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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27110 |
CypD inhibitor C-9
CypD inhibitor C 9 |
Others | Others |
CypD inhibitor C-9 is a CypD inhibitor, it attenuates mitochondrial and cellular perturbation insulted by Aß and calcium stress. | |||
T71997 |
CypD-IN-29
|
Others | Others |
CypD-IN-29 is a non-peptidic inhibitor of cyclophilin D as a neuroprotective agent in Aβ-induced mitochondrial dysfunction. | |||
T74963 |
CypD-IN-3
|
Others | Others |
CypD-IN-3是一种高效的CypD (亲环蛋白D) 选择性抑制剂,其对CypD的IC50值仅为0.01 μM。该化合物在氧化应激、神经退行性疾病、肝病、衰老、自噬及糖尿病等多种疾病的研究中有潜在应用。 | |||
T74964 |
CypD-IN-4
|
Others | Others |
CypD-IN-4是一种针对亲环蛋白D(CypD)的有效亚型选择性抑制剂,展现出0.057 μM的IC50,表明其对CypD具有高度亲和力。该化合物适用于氧化应激、神经退行性疾病、肝病、衰老、自噬及糖尿病等多种疾病的研究。 | |||
T71432 |
MDL-27088
|
Others | Others |
MDL-27088 is an angiotensin-covering enzyme inhibitor. | |||
T74965 |
CypE-IN-1
|
Others | Others |
CypD-IN-1 是一种有效的亚型选择性亲环蛋白 E (CypE) 抑制剂。CypD-IN-1 具有 CypE 亲和力,IC50和 Ki 值分别为 0.013 μM 和 0.072 μM。CypD-IN-1 可用于多种疾病的研究,如氧化应激、神经退行性疾病、肝病、衰老、自噬和糖尿病。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S1133 |
Ganoderic acid D
灵芝酸D,灵芝酸 D |
Apoptosis; Sirtuin | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Ganoderic acid D 是高度氧化的四环三萜,是灵芝的主要活性成分,可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程,包括结肠癌细胞中的葡萄糖摄取,乳酸、丙酮酸和乙酰辅酶的产生。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00156 |
Cyclophilin F Protein, Human, Recombinant (His)
peptidylprolyl isomerase F,CYP3,Cyp-D,CyP-M,CypD |
Human | HEK293 Cells |
Cyclophilin F Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.3 kDa and the accession number is A0A024QZS4. | |||
TMPJ-01090 |
PPID Protein, Human, Recombinant (His)
Cyclophilin-40,CYPD,Peptidyl-Prolyl Cis-Trans Isome... |
Human | E. coli |
Peptidyl-Prolyl Cis-Trans Isomerase D (PPID) belongs to the cyclophilin-type PPIase family and PPIase D subfamily. PPID is widely expressed and it contains one PPIase cyclophilin-type domain and three TPR repeats. PPID catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. PPID can bind to the immunosuppressant cyclosporine A and is known that its overexpression suppresses the apoptosis in cancer cells. |