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Cat. No. | Product Name | ||
---|---|---|---|
L6750 | 活血化瘀中药单体库 | 580 compounds | |
580种来源于常见活血化瘀中药的单体化合物,是药物开发、药理研究等领域的有效工具。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35424 |
8-bromo-Cyclic AMP
|
Others | Others |
8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase. It can activate cAMP-dependent protein kinase, inhibiting growth, decreasing proliferation, increasing differentiation, and inducing apoptosis of cancer cells. | |||
T35595 |
Cyclic di-AMP (sodium salt)
|
Others | Others |
Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals. Generated by a family of diadenylate cyclases, c-di-AMP can impact bacterial cell growth, cell wall homeostasis, pathogenicity, and other cellular functions. Bacteria-derived cyclic dinucleotides, including c-di-AMP, trigger the expression of interferon genes in mammalian cells. | |||
T9213 |
G140
|
cGAS | Immunology/Inflammation |
G140 是选择性环状GMP-AMP 合酶抑制剂,具有抗炎活性,对 h-cGAS 和 m-cGAS 的IC50值分别为 14.0 和 442 nM。 | |||
T21705 |
8-CPT-Cyclic AMP (sodium salt)
|
Others | Others |
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium 是环 AMP 依赖性蛋白激酶的选择性激活剂。 8-CPT-Cyclic AMP sodium 也是有效的环 GMP 特异性磷酸二酯酶(PDE VA)抑制剂,IC50为 0.9 μM。 8-CPT-Cyclic AMP sodium 还抑制 PDE III 和 PDE IV,IC50分别为 24 和 25 μM。8-CPT-Cyclic AMP sodium 对 Epac 具有非常高的亲和力,是一种有效的Epac 活化剂。 | |||
T12432 |
PF-06928215
|
cGAS | Immunology/Inflammation |
PF-06928215 是高亲和力 cGAS 抑制剂,IC50为 4.9 μΜ,亲和力 Kd 值为 0.2 μΜ。 | |||
T5486 |
RU.521
RU320521 |
DNA; cGAS | DNA Damage/DNA Repair; Immunology/Inflammation |
RU.521 (RU3205217) 是选择性的环状 GMP-AMP 合成酶 (cGAS) 抑制剂,抑制 cGAS 介导的干扰素上调。它也抑制dsDNA 激活受体的活性,IC50为 700 nM。它可降低来自 Aicardi-Goutières 综合征小鼠模型的巨噬细胞中干扰素的组成型表达。 | |||
T10642 |
c-di-AMP
环二腺苷酸,Cyclic diadenylate,Cyclic-di-AMP |
Others | Others |
c-di-AMP (Cyclic diadenylate) is a STING agonist. It binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway. | |||
T11673 |
IRAK4-IN-4
|
IRAK; cGAS | Immunology/Inflammation; NF-κB |
IRAK4-IN-4 (化合物 15) 是白介素-1 受体相关激酶抑制剂,IC50为 2.8 nM。它还抑制环 GMP-AM 合酶 ,IC50为 2.1 nM。 | |||
T11344 |
G150
|
DNA; cGAS | DNA Damage/DNA Repair; Immunology/Inflammation |
G150 是高选择性h-cGAS 抑制剂,IC50值为 10.2 nM,用于抑制 dsDNA 引发的干扰素表达。 | |||
T13606 |
cGAMP
3',3'-cGAMP,Cyclic GMP-AMP |
Others | Others |
cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand. | |||
T10065 |
2',3'-cGAMP
2'-3'-cyclic GMP-AMP |
STING; cGAS | Immunology/Inflammation |
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) 是细胞天然免疫中第二信使,在DNA结合条件下由 cGAMP 合成酶 (cGAS) 催化形成。2',3'-cGAMP 可与 STING 结合形成二聚体,诱导干扰素-β(IFN-β)及其他细胞因子的产生和表达。 | |||
T36678 |
Rp-8-CPT-cAMPS sodium
|
Others | Others |
Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS .[1] It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II.2 By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.[2],[3] | |||
T2137 |
Ibudilast
AV-411,KC-404,MN-166,异丁司特 |
PDE | Metabolism |
