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Search Results for " ceramide "

Targets Recommended: p53

137

抑制剂 & 化合物

17

天然产物

7

重组蛋白

6

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T37562	C16 Ceramide N-acylsphingosine,C16 Ceramide (d18:1/16:0),Palmitoyl Ceramide,N-Palmitoylsphingosine	p53	Apoptosis
	C16 Ceramide (Palmitoyl Ceramide) 是一种天然小分子，通过直接选择性结合激活 p53。
T37436	C12-Ceramide N-Laurylsphingosine,C12 Ceramide (d18:1/12:0),N-Lauroyl-D-erythro-sphingosine
	C12-Ceramide (C12 Ceramide (d18:1/12:0)) 是一种存在于先兆子痫妇女所生婴儿围绕脐带血管的保护膜的神经酰胺，是 C12 鞘磷脂被酸性鞘磷脂酶（ASM）水解后形成的，可用于评估 A 型或 B 型尼曼-皮克病患者血浆中的 ASM 活性水平。
T37563	C22 Ceramide (d18:1/22:0) Cer(d18:1/22:0),C22 Ceramide,Ceramide (d18:1/22:0)
	C22 Ceramide (d18:1/22:0) (C22 Ceramide) 是一种从海绵Haliclona koremella 中分离出含有山嵛酸的长链神经酰胺，是一种内源性生物活性鞘脂。C22 Ceramide (d18:1/22:0) 可特异性抑制MCSR，降低离体大鼠肝线粒体和脂质体中 C16-神经酰胺通道的形成。
T61884	C6 Ceramide N-hexanoylsphingosine,N-(hexanoyl)sphing-4-enine	Apoptosis	Apoptosis
	C6 Ceramide (N-hexanoylsphingosine) 是神经酰胺途径的一种激活剂，通过激活ERK使细胞停滞在G0/G1期，可以在多种癌细胞系中发挥作用。
T35803	C14 Ceramide (d18:1/14:0) Cer(d18:1/14:0),N-Myristoyl-D-sphingosine
	C14 Ceramide (d18:1/14:0) 是由神经酰胺合成酶 6 生成的一种内源性神经酰胺,可用于研究帕金森。
T78461	C6 NBD Ceramide Nbd-ceramide
	C6 NBD Ceramide 是一种细胞膜渗透性高尔基体荧光探针（Ex=466 nm, Em=536 nm），是一种带有绿色荧光标记的神经酰胺，可识别活体及固定细胞的高尔基体，观测活细胞中高尔基体形态变化。C6 NBD Ceramide 在细胞内可代谢生成荧光鞘磷脂和葡糖基甘油酰胺，从而应用于鞘脂转运和代谢机制研究。
T35806	N-Stearoylsphingosine C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide	Phosphatase	Metabolism
	N-Stearoylsphingosine (Cer(d18:1/18:0)) 是一种广泛存在真核生物体内的酰胺类化合物，通过干扰PP2A与PP2A抑制剂2的结合来增强蛋白质磷酸酶2A(PP2A)活性，导致Akt去磷酸化。N-Stearoylsphingosine 可用于研究前列腺癌。
T36230	C2 Ceramide (d14:1/2:0) C2 Ceramide (d14:1/2:0)	Others	Others
	C2 Ceramide (d14:1/2:0) is a bioactive sphingolipid. Dietary administration of C2 ceramide (d14:1/2:0) (100 μM) induces lipotoxic cardiomyopathy via increasing diastolic and systolic diameter as well as reducing fractional shortening and the number of normal cardiac contractile events in Drosophila.
T36188	Ceramide Phosphoethanolamines (bovine)
	Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lacks sphingomyelin. It is only produced in small amounts in mammalian cells, accounting for approximately 0.02 mol% of total phospholipids in mouse testis and brain. In Drosophila, CPE is biosynthesized by CPE synthase from ceramide and cytidine diphosphate-ethanolamine in the Golgi...
T36321	C6 Urea Ceramide	Others	Others
	C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the ...
T37457	C18 L-threo Ceramide (d18:1/18:0) C18 L-threo Ceramide (d18:1/18:0)	Others	Others
	C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.21 mol% (16.8 μM).
T84619	C8 Ceramide-1-phosphate (d18:1/8:0) C8 Ceramide-1-phosphate	Others	Others

