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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37958 |
Acetyl Coenzyme A trisodium
Acetyl-CoA trisodium |
OXPHOS; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism |
Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) 是糖代谢和脂代谢的重要化合物,参与三羧酸循环。 | |||
T32768 |
Linoleoyl-coenzyme A
Coenzyme A,linoleoyl- |
Others | Others |
Linoleoyl-coenzyme A is a substrate used to investigate the specificity and kinetics of acyl-CoA. | |||
T30997 |
Coenzyme Q12
Ubiquinone Q-12,Ubiquinone 12,trans-Coenzyme Q12,Coenzyme Q-12,J93.222A |
Others | Others |
Coenzyme Q10 is a vitamin-like substance found throughout the body, especially in the heart, liver, kidneys, and pancreas. | |||
T32598 |
Lauroyl-coenzyme A
Dodecanoyl-coa,Coenzyme A, lauroyl-,Lauroyl-coa |
Others | Others |
Lauroyl-coenzyme A can function as an acyl group carrier, acetyl-CoA. It can be used as an intermediate in lipid metabolism and is involved in lipid biosynthesis and fatty acid transport. | |||
T84950 |
Palmitoyl Alkyne-Coenzyme A
Click Tag™ Palmitoyl Alkyne-Coenzyme A |
Others | Others |
Palmitoyl alkyne-coenzyme A (palmitoyl alkyne-CoA), a thioester formed from ω-alkynylated palmitic acid and CoA, serves as a chemical reporter for the labeling of palmitoylated proteins through click chemistry. This process utilizes probes such as biotin-azide or 3-azido-7-hydroxycoumarin for both in vitro and in vivo studies. | |||
T38025 |
Cyclohexanoyl Coenzyme A
|
Others | Others |
Cyclohexanoyl coenzyme A (CHCoA) is an acyl CoA that contains a cyclohexane group. It is the activated form of cyclohexane carboxylic acid (CHC) in R. palustris. CHC is converted to CHCoA by a succinyl-CoA CHC CoA transferase, and CHCoA is then degraded by a dehydrogenase. CHCoA is converted to hippuric acid in submitochondrial fractions isolated from guinea pig liver. | |||
T37978 |
Coenzyme FO
|
Others | Others |
Coenzyme FO, a deazaflavin chromophore, plays a crucial role as a hydride acceptor/donor in the central methanogenic pathway [1][2]. | |||
T36114 |
Coenzyme Q2
|
Others | Others |
Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, it acts as an antioxidant. Coenzyme Q2 is a precursor of coenzyme Q10 that has 2, rather than 10, isoprenoid units on the ubiquinone base. It can act as an electron acceptor for bacterial Complex I. In mammalian cells, exogenous coenzyme Q2 prevents the production of reactive oxygen species associated with Complex I activity. For... | |||
T35691 |
Myristoyl Coenzyme A (hydrate)
|
Others | Others |
Myristoyl coenzyme A (myristoyl-CoA) is a derivative of CoA that contains the long-chain fatty acid myristic acid . It is a substrate for N-myristoyltransferase during myristoylation, a process that adds a myristoyl group to proteins either during translation to modify protein activity or post-translationally in apoptotic cells. It is also a substrate in the de novo synthesis of phosphatidylinositol . | |||
T37405 |
Octanoyl Coenzyme A (sodium salt)
|
Others | Others |
Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase. | |||
T38473 |
Malonyl Coenzyme A lithium
|
Others | Others |
Malonyl Coenzyme A (lithium) is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl Coenzyme A (lithium) is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl Coenzyme A (lithium) is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides. | |||
T37249 |
Methylmalonyl-Coenzyme A (sodium salt)
|
Others | Others |
Methylmalonyl coenzyme A (methylmalonyl-CoA) is an intermediate in multiple metabolic pathways in bacteria and eukaryotes.1,2,3It is an intermediate in carbon assimilation in certain bacteria and carbon fixation in plants.1,2Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase with vitamin B12as a coenzyme.3A deficiency in vitamin B12leads to a build-up of methylmalonyl-CoA.4 1.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C... | |||
T36842 |
Isobutyryl Coenzyme A (sodium salt)
|
Others | Others |
Isobutyryl coenzyme A (isobutyryl-CoA) is a short-chain branched acyl CoA. Isobutyryl-CoA is a substrate for isobutyryl-CoA dehydrogenase (IBDH) in the catabolism of valine and an intermediate in the synthesis of isobutyryl-L-carnitine , which accumulates in IBDH deficiency. | |||
T37116 |
Ethylmalonyl Coenzyme A (sodium salt)
|
Others | Others |
