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Search Results for " class ib "

Targets Recommended: AhR Sodium Channel

3

抑制剂 & 化合物

1

天然产物

1

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1046	Mexiletine hydrochloride KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律	AhR; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Mexiletine hydrochloride (KOE-1173 hydrochloride) 是一种电压门控钠通道阻滞剂，是 IB 类抗心律失常药。 Mexiletine hydrochloride 通过抑制心肌细胞内钠电流，从而降低心脏动作电位（0相）上升速率，并且降低浦肯野纤维的自律性而发挥抗心律失常作用。
T32030	GYKI-16638 HCl GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638	Others	Others
	GYKI-16638 is a novel antiarrhythmic agent that demonstrates combined class IB and class III antiarrhythmic properties in human ventricular muscles, similar to the electrophysiological findings after chronic amiodarone treatment. In addition, GYKI 16638 h
T21427	Mexiletine Mexitil,Mexiletene,KO-1173,KO1173,KO 1173	Others	Others
	Mexiletine is a non-selective voltage-gated sodium channel blocker. It is a medicine in the class of IB anti-arrhythmic. Mexiletine may also be used in patients experiencing refractory pain and is effective to treat muscle stiffness resulting from myotonic dystrophy or non-dystrophic myotonias.

化合物

Mexiletine hydrochloride

Cat.No: T1046

Synonym: KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律

Target: AhR, Sodium Channel

Cat.No: T32030

Synonym: GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638

Target: Others

Cat.No: T21427

Synonym: Mexitil,Mexiletene,KO-1173,KO1173,KO 1173

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1879	3-Methyladenine 3-MA,3-甲基腺嘌呤,NSC 66389	Mitophagy; PI3K; Endogenous Metabolite; Autophagy	Autophagy; Metabolism; PI3K/Akt/mTOR signaling
	3-Methyladenine (3-MA) 是一种 PI3K 抑制剂，选择性抑制 IB 类 PI3Kγ (IC50=60 μM) 和 III 类 VPS34 (IC50=25 μM)。3-Methyladenine 具有自噬抑制活性。

天然产物

3-Methyladenine

Cat.No: T1879

Synonym: 3-MA,3-甲基腺嘌呤,NSC 66389

Target: Mitophagy, PI3K, Endogenous Metabolite, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00836	HLA-G Free Heavy Chain Protein, Human, Recombinant (His & Avi) MHC Class I Antigen G,HLA G antigen,HLA-G,sHLA-G,HL...	Human	E. coli
	HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.

重组蛋白

HLA-G Free Heavy Chain Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00836

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T12023	Mexiletine-d6 hydrochloride KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride	Others	Others
	Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.

同位素标记化合物

Mexiletine-d6 hydrochloride

Cat.No: T12023

Synonym: KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride

Target: Others

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