Ibudilast (MN-166) 是一种环腺苷酸磷酸二酯酶 (PDE) 抑制剂,具有抗血小板聚集作用。它能够抑制气管平滑肌收缩性,可用于研究哮喘。它可对抗活化小胶质细胞的神经毒性,可能是一种有效的神经保护和抗痴呆药物。 | |||
T29038 |
KL8604166
UCB11056,UCB-11056,UCB 11056 |
Others | Others |
KL8604166(UCB-11056) 是一种潜在的益智化合物。UCB-11056 能扩大大鼠脑组织中诱导环 AMP 的形成。 | |||
T6747 |
8-Bromo-cAMP sodium salt
8-Br-Camp sodium salt,8-溴腺苷-3',5'-环单磷酸钠,8-Bromo-cAMP(sodium salt),8-Bromo-cAMP |
PKA | Tyrosine Kinase/Adaptors |
8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) 是一种环 AMP (cAMP) 类似物,一种 cAMP 依赖性蛋白激酶 (PKA) 的激活剂。8-Bromo-cAMP sodium salt 具有抗肿瘤活性。 | |||
T39217 |
PKA-IN-1
|
PKA | Tyrosine Kinase/Adaptors |
PKA-IN-1 是一种具有选择性和有效性的 cyclic AMP 依赖性蛋白激酶 (PKA) 催化亚基 (cAK) 抑制剂(IC50 : 0.03 μM)。PKA-IN-1 可用于研究免疫系统疾病。 | |||
TP1789L |
Malantide acetate(86555-35-3 free base)
|
PKA; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Malantide acetate(86555-35-3 free base) 是一种由环 AMP 依赖性蛋白激酶 (PKA) 磷酸化的十二肽,可增加 PKA 活性。 Malantide 是一种由 PKA 磷酸化的合成肽,用于在体外测量 PKA 活性。 | |||
T21761 |
HNMPA
|
IGF-1R | Tyrosine Kinase/Adaptors |
HNMPA 是膜不可渗透的胰岛素受体酪氨酸激酶 (insulin receptor tyrosine kinase) 抑制剂。HNMPA 可以抑制人胰岛素受体的酪氨酸和丝氨酸自磷酸化。HNMPA 对环 AMP 依赖性蛋白激酶或蛋白激酶 C 活性没有影响。 | |||
T6649 |
(S)-(+)-Rolipram
(S)-Rolipram,(+)-Rolipram,盐酸环胞苷,S- (+)-Rolipram |
Apoptosis; PDE | Apoptosis; Metabolism |
(S)-(+)-Rolipram ((+)-Rolipram) 是一种 cAMP 依赖性磷酸二酯酶 4 (PDE4) 抑制剂,IC50=1100 nM。它能够抑制人单核细胞产生的肿瘤坏死因子 α (TNFα)。 | |||
T4436 |
RO1138452
CAY10441 |
Others; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Others |
RO1138452 (CAY10441) 是一种选择性和可口服的前列环素受体拮抗剂,pKi 为8.3。它拮抗卡前列环素诱导的人神经母细胞瘤腺苷酸环化酶的激活,以剂量依赖性方式阻断环 AMP 积累,具有镇痛活性。 | |||
T35666 |
PRGL493
|
Others | Others |
PRGL493为高效、选择性的长链酰基辅酶a合成酶4 (ACSL4) 抑制剂,能在乳腺和前列腺细胞以及动物模型中抑制细胞增殖和肿瘤生长,主要应用于癌症研究。 | |||
T35422 |
5'-pApA (sodium salt)
|
Others | Others |
5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3,4It is a metabolite of cyclic di-AMP formedviahydrolysis by various phosphodiesterases (PDEs).55'-pApA is intended for use as a negative control for cyclic di-AMP signaling. 1.Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al.STING is a direct innate immune sensor of cyclic-di-GMPNature478(7370)515-518(2011) 2.Parvatiyar... | |||
T84965 |
C82
|
Others | Others |
C82 acts as an inhibitor of Mycobacterium tuberculosis (Mtb) cyclic dinucleotide phosphodiesterase (CdnP), with an IC50 value of 17.5 µM. This particular enzyme is responsible for breaking down cyclic di-AMP (c-di-AMP) into adenosine 5'-monophosphate (AMP). Notably, C82 demonstrates selectivity for Mtb CdnP over other bacterial cyclic dinucleotide phosphodiesterases (CDN PDEs) such as Yybt, RocR, and Group B Streptococcus (GBS) CdnP, as well as the mammalian CDN PDE ENPP1, and the viral CDN PDE ... | |||
T71016 |
U 84569
|
Others | Others |
U-84569 is a potent inhibitor of human platelet aggregation by inhibiting cyclic AMP-dependent phosphodiesterase leading to reduced platelet phospholipase C activity. | |||
T71421 |
Bemoradan
|
Others | Others |
Bemoradan is an inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue | |||
