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Search Results for " clopidogrel "

Targets Recommended: P2Y Receptor

17

抑制剂 & 化合物

1

化合物库

4

同位素标记化合物

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Cat. No.	Product Name
L9410	共价抑制剂库		1920 compounds
	1920 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发；

化合物库

共价抑制剂库

Cat.No: L9410

Compounds: 1920

Cat. No.	Product Name	Target	Signaling Pathways
T0182	Clopidogrel (S)-Clopidogrel,SR-25990C,氯吡格雷	P2Y Receptor	GPCR/G Protein; Neuroscience
	Clopidogrel (SR-25990C) 是一种 P2Y12 受体拮抗剂，可降低血小板聚集，用于抑制冠状动脉疾病、周围血管疾病和脑血管疾病中的血凝块。
T0182L	Clopidogrel hydrogen sulfate 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷	P450; P2Y Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) 是一种抗血小板药物，可防止血栓形成。它抑制 CYP2B6和 CYP2C19，IC50分别为 18.2 和 524 nM。它是一种选择性的高亲和力 P2Y12 受体拮抗剂，可抑制纤维蛋白原与血小板的结合以及血小板的粘附和聚集。
T0182L2	(±) Clopidogrel hydrogen sulfate 硫酸氢氯吡格雷,Plavix,Clopidogrel hydrogen sulfate,Iscover	P2Y Receptor	GPCR/G Protein; Neuroscience
	(±) Clopidogrel hydrogen sulfate (Iscover) 是一种在药理学和结构上类似于ticlopidine 的抗血小板药物，用于抑制脑血管疾病、外周血管疾病和冠状动脉疾病等各种疾病中的血栓。
T38506	cis-Clopidogrel-MP derivative cis-Clopidogrel-MP derivative,Clopidogrel-MP-AM	Others	Others
	cis-Clopidogrel-MP derivative, also known as Clopidogrel-MP-AM, is a 3’-methoxyacetophenone derivative of Clopidogrel active metabolite. This compound is an orally-active platelet inhibitor specifically targeting the P2Y12 receptor.
T35431	(±)-Clopidogrel (hydrochloride)	Others	Others
	Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity. Marketed under the name Plavix , clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascu...
T71254	Clopidogrel HCl	Others	Others
	Clopidogrel HCl is the salt form of Clopidogrel (free base), an inhibitor of ADP-induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex.
T36222	2-oxo Clopidogrel	Others	Others
	2-oxo Clopidogrel is an intermediary metabolite of clopidogrel . Clopidogrel is a prodrug that is converted to its active metabolite via two sequential oxidative steps. The first step leads to formation of 2-oxo clopidogrel, followed by conversion to the active metabolite, which binds specifically and irreversibly to the platelet P2Y12 purinergic receptor, inhibiting ADP-mediated platelet activation and aggregation.
T36112	Clopidogrel Carboxylic Acid (hydrochloride)	Others	Others
	Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid i...
T5501	Clopidogrel thiolactone 2-oxoclopidogrel	P2Y Receptor	GPCR/G Protein; Neuroscience
	Clopidogrel thiolactone (2-oxoclopidogrel) 是一种有效的 P2Y12 受体抑制剂, 是一种有效的抗血小板聚集化合物。Clopidogrel thiolactone是Clopidogrel第一次氧化活化产生的活性代谢中间体。
T125853	Clopidogrel Related Compound A	Others	Others
	Clopidogrel Related Compound A 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125853，CAS号为 144457-28-3。
T126236	Clopidogrel Related Compound C	Others	Others
	Clopidogrel Related Compound C 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126236，CAS号为 120202-71-3。
T125846	Clopidogrel Related Compound B	Others	Others
	Clopidogrel Related Compound B 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125846，CAS号为 144750-52-7。
T21059	Ticagrelor metabolite M5 Ticagrelor metabolite M5,,T437700,替格瑞洛杂质H,AR-C133913XX	P2Y Receptor	GPCR/G Protein; Neuroscience
	Ticagrelor metabolite M5 (T437700) 是 Ticagrelor 的代谢物，是 P2Y12 受体的第一个可逆口服拮抗剂。与氯吡格雷相比，替格瑞洛对 ADP 受体具有更快和更一致的抑制作用。替格瑞洛用于治疗急性冠状动脉综合征(ACS)。
T0179	Ticagrelor 替格瑞洛,替卡格雷,AR-C 126532XX,AZD6140	P450; P2Y Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Ticagrelor (AR-C 126532XX) (AZD6140) 是可逆的，可口服的 P2Y12受体拮抗剂，可抑制血小板聚集。
T71363	ACT-281959	Others	Others
	ACT-281959, a prodrug of ACT-246475, is a novel potent and selective P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel. ACT-281959 showed antithrombotic efficacy after oral administration in the rat ferric chloride model. ACT-281959 entered clinical studies in healthy volunteers.
T20765	Atorvastatin 阿托伐他汀,阿伐他汀	HMG-CoA Reductase; Autophagy	Autophagy; Metabolism
	Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂，通过激活肝细胞色素p450加快代谢，具有有效降低血脂的能力。Atorvastatin 以 IC50 值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。Atorvastatin 与氯吡格雷同时服用两种可能会导致患者血栓事件增加。
T75242	Bivalirudin TFA
	Bivalirudin TFA 是20个氨基多肽，可逆地抑制凝血酶。

