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Targets Recommended: Caspase

34

抑制剂 & 化合物

10

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1

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Cat. No. Product Name
L8720 细胞焦亡化合物库

1066 compounds
1066 种细胞焦亡相关的化合物,可以用于细胞焦亡相关研究。

化合物库

细胞焦亡化合物库
Cat.No: L8720
Compounds: 1066
Cat. No. Product Name Target Signaling Pathways
TP1466 Z-YVAD-FMK

Caspase Apoptosis; Proteases/Proteasome
Z-YVAD-FMK 是一种不可逆的 caspase-1 抑制剂,具有抗炎和抗肿瘤活性。
T27242 EF24

EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone

ERK; MEK; Caspase Apoptosis; MAPK; Proteases/Proteasome
EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) 是姜黄素类似物,口服生物利用度高,抗肿瘤作用强。它可增强活化的 Caspase3 及 Caspase9 的水平,并抑制 MEK1 及 ERK 的磷酸化形式的表达。它可以抑制口腔鳞状细胞癌细胞的 MAPK/ERK 信号通路,从而发挥抗肿瘤作用。
T18909 Ac-DEVD-AMC

AC-ASP-MET-GLN-ASP-AMC,AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN

Caspase Apoptosis; Proteases/Proteasome
Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) 是一种 Caspase-3底物。
T12412L PDK4-IN-1 hydrochloride

Apoptosis; PDK Apoptosis; PI3K/Akt/mTOR signaling
PDK4-IN-1 hydrochloride 是一种蒽醌衍生物,对丙酮酸脱氢酶激酶 4有抑制作用,IC50为 84 nM,具有口服活性。它抑制细胞转化和细胞增殖并诱导细胞凋亡。它具有抗过敏,抗糖尿病和抗癌作用。
T36819 Ac-FLTD-CMK

Caspase Apoptosis; Proteases/Proteasome
Ac-FLTD-CMK 是由消皮素 D (GSDMDD) 衍生的抑制剂,具有对炎症性 caspases 特异性的抑制作用。Ac-FLTD-CMK 对 Ac-FLTD-CMK 对 caspases-1、caspases-4caspases-11有抑制作用 ,IC50分别为 为 46.7 nM、 1.49 μM 和 329 nM。 Ac-FLTD-CMK 对 caspases-1、caspases-4caspases-11均表现出有效性,但对凋亡相关的 caspase-3 无效。
T77579 JC2-11

IL Receptor; Dehydrogenase; ROS; Caspase; NOD-like Receptor (NLR); AIM2 Apoptosis; Immunology/Inflammation; Metabolism; Proteases/Proteasome
JC2-11 是一种对炎症有抑制作用的化合物。JC2-11 对含有募集结构域的蛋白质 NLRC 4、黑色素瘤 2 中缺失 (AIM 2) 和非典型 (NC) 炎症小体有抑制作用,通过破坏活性氧的产生和 caspase-1 的活性来抑制炎症小体的活化。JC2-11 减少了炎症小体中 caspase-1 (p20) 的分泌、gasdermin D (GSDMD) 的裂解、IL-1β 和乳酸脱氢酶 (LDH) 的释放。
T16977 Talampanel

GYKI-53773,LY-300164

Apoptosis; GluR Apoptosis; Neuroscience
Talampanel (LY-300164) 是一种口服和选择型 AMPA 受体拮抗剂,具有抗癫痫活性。在啮齿动物的中风模型中,它 具有神经保护作用。Talampanel 减弱 caspase-3 依赖性细胞凋亡。
T6090 Belnacasan

VX-765

Caspase Apoptosis; Proteases/Proteasome
Belnacasan (VX-765) 是一种 IL 转换酶 (ICE)/caspase-1 抑制剂,是 VRT-043198 的口服生物活性前药。Belnacasan 可以修饰 Caspase-1 的活性位点并导致 Caspase-1 阻断,从而与动物模型中炎症疾病的组织保护相关。
T0432 Diclofenac diethylamine

Apoptosis; COX Apoptosis; Immunology/Inflammation; Neuroscience
Diclofenac diethylamine 是非选择性抗炎剂,通过活化 caspase 级联反应来诱导神经干细胞凋亡。它是一种COX 抑制剂,在 CHO 细胞中,对人COX-1和COX-2的IC50值分别为 4 和 1.3 nM。它对绵羊COX-1和COX-2的IC50值分别为 5.1 μM 和0.84 μM。
T1266 Terfenadine