T69088 |
Oxagrelate
|
Others | Others |
Oxagrelate is a specific inhibitor of cyclic AMP phosphodiesterase, produced in vitro a concentration-dependent inhibition of platelet aggregation induced by collagen and ADP in human platelets. | |||
T70342 |
MRS542
|
Others | Others |
MRS542 is a A3AR antagonist as found by cyclic AMP assays, and a partial agonist as found by beta-arrestin translocation. LUF6000 is responsible for the partial agonist nature of MRS542. | |||
T13340 |
Win-62005
|
Others | Others |
Win-62005 is an inhibitor of cyclic AMP phosphodiesterase III (PDE III)(Kis: 25 and 26 nM for rat heart and canine aorta). | |||
T70916 |
AGN-190851
|
Others | Others |
AGN-190851 is an alpha-2 adrenoceptor agonist which acts as a water diuretic by inhibiting vasopressin-stimulated cyclic AMP accumulation in cortical collecting tubules in mouse models. | |||
T76481 |
PKI (14-24)amide
|
||
PKI (14-24)amide 是一种有效的 PKA 抑制剂。PKI (14-24)amide 在细胞匀浆中强烈抑制环 AMP 依赖性蛋白激酶活性。 | |||
T29223 |
ZK110841
ZK-110841,ZK 110841 |
Others | Others |
ZK110841 is an agonist of prostaglandin DP-receptors on human platelet. ZK110841 elevated the cyclic AMP level in EBTr cells dose-dependently, being more than 100 fold over the basal level at 1 microM. | |||
T76481L |
PKI (14-24)amide TFA
|
||
PKI (14-24)amide TFA 是一种有效的PKA 抑制剂。PKI (14-24)amide 在细胞匀浆中强烈抑制环 AMP 依赖性蛋白激酶活性。 | |||
T11524 |
H-89
Protein kinase inhibitor H-89 |
Others | Others |
H-89 is a selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A; IC50: 48 nM). H-89 has weak inhibition on PKG, Casein Kinase, PKC, and other kinases. | |||
T76510 |
[Asu1,6-Arg8]Vasopressin
|
||
[Asu1,6-Arg8]Vasopressin 是一种加压素 (vasopressin) 激动剂,可增强培养的大鼠垂体前叶细胞中由促肾上腺皮质激素释放因子 (CRF) 诱导的环AMP 积累和ACTH 释放。 | |||
T76399 |
PKI(5-22)amide
|
||
PKI(5-22)amide 是环 AMP 依赖性蛋白激酶 (PKA) 抑制剂的活性片段。PKI(5-22)amide 抑制PKA 激活,但不能减弱 CRF1 受体的同源脱敏作用。 | |||
T76392 |
β-Bag cell peptide
|
||
β-Bag cell peptide是一种提高袋细胞神经元(bag cell neuron)中cAMP水平、并能降低电压依赖性钾电流的神经活性肽。 | |||
T76461 |
[Nle8] Somatostatin (1-28)
|
||
[Nle8] Somatostatin (1-28)为生长抑素(1-28)的衍生物,其特征在于第8位的甲硫氨酸被正亮氨酸所替代。该化合物能够促使淀粉酶的释放,并增加胰腺腺泡中的环AMP水平。 | |||
TP1789 |
Malantide
|
||
Malantide is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide that is phosphorylated by PKA and is used to measure PKA activity in vitro. | |||
T78858 |
cGAS-IN-1
|
Others | Others |
cGAS-IN-1(化合物C20)是一种黄酮类化合物,作为Cyclic GMP-AMP Synthase(cGAS)的抑制剂,其IC50分别为2.28 μM(针对人类cGAS)和1.44 μM(针对小鼠cGAS)。由于cGAS异常激活与众多免疫介导的炎症性疾病相关,cGAS-IN-1显示出了其抗炎潜力。 | |||
T69072 |
Brovincamine
|
Others | Others |
Brovincamine also known as brovincamine fumarate (BV, Sabromin) was used in Japan mainly as an improver of cerebral circulation and metabolism, and also as an inhibitor of the aggregation of platelets through the cyclic AMP pathway in patients with normal tension glaucoma. Brovincamine exerts its action via calcium channels blockade. Brovincamine is also a vasodilator. | |||