Ethylmalonyl coenzyme A (CoA) is a key intermediate in the ethylmalonyl-CoA pathway for carbon metabolism in certain bacteria, such asM. extorquens, which uses this pathway when grown on ethylamine.1,2It is produced from crotonyl-CoA by crotonyl-CoA reductase/carboxylase and modified by ethylmalonyl-CoA mutase to make methylsuccinyl-CoA. 1.Good, N.M., Martinez-Gomez, N.C., Beck, D.A.C., et al.Ethylmalonyl coenzyme A mutase operates as a metabolic control point in Methylobacterium extorquens AM1J... | |||
T37323 |
Succinyl-Coenzyme A sodium salt
Succinyl-CoA sodium salt,Succinyl-Coenzyme A (sodium salt),Succinyl-CoA |
Endogenous Metabolite | Metabolism |
Succinyl-Coenzyme A sodium salt(Succinyl-CoA sodium salt) 参与柠檬酸循环,在柠檬酸循环中转化为琥珀酸。Succinyl-Coenzyme A (sodium salt) 在生物体内参与多种代谢反应,在体内有着举足轻重的作用 Succinyl-Coenzyme A sodium salt 参与血红素的合成,可用于研究由营养性维生素 B12 缺乏症 (致使 Succinyl-Coenzyme A 合成缺乏) 所引起的代谢疾病、神经疾病和血液学异常导致的疾病。 | |||
T78511 |
Oleoyl coenzyme A lithium
Oleoyl-CoA lithium |
Others | Others |
Oleoyl-CoA lithium是一种由油酸与辅酶A形成的硫酯,它是大肠杆菌和小鼠代谢产物。 | |||
T127402 |
Coenzyme Q0
CoQ0 |
Others | Others |
Coenzyme Q0 (CoQ0),一种从Antrodia cinnamomea提取的口服醌类化合物,具备促进细胞凋亡(apoptosis)与自噬(autophagy)的作用。该化合物通过抑制HER-2/AKT/mTOR信号通路,增强凋亡和自噬机制;同时,调控NFκB/AP-1活化,提升Nrf2稳定性,从而缓解炎症及氧化还原失衡。此外,Coenzyme Q0还表现出抗血管生成特性,通过下降MMP-9/NF-κB并提升HO-1信号路径发挥作用。 | |||
T37755 |
Phenylacetyl-Coenzyme A (sodium salt)
|
Others | Others |
Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such asPseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains ofP. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR inT. thermophilusand the GntR family transcriptional regulator PaaX inE. coliandPseudo... | |||
T36827 |
Acetoacetyl Coenzyme A (sodium salt hydrate)
Acetoacetyl-CoA |
Others | Others |
Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.[1],[2] It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis.[3],[4] Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.[5] | |||
T74115 |
Decanoyl coenzyme A
|
Others | Others |
Decanoyl coenzyme A (Decanoyl CoA) 是 Mycobacterium smegmat 中脂肪酸延伸系统的引物。 | |||
T73918 |
Lauroyl coenzyme A lithium
|
Others | Others |
Lauroyl coenzyme A lithium salt 是一种辅酶 A。辅酶 A 作为酰基载体,即乙酰辅酶 A。十二烷酰辅酶 A (C12-CoA) 是一种长链 (C-12) 饱和脂肪酰辅酶 A,用作脂质代谢的中间体,参与脂质生物合成和脂肪酸转运。月桂酰辅酶 A 是底物用于 FAM34A 蛋白和萤火虫荧光素酶的产物。 | |||
T82293 |
Glutaryl coenzyme A lithium
|
Others | Others |
Glutaryl coenzyme A lithium为Glutaryl coenzyme A的衍生物,后者为一重要内源性代谢物。该化合物常应用于HMG-CoA及Glutaryl coenzyme A相关实验。 | |||
T84743 |
Myristoyl coenzyme A lithium
|
Others | Others |
Myristoyl coenzyme A lithium 为含锂标记的 Myristoyl coenzyme A (CoA),关键参与病毒生物学中N-肉豆蔻酰转移酶 (NMT) 控制的肉豆蔻酰化过程。NMT 在结肠上皮肿瘤细胞中相较正常细胞展现出更高的活性。已知,还原形态的 CoA 是调控 NMT 活性的主要因素,反之氧化态的 CoA 则抑制 NMT 促进的肉豆蔻酰化。因此,Myristoyl coenzyme A 表现出通过阻断肉豆蔻酰化过程的潜在抗癌和抗病毒作用。 | |||
T73796 |
Acetyl coenzyme A lithium
|
Others | Others |
Acetyl-coenzyme A (Acetyl-CoA) lithium 是一种膜非渗透性的中枢代谢中间体,参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A lithium 通过向目标氨基酸残基提供乙酰基团,来完成蛋白质的翻译后乙酰化反应,从而调节各种细胞机制。Acetyl Coenzyme A lithium 也是脂质合成的关键前体。 | |||
T73805 |
Acetyl coenzyme A
|
Others | Others |
Acetyl-coenzyme A (Acetyl-CoA) 是一种具有膜非渗透性的中枢代谢中间体,参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A 通过向目标氨基酸残基提供乙酰基团,来完成蛋白质的翻译后乙酰化反应,从而调节各种细胞机制。Acetyl Coenzyme A 也是脂质合成的关键前体。 | |||
T76124 |
Acyl coenzyme A synthetase
|
Others | Others |
Acyl coenzyme A synthetase (ACS),一种生化研究中常用的酶,主要通过两步硫酯化反应激活脂肪酸与辅酶A结合,形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径,以及参与TCA循环中的有氧呼吸提供了关键中间物。 | |||
T74039 |
Arachidonoyl coenzyme A lithium
|
Others | Others |
Arachidonoyl coenzyme A lithium是一种由辅酶A的硫醇基与花生四烯酸的羧基缩合生成的不饱和脂肪酰基辅酶A。 | |||
T64276 |
Octanoyl coenzyme A lithium
|
Others | Others |
Octanoyl coenzyme A lithium 是一种脂肪酸酰基辅酶 A 的衍生物。Octanoyl coenzyme A lithium 能够抑制柠檬酸合成酶和谷氨酸脱氢酶 (IC50: 0.4-1.6 mM)。 | |||
T74172 |
Acetoacetyl coenzyme A sodium
|
Others | Others |
Acetoacetyl coenzyme A sodium 是重要内源性代谢物,在pH 7.5时其Km值达1.10 mM,主要用于磷酸转丁基酶 (PTB) 与poly-3-hydroxybutyrate (PHB) 的合成。 | |||
T74038 |
Palmitoyl coenzyme A lithium
|
Others | Others |
Palmitoyl coenzyme A lithium,一种酰基-CoA 硫酯,通过肉碱穿梭系统转运至线粒体基质,参与β-氧化,亦作为鞘氨醇生物合成底物。 | |||
T74036 |
β-Methylcrotonyl coenzyme A lithium
|
Others | Others |
β-Methylcrotonyl coenzyme A lithium,作为亮氨酸代谢的中间体,可用于研究β-甲基巴豆酰辅酶 A 羧化酶(MCCase)的特异性及动力学,用作底物。 | |||
T74037 |
DL-β-Hydroxybutyryl coenzyme A lithium
|
Others | Others |
DL-β-Hydroxybutyryl coenzyme A lithium,是丁酸发酵以及赖氨酸和色氨酸代谢过程中的中间体,通过β-羟基丁酸经短链-CoA 合成酶作用生成。 | |||
T3510 |
Olumacostat Glasaretil
|
Acetyl-CoA Carboxylase | Metabolism |
Olumacostat glasaretil 是乙酰辅酶A 羧化酶的有效抑制剂。 | |||
T74043 |
Hexanoyl coenzyme A trilithium
