搜索结果

Search Results for " cyclic di-amp "

Targets Recommended: Others

抑制剂 & 化合物

天然产物

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T35595	Cyclic di-AMP (sodium salt)	Others	Others
	Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals. Generated by a family of diadenylate cyclases, c-di-AMP can impact bacterial cell growth, cell wall homeostasis, pathogenicity, and other cellular functions. Bacteria-derived cyclic dinucleotides, including c-di-AMP, trigger the expression of interferon genes in mammalian cells.
T10642	c-di-AMP 环二腺苷酸,Cyclic diadenylate,Cyclic-di-AMP	Others	Others
	c-di-AMP (Cyclic diadenylate) is a STING agonist. It binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway.
T35422	5'-pApA (sodium salt)	Others	Others
	5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3,4It is a metabolite of cyclic di-AMP formedviahydrolysis by various phosphodiesterases (PDEs).55'-pApA is intended for use as a negative control for cyclic di-AMP signaling. 1.Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al.STING is a direct innate immune sensor of cyclic-di-GMPNature478(7370)515-518(2011) 2.Parvatiyar...
T84965	C82	Others	Others
	C82 acts as an inhibitor of Mycobacterium tuberculosis (Mtb) cyclic dinucleotide phosphodiesterase (CdnP), with an IC50 value of 17.5 µM. This particular enzyme is responsible for breaking down cyclic di-AMP (c-di-AMP) into adenosine 5'-monophosphate (AMP). Notably, C82 demonstrates selectivity for Mtb CdnP over other bacterial cyclic dinucleotide phosphodiesterases (CDN PDEs) such as Yybt, RocR, and Group B Streptococcus (GBS) CdnP, as well as the mammalian CDN PDE ENPP1, and the viral CDN PDE ...
T36984	Cyclic di-IMP (sodium salt)	Others	Others
	Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p...
T73873	c-di-AMP disodium	Others	Others
	c-di-AMP (Cyclic diadenylate) sodium 作为一种STING 激动剂，通过结合STING 激活TBK3-IRF3 信号途径，引发I 型 IFN 和 TNF 产生，兼具细菌第二信使功能，在革兰氏阳性细菌中调控细胞生长、存活及毒力，并影响宿主免疫反应。此外，作为有效的粘膜佐剂，它能刺激体液和细胞反应。
T36985	Cyclic di-UMP (sodium salt)	Others	Others
	Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling. 1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nuc...

化合物

Cyclic di-AMP (sodium salt)

Synonym: 环二腺苷酸,Cyclic diadenylate,Cyclic-di-AMP

Target: Others

5'-pApA (sodium salt)

Cyclic di-IMP (sodium salt)

Cyclic di-UMP (sodium salt)

Cat.No: T36985

Synonym:

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN4510	(+)-Medioresinol Di-O-β-D-glucopyranoside (+)-Mediresinol Di-O-beta-D-glucopyranoside,(+)-Medioresinol Di-O-β-D-glucopyranoside	PDE	Metabolism
	(+)-Medioresinol Di-O-β-D-glucopyranoside 对环 AMP 磷酸二酯酶具有很强的抑制活性。

天然产物

(+)-Medioresinol Di-O-β-D-glucopyranoside

Cat.No: TN4510

Synonym: (+)-Mediresinol Di-O-beta-D-glucopyranoside,(+)-Medioresinol Di-O-β-D-glucopyranoside

Target: PDE

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02993	DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc) disA,c-di-AMP synthase,DNA integr...	Mycobacterium paratuberculosis	E. coli
	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predict...

重组蛋白

DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc)

Cat.No: TMPH-02993

Species: Mycobacterium paratuberculosis

Expression System: E. coli

* 搜索：		* 机关/企业：
* 邮箱：		* 电话：
备注：
验证码：

搜索结果

抑制剂 & 化合物

天然产物

重组蛋白

提交您的定制咨询

化合物

天然产物

重组蛋白