(±)-Terfenadine,特非那定,MDL-991

Apoptosis; Potassium Channel; 5-HT Receptor; Caspase; Na+/Ca2+ Exchanger; HER; AChR; Histamine Receptor Angiogenesis; Apoptosis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome; Tyrosine Kinase/Adaptors
Terfenadine ((±)-Terfenadine) 是一种hERG 开放通道抑制剂,IC50为 204 nM。它也是一种 H1 组胺受体拮抗剂,通过调节Ca2+稳态在黑素瘤细胞中起到有效的细胞凋亡诱导作用。 Terfenadine 诱导 ROS 依赖性细胞凋亡,同时激活Caspase-4,-2,-9。
T1555 Diclofenac sodium

GP 45840,双氯芬酸钠

Apoptosis; COX Apoptosis; Immunology/Inflammation; Neuroscience
Diclofenac sodium (GP 45840) 是一种非选择性抗炎剂,是 COX 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。
T6470 Diclofenac Potassium

双氯芬酸钾,CGP-45840B,Cataflam,Voltfast

Apoptosis; Others; COX Apoptosis; Immunology/Inflammation; Neuroscience; Others
Diclofenac Potassium (CGP-45840B) 是一种非甾体抗炎药,用于减轻炎症并在某些情况下作为镇痛剂减轻疼痛。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。它是一种COX 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM 和0.84 μM。
T0196 Diclofenac

双氯芬酸,奥尔芬,Diclofenacum,Voltaren

Apoptosis; COX Apoptosis; Immunology/Inflammation; Neuroscience
Diclofenac (Diclofenacum) 是一种具有抗炎活性的非甾体苯乙酸衍生物,是 COX 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。
T76665 Z-LEED-FMK

Z-LEED-FMK 是 caspase-13和 caspase-4抑制剂。Z-LEED-FMK 还能抑制S. typhimurium 感染的巨噬细胞中caspase-1的加工。
T36354 Suc-YVAD-AMC (acetate)

Others Others
Suc-YVAD-AMC is a fluorogenic substrate for caspase-1. Upon enzymatic cleavage by caspase-1, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
T69632 VRT-043198

Others Others
VRT-043198 是 VX-765 (Belnacasan) 的活性代谢物,是有效的、选择性的、能透过血脑屏障的caspase-1的抑制剂。VRT-043198 对caspase-1和 caspase-4 的 Ki 值分别为 0.8 nM 和 0.6 nM。
T36334 Z-VAD-AMC (acetate)

Others Others
Z-VAD-AMC is a fluorogenic substrate for caspase-1. Upon enzymatic cleavage by caspase-1, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
T73096 Z-LEVD-FMK

Others Others
Z-LEVD-FMK 是一种细胞渗透性的caspase-4抑制剂。 Z-LEVD-FMK 阻断 ER 应激诱导的癌细胞凋亡。
T36341 Ac-DNLD-AMC

Ac-DNLD-AMC is a fluorogenic caspase-3 substrate. Upon enzymatic cleavage by caspase-3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-3 activity. AMC displays excitation/emission maxima of 340-360 and 440-460 nm, respectively.
T36342 Ac-LEHD-AMC (trifluoroacetate salt)

Others Others
Ac-LEHD-AMC is a fluorogenic substrate for caspase-9.[1] Upon cleavage by caspase-9, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-9 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
T80536 Ac-AAVALLPAVLLALLAP-LEVD-CHO

Caspase Apoptosis; Proteases/Proteasome
Ac-AAVALLPAVLLALLAP-LEVD-CHO是一caspase-4抑制剂,可穿透细胞膜,并表现出抗肿瘤特性。
T37417 Z-LLE-AMC

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.
T80537 Ac-AAVALLPAVLLALLAP-LEHD-CHO

Caspase Apoptosis; Proteases/Proteasome
Ac-AAVALLPAVLLALLAP-LEHD-CHO 是半胱天冬酶4、5和9的抑制剂,能够对Neocarzinostatin处理的MCF-7细胞展现保护效果。
T36346 Ac-VEID-AMC (ammonium acetate salt)

Others Others
Ac-VEID-AMC is a fluorogenic substrate based on the caspase-6 cleavage site in lamin A at amino acids VEID during apoptosis.1It has also been reported to be cleaved by related proteases, including caspase-8.2Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. 1.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9...
T60583 CDK1/2/4-IN-1

