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Search Results for " chikungunya "

Targets Recommended: Dehydrogenase

10

抑制剂 & 化合物

3

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9394	CHIKV-IN-2	Dehydrogenase	Metabolism
	CHIKV-IN-2 基孔肯雅病毒的选择性抑制剂，具有强大的细胞抗病毒活性 (EC90=270 nM) 以及能够改善肝微粒体稳定性。它能够抑制细胞靶二氢乳清酸脱氢酶的活性。
T8498	EIDD-1931 Beta-d-N4-hydroxycytidine	Virus Protease; HCV Protease; SARS-CoV; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	EIDD-1931 (Beta-d-N4-hydroxycytidine) 是一种核苷类抗病毒试剂，可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。
T5103	AKOS B018304 (5E)-5-(2-硝基苯亚甲基)-2-硫代-四氢噻唑-4-酮	Others; Antiviral	Immunology/Inflammation; Others
	AKOS B018304 是芳基衍生物，能够在para位置进行极性替换。AKOS B018304 是一种基孔肯雅病毒抑制剂.
T10835L1	Cletoquine hydrochloride Cletoquine hydrochloride( 4298-15-1 Free base)	Influenza Virus; Parasite	Microbiology/Virology
	Cletoquine hydrochloride 是 Hydroxychloroquine 的主要活性代谢产物。Cletoquine hydrochloride 也是一种 Chloroquine 衍生物，具有抗基孔肯雅热病毒 (CHIKV) 的能力。Cletoquine hydrochloride 具有抗疟作用。
T10835L	Cletoquine oxalate Desethylhydroxychloroquine oxalate	Others	Others
	Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disea
T36880	NHC-diphosphate	Others	Others
	NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1]. Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and ...
T38861	Tat-beclin 1
	Tat-beclin 1, a peptide derived from the autophagy protein beclin 1, is a powerful inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a negative regulator of autophagy. Tat-beclin 1 effectively reduces the buildup of polyglutamine expansion protein aggregates and inhibits the replication of various pathogens, such as HIV-1, in laboratory experiments. In addition, it has demonstrated the ability to decrease mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).
T38161	STING Agonist C11 STING Agonist C11	Others	Others
	STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses gro...
T76058	Tat-beclin 1 TFA
	Tat-beclin 1 TFA是一种来源于自噬蛋白区域(beclin 1)的肽，有效诱导自噬(autophagy)并与GAPR-1 (GLIPR2)发生相互作用，具有显著的自噬负调控作用。该化合物能有效减少体外聚谷氨酰胺扩增蛋白聚集体的积累，并抑制HIV-1等多种病原体的复制。同时，Tat-beclin 1 TFA能显著降低感染基孔肯雅病(CHIKV)或西尼罗河病毒(WNV)小鼠的死亡率。
T36881	NHC-diphosphate triammonium	Others	Others
	NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono...

化合物

Cat.No: T9394

Target: Dehydrogenase

Cat.No: T8498

Synonym: Beta-d-N4-hydroxycytidine

Target: Virus Protease, HCV Protease, SARS-CoV, Topoisomerase

Cat.No: T5103

Synonym: (5E)-5-(2-硝基苯亚甲基)-2-硫代-四氢噻唑-4-酮

Target: Others, Antiviral

Cletoquine hydrochloride

Cat.No: T10835L1

Synonym: Cletoquine hydrochloride( 4298-15-1 Free base)

Target: Influenza Virus, Parasite

Cletoquine oxalate

Cat.No: T10835L

Synonym: Desethylhydroxychloroquine oxalate

Target: Others

NHC-diphosphate

Cat.No: T36880

Target: Others

Cat.No: T38861

STING Agonist C11

Cat.No: T38161

Synonym: STING Agonist C11

Target: Others

Tat-beclin 1 TFA

Cat.No: T76058

NHC-diphosphate triammonium

Cat.No: T36881

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T8281	(R)-Sulforaphane L-Sulforaphane,(R)-1-异硫氰酰-4-(甲基亚磺酰)丁烷	Nrf2	Immunology/Inflammation
	L-Sulforaphane 是高效的Keap1/Nrf2/ARE途径诱导剂。与 S-异构体相比，它对大鼠肝脏和肺部的致癌解毒酶系统的诱导能力更强。
T10835	Cletoquine Desethylhydroxychloroquine	Parasite; Antifection	Microbiology/Virology
	Cletoquine 是 Hydroxychloroquine 的主要活性代谢物。 Cletoquine 具有对抗基孔肯雅病毒 (CHIKV) 的能力。 Cletoquine 具有抗疟作用，并具有治疗自身免疫性疾病的潜力。
TN3500	beta-Amyrone β-Amyron,β-香树脂酮	COX; AChR; PPAR; Antifection	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性，EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。

天然产物

(R)-Sulforaphane

Cat.No: T8281

Synonym: L-Sulforaphane,(R)-1-异硫氰酰-4-(甲基亚磺酰)丁烷

Target: Nrf2

Cat.No: T10835

Synonym: Desethylhydroxychloroquine

Target: Parasite, Antifection

Cat.No: TN3500

Synonym: β-Amyron,β-香树脂酮

Target: COX, AChR, PPAR, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04865	Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His)	CHIKV	Baculovirus Insect Cells
	Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 39.8 kDa and the accession number is A5Y7Y5.
TMPH-00385	Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His) P1234,Non-structural polyprotein,Polyprotein P1234	CHIKV	E. coli
	Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is Q8JUX6.
TMPK-01151	MXRA8 Protein, Human, Recombinant (His) Asp3,Limitrin,Adipocyte-specific 3,DICAM,Adipocyte-specific ...	Human	HEK293 Cells
	Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 36.70 kDa and the accession number is Q9BRK3-1.
TMPK-01166	MXRA8 Protein, Mouse, Recombinant (His) Asp3,DICAM,Adipocyte-specific protein 3,Adipocyte-specific 3...	Mouse	HEK293 Cells
	Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 37.11 kDa and the accession number is Q9DBV4.

重组蛋白

Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His)

Cat.No: TMPY-04865

Species: CHIKV

Expression System: Baculovirus Insect Cells

Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His)

Cat.No: TMPH-00385

Species: CHIKV

Expression System: E. coli

MXRA8 Protein, Human, Recombinant (His)

Cat.No: TMPK-01151

Species: Human

Expression System: HEK293 Cells

MXRA8 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01166

Species: Mouse

Expression System: HEK293 Cells

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