T81244 |
RXFP1 receptor agonist-3
|
Others | Others |
RXFP1 receptor agonist-3 (Example 223) 是一种高效的RXFP1 受体激动剂,其通过抑制稳定表达人RXFP1的HEK293细胞中cAMP的产生,展现出显著的活性,EC50值仅为2 nM。 | |||
T38329 |
CU-76
|
Others | Others |
CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP sy... | |||
T73873 |
c-di-AMP disodium
|
Others | Others |
c-di-AMP (Cyclic diadenylate) sodium 作为一种STING 激动剂,通过结合STING 激活TBK3-IRF3 信号途径,引发I 型 IFN 和 TNF 产生,兼具细菌第二信使功能,在革兰氏阳性细菌中调控细胞生长、存活及毒力,并影响宿主免疫反应。此外,作为有效的粘膜佐剂,它能刺激体液和细胞反应。 | |||
T38328 |
CU-32
|
Others | Others |
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas... | |||
T36238 |
6α-Prostaglandin I1
6α-Prostaglandin I1 |
Others | Others |
6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI... | |||
T84658 |
17-Phenyl-18,19,20-trinor-PGD2
17-Phenyl-PGD2 |
Others | Others |
17-Phenyl-18,19,20-trinor-PGD2(17-Phenyl-PGD2)为前列腺素D2(PGD2)的衍生物,有效抑制由腺苷二磷酸(ADP)引发的血小板聚集,其IC50值为8.4μM,相比PGD2的IC50为18.6nM。此外,该化合物还是环AMP积累的弱激动剂。 | |||
T37212 |
5-hydroxy-Nω-methyl Tryptamine (oxalate)
|
Others | Others |
5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants. It is an agonist of the 5-HT receptor subtype 5-HT7 (IC50 = 23 pM in a radioligand binding assay). 5-hydroxy-Nω-methyl Tryptamine increases intracellular cyclic AMP production in HEK293 cells expressing 5-HT7 (EC50 = 22 nM). It inhibits serotonin uptake in HEK293 cells expressing human serotonin transporters (IC50 = 490 nM). Elevated levels of urinary 5-hydroxy-Nω-methyl tryptamine have been... | |||
T28240 |
Ono 1301
Ono-1301,Ono1301 |
Others | Others |
Ono 1301 is a prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. Ono 1301 suppresses pancreatic fibrosis in the DBTC-induced CP model by inhibiting monocyte activity not only with induction of HGF but also by Ono | |||
T36984 |
Cyclic di-IMP (sodium salt)
|
Others | Others |
Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p... | |||
T36985 |
Cyclic di-UMP (sodium salt)
|
Others | Others |
Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling. 1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nuc... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TCO2745 |
Cyclic AMP
Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate |
Others; Endogenous Metabolite | Metabolism; Others |
Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使,可以促进 G1期到 S 期的细胞周期进程。 | |||
T10065L |
2',3'-cGAMP sodium
2'-3'-cyclic GMP-AMP sodium |
STING; cGAS | Immunology/Inflammation |
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) 是细胞天然免疫中第二信使,在 DNA 结合条件下由 cGAMP 合成酶 (cGAS) 催化形成。2',3'-cGAMP sodium 可与 STING 结合形成二聚体,诱导 IFN-β 及其他细胞因子的产生和表达。 | |||
T1083 |
Theophylline
Theo-24,1,3-Dimethylxanthine,茶碱 |
Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物,具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。 | |||
TN4510 |
(+)-Medioresinol Di-O-β-D-glucopyranoside
(+)-Mediresinol Di-O-beta-D-glucopyranoside,(+)-Medioresinol Di-O-β-D-glucopyranoside |
PDE | Metabolism |