Others Others
CDK1/2/4-IN-1 (compound 3a) 是 CDK 的有效抑制剂, 其对于 CDK1、CDK2 和 CDK4 的 IC50值分别为 1.47、0.78 和 0.87 μM。CDK1/2/4-IN-1 可用于癌症研究。CDK1/2/4-IN-1 可将细胞周期阻滞在 G2/M 期并诱导细胞凋亡。CDK1/2/4-IN-1 提高 Bax、caspase-3和 P53 的水平并降低 Bcl-2 水平。
T71852 Lig4-4

Others Others
Lig4-4 is a TREK-1 current inhibitor (IC50 = 2.06 μM) that has demonstrated potential for use as a protective agent against cerebral ischemia. It has been postulated that the neuroprotective effects of Lig4-4 against cerebral ischemia may be attributed to the modulation of Bcl-2 and cleaved-caspase-3 expression, leading to the inhibition of neuronal apoptosis.
T39909 XZ739

XZ739

PROTACs PROTAC
XZ739 is a Cereblon-dependent PROTAC BCL-XL degrader, targeting a member of the Bcl-2 family, with a DC50 value of 2.5 nM in MOLT-4 cells after 16 hours of treatment. Additionally, XZ739 elicits cell death via caspase-mediated apoptosis.
T25032 ALC67

ALC-67,ALC 67

Others Others
ALC67 has a promising anticancer activity that results in the recent discovery of a series of 3-propionyl thiazolidine-4-carboxylic acid ethyl esters as a family of novel antiproliferative agents. It is an activator of the caspase-9 involved apoptotic pat
T62814 Antitumor agent-77

Others Others
Antitumor agent-77 对癌细胞的生长和迁移具有抑制作用,具有抗癌作用。Antitumor agent-77 能够抑制 GPx-4 和提高 COX2 引发铁下垂。Antitumor agent-77 可以激活肿瘤细胞固有凋亡通路 (Bax-Bcl-2-caspase-3),阻碍肿瘤细胞上皮间质转化 (EMT) 过程。
T81579 P2X7 receptor antagonist-4

Others Others
P2X7 receptor antagonist-4(Compound 14a)是一种选择性P2X7R拮抗剂,其对人类和小鼠P2X7R的IC50值分别为64.7 nM和10.1 nM。该化合物能有效抑制NLRP3炎性体的激活,并在脓毒症模型小鼠中减少肾损伤,降低caspase-1、gasdermin D、IL-1β和IL-18的表达。
T69200 CGP74514A

Others Others
CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...
T63768 Antitumor agent-78

Others Others
Antitumor agent-78 能够抑制 GPx-4 和升高 COX2 ,进而导致铁下垂 (ferroptosis)。Antitumor agent-78 可以激活肿瘤细胞固有凋亡通路 (Bax-Bcl-2-caspase-3),抑制肿瘤细胞上皮间质转化 (EMT) 过程。Antitumor agent-78 表现出抗肿瘤效果,并能够抑制癌细胞的生长和迁移。
T21978 p-nitro-Pifithrin-α

Others Others
p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].
T37861 Talabostat

Others Others
Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...

