMPH-03593

Species: Streptococcus pneumoniae

Expression System: E. coli

Perforin-1/PRF1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02824

Species: Mouse

Expression System: E. coli

Perforin-1/PRF1 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03349

Species: Rat

Expression System: E. coli

Perfringolysin O Protein, Clostridium perfringens, Recombinant (His & SUMO)

Cat.No: TMPH-00420

Species: C.perfringens

Expression System: E. coli

Perforin-1/PRF1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01854

Species: Human

Expression System: E. coli

Perforin-1/PRF1 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPH-01853

Species: Human

Expression System: Baculovirus Insect Cells

Lysenin Protein, Eisenia fetida, Recombinant (His)

Cat.No: TMPH-00511

Species: Eisenia fetida

Expression System: E. coli

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