|
Endogenous Metabolite | Metabolism |
Hexanoyl coenzyme A trilithium 是一种广泛存在于动植物体内的化合物,参与生物体的多种代谢,可用于研究代谢异常引起的疾病。 | |||
T5046 |
Haloxyfop
Haloxyfop Acid,(±)-Haloxyfop,吡氟氯禾灵 |
Others; Acetyl-CoA Carboxylase | Metabolism; Others |
Haloxyfop (Haloxyfop Acid) 是有效的芳氯氧苯氧丙酸除草剂,广泛应用于阔叶作物的野草。对玉米幼苗叶绿体中乙酰辅酶 A 羧化酶 (EC 6.4.1.2) 具有抑制作用,IC50为 0.5 μM,而对豌豆中该酶无影响。 | |||
TQ0243 |
ND-646
|
Acetyl-CoA Carboxylase | Metabolism |
ND-646 是乙酰辅酶 A 羧化酶(ACC)抑制剂,对重组 hACC1 和 hACC2的IC50分别为 3.5 nM 和 4.1 nM。 | |||
T7163 |
PF-05175157
|
Acetyl-CoA Carboxylase | Metabolism |
PF 05175157 是一种广谱的乙酰辅酶 A 羧化酶 (ACC) 抑制剂,对 ACC1 (human),ACC2 (human), ACC1 (rat) 和 ACC2 (rat) 具有抑制作用,IC50分别为 27.0, 33.0, 23.5 和 50.4 nM。 | |||
T3988 |
TOFA
MDL14514,RMI14514 |
Acetyl-CoA Carboxylase | Metabolism |
TOFA (MDL14514) 是有效的乙酰辅酶 A 羧化酶-α (ACCA)的变构抑制剂。 | |||
T14991 |
CMS-121
CMS121 |
Acetyl-CoA Carboxylase | Metabolism |
CMS-121 是喹诺酮衍生物,对乙酰辅酶 A 羧化酶 1 具有抑制作用,具有口服活性。CMS-121具有保护 HT22 细胞免受缺血和氧化损伤的活性,EC50分别为7 nM 和200 nM。CMS-121具有强大的抗炎,抗氧化,神经保护和肾保护作用。 | |||
T0412 |
Idebenone
艾地苯醌,CV-2619 |
Apoptosis; Antioxidant; Mitochondrial Metabolism | Apoptosis; Metabolism; oxidation-reduction |
Idebenone (CV-2619) 是一种线粒体保护剂,具有神经保护功效,可用于研究阿尔茨海默病、亨廷顿舞蹈病,可透过血脑屏障,诱导细胞凋亡。 | |||
T1889 |
CP-640186
CP 640186 |
Acetyl-CoA Carboxylase | Metabolism |
CP-640186 是一种有效的乙酰辅酶 A 羧化酶 (ACC)抑制剂,抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50分别为 53 nM 和 61 nM。 | |||
T7184 |
Firsocostat
ND-630,NDI-010976,GS-0976 |
Acetyl-CoA Carboxylase | Metabolism |
Firsocostat (GS-0976) 是有效的乙酰辅酶A 羧化酶 (ACC) 抑制剂,抑制人类 ACC1 和 ACC2 的IC50分别为2.1和6.1 nM。 | |||
T3622 |
CP-640186 hydrochloride
CP 640186 HCl,盐酸CP-640186 |
Acetyl-CoA Carboxylase | Metabolism |
CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶(ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。 | |||
T12225L |
Nevanimibe hydrochloride
PD-132301 hydrochloride,ATR101 hydrochloride |
Apoptosis; Acyltransferase | Apoptosis; Metabolism |
Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的,选择性酰基辅酶 A:胆固醇 O-酰基转移酶 1 抑制剂,EC50为 9 nM。它抑制 ACAT2,EC50为 368 nM。它诱导细胞凋亡,具有抗肾上腺皮质癌的潜力。 | |||
T35659 |
3'-Dephosphocoenzyme A
|
Others | Others |
3'-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A from pantothenic acid .1 It is phosphorylated by CoA synthase in humans to form CoA. 3'-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.2,3 References1. Leonardi, R., Zhang, Y.M., Rock, C.O., et al. Coenzyme A: Back in action. Prog. Lipid Res. 44(2-3), 125-153 (2005).2. Huang, F. Efficient incorporation of CoA, NAD and FAD into RNA by in vitro transcripti... | |||
T25651 |
Lecimibide
DuP128,DuP-128,DuP 128 |
Acyltransferase | Metabolism |
Lecimibide (DuP 128) 是一种有效且具有选择性的酰辅酶 A 胆固醇酰基转移酶(ACAT)抑制剂,可用于研究由于高脂带来的疾病。 | |||
T30961 |
CL 277082
CL277082,CL-277082,Ddpmhu |
Others | Others |
CL 277082 (Ddpmhu) 是一种酰基辅酶A:胆固醇O-酰基转移酶抑制剂,抑制肉芽肿组织 ACAT 活性。 | |||
T8314 |
RP-64477
RP64477 |
Acyltransferase | Metabolism |
RP-64477 是有效的胆固醇酯化酶酰基辅酶 A:胆固醇 O-酰基转移酶 (ACAT) 抑制剂。 | |||
T8754 |
CPD2028
|
Others | Others |
CPD2028 是ND630的中间体。ND-630 是有效的乙酰辅酶A 羧化酶 (ACC) 抑制剂。 | |||
T6450 |
Clinofibrate
克利贝特,S-8527,Lipoclin |
HMG-CoA Reductase; Autophagy | Autophagy; Metabolism |
Clinofibrate (Lipoclin) 是一种降脂剂,可抑制羟甲基戊二酰辅酶 A 还原酶。它用于控制血液中的高胆固醇和甘油三酯水平。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2796 |
Coenzyme Q10
Ubiquinone-10,辅酶Q10,CoQ10 |
Ferroptosis; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
Coenzyme Q10 (CoQ10)是来自藤仓赤霉菌的一种天然产物,在线粒体呼吸链中充当电子载体。 | |||
T10857 |
Coenzyme A
|
Endogenous Metabolite | Metabolism |
Coenzyme A 是所有活细胞中必需的辅助因子,由泛酸,三磷酸腺苷和半胱氨酸合成的。Coenzyme A 与过氧化物酶 5 共价结合导致其过氧化物酶活性完全抑制,通过 DTT 还原能够逆转。Coenzyme A 及其硫酯衍生物是主要分解代谢,合成代谢途径和基因表达调控的关键参与者。 | |||
T5573 |
Coenzyme Q9
辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Coenzyme Q9 (Ubiquinone 9) 是啮齿类动物泛醌的主要形式,是电子传递链中的一种双亲分子组分,具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降,改善左心室功能,减少心肌梗死面积和心肌细胞凋亡。 | |||
T14128 |
Adenosylcobalamin
Cobamamide,Coenzyme B12,腺苷钴胺,AdoCbl |
Endogenous Metabolite | Metabolism |
Adenosylcobalamin (AdoCbl) 是一种 Vitamin B12的特性形式,其中 Vitamin B12 是是甲基丙二酰 CoA 突变酶的辅助因子。 | |||
T75699 |
Coenzyme Q6
|
Others | Others |
Coenzyme Q6 (Ubiquinone 30),一种异戊二烯化的苯醌脂质,主要在呼吸电子传输链中发挥作用,并作为脂质抗氧化剂,具备抗氧化性能,能够防止自由基生成和氧化损伤。 | |||
T5283 |
NADH disodium salt
Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠 |
Others; Endogenous Metabolite | Metabolism; Others |
NADH disodium salt hydrate是氧化还原酶的辅酶。 NADH在分解代谢过程中起到再生电子供体的作用,包括糖酵解,柠檬酸循环和β-氧化。 | |||
T8083 |
Pyridoxal 5'-phosphate monohydrate
Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛 |
Others | Others |
Pyridoxal 5-phosphate monohydrate 是维生素B6的活性形式,也是多种酶的重要辅因子。它是维生素 B6 在细胞内磷酸化过程中最重要的辅酶变异体,能够与其他变异体(如 PNP 、 PMP)发生互换。 | |||
T4761 |
Pyridoxal hydrochloride
|
Others; Endogenous Metabolite | Metabolism; Others |
Pyridoxal hydrochloride 是内源性代谢产物的一种。 | |||
TN1800 |
Isosakuranin
|
Others | Others |
Isosakuranin 是一种提取自Paliurus ramosissimus果实中的天然产物,具有抗糖尿病作用。 | |||
T17048 |
Tetradecanoylcarnitine
L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine |
Endogenous Metabolite | Metabolism |
Tetradecanoylcarnitine (L-Myristoylcarnitine) 是一种酰基肉碱,参与长链脂肪酸的β-氧化,是极长链酰辅酶A脱氢酶缺乏症的一种潜在标记物。 | |||
T7481 |
2-Hydroxycaprylic acid
2-hydroxyoctanoic acid,2-羟基辛酸 |
Others | Others |
2-Hydroxyoctanoic acid 是中链酰基辅酶 A 合成酶抑制剂 (Ki:500 μM)。 | |||
T0973L |
Pyridoxine hydrochloride
Pyridoxine HCl,吡哆醇盐酸盐,Pyridoxol (hydrochloride),吡哆醇盐酸盐(维生素B6),Vitamin B6 (hydrochloride),Vitamin B6 |
Nrf2; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
Pyridoxine hydrochloride (Vitamin B6) 是一种吡啶衍生物。在于阿尔茨海默病细胞模型中,通过 Nrf-2/HO-1 途径发挥抗氧化作用。 | |||
T2812 |
ATP disodium salt hydrate
ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐 |
Others; Endogenous Metabolite | Metabolism; Others |
ATP disodium salt hydrate (Adenosine disodium triphosphate) 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。同时,它是也是免疫和炎症中重要的内源性信号分子。 | |||
T4874 |
Thiamine pyrophosphate
Cocarboxylase,焦磷酸硫胺素,Aneurinepyrophosphoric acid,Thiamine pyrophosphate chloride |
Endogenous Metabolite | Metabolism |
Thiamine pyrophosphate (Cocarboxylase) 是维生素 B1 的辅酶形式,是丙酮酸脱氢酶复合物和酮戊二酸脱氢酶复合物的必需中间体,能够用于研究评估生物系统中的脱羧机制。 | |||
T5067 |
Flavin adenine dinucleotide disodium salt
Flavin Adenine Dinucleotide Disodium,黄素腺嘌呤二核苷酸二钠,FAD sodium salt,FAD-Na2 |
Others; Endogenous Metabolite | Metabolism; Others |
Flavin adenine dinucleotide disodium salt (FAD sodium salt) 是一种辅酶,作用是促进细胞氧化还原反应中黄素酶的电子转移。 | |||
T5287 |
N-Acetyl-L-aspartic acid
AC-ASP-OH,N-Acetylaspartic acid,N-乙酰-L-天门冬氨酸 |
Others; Antioxidant; Endogenous Metabolite | Metabolism; Others; oxidation-reduction |
N-Acetyl-L-aspartic acid 是天冬氨酸的衍生物, 是由氨基酸天冬氨酸和乙酰辅酶 A 在神经元中合成的。N-Acetyl-L-aspartic acid 具有抗氧化活性。 | |||
T4766 |
3-Methylglutaric acid
|
Endogenous Metabolite | Metabolism |
3-Methylglutaric acid 是亮氨酸代谢物,是一种与两种亮氨酸途径 HMGCL、AUH 酶缺陷显著相关的 C6 二元羧酸有机酸。 | |||
TN1011 |
Rhodionin
|
P450; AChE | Metabolism; Neuroscience |
Rhodionin 是从红景天的根中分离的特异性非竞争性细胞色素 P450 2D6 抑制剂,IC50=0.761 μM,Ki=0.769 μM。它有 DPPH 自由基清除活性,IC50为 19.49 μM。它抑制乙酰胆碱酯酶,IC50范围为 57.50 至 2.43 μg/mL。 | |||
T7989 |
Trimethyl phosphate
|
Others | Others |
Trimethyl phosphate 是一种有机磷化合物,是催化磷酸化化合物水解的酶的抑制剂,已被用作合成肽和其他蛋白质的反应物,用作合成有机和无机化合物的催化剂,以及用作合成药物的试剂。 | |||
T0069 |
Uracil
|
Others; Endogenous Metabolite | Metabolism; Others |
Uracil 是普遍存在的天然嘧啶衍生物,是 RNA 核酸中的四个碱基之一。 | |||
T64980 |
ATP disodium trihydrate
Adenosine-5'-triphosphate disodium trihydrate |
Endogenous Metabolite | Metabolism |
ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) 是体内能量储存和代谢的重要物质,是免疫和炎症中重要的内源性信号分子,可为机体代谢提供能量,同时在细胞中作为辅酶发挥作用。 | |||
T0200 |
α-Lipoic Acid
Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸 |
Apoptosis; NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子,是一种抗氧化剂,可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。 | |||
T0894 |
Thiamine hydrochloride
盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride |
Apoptosis; HBV; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology |
Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。 | |||
T0934 |
Nicotinamide
Nicotinic acid amide,Vitamin B3,Niacinamide,烟酰胺,Vitamin PP |
Sirtuin; Endogenous Metabolite | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Nicotinamide 是维生素 B3 的吡啶核苷形式,可作为烟酰胺腺嘌呤二核苷酸或 NAD+ 的前体,可通过膳食摄入来补充,能预防或治疗黑舌病和糙皮病。 | |||
T1609 |
NAD+
烟酰胺腺嘌呤二核苷酸,Cozymase,煙酸胺,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD |
NADPH; Endogenous Metabolite | Metabolism |
NAD+ (β-Nicotinamide Adenine Dinucleotide) 是一种转递氢离子的辅酶,参与细胞中的氧化还原反应。NAD+ 参与糖酵解、柠檬酸循环、脂肪酸氧化等。NAD+ 接受来自其他分子的电子形成 NADH,然后又作为还原剂来给电子。 | |||
T1664 |
Meglutol
Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托 |
Endogenous Metabolite; HMG-CoA Reductase; Autophagy | Autophagy; Metabolism |
Meglutol (3-Hydroxy-3-methylglutaric acid) 是一种抗血脂剂,可降低胆固醇、甘油三酯、血清 β-脂蛋白和磷脂。它抑制胆固醇生物合成中的限速酶羟甲基戊二酰辅酶 A 还原酶的活性。 | |||
T1020 |
Doxorubicin hydrochloride
Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,DOX hydrochloride,盐酸阿霉素,NSC 123127 |
Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素,是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化,还可诱导凋亡和自噬。 | |||