T35873	C19 Ceramide (d18:1/19:0) C19 Ceramide (d18:1/19:0)	Others	Others
	C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]
T37564	C4 Ceramide (d18:1/4:0) C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)	Others	Others
	C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing...
T36322	C8 D-threo Ceramide (d18:1/8:0) C8 D-threo Ceramide (d18:1/8:0)	Others	Others
	C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein r...
T36140	BODIPY-C12 Ceramide (d18:1/12:0) BODIPY-C12 Ceramide (d18:1/12:0)	Others	Others
	BODIPY-C12 Ceramide（B12Cer）是C12鞘氨醇的荧光标记形式，其激发/发射最大值分别为505/540 nm。BODIPY-C12 Ceramide 是一种带有荧光标记的神经酰胺。BODIPY-C12 Ceramide已被用于量化尼曼-匹克病患者血浆中酸性鞘磷脂酶的活性。
T36324	C8 L-threo Ceramide (d18:1/8:0) C8 L-threo Ceramide (d18:1/8:0)	Others	Others
	C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide , induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 L-erythro ceramide . C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~30 μg/ml.
T37455	C18 D-threo Ceramide (d18:1/18:0) C18 D-threo Ceramide (d18:1/18:0)	Others	Others
	C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855] 1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine bas...
T85193	C10 Ceramide (d18:1/10:0) Ceramide (d18:1/10:0),N-decanoyl-D-erythro-Sphingosine,C10 Ceramide,Cer(d18:1/10:0)	Others	Others

T36320	C6 L-threo Ceramide (d18:1/6:0) C6 L-threo Ceramide (d18:1/6:0)	Others	Others
	C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 L-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 L-threo Ceramide enhances IL-4 production induced by phorbol 12-myristate 13-acetate in EL4 T cells when used at a concentration of 10 μM.
T37565	C6 D-threo Ceramide (d18:1/6:0) C6 D-threo Ceramide (d18:1/6:0)	Others	Others
	C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater...
T35927	C2 L-threo Ceramide (d18:1/2:0) C2 L-threo Ceramide (d18:1/2:0)	Others	Others
	C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide . C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1...
T85290	C6 Biotin Ceramide (d18:1/6:0) N-hexanoyl-biotin-D-erythro-Sphingosine,N-C6:0-biotin-D-erythro-Ceramide,Biotin Cer(d18:1/6:0),Biotin Ceramide (d18:1/6:0),C6 Ceramide-biotin	Others	Others

T40849	C20 Ceramide N-Arachidoyl-D-sphingosine	Endogenous Metabolite	Metabolism
	C20 Ceramide (N-Arachidoyl-D-sphingosine) 是一种存在于大脑中的 20:0 神经酰胺，可穿越血脑屏障激活小胶质细胞，诱导抑郁样行为。
T35807	C18 dihydro Ceramide (d18:0/18:0) C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0)	Others	Others
	C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes. [2] It is also elevated in...
T36319	C6 L-erythro Ceramide (d18:1/6:0) C6 L-erythro Ceramide (d18:1/6:0)	Others	Others
	C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide is cytotoxic to U937 cells (IC50 = 18 μM).
T85197	C16 Ceramide-1-phosphate (d18:1/16:0) (ammonium salt) CerP(d18:1/16:0),C16 Ceramide-1-phosphate,Ceramide-1-phosphate (d18:1/16:0),C16 C1P	Others	Others

T20827	C8-Ceramide N-辛酰基-D-神经鞘氨醇,N-Octanoyl-D-erythro-Sphingosine	Others	Others
	C8 Ceramide, a cell-permeable analog, is analog to naturally occur ceramides.
T85284	C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0) N-(2'-(S)-hydroxypalmitoyl)-D-erythro-Sphingosine,2'(S)-hydroxy Cer(d18:1/16:0),2'-hydroxy C16-Ceramide,(2'(S)-hydroxy) Ceramide (d18:1/16:0),16:0 (2S-OH)-Ceramide	Others	Others