化合物

Z-YVAD-FMK
Cat.No: TP1466
Synonym:
Target: Caspase
EF24
Cat.No: T27242
Synonym: EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
Target: ERK, MEK, Caspase
Ac-DEVD-AMC
Cat.No: T18909
Synonym: AC-ASP-MET-GLN-ASP-AMC,AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN
Target: Caspase
PDK4-IN-1 hydrochloride
Cat.No: T12412L
Synonym:
Target: Apoptosis, PDK
Ac-FLTD-CMK
Cat.No: T36819
Synonym:
Target: Caspase
JC2-11
Cat.No: T77579
Synonym:
Target: IL Receptor, Dehydrogenase, ROS, Caspase, NOD-like Receptor (NLR), AIM2
Talampanel
Cat.No: T16977
Synonym: GYKI-53773,LY-300164
Target: Apoptosis, GluR
Belnacasan
Cat.No: T6090
Synonym: VX-765
Target: Caspase
Diclofenac diethylamine
Cat.No: T0432
Synonym:
Target: Apoptosis, COX
Terfenadine
Cat.No: T1266
Synonym: (±)-Terfenadine,特非那定,MDL-991
Target: Apoptosis, Potassium Channel, 5-HT Receptor, Caspase, Na+/Ca2+ Exchanger, HER, AChR, Histamine Receptor
Diclofenac sodium
Cat.No: T1555
Synonym: GP 45840,双氯芬酸钠
Target: Apoptosis, COX
Diclofenac Potassium
Cat.No: T6470
Synonym: 双氯芬酸钾,CGP-45840B,Cataflam,Voltfast
Target: Apoptosis, Others, COX
Diclofenac
Cat.No: T0196
Synonym: 双氯芬酸,奥尔芬,Diclofenacum,Voltaren
Target: Apoptosis, COX
Z-LEED-FMK
Cat.No: T76665
Synonym:
Target:
Suc-YVAD-AMC (acetate)
Cat.No: T36354
Synonym:
Target: Others
VRT-043198
Cat.No: T69632
Synonym:
Target: Others
Z-VAD-AMC (acetate)
Cat.No: T36334
Synonym:
Target: Others
Z-LEVD-FMK
Cat.No: T73096
Synonym:
Target: Others
Ac-DNLD-AMC
Cat.No: T36341
Synonym:
Target:
Ac-LEHD-AMC (trifluoroacetate salt)
Cat.No: T36342
Synonym:
Target: Others
Ac-AAVALLPAVLLALLAP-LEVD-CHO
Cat.No: T80536
Synonym:
Target: Caspase
Z-LLE-AMC
Cat.No: T37417
Synonym:
Target:
Ac-AAVALLPAVLLALLAP-LEHD-CHO
Cat.No: T80537
Synonym:
Target: Caspase
Ac-VEID-AMC (ammonium acetate salt)
Cat.No: T36346
Synonym:
Target: Others
CDK1/2/4-IN-1
Cat.No: T60583
Synonym:
Target: Others
Lig4-4
Cat.No: T71852
Synonym:
Target: Others
XZ739
Cat.No: T39909
Synonym: XZ739
Target: PROTACs
ALC67
Cat.No: T25032
Synonym: ALC-67,ALC 67
Target: Others
Antitumor agent-77
Cat.No: T62814
Synonym:
Target: Others
P2X7 receptor antagonist-4
Cat.No: T81579
Synonym:
Target: Others
CGP74514A
Cat.No: T69200
Synonym:
Target: Others
Antitumor agent-78
Cat.No: T63768
Synonym:
Target: Others
p-nitro-Pifithrin-α
Cat.No: T21978
Synonym:
Target: Others
Talabostat
Cat.No: T37861
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T8296 5,​7,​4'-​Trimethoxyflavone

5,7,4'-三甲氧基黄酮,芹菜素三甲醚,4',5,7-三甲氧基黄酮,4',5,7-Trimethoxyflavone

Apoptosis; PARP; Caspase Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
5,​7,​4'-​Trimethoxyflavone (4',5,7-Trimethoxyflavone) 是从泰国著名的药用植物 Kaempferia parviflora 中分离出来的一种天然产物。它以浓度依赖性方式显著有效抑制 SNU-16 人胃癌细胞的增殖,诱导细胞凋亡。
T5S1805 5,7-Dihydroxychromone

5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮

Others; Virus Protease; PARP; Caspase; Nrf2 Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome
5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物,通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3,caspase-9以及切割的PARP 表达。
T2S2362 Dehydrocorydaline nitrate

去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。
T5S2358 Dehydrocorydaline

Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine

BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。
T4S0498 Glaucocalyxin A

蓝萼甲素,Wangzaozin B,Leukamenin F

Apoptosis; Akt; Caspase; PI3K Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。
T4S2326 Cornuside

7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

ERK; p38 MAPK; NF-κB; JNK MAPK; NF-κB
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。
T4S2126 Ginkgetin

银杏双黄酮,银杏素

Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。
TN5456 Isoerysenegalensein E

Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the cas
T27305 Fascaplysin chloride

NSC622398,NSC 622398,Fascaplysin,NSC-622398

Others Others
Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells.
T80656 Cannflavin A

Others Others
Cannflavin A,源自大麻(Cannabis sativa L),具备抗癌、神经保护及抗炎活性。该化合物有效抑制Aβ1-42的聚集,并阻断犬尿氨酸-3-单加氧酶(KMO)的活性,进而通过caspase-3裂解途径激活细胞凋亡(apoptosis)。