T5066 |
Nε,Nε,Nε-Trimethyllysine chloride
Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) 是肠道菌群依赖性形成 N,N,N-trimethyl-5-aminovaleric acid (TMAVA) 的前体。 | |||
T3578 |
Pyridoxal phosphate
PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate |
Reverse Transcriptase; Endogenous Metabolite | Metabolism; Microbiology/Virology |
Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式,可抑制逆转录酶活性,用于研究迟发性运动障碍症。 | |||
T6480 |
D-Pantothenic acid
vitamin B5,pantothenate,D-泛酸 |
Others | Others |
D-Pantothenic acid (vitamin B5) 是必需的微量营养素,是辅酶 A 的前体,在很多生物过程中发挥关键作用,如调节碳水化合物,脂质,蛋白和核酸代谢。 | |||
T4867 |
Erucic acid
Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid |
PI3K; Endogenous Metabolite | Metabolism; PI3K/Akt/mTOR signaling |
Erucic acid (13(Z)-Docosenoic Acid) 是单不饱和脂肪酸,分离自萝卜的种子。Erucic acid 可以容易地穿过血脑屏障,使大脑中长链脂肪酸的积累正常化。Erucic acid 能够改善认知障碍并有效预防痴呆。 | |||
T1437 |
D-Panthenol
D-泛醇,D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol |
Endogenous Metabolite | Metabolism |
D-Panthenol (D-Pantothenyl alcohol) 是 D-pantothenic acid 和胆碱能剂的酒精类似物。D-Panthenol 作为乙酰化反应所必需的辅酶A的前体,参与乙酰胆碱的合成。虽然 D-Panthenol 作用的确切机制尚不清楚,但它可能增强乙酰胆碱的作用。D-Panthenol 作用于胃肠道,增加下肠蠕动。它也适用于局部皮肤,以缓解瘙痒和促进愈合。 | |||
T2O2721 |
L-Cysteine
Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine |
Endogenous Metabolite | Metabolism |
L-Cysteine (L-(+)-Cysteine) 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中,对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分,在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用,也是氨基酸牛磺酸的制造所必需的。 | |||
T12592 |
Pyripyropene A
|
Others | Others |
Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 µM). | |||
T19594 |
Ubiquinone-1
|
Others | Others |
Ubiquinone-1 is an intermediate for coenzyme Q synthesis. | |||
T13199 |
Triacsin C
WS 1228A,FR 900190 |
Others | Others |
Triacsin C (WS 1228A) 来自金黄色链霉菌 (Streptomyces aureofaciens) ,是一种花生四烯酰辅酶A合成酶和非特异性长链酰辅酶A合成酶的差异抑制剂,抗动脉粥样硬化活性,抑制 ACSL 活性, 抑制 TAG 积聚成脂滴 (LD) 。Triacsin C 可用于研究轮状病毒感染和阿尔茨海默症。 | |||
TN1751 |
Hydroxycitric acid
|
ERK; p38 MAPK; Fatty Acid Synthase | MAPK; Metabolism |
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis. | |||
T75552 |
Pomonic acid
|
Others | Others |
Pomonic酸,作为一种三萜化合物,能显著抑制胆固醇酯的积累,并降低酰基辅酶A:胆固醇酰基转移酶(ACAT)的活性。 | |||
T36776 |
Terpendole C
|
Others | Others |
Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It also inhibits ACAT in J774 macrophages (IC50 = 0.46 μM) without affecting cell growth. | |||
TN4860 |
Pueroside B
|
COX; PPAR | DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience |
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A receptor (HMGR), cyclooxygenase-2 (COX2 | |||
T40526 |
ATP dipotassium
腺苷三磷酸二钾盐,Adenosine5'-triphosphatedipotassium |
Others | Others |
ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital compound involved in energy storage and metabolism within living organisms. It plays a crucial role in supplying metabolic energy for driving pumps and acts as a coenzyme in cellular processes. Additionally, ATP dipotassium functions as a significant endogenous signaling molecule contributing to immunity and inflammation. | |||
TN7563 |
Chloramphenicol Acetate
|
Others | Others |
Chloramphenicol acetate, an acetylated and inactive derivative of chloramphenicol, is synthesized in E. coli and S. aureus through the action of the inducible enzyme chloramphenicol acetyltransferase, utilizing acetyl coenzyme A (acetyl-CoA), to impart resistance to chloramphenicol. This compound exhibits no antibiotic activity against S. sonnei in turbidimetric assays. | |||
T36931 |
Penicillide
|
Others | Others |
Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells. | |||
T83582 |
(±)-Pantothenic acid
(±)-Vitamin B5,(±)-Pantothenate |
||
(±)-Pantothenic acid ((±)-Pantothenate) 作为 B 组维生素的一员,对于哺乳动物细胞中辅酶 A (CoA) 的生物合成是不可或缺的。此外,该化合物能防护丙戊酸 (VPA) 在 CD-1 小鼠中引起的神经管缺陷 (NTD)。 | |||
T36226 |
Beauveriolide I
|
Others | Others |
Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i... | |||
T38250 |
L-Sepiapterin
|
Others | Others |
L-Sepiapterin, also known as Sepiapterin, is a precursor compound crucial for the production of tetrahydrobiopterin (BH4), which serves as a coenzyme for endothelial nitric oxide synthase (eNOS). This compound demonstrates its efficacy by improving endothelial dysfunction in small mesenteric arteries from db/db mice and promoting angiogenesis. Moreover, L-Sepiapterin exerts inhibitory effects on cellular proliferation and migration in ovarian cancer cells through the down-regulation of p70S6K-de... | |||