T30797	Ceramide 1 A Linoleoyloxyheptacosanoyl-C18-phytosphingosine	Others	Others
	Ceramide 1 A 是一种蜡状脂质化合物，是顶端皮肤层的脂质。它具有特殊的分子结构，因为它含有一种与长链ω-羟基酸相连的亚油酸。
T69361	C16-Urea-Ceramide	Others	Others
	C16-Urea-Ceramide s a neutral ceramidase (nCDase) inhibitor. It is a bioactive ceramide.
T37454	C16 dihydro Ceramide (d18:0/16:0) N-Palmitoyl Sphinganine,Cer(d18:0/16:0),N-hexadecanoyl-D-erythro-Dihydrosphingosine,C16 dihydroceramide,Ceramide (d18:0/16:0)	Others	Others
	C16 dihydro Ceramide (d18:0/16:0) (Cer(d18:0/16:0)) 是合成神经酰胺的前体，诱导核周区域自噬，可用于研究细胞膜的稳定性和神经系统疾病。
T85189	C15 Ceramide (d18:1/15:0) Ceramide (d18:1/15:0),N-pentadecanoyl-D-erythro-Sphingosine,Cer(d18:1/15:0)	Others	Others

T85289	C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0) ((±)-2'-hydroxy) Cer(d18:1/18:0),((±)-2'-hydroxy) Ceramide (d18:1/18:0),18:0 (2R/S-OH)-Ceramide,N-(2'-(R,S)-hydroxystearoyl)-D-erythro-Sphingosine	Others	Others

T85187	C6 dihydro Ceramide (d18:0/6:0) Ceramide (d18:0/6:0),Cer(d18:0/6:0),N-hexanoyl-D-erythro-Dihydrosphingosine	Others	Others

T85275	C32 Ceramide (d18:1/32:0) Cer(d18:1/32:0),N-dotriacontanoyl-D-erythro-Sphingosine,Ceramide (d18:1/32:0)	Others	Others

T85279	C17 dihydro Ceramide (d18:0/17:0) N-heptadecanoyl-D-erythro-Dihydrosphingosine,Cer(d18:0/17:0),Ceramide (d18:0/17:0)	Others	Others

T37437	C17 Ceramide (d18:1/17:0)	Others	Others
	C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzyme replacement therapy for the genetic disease metachromatic leukodystrophy.
T85065	C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0/24:0) (R)-2'-hydroxy Ceramide (d18:0/24:0),N-(R)-α-C24 dihydro Ceramide (d18:0/24:0),N-(R)-α-hydroxytetracosanoyl-D-erythro-Dihydrosphingosine,(R)-2'-hydroxy Cer(d18:0/24:0)	Others	Others

T83880	C18 Ceramide-1-phosphate (d18:1/18:0) ammonium Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate	Others	Others
	C18 Ceramide-1-phosphate (d18:1/18:0) 是一种在鼠皮肤中发现的长链ceramide-1-phosphate。它能在0.5至5 µM的浓度范围内促进分离的小鼠骨髓来源的多能间充质细胞和人脐静脉内皮细胞（HUVECs）的迁移。与胰腺癌干细胞相比，CFPAC-1胰管腺癌细胞中C18 Ceramide-1-phosphate (d18:1/18:0)的水平有所增加。在Langendorff分离的灌流小鼠心脏的离体缺血模型中，心肌中C18 ceramide-1-phosphate (d18:1/18:0)的水平有所增加。
T85188	C2 L-erythro Ceramide (d18:1/2:0) L-erythro Cer(d18:1/2:0),L-erythro Ceramide (d18:1/2:0),N-acetyl-L-erythro-Sphingosine	Others	Others

T85175	C16((±)-2'-hydroxy) dihydro Ceramide (d18:0/16:0) N-(R,S)-α-hydroxyhexadecanoyl-D-erythro-Dihydrosphingosine,(±)-2'-hydroxy Ceramide (d18:0/16:0)	Others	Others

T35810	C24 dihydro Ceramide (d18:0/24:0) Cer(d18:0/24:0)	Others	Others
	C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.[4] Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squam...
T84383	C2 dihydro Ceramide (d18:0/2:0) Cer(d18:0/2:0),N-acetyl-D-erythro-Sphinganine,N-acetyl-dihydro-Sphingosine,Ceramide (d18:0/2:0),N-acetyl-D-erythro-dihydro-Sphingosine	Others	Others