天然产物

5,​7,​4'-​Trimethoxyflavone
Cat.No: T8296
Synonym: 5,7,4'-三甲氧基黄酮,芹菜素三甲醚,4',5,7-三甲氧基黄酮,4',5,7-Trimethoxyflavone
Target: Apoptosis, PARP, Caspase
5,7-Dihydroxychromone
Cat.No: T5S1805
Synonym: 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮
Target: Others, Virus Protease, PARP, Caspase, Nrf2
Dehydrocorydaline nitrate
Cat.No: T2S2362
Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱
Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy
Dehydrocorydaline
Cat.No: T5S2358
Synonym: Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine
Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy
Glaucocalyxin A
Cat.No: T4S0498
Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F
Target: Apoptosis, Akt, Caspase, PI3K
Cornuside
Cat.No: T4S2326
Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside
Target: ERK, p38 MAPK, NF-κB, JNK
Ginkgetin
Cat.No: T4S2126
Synonym: 银杏双黄酮,银杏素
Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy
Isoerysenegalensein E
Cat.No: TN5456
Synonym:
Target:
Fascaplysin chloride
Cat.No: T27305
Synonym: NSC622398,NSC 622398,Fascaplysin,NSC-622398
Target: Others
Cannflavin A
Cat.No: T80656
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPJ-01256 Caspase-10 Protein, Human, Recombinant (His)

CASP10,FAS-Associated Death Domain Protein Interleukin-1B-Co...

Human E. coli
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca...
TMPH-01738 NLRP1 Protein, Human, Recombinant (GST)

Caspase recruitment domain-containing protein 7,Nuc...

Human E. coli
NLRP1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 42.9 kDa and the accession number is Q9C000.
TMPJ-00358 DR6 Protein, Mouse, Recombinant (hFc & His)

BM-018,CD358,DR6,Tnfrsf21,Tumor necrosis factor receptor sup...

Mouse HEK293 Cells
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragm...
TMPY-02831 Caspase-7 Protein, Human, Recombinant (His)

ICE-LAP3,LICE2,MCH3,CASP-7,caspase 7, apoptosis-rel...

Human E. coli
Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are r...
TMPY-00749 FGF-2 Protein, Human, Recombinant

fibroblast growth factor 2 (basic),FGF-2,FGFB,HBGF-2,BFGF

Human E. coli
FGF-2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.5 kDa and the accession number is P09038-4.
TMPJ-00864 VEGF165 Protein, Human, Recombinant

Vascular Endothelial Growth Factor Isoform 165,血管内皮生长因子,VEGF...

Human HEK293 Cells
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul...
TMPK-00823 VEGF165 Protein, Human, Recombinant (His & Avi)

血管内皮生长因子,RP1-261G23.1,MVCD1,MGC70609,VEGFA,VEGFMGC70609,VPF,...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
TMPK-00952 CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc)

BILL-cadherin,Cadherin-17,LI-cadherin,CDH16,cadherin-16,Cdh1...

Human HEK293 Cells
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc) is exp...
TMPY-04911 VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated

vascular endothelial growth factor A,血管内皮生长因子

Human,Cynomolgus HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.1 kDa and the accession number is P15692-4.
TMPY-02893 NT5C3A/NT5C3 Protein, Human, Recombinant

P5N1,P5N-1,hUMP1,NT5C3,cN-III,PSN1,UMPH1,UMPH,POMP,5'-nucleo...

Human E. coli
NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but...
TMPK-00424 CD45 Protein, Human, Recombinant (His & Avi), Biotinylated

LCA,LY5,EC 3.1.3.48,CD45,L-CA,T200,CD4...

Human HEK293 Cells
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi...
TMPK-00822 VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled

RP1-261G23.1,VEGFA,MGC70609,VEGF,VEGFMGC70609,VPF,VAS,MVCD1,...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
TMPY-05598 Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated

SIGLEC2,SIGLEC-2,CD22 molecule

Human HEK293 Cells
Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 103.7 kDa and the accession number is P20273-4.
TMPY-04471 APEG1 Protein, Human, Recombinant (His)

SPEG complex locus,BPEG,SPEGalpha,SPEGβ,APEG-1,SPEGbeta,APEG...

Human E. coli
Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein that belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG / APEG-1 contains two fibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform 1 of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 of SPEG is predominantly expre...
TMPJ-01333 TEM8/ANTXR1 Protein, Human, Recombinant (His)

ATR,ANTXR1,TEM8,Tumor Endothelial Marker 8,Anthrax Toxin Rec...