T37690 |
Phenylpyropene A
|
Others | Others |
Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 |1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ... | |||
T36227 |
Beauveriolide III
|
Others | Others |
Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ... | |||
T36329 |
Terpendole I
|
Others | Others |
Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 |1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00007 |
HMGCR Protein, Human, Recombinant (His)
HMGCR,3-hydroxy-3-methylglutaryl-coenzyme A reducta... |
Human | E. coli |
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs. | |||
TMPH-02151 |
OXCT1 Protein, Human, Recombinant (His)
OXCT1,Succinyl-CoA:3-ketoacid coenzyme A transferas... |
Human | E. coli |
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. OXCT1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 56.1 kDa and the accession number is P55809. | |||
TMPY-01948 |
COQ7 Protein, Human, Recombinant (His)
CLK1,coenzyme Q7 homolog, ubiquinone (yeast),CAT5,C... |
Human | HEK293 Cells |
Ubiquinone biosynthesis protein COQ7 homolog, also known as Coenzyme Q biosynthesis protein 7 homolog, Timing protein clk-1 homolog and COQ7, is a mitochondrion inner membrane and peripheral membrane protein which belongs to theCOQ7 family. It is expressed dominantly in heart and skeletal muscle. COQ7 is synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane. Th... | |||
TMPH-02476 |
HMGCR Protein, Mouse, Recombinant (His)
Hmgcr,3-hydroxy-3-methylglutaryl-coenzyme A reducta... |
Mouse | E. coli |
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.4 kDa and the accession number is Q01237. | |||
TMPH-02716 |
HADH Protein, Mouse, Recombinant (His & SUMO)
Short-chain 3-hydroxyacyl-CoA dehydrogenase,Hydroxyacyl-... |
Mouse | E. coli |
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. HADH Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted... | |||
TMPH-02717 |
HMGCS1 Protein, Mouse, Recombinant (His & SUMO)
Hmgcs1,3-hydroxy-3-methylglutaryl coenzyme A syntha... |
Mouse | E. coli |
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. HMGCS1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 73.6 kDa and the accession number is Q8JZK9. | |||
TMPH-02825 |
ACOX1 Protein, Mouse, Recombinant (Myc)
AOX,Peroxisomal fatty acyl-CoA oxidase,EC:1.3.3.6,Peroxisoma... |
Mouse | E. coli |
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.; Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length.; Is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA. | |||
TMPH-02488 |
ACSS2 Protein, Mouse, Recombinant (His)
Propionate--CoA ligase,AceCS1,Acyl-activating enzyme,Acetyl-... |
Mouse | E. coli |
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity. ACSS2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82.9 kDa and the accession number is Q9QXG4. | |||
TMPH-00876 |
ACSS1 Protein, Human, Recombinant (E. coli, His)
Acetate--CoA ligase 2,Acetyl-coenzyme A synthetase ... |
Human | E. coli |
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient. ACSS1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted... | |||
TMPH-00877 |
ACSS1 Protein, Human, Recombinant (His)
Acetate--CoA ligase 2,KIAA1846,Acetyl-coenzyme A sy... |
Human | P. pastoris (Yeast) |
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient. ACSS1 Protein, Human, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 73.6 kD... | |||
TMPY-02481 |
ACOX1 Protein, Human, Recombinant (His)
PALMCOX,ACOX,SCOX,acyl-CoA oxidase 1, palmitoyl |
Human | Baculovirus Insect Cells |
Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a... | |||
TMPJ-00462 |
NADK Protein, Human, Recombinant (His)
Poly(P)/ATP NAD Kinase,NADK,NAD Kinase |
Human | E. coli |
NAD Kinase (NADK) is an enzyme that belongs to the NAD Kinase family. It is a widely expressed enzyme, but it is not detected in skeletal muscle. NADK converts Nicotinamide Adenine Dinucleotide (NAD+) into NADP+, through phosphorylating the NAD+ coenzyme. NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis. The structure of the NADK from the archaean Archaeoglobus fulgidus has been determined. | |||
TMPH-01321 |
FLAD1 Protein, Human, Recombinant (His)
FLAD1,FMN adenylyltransferase,FAD pyrophosphorylase,FAD synt... |
Human | E. coli |
Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. FLAD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.3 kDa and the accession number is Q8NFF5. | |||