T37456	C18 L-erythro Ceramide (d18:1/18:0)	Beta Amyloid	Neuroscience
	C18 L-erythro Ceramide (d18:1/18:0)可显著降低细胞外 Aβ 水平，可用于研究阿尔茨海默病。
T35808	C18:1 Ceramide (d18:1/18:1(9Z)) Cer(d18:1/18:1(9Z))	Others	Others
	C18:1 Ceramide is a naturally occurring ceramide.[1][2][3] Levels of C18:1 ceramide are elevated in overweight and insulin-resistant mice and cattle.[1][2] C18:1 Ceramide is also increased in the plasma and ovarian tissue of patients with advanced ovarian cancer. [3]
T84733	C24-Ceramide	Others	Others
	C24-Ceramide，一种参与构成脂质膜的鞘磷脂，具有诱导膜特性时间依赖性变化及促进膜重组的功能。
T85276	C12((±)-2'-hydroxy) dihydro Ceramide (d18:0/12:0) N-(R,S)-α-hydroxydodecanoyl-D-erythro-Dihydrosphingosine,(±)-2'-hydroxy Cer(d18:0/12:0),(±)-2'-hydroxy Ceramide (d18:0/12:0)	Others	Others

T82800	C12-NBD-ceramide
	C12-NBD-ceramide，一种荧光标记的神经酰胺类似物，常用作神经酰胺酶实验的底物。
T74304	C16 PEG-Ceramide	Others	Others
	C16 PEG-Ceramide为一种聚乙二醇化神经酰胺，具备脂质载体传递功能，并能诱导自噬(autophagy)，在癌症研究中有应用。

化合物

Cat.No: T37562

Synonym: N-acylsphingosine,C16 Ceramide (d18:1/16:0),Palmitoyl Ceramide,N-Palmitoylsphingosine

Target: p53

Cat.No: T37436

Synonym: N-Laurylsphingosine,C12 Ceramide (d18:1/12:0),N-Lauroyl-D-erythro-sphingosine

C22 Ceramide (d18:1/22:0)

Cat.No: T37563

Synonym: Cer(d18:1/22:0),C22 Ceramide,Ceramide (d18:1/22:0)

Cat.No: T61884

Synonym: N-hexanoylsphingosine,N-(hexanoyl)sphing-4-enine

Target: Apoptosis

C14 Ceramide (d18:1/14:0)

Cat.No: T35803

Synonym: Cer(d18:1/14:0),N-Myristoyl-D-sphingosine

C6 NBD Ceramide

Cat.No: T78461

Synonym: Nbd-ceramide

N-Stearoylsphingosine

Cat.No: T35806

Synonym: C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide

Target: Phosphatase

C2 Ceramide (d14:1/2:0)

Cat.No: T36230

Synonym: C2 Ceramide (d14:1/2:0)

Target: Others

Ceramide Phosphoethanolamines (bovine)

Cat.No: T36188

C6 Urea Ceramide

Cat.No: T36321

Target: Others

C18 L-threo Ceramide (d18:1/18:0)

Cat.No: T37457

Synonym: C18 L-threo Ceramide (d18:1/18:0)

Target: Others

C8 Ceramide-1-phosphate (d18:1/8:0)

Cat.No: T84619

Synonym: C8 Ceramide-1-phosphate

Target: Others

C19 Ceramide (d18:1/19:0)

Cat.No: T35873

Synonym: C19 Ceramide (d18:1/19:0)

Target: Others

C4 Ceramide (d18:1/4:0)

Cat.No: T37564

Synonym: C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)

Target: Others

C8 D-threo Ceramide (d18:1/8:0)

Cat.No: T36322

Synonym: C8 D-threo Ceramide (d18:1/8:0)

Target: Others

BODIPY-C12 Ceramide (d18:1/12:0)

Cat.No: T36140

Synonym: BODIPY-C12 Ceramide (d18:1/12:0)

Target: Others

C8 L-threo Ceramide (d18:1/8:0)

Cat.No: T36324

Synonym: C8 L-threo Ceramide (d18:1/8:0)

Target: Others

C18 D-threo Ceramide (d18:1/18:0)

Cat.No: T37455

Synonym: C18 D-threo Ceramide (d18:1/18:0)

Target: Others

C10 Ceramide (d18:1/10:0)

Cat.No: T85193

Synonym: Ceramide (d18:1/10:0),N-decanoyl-D-erythro-Sphingosine,C10 Ceramide,Cer(d18:1/10:0)

Target: Others

C6 L-threo Ceramide (d18:1/6:0)

Cat.No: T36320

Synonym: C6 L-threo Ceramide (d18:1/6:0)

Target: Others

C6 D-threo Ceramide (d18:1/6:0)