(+)-Medioresinol Di-O-β-D-glucopyranoside 对环 AMP 磷酸二酯酶具有很强的抑制活性。 | |||
T6S0627 |
Mesaconitine
新乌碱,新乌头碱;中乌头碱 |
TNF | Apoptosis |
Mesaconitine 是乌头属植物的一种主要活性成分,通过循环 AMP 和刺激中枢 β-肾上腺素能系统具有镇痛活性,还有抗炎活性。 | |||
TMA2419 |
Catalponol
|
cAMP | GPCR/G Protein |
Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP. | |||
T38415 |
Adenosine 5′-monophosphoramidate sodium
|
Others | Others |
Adenosine 5′-monophosphoramidate sodium is a derivative of adenosine used as an intermediate for nucleotide synthesis. It significantly influences the accumulation of cyclic AMP. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02993 |
DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc)
disA,c-di-AMP synthase,DNA integrity scanning prote... |
Mycobacterium paratuberculosis | E. coli |
Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predict... | |||
TMPJ-00886 |
ATF1 Protein, Human, Recombinant (His)
Cyclic AMP-dependent transcription factor ... |
Human | E. coli |
Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the ... | |||
TMPH-01164 |
ATF-3 Protein, Human, Recombinant (His)
ATF3,cAMP-dependent transcription factor ATF-3,Acti... |
Human | E. coli |
ATF3 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01166 |
CGAS Protein, Human, Recombinant (His)
Cyclic GMP-AMP synthase,cGAMP syn... |
Human | E. coli |
CGAS Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01165 |
CREB1 Protein, Human, Recombinant (His)
CREB-1,cAMP-responsive element-binding protein 1, |
Human | E. coli |
CREB1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-02614 |
CREB5 Protein, Mouse, Recombinant (His)
Creb5,Cyclic AMP-responsive element-bindin... |
Mouse | E. coli |
Binds to the cAMP response element and activates transcription. | |||
TMPH-03274 |
ATF-4 Protein, Rat, Recombinant (His & Myc)
cAMP-dependent transcription factor ATF-4,Activatin... |
Rat | E. coli |
ATF-4 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 43.2 kDa and the accession number is Q9ES19. | |||
TMPH-02613 |
ATF-5 Protein, Mouse, Recombinant (His & Myc)
Transcription factor ATFx,Transcription factor-like protein ... |
Mouse | E. coli |
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcrip... | |||
TMPY-01819 |
PDE1B Protein, Human, Recombinant (His & GST)
PDES1B,phosphodiesterase 1B, calmodulin-dependent,PDE1B1 |
Human | Baculovirus Insect Cells |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-1A (PDE1A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It b... | |||
TMPY-04402 |
CSNK1G1 Protein, Human, Recombinant (His & GST)
CK1γ1,casein kinase 1, gamma 1,casein kinase 1, γ1,CK1gamma1 |
Human | Baculovirus Insect Cells |
Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are serine / threonine-selective enzymes that function as regulators ofsignal transductionpathways in most eukaryotic cell types. Casein has been used as a substrate since the earliest days of research on protein phosphorylation. Casein kinase activity associated with the endopla... |