TMPH-00164 |
4'-phosphopantetheinyl transferase ffp Protein, Bacillus subtilis, Recombinant (His & Myc)
4'-phosphopantetheinyl transferase ffp,EC:2.7.8.-,Fengycin s... |
Bacillus subtilis | E. coli |
May activate the peptidyl carrier protein (PCP) domains of fengycin synthase by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. 4'-phosphopantetheinyl transferase ffp Protein, Bacillus subtilis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.0 kDa and the accession number is Q9F4F7. | |||
TMPH-02148 |
SDHA Protein, Human, Recombinant (His)
SDHA,Succinate dehydrogenase [ubiquinone] flavoprotein subun... |
Human | E. coli |
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor. | |||
TMPH-00017 |
acpS Protein, Acholeplasma laidlawii, Recombinant (His & Myc)
Holo-ACP synthase,Holo-[acyl-carrier-protein] synthase,acpS,... |
Acholeplasma laidlawii | E. coli |
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. acpS Protein, Acholeplasma laidlawii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.9 kDa and the accession number is A9NHV3. | |||
TMPY-03507 |
PPC-DC Protein, Human, Recombinant (E. coli, His)
coaC,MDS018,PPC-DC,phosphopantothenoylcysteine decarboxylase |
Human | E. coli |
PPC-DC, also known as PPCDC, belongs to the HFCD (homo oligomeric flavin containing Cys decarboxylase) superfamily which takes a part in the biosynthesis of coenzyme A (CoA) from pantothenate (Vitamin B). Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. This process include several steps: the phosphorylation of pantothenate, the conversion of 4’-hosphopantothenate to 4''-phosphopantetheine, the adenylation by pho... | |||
TMPY-04767 |
PMVK Protein, Human, Recombinant (His)
PMK,PMKA,phosphomevalonate kinase,HUMPMKI,PMKASE |
Human | E. coli |
PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. | |||
TMPH-03596 |
Holo-ACP synthase Protein, S. pyogenes serotype M28, Recombinant (His & Myc)
acpS,4'-phosphopantetheinyl transferase AcpS,Holo-[acyl-carr... |
Streptococcus pyogenes | Baculovirus Insect Cells |
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. Holo-ACP synthase Protein, S. pyogenes serotype M28, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 17.1 kDa and the accession number is Q48RM7. | |||
TMPH-03597 |
Holo-ACP synthase Protein, S. pyogenes serotype M28, Recombinant (E. coli, His & Myc)
4'-phosphopantetheinyl transferase AcpS,Holo-[acyl-carrier-p... |
Streptococcus pyogenes | E. coli |
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. Holo-ACP synthase Protein, S. pyogenes serotype M28, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.3 kDa and the accession number is Q48RM7. | |||
TMPH-00425 |
DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His)
ligA,DNA ligase,Polydeoxyribonucleotide synthase [NAD(+)] |
Colwellia psychrerythraea | E. coli |
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 42.1 kDa and the accession number is Q47YI0. | |||
TMPH-00590 |
GlmU Protein, E. coli, Recombinant (His & Myc)
glmU,Bifunctional protein GlmU |
E. coli | E. coli |
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. | |||
TMPH-02142 |
ERR1 Protein, Human, Recombinant (GST)
Steroid hormone receptor ERR1,Estrogen receptor-like 1,Nucle... |
Human | E. coli |
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. | |||
TMPJ-00724 |
LDHA Protein, Human, Recombinant (His)
LDH-M,Renal Carcinoma Antigen NY-REN-59,Cell Proliferation-I... |
Human | E. coli |
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria. | |||
TMPH-02150 |
SUCLG2 Protein, Human, Recombinant (His & SUMO)
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondr... |
Human | E. coli |
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. SUCLG2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system wit... | |||
TMPJ-01265 |
PPC-DC Protein, Human, Recombinant (aa 1-204, His)
Phosphopantothenoylcysteine Decarboxylase,PPC-DC,PPCDC,COAC |
Human | E. coli |
Phosphopantothenoylcysteine Decarboxylase (PPC-DC) is an essential enzyme in the biosynthesis ofCoenzyme A and catalyzes the decarboxylation of PPC to Phosphopantetheine. PPC-DC catalyzes the decarboxylation of the Cysteine moiety of 4-Phosphopantothenoylcysteine (PPC) to form 4-Phosphopantetheine (PPantSH), this reaction forms part of the biosynthesis of Coenzyme A. The enzyme is a member of the larger family of Cysteine Decarboxylases including the Lantibiotic-Biosynthesizing enzymes EpiD and ... | |||
TMPY-03406 |