Cat.No: T37565

Synonym: C6 D-threo Ceramide (d18:1/6:0)

Target: Others

C2 L-threo Ceramide (d18:1/2:0)

Cat.No: T35927

Synonym: C2 L-threo Ceramide (d18:1/2:0)

Target: Others

C6 Biotin Ceramide (d18:1/6:0)

Cat.No: T85290

Synonym: N-hexanoyl-biotin-D-erythro-Sphingosine,N-C6:0-biotin-D-erythro-Ceramide,Biotin Cer(d18:1/6:0),Biotin Ceramide (d18:1/6:0),C6 Ceramide-biotin

Target: Others

Cat.No: T40849

Synonym: N-Arachidoyl-D-sphingosine

Target: Endogenous Metabolite

C18 dihydro Ceramide (d18:0/18:0)

Cat.No: T35807

Synonym: C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0)

Target: Others

C6 L-erythro Ceramide (d18:1/6:0)

Cat.No: T36319

Synonym: C6 L-erythro Ceramide (d18:1/6:0)

Target: Others

C16 Ceramide-1-phosphate (d18:1/16:0) (ammonium salt)

Cat.No: T85197

Synonym: CerP(d18:1/16:0),C16 Ceramide-1-phosphate,Ceramide-1-phosphate (d18:1/16:0),C16 C1P

Target: Others

Cat.No: T20827

Synonym: N-辛酰基-D-神经鞘氨醇,N-Octanoyl-D-erythro-Sphingosine

Target: Others

C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0)

Cat.No: T85284

Synonym: N-(2'-(S)-hydroxypalmitoyl)-D-erythro-Sphingosine,2'(S)-hydroxy Cer(d18:1/16:0),2'-hydroxy C16-Ceramide,(2'(S)-hydroxy) Ceramide (d18:1/16:0),16:0 (2S-OH)-Ceramide

Target: Others

Cat.No: T30797

Synonym: Linoleoyloxyheptacosanoyl-C18-phytosphingosine

Target: Others

C16-Urea-Ceramide

Cat.No: T69361

Target: Others

C16 dihydro Ceramide (d18:0/16:0)

Cat.No: T37454

Synonym: N-Palmitoyl Sphinganine,Cer(d18:0/16:0),N-hexadecanoyl-D-erythro-Dihydrosphingosine,C16 dihydroceramide,Ceramide (d18:0/16:0)

Target: Others

C15 Ceramide (d18:1/15:0)

Cat.No: T85189

Synonym: Ceramide (d18:1/15:0),N-pentadecanoyl-D-erythro-Sphingosine,Cer(d18:1/15:0)

Target: Others

C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0)

Cat.No: T85289

Synonym: ((±)-2'-hydroxy) Cer(d18:1/18:0),((±)-2'-hydroxy) Ceramide (d18:1/18:0),18:0 (2R/S-OH)-Ceramide,N-(2'-(R,S)-hydroxystearoyl)-D-erythro-Sphingosine

Target: Others

C6 dihydro Ceramide (d18:0/6:0)

Cat.No: T85187

Synonym: Ceramide (d18:0/6:0),Cer(d18:0/6:0),N-hexanoyl-D-erythro-Dihydrosphingosine

Target: Others

C32 Ceramide (d18:1/32:0)

Cat.No: T85275

Synonym: Cer(d18:1/32:0),N-dotriacontanoyl-D-erythro-Sphingosine,Ceramide (d18:1/32:0)

Target: Others

C17 dihydro Ceramide (d18:0/17:0)

Cat.No: T85279

Synonym: N-heptadecanoyl-D-erythro-Dihydrosphingosine,Cer(d18:0/17:0),Ceramide (d18:0/17:0)

Target: Others

C17 Ceramide (d18:1/17:0)

Cat.No: T37437

Target: Others

C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0/24:0)

Cat.No: T85065

Synonym: (R)-2'-hydroxy Ceramide (d18:0/24:0),N-(R)-α-C24 dihydro Ceramide (d18:0/24:0),N-(R)-α-hydroxytetracosanoyl-D-erythro-Dihydrosphingosine,(R)-2'-hydroxy Cer(d18:0/24:0)

Target: Others

C18 Ceramide-1-phosphate (d18:1/18:0) ammonium

Cat.No: T83880

Synonym: Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate

Target: Others

C2 L-erythro Ceramide (d18:1/2:0)