Human HEK293 Cells
Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothelial cells. ANTXR1 plays a role in cell attachment and migration. ANTXR1 interacts with extracellular matrix proteins and the actin cytoskeleton, it mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It ...
TMPK-00423 CD45 Protein, Human, Recombinant (His & Avi)

CD45R,LY5,EC 3.1.3.48,B220,CD45,T...

Human HEK293 Cells
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi...
TMPY-04754 CASK Protein, Human, Recombinant

CMG,LIN2,MRXSNA,CAMGUK,calcium/calmodulin-dependent serine p...

Human Baculovirus Insect Cells
CASK Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 102.1 kDa and the accession number is O14936-4.
TMPY-00225 CLEC9A Protein, Mouse, Recombinant (hFc)

C-type lectin domain family 9, member A,9830005G06Rik,DNGR-1

Mouse HEK293 Cells
CLEC9A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.1 kDa and the accession number is Q8BRU4-4.
TMPY-01117 MRAP Protein, Human, Recombinant (hFc)

FALP,FGD2,melanocortin 2 receptor accessory protein,GCCD2,B2...

Human HEK293 Cells
MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain, has a unique structure, an antiparallel homodimer. MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. MRAP is highly expressed in the adrenal gland and is essential for adrenocorticotropin hormone (ACTH) rece...
TMPJ-00782 Amyloid Precursor Protein, Human, Recombinant (hFc)

Amyloid Precursor,Amyloid Precursor Protein 695,APP695

Human HEK293 Cells
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Of the three major splice isoforms of APP (APP695, APP751, and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective process...
TMPJ-00233 CD200R1/CRTR2 Protein, Human, Recombinant (His)

Cell Surface Glycoprotein CD200 Receptor 1,OX2R,MOX2R,CD200 ...

Human HEK293 Cells
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytopla...
TMPY-01823 PTK9 Protein, Human, Recombinant

MGC41876,twinfilin actin binding protein 1,A6,MGC23...

Human E. coli
PTK9 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 29 kDa and the accession number is Q12792-4.
TMPY-01033 IL-32 Protein, Human, Recombinant (isoform alpha, His)

IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform...

Human HEK293 Cells
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,...
TMPY-00119 FLT1 Protein, Human, Recombinant (hFc)

VEGFR1,VEGFR-1,fms-related tyrosine kinase 1,FLT-1,FLT

Human HEK293 Cells
FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is P17948-4.
TMPK-00702 ANTXR2 Protein, Human, Recombinant (His)

cI-35,Antxr2,JHS,CMG-2,CMG2,JHF,HFS,ISH

Human HEK293 Cells
The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2),ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultured in vitro. ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds.
TMPY-04565 SRPK3 Protein, Human, Recombinant (His & GST)

MSSK1,MGC102944,STK23,MSSK-1,SRSF protein ...

Human Baculovirus Insect Cells
Serine / threonine-protein kinase SRPK3, also known as Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, SR-protein-specific kinase 3, Serine / threonine-protein kinase 23, MSSK-1, SRPK3 and MSSK1, is a member of the protein kinase superfamily and CMGC Ser / Thr protein kinase family. SRPK3 is a protein kinase belonging to serine/arginine protein kinases (SRPK) family, which phosphorylates serine / arginine repeat-containing proteins, and is controlled by a muscle-...
TMPY-04563 CASK Protein, Human, Recombinant (His & GST)

calcium/calmodulin-dependent serine protein kinase (MAGUK fa...

Human Baculovirus Insect Cells
CASK Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 130 kDa and the accession number is O14936-4.
TMPY-01822 PTK9 Protein, Human, Recombinant (His & GST)

PTK9,MGC41876,A6,MGC23788,twinfilin actin binding p...

Human E. coli
PTK9 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 57 kDa and the accession number is Q12792-4.
TMPY-01933 CHI3L2 Protein, Human, Recombinant (His)

YKL-39,CHIL2,chitinase 3 like 2,YKL39

Human HEK293 Cells
Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in b...
TMPY-00380 ANTXR2 Protein, Human, Recombinant (hFc)

HFS,JHF,anthrax toxin receptor 2,ISH,CMG-2,CMG2

Human HEK293 Cells
ANTXR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.4 kDa and the accession number is P58335-4.
TMPY-00711 CD45 Protein, Human, Recombinant (hFc)

GP180,L-CA,LY5,T200,protein tyrosine phosphatase, receptor t...