化合物

Cat.No: T0182

Synonym: (S)-Clopidogrel,SR-25990C,氯吡格雷

Target: P2Y Receptor

Clopidogrel hydrogen sulfate

Cat.No: T0182L

Synonym: 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷

Target: P450, P2Y Receptor

(±) Clopidogrel hydrogen sulfate

Cat.No: T0182L2

Synonym: 硫酸氢氯吡格雷,Plavix,Clopidogrel hydrogen sulfate,Iscover

Target: P2Y Receptor

cis-Clopidogrel-MP derivative

Cat.No: T38506

Synonym: cis-Clopidogrel-MP derivative,Clopidogrel-MP-AM

Target: Others

(±)-Clopidogrel (hydrochloride)

Cat.No: T35431

Target: Others

Clopidogrel HCl

Cat.No: T71254

Target: Others

2-oxo Clopidogrel

Cat.No: T36222

Target: Others

Clopidogrel Carboxylic Acid (hydrochloride)

Cat.No: T36112

Target: Others

Clopidogrel thiolactone

Cat.No: T5501

Synonym: 2-oxoclopidogrel

Target: P2Y Receptor

Clopidogrel Related Compound A

Cat.No: T125853

Target: Others

Clopidogrel Related Compound C

Cat.No: T126236

Target: Others

Clopidogrel Related Compound B

Cat.No: T125846

Target: Others

Ticagrelor metabolite M5

Cat.No: T21059

Synonym: Ticagrelor metabolite M5,,T437700,替格瑞洛杂质H,AR-C133913XX

Target: P2Y Receptor

Cat.No: T0179

Synonym: 替格瑞洛,替卡格雷,AR-C 126532XX,AZD6140

Target: P450, P2Y Receptor

Cat.No: T71363

Target: Others

Cat.No: T20765

Synonym: 阿托伐他汀,阿伐他汀

Target: HMG-CoA Reductase, Autophagy

Bivalirudin TFA

Cat.No: T75242

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0156	cis-Clopidogrel-MP-13C-d3 Derivative
	cis-Clopidogrel-MP-13C-d3 Derivative 是 cis-Clopidogrel-MP Derivative 的 13C 和氘代化合物。
TMID-0200	rac-Clopidogrel-d4 Carboxylic Acid
	rac-Clopidogrel-d4 Carboxylic Acid 是 rac-Clopidogrel Carboxylic Acid 的氘代化合物。rac-Clopidogrel Carboxylic Acid 的 CAS 号为 113665-84-2。Clopidogrel 是一种 P2Y12 受体拮抗剂，可降低血小板聚集，用于抑制冠状动脉疾病、周围血管疾病和脑血管疾病中的血凝块。
TMIJ-0117	rac-Clopidogrel-d4 Hydrogen Sulfate
	rac-Clopidogrel-d4 Hydrogen Sulfate 是 rac-Clopidogrel Hydrogen Sulfate 的氘代化合物。rac-Clopidogrel Hydrogen Sulfate 的 CAS 号为 135046-48-9。(±) Clopidogrel hydrogen sulfate是一种在药理学和结构上类似于ticlopidine的抗血小板药物，用于抑制脑血管疾病、外周血管疾病和冠状动脉疾病等各种疾病中的血栓。
TMIJ-0139	Ticagrelor-d7
	Ticagrelor-d7 是 Ticagrelor 的氘代化合物。Ticagrelor 的 CAS 号为 274693-27-5。Ticagrelor (AZD6140) 是可逆的，可口服的P2Y12受体拮抗剂，可抑制血小板聚集。

同位素标记化合物

cis-Clopidogrel-MP-13C-d3 Derivative

Cat.No: TMIH-0156

rac-Clopidogrel-d4 Carboxylic Acid

Cat.No: TMID-0200

rac-Clopidogrel-d4 Hydrogen Sulfate

Cat.No: TMIJ-0117

Cat.No: TMIJ-0139

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