Cat.No: T85188

Synonym: L-erythro Cer(d18:1/2:0),L-erythro Ceramide (d18:1/2:0),N-acetyl-L-erythro-Sphingosine

Target: Others

C16((±)-2'-hydroxy) dihydro Ceramide (d18:0/16:0)

Cat.No: T85175

Synonym: N-(R,S)-α-hydroxyhexadecanoyl-D-erythro-Dihydrosphingosine,(±)-2'-hydroxy Ceramide (d18:0/16:0)

Target: Others

C24 dihydro Ceramide (d18:0/24:0)

Cat.No: T35810

Synonym: Cer(d18:0/24:0)

Target: Others

C2 dihydro Ceramide (d18:0/2:0)

Cat.No: T84383

Synonym: Cer(d18:0/2:0),N-acetyl-D-erythro-Sphinganine,N-acetyl-dihydro-Sphingosine,Ceramide (d18:0/2:0),N-acetyl-D-erythro-dihydro-Sphingosine

Target: Others

C18 L-erythro Ceramide (d18:1/18:0)

Cat.No: T37456

Target: Beta Amyloid

C18:1 Ceramide (d18:1/18:1(9Z))

Cat.No: T35808

Synonym: Cer(d18:1/18:1(9Z))

Target: Others

Cat.No: T84733

Target: Others

C12((±)-2'-hydroxy) dihydro Ceramide (d18:0/12:0)

Cat.No: T85276

Synonym: N-(R,S)-α-hydroxydodecanoyl-D-erythro-Dihydrosphingosine,(±)-2'-hydroxy Cer(d18:0/12:0),(±)-2'-hydroxy Ceramide (d18:0/12:0)