NMNAT1 Protein, Human, Recombinant (His)
PNAT1,LCA9,nicotinamide nucleotide adenylyltransferase 1,NMN... |
Human | Baculovirus Insect Cells |
NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to protect against axonal degeneration following mechanical or toxic insults. The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT enz... | |||
TMPJ-01066 |
CYCS Protein, Human, Recombinant (His)
CYC,Cytochrome C,CYCS |
Human | E. coli |
Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic... | |||
TMPY-01878 |
L-FABP Protein, Human, Recombinant (His)
fatty acid binding protein 1, liver,FABPL,L-FABP |
Human | E. coli |
Fatty acid-binding protein, liver, also known as Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, FABP1 and FABPL,is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is t... | |||
TMPY-01140 |
ACOT13/THEM2 Protein, Human, Recombinant (His)
THEM2,HT012,ACOT13,PNAS-27,acyl-CoA thioesterase 13 |
Human | E. coli |
The metabolites of fatty acyl-Coenzyme A (CoA) and metabolic enzymes contribute to lipid biosynthesis, signal transduction, and gene transcription. Members of the acyl-CoA thioesterase (Acot) gene family hydrolyze fatty acyl-CoAs, but their biological functions remain incompletely understood. Thioesterase superfamily member 2 (Them2; synonym Acot13) is enriched in oxidative tissues, associated with mitochondria, and relatively specific for long chain fatty acyl-CoA substrates. Using Them2(-/-) m... | |||
TMPY-01345 |
ACBD6 Protein, Human, Recombinant (His)
acyl-CoA binding domain containing 6 |
Human | Baculovirus Insect Cells |
Human acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. In mammals, there are six members of the acyl-CoA binding domain-containing (ACBD) family, and their annotation is not uniform. All six ACBD proteins contain an ACB domain at the N terminus, but they do not share significant homology at the C-terminal region. ACBD6 is a 32 kDa protein that is predicted by sequenc... | |||
TMPY-04813 |
ACAT2 Protein, Rat, Recombinant (His)
acetyl-CoA acetyltransferase 2 |
Rat | E. coli |
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distributio... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0444 |
Coenzyme Q10-d6
|
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Coenzyme Q10-d6 是 Coenzyme Q10 的氘代化合物。Coenzyme Q10 的 CAS 号为 303-98-0。Coenzyme Q10是来自藤仓赤霉菌的一种天然产物,在线粒体呼吸链中充当电子载体。 | |||
TMIH-0242 |
Fluvastatin-d6 Sodium Salt
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Fluvastatin-d6 Sodium Salt 是 Fluvastatin Sodium Salt 的氘代化合物。Fluvastatin Sodium Salt 的 CAS 号为 93957-55-2。Fluvastatin sodium salt 是羟甲基戊二酰辅酶 A 还原酶的竞争性抑制剂,IC50为 8 nM。它通过依赖 Nrf2 的抗氧化通路保护血管平滑肌细胞免受氧化应激,是一种常用的降胆固醇剂。 | |||
TMIH-0037 |
2-Methylpropanedioic acid-d3
methyl-d3-malonic acid |
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2-Methylpropanedioic acid-d3 是 2-Methylpropanedioic acid 的氘代化合物。2-Methylpropanedioic acid 的 CAS 号为 516-05-2。Methylmalonic acid 是癌症患者缺乏维生素 B-12的指标。 | |||
TMID-0152 |
Pyridoxine-d2 HCl
|
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Pyridoxine-d2 HCl 是 Pyridoxine HCl 的氘代化合物。Pyridoxine HCl 的 CAS 号为 58-56-0。Pyridoxine hydrochloride 是一种吡啶衍生物。在于阿尔茨海默病细胞模型中,通过Nrf-2/HO-1 途径发挥抗氧化作用。 | |||
TMIH-0191 |
dimethyl 2-(methyl-d3)malonate
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dimethyl 2-(methyl-d3)malonate 是 dimethyl 2-(methyl)malonate 的氘代化合物。dimethyl 2-(methyl)malonate 的 CAS 号为 516-05-2。Methylmalonic acid 是癌症患者缺乏维生素 B-12的指标。 | |||
TMIJ-0377 |
Thiamine Hydrochloride-13C4
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Thiamine Hydrochloride-13C4 是 Thiamine Hydrochloride 的 13C 的标记化合物。Thiamine Hydrochloride 的 CAS 号为 67-03-8。Thiamine hydrochloride 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。 | |||
TMIH-0504 |
Rosuvastatin-d6 Calcium Salt
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Rosuvastatin-d6 Calcium Salt 是 Rosuvastatin Calcium Salt 的氘代化合物。Rosuvastatin Calcium Salt 的 CAS 号为 147098-20-2。Rosuvastatin calcium 是肝羟甲基戊二酰辅酶 A 还原酶的选择性和竞争性抑制剂,具有抗血脂活性。它降低成熟 hERG 的表达以及热休克蛋白 70 与 hERG 蛋白的相互作用,还降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go相关基因电流,延迟心脏复极化,来延长动作电位持续时间和校正 QT 间期间隔。 | |||
TMIJ-0384 |
L-Cysteine-d3
|
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L-Cysteine-d3 是 L-Cysteine 的氘代化合物。L-Cysteine 的 CAS 号为 52-90-4。L-Cysteine 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中,对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分,在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用,也是氨基酸牛磺酸的制造所必需的。 |