Human HEK293 Cells
CD45 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.1 kDa and the accession number is P08575-4.
TMPJ-00410 CD45R0 Protein, Human, Recombinant (His)

CD45 antigen,L-CA,protein tyrosine phosphatase, rec...

Human HEK293 Cells
CD45R0 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 80-120 KDa and the accession number is P08575-4.
TMPJ-01188 CORO6 Protein, Human, Recombinant (His)

Coronin-6,Clipin-E,CORO6

Human E. coli
Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is promin...
TMPK-01362 SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated

MYD1,SIRP α V4,PTPNS1,BIT,SHPS1,SIRP alpha,SHPS-1,S...

Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...
TMPK-01356 SIRP alpha V4 Protein, Human, Recombinant (His & Avi)

BIT,SIRP α V4,MFR,SHPS1,SIRPA,SIRP α,P84,M...

Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-Hi...

重组蛋白

Caspase-10 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01256
Species: Human
Expression System: E. coli
NLRP1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-01738
Species: Human
Expression System: E. coli
DR6 Protein, Mouse, Recombinant (hFc & His)
Cat.No: TMPJ-00358
Species: Mouse
Expression System: HEK293 Cells
Caspase-7 Protein, Human, Recombinant (His)
Cat.No: TMPY-02831
Species: Human
Expression System: E. coli
FGF-2 Protein, Human, Recombinant
Cat.No: TMPY-00749
Species: Human
Expression System: E. coli
VEGF165 Protein, Human, Recombinant
Cat.No: TMPJ-00864
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00823
Species: Human
Expression System: HEK293 Cells
CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc)
Cat.No: TMPK-00952
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-04911
Species: Human,Cynomolgus
Expression System: HEK293 Cells
NT5C3A/NT5C3 Protein, Human, Recombinant
Cat.No: TMPY-02893
Species: Human
Expression System: E. coli
CD45 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00424
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled
Cat.No: TMPK-00822
Species: Human
Expression System: HEK293 Cells
Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPY-05598
Species: Human
Expression System: HEK293 Cells
APEG1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04471
Species: Human
Expression System: E. coli
TEM8/ANTXR1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01333
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00423
Species: Human
Expression System: HEK293 Cells
CASK Protein, Human, Recombinant
Cat.No: TMPY-04754
Species: Human
Expression System: Baculovirus Insect Cells
CLEC9A Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-00225
Species: Mouse
Expression System: HEK293 Cells
MRAP Protein, Human, Recombinant (hFc)
Cat.No: TMPY-01117
Species: Human
Expression System: HEK293 Cells
Amyloid Precursor Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00782
Species: Human
Expression System: HEK293 Cells
CD200R1/CRTR2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00233
Species: Human
Expression System: HEK293 Cells
PTK9 Protein, Human, Recombinant
Cat.No: TMPY-01823
Species: Human
Expression System: E. coli
IL-32 Protein, Human, Recombinant (isoform alpha, His)
Cat.No: TMPY-01033
Species: Human
Expression System: HEK293 Cells
FLT1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00119
Species: Human
Expression System: HEK293 Cells
ANTXR2 Protein, Human, Recombinant (His)
Cat.No: TMPK-00702
Species: Human
Expression System: HEK293 Cells
SRPK3 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04565
Species: Human
Expression System: Baculovirus Insect Cells
CASK Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04563
Species: Human
Expression System: Baculovirus Insect Cells
PTK9 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-01822
Species: Human
Expression System: E. coli
CHI3L2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01933
Species: Human
Expression System: HEK293 Cells
ANTXR2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00380
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00711
Species: Human
Expression System: HEK293 Cells
CD45R0 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00410
Species: Human
Expression System: HEK293 Cells
CORO6 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01188
Species: Human
Expression System: E. coli
SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01362
Species: Human
Expression System: HEK293 Cells
SIRP alpha V4 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-01356
Species: Human
Expression System: HEK293 Cells
Cat. No. Product Name Target Signaling Pathways
TMIJ-0127 Diclofenac-d4

Diclofenac-d4 是 Diclofenac 的氘代化合物。Diclofenac 的 CAS 号为 15307-86-5。Diclofenac 是一种具有抗炎活性的非甾体苯乙酸衍生物,是COX抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。

同位素标记化合物

Diclofenac-d4
Cat.No: TMIJ-0127
Synonym:
Target:
TargetMol Loading
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