Target: Others

C12-NBD-ceramide

Cat.No: T82800

C16 PEG-Ceramide

Cat.No: T74304

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T22644	C2 Ceramide Ceramide	Others	Others
	A potent modulator of cell proliferation and differentiation.
T41338	C30(ω-hydroxy) Ceramide (d18:1/30:0)
	C30(ω-hydroxy) Ceramide (d18:1/30:0) 在生命科学相关研究中具有广泛的应用。
T64533	Ceramide (Egg, Chicken)	Apoptosis	Apoptosis
	Ceramide (Egg, Chicken)在鞘脂的合成代谢和分解代谢途径中起主要作用。Ceramide (Egg, Chicken)刺激许多细胞分化，生长抑制，细胞衰老和凋亡。
T9267	Aureobasidin A	Others; Antifungal	Microbiology/Virology; Others
	Aureobasidin A 是一种环肽和抗真菌抗生素。它是肌醇磷酸神经酰胺合酶 AUR1 的抑制剂。
T82572	D-Glucosyl-β-1,1′-N-palmitoylsphingosine C16 Glucosyl(β) Ceramide (d18:1/16:0)	Others	Others
	D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) 是内源性Mincle配体，具免疫刺激活性。
T12039	Miglustat N-Butyldeoxynojirimycin,OGT918,美格鲁特,NB-DNJ,N-丙基脱氧野尻霉素	Others	Others
	Miglustat (NB-DNJ) 是一种葡萄糖神经酰胺合成酶抑制剂，可用于I 型戈谢病。
T14193	α-Galactosylceramide KRN7000,α-GalCer	Others	Others
	α-Galactosylceramide (KRN7000) 是一种具有抗肿瘤和免疫刺激作用的合成糖脂。它是一种高效的 NKT 细胞激动剂，可与 CD1d 有效结合。它与 CD1d 的复合物可与 NKT 细胞的 T 细胞抗原受体结合。
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)	Others	Others
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...
T38285	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))	Others	Others
	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))是成熟髓鞘中主要的硫酸盐类化合物。C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) 在大鼠小脑中发现活跃的髓发生鞘化反应时积累率高于C24 3'-sulfo 半乳糖甘油酰胺。C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))与C 型凝集素和免疫球蛋白样受体相互作用使对LMIR5的亲和力高。C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))诱导嗜碱细胞产生MCP-1，可通过增加LMIR5激活NFAT，但不能诱导肥大细胞。C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))在体外与CD1d 结合，并增加游离小鼠脾细胞的增殖。
T38179	C16 3'-sulfo Galactosylceramide (d18:1/16:0) C16 3'-sulfo Galactosylceramide (d18:1/16:0)	Others	Others
	C16 3'-sulfo Galactosylceramide (d18:1/16:0)是硫酸盐类糖脂的一种。C16 3'-sulfo Galactosylceramide (d18:1/16:0)是在猪脑和血浆中发现的一种比较丰富的硫化物，在小鼠的整个发育过程中会有所减少。C16 3'-sulfo Galactosylceramide (d18:1/16:0)在体外可抑制视网膜神经节细胞生长。C16 3'-sulfo Galactosylceramide (d18:1/16:0)已被用作量化大鼠小脑和多发性硬化症患者分离的白质中的硫化物的参照物。
T4703	(2-Aminoethyl)phosphonic acid 2-Aminoethylphosphonic acid,2-氨基乙基膦酸,Ciliatine,2-AEP	Others; Endogenous Metabolite	Metabolism; Others
	(2-Aminoethyl)phosphonic acid (2-Aminoethylphosphonic acid) 主要在尿液中检测到。(2-Aminoethyl)phosphonic acid 参与许多酶促反应，也是其他转化产物的母体化合物，包括但不限于神经酰胺 2-(甲氨基)乙基膦酸酯、N-(2-膦乙基)胆酰胺和 CMP-2-氨基乙基膦酸酯。
T1208	Citicoline sodium Citicoline sodium salt,CDP-choline,胞磷胆碱钠	Apoptosis; Others; Endogenous Metabolite	Apoptosis; Metabolism; Others
	Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体，有神经保护作用。
T4A2399	Cinobufotalin 华蟾毒它灵,华蟾素	IL Receptor; Akt; MRP; P-gp	Cytoskeletal Signaling; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; PI3K/Akt/mTOR signaling
	Cinobufotalin 是一种从蟾蜍的皮肤分泌物中提取的强心类固醇或丁二烯内酯。它已被用作强心药，利尿药和止血药，也是潜在的抗肺癌药物。
T15357	Fumonisin B2 伏马菌素B2	Others	Others
	Fumonisin B2 is a mycotoxin produced by Fusarium moniliforme in various grains. It also is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase). Which disrupts de novo sphingolipid biosynthesis.
T13729	Hydrolyzed Fumonisin B1 Aminopentol	Others	Others
	Hydrolyzed Fumonisin B1 is the backbone and the main hydrolysis product of the mycotoxin fumonisin B1 (FB1), can weakly inhibit ceramide synthase.
T15356	Fumonisin B1 伏马菌素B1	Others	Others
	Fumonisin B1 is the most abundant and toxic fumonisin and is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is also a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis.
TN4473	Macrocarpal A	Antifection	Microbiology/Virology
	Macrocarpal A is the key component that stimulates the synthesis of ceramide in the stratum corneum. Macrocarpal A has cytotoxic, and antibacterial activities.

天然产物

Cat.No: T22644

Synonym: Ceramide

Target: Others

C30(ω-hydroxy) Ceramide (d18:1/30:0)

Cat.No: T41338

Ceramide (Egg, Chicken)

Cat.No: T64533

Target: Apoptosis

Cat.No: T9267

Target: Others, Antifungal

D-Glucosyl-β-1,1′-N-palmitoylsphingosine

Cat.No: T82572

Synonym: C16 Glucosyl(β) Ceramide (d18:1/16:0)

Target: Others

Cat.No: T12039

Synonym: N-Butyldeoxynojirimycin,OGT918,美格鲁特,NB-DNJ,N-丙基脱氧野尻霉素

Target: Others

α-Galactosylceramide

Cat.No: T14193

Synonym: KRN7000,α-GalCer

Target: Others

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

Target: Others

C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))

Cat.No: T38285

Synonym: C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))

Target: Others

C16 3'-sulfo Galactosylceramide (d18:1/16:0)

Cat.No: T38179

Synonym: C16 3'-sulfo Galactosylceramide (d18:1/16:0)

Target: Others

(2-Aminoethyl)phosphonic acid

Cat.No: T4703

Synonym: 2-Aminoethylphosphonic acid,2-氨基乙基膦酸,Ciliatine,2-AEP

Target: Others, Endogenous Metabolite

Citicoline sodium

Cat.No: T1208

Synonym: Citicoline sodium salt,CDP-choline,胞磷胆碱钠

Target: Apoptosis, Others, Endogenous Metabolite

Cat.No: T4A2399

Synonym: 华蟾毒它灵,华蟾素

Target: IL Receptor, Akt, MRP, P-gp

Cat.No: T15357

Synonym: 伏马菌素B2

Target: Others

Hydrolyzed Fumonisin B1

Cat.No: T13729

Synonym: Aminopentol

Target: Others

Cat.No: T15356

Synonym: 伏马菌素B1

Target: Others

Cat.No: TN4473

Target: Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01077	UGCG Protein, Human, Recombinant (His) Glycosylceramide synthase,Ceramide glucosy...	Human	E. coli
	UGCG Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 47.7 kDa and the accession number is Q16739.
TMPY-02585	Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His) aSMase,ASM,Zn-SMase,A-SMase,sphingomyelin phosphodiesterase ...	Mouse	Baculovirus Insect Cells
	Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monome...
TMPH-01623	GBA Protein, Human, Recombinant (His & Myc & SUMO) Lysosomal acid glucosylceramidase,GBA1,Lysosomal galactosylc...	Human	E. coli
	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha...
TMPH-01624	GBA Protein, Human, Recombinant Lysosomal glycosylceramidase,Acid beta-glucosidase,Alglucera...	Human	E. coli
	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha...
TMPY-03266	COL4A3BP Protein, Human, Recombinant (His & GST) CERTL,GPBP,collagen, type IV, alpha 3 (Goodpasture antigen) ...	Human	Baculovirus Insect Cells
	COL4A3BP is a member of the StarD2 subfamily. It contains a pleckstrin homology domain at its amino terminus and a START domain towards the end of the molecule. COL4A3BP has a lipid-binding domain that mediates intracellular trafficking of ceramide in a non-vesicular manner. One isoform of COL4A3BP is also involved in ceramide intracellular transport. COL4A3BP specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as t...
TMPY-05003	GLTP Protein, Human, Recombinant (His) glycolipid transfer protein	Human	HEK293 Cells
	Glycolipid transfer proteins (GLTPs) originally were identified as small (~24 kDa), soluble, amphitropic proteins that specifically accelerate the intermembrane transfer of glycolipids. Human GLTP-motifs have evolved to function not only as glucosylceramide binding/transferring domains for phosphoinositol 4-phosphate adaptor protein-2 during glycosphingolipid biosynthesis but also as selective binding/transfer proteins for ceramide-1-phosphate. Glycolipid transfer protein (GLTP) accelerates glyc...
TMPH-03267	CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO) Clm1,Cd300lf,CD300 antigen-like family member F,CLM-1,CD300f...	Rat	E. coli
	Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell ...

重组蛋白

UGCG Protein, Human, Recombinant (His)

Cat.No: TMPH-01077

Species: Human

Expression System: E. coli

Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02585

Species: Mouse

Expression System: Baculovirus Insect Cells

GBA Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-01623

Species: Human

Expression System: E. coli

GBA Protein, Human, Recombinant

Cat.No: TMPH-01624

Species: Human

Expression System: E. coli

COL4A3BP Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03266

Species: Human

Expression System: Baculovirus Insect Cells

GLTP Protein, Human, Recombinant (His)

Cat.No: TMPY-05003

Species: Human

Expression System: HEK293 Cells

CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03267

Species: Rat

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0131	C16 Ceramide-d7
	C16 Ceramide-d7 是 C16 Ceramide 的氘代化合物。
TMIH-0132	C18 Ceramide-d7
	C18 Ceramide-d7 是 C18 Ceramide 的氘代化合物。
TMIH-0133	C24 Ceramide-d7
	C24 Ceramide-d7 是 C24 Ceramide 的氘代化合物。
TMIH-0134	C24:1 Ceramide-d7
	C24:1 Ceramide-d7 是 C24:1 Ceramide 的氘代化合物。
T36149	13C C16 Sphingomyelin (d18:1/16:0)
	13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in or...
T69395	Nicotinamide-d4
	Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl...

同位素标记化合物

C16 Ceramide-d7

Cat.No: TMIH-0131

C18 Ceramide-d7

Cat.No: TMIH-0132

C24 Ceramide-d7

Cat.No: TMIH-0133

C24:1 Ceramide-d7

Cat.No: TMIH-0134

13C C16 Sphingomyelin (d18:1/16:0)

Cat.No: T36149

Nicotinamide-d4

Cat.No: T69395

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