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Cat. No. | Product Name | ||
---|---|---|---|
L8720 | 细胞焦亡化合物库 | 1066 compounds | |
1066 种细胞焦亡相关的化合物,可以用于细胞焦亡相关研究。 | |||
L9700 | 内质网应激化合物库 | 193 compounds | |
193 个内质网应激相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6005 |
Z-DEVD-FMK
Caspase-3 Inhibitor |
Caspase | Apoptosis; Proteases/Proteasome |
Z-DEVD-FMK (Caspase-3 Inhibitor) 是一种 Caspase-3 抑制剂 (IC50=18 μM),具有选择性、不可逆性和细胞渗透性。Z-DEVD-FMK 可以抑制 Caspase 激活诱导的细胞凋亡。 | |||
T11696 |
Ivachtin
Caspase-3 Inhibitor VII |
Caspase | Apoptosis; Proteases/Proteasome |
Ivachtin (Caspase-3 Inhibitor VII) 是一种非肽,非竞争性和可逆的caspase-3抑制剂,IC50为 23 nM。它是其余胱天蛋白酶的适度抑制剂。 | |||
T21871 |
MMPSI
Caspase-3/7 Inhibitor I |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
MMPSI (Caspase-3/7 Inhibitor I) 是一种新型的、非肽类的小分子 caspase 3 和 caspase 7 抑制剂,可减少离体兔心脏或心肌细胞缺血性损伤的作用,以浓度依赖性方式抑制 H16c2 细胞凋亡 。MMPSI 可用于研究心脏保护和心肌损伤。 | |||
T7020 |
Z-VAD-FMK
Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD |
Caspase | Apoptosis; Proteases/Proteasome |
Z-VAD-FMK (Caspase Inhibitor VI) 是一种 caspase 的广谱抑制剂。Z-VAD-FMK 可以与活化的 caspase 结合,从而抑制细胞凋亡。Z-VAD-FMK即使在高达 440μM 的浓度下也不会抑制 UCHL1 的活性。 | |||
T7019 |
Z-IETD-FMK
Z-IE(OMe)TD(OMe)-FMK,Caspase-8 Inhibitor |
Caspase | Apoptosis; Proteases/Proteasome |
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) 是一种选择性 caspase 8 抑制剂,具有细胞渗透性。它也是颗粒酶 B 抑制剂。 | |||
T36347 |
Ac-YVAD-CMK
Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK |
IL Receptor; Caspase; Immunology/Inflammation related; Pyroptosis | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) 是一种选择性的、不可逆的Caspase-1抑制剂,并能抑制焦亡作用、IL-1β和IL-18。Ac-YVAD-CMK 显示出神经保护和抗炎的能力。 | |||
T70650 |
Caspase-6-IN-1
|
Others | Others |
Caspase-6-IN-1 is a novel Allosteric Inhibitor of Caspase-6 Activation, blocking the interaction between C6 and mHTT1-586. | |||
T72281 |
Caspase-9 Inhibitor III
Ac-LEHD-cmk |
Others | Others |
Caspase-9 Inhibitor III (Ac-LEHD-cmk) 是一种 caspase-9抑制剂。Caspase-9 Inhibitor III 对局部缺血-重新灌注诱导的心肌损伤表现出保护作用。 | |||
T63479 |
Caspase-3-IN-1
|
Others | Others |
Caspase-3-IN-1 是 Caspase-3 的有效抑制剂 (IC50: 14.5 nM)。 | |||
TP1466 |
Z-YVAD-FMK
|
Caspase | Apoptosis; Proteases/Proteasome |
Z-YVAD-FMK 是一种不可逆的 caspase-1 抑制剂,具有抗炎和抗肿瘤活性。 | |||
T79743 |
Caspase-3 activator 1
|
Pyroptosis | Apoptosis; Immunology/Inflammation |
Caspase-3 activator 1 (compound 4b) 是一种Ru(III)金属复合物,它能够有效抑制胃肿瘤细胞的生长与转移。该化合物通过介导caspase-3的活化而促进GSDME的裂解,产生GSDME-N末端,导致胃肿瘤细胞发生膜穿孔。Caspase-3 activator 1还能诱导焦亡及其引发的免疫应答,并可与地西他滨(DCT)构建成4b-DCT-Lip脂质纳米粒子,用于高效药物递送。 | |||
T76571 |
Caspase-8-IN-1
|
||
Caspase-8-IN-1 是一种有效的caspase-8抑制剂。 | |||
T82774 |
Caspase-3 activator 3
|
Caspase | Apoptosis; Proteases/Proteasome |
Caspase-3 activator 3 (compound 2h) 通过激活caspase 3诱导HL-60和K562细胞apoptosis,表现出抗白血病活性。其对HL-60细胞的IC50值为42.89 μM,对K562细胞的IC50值为33.61 μM。 | |||
T82775 |
Caspase-3 activator 2
|
Caspase | Apoptosis; Proteases/Proteasome |
Caspase-3 activator 2 (Compound 2f) 是诱导细胞凋亡的caspase 3激活剂,适用于癌症研究。该化合物对 HL-60 细胞和 K562 细胞展示出细胞毒性,IC50 值分别为 33.52 μM 和 76.90 μM。 | |||
T72315 |
Caspase-3/7 activator 2
|
Others | Others |
Caspase-3/7 activator 2 是一种有效的 Caspase-3/7激活剂。Caspase-3/7 activator 2 具有肿瘤选择性、抗增殖活性和高诱导凋亡 (Apoptosis) 能力。 | |||
T72316 |
Caspase-3/7 activator 3
|
Others | Others |
Caspase-3/7 activator 3 是一种有效的 Caspase-3/7激活剂。Caspase-3/7 activator 3 具有肿瘤选择性、抗增殖活性和高诱导凋亡 (Apoptosis) 能力。 | |||
T83963 |
Z-DEVD-FMK Caspase-3 Inhibitor
|
Others | Others |
Z-DEVD-FMK Caspase-3 Inhibitor 是一种可渗透细胞膜的、不可逆的 caspase-3/CPP32 抑制剂,能够抑制肿瘤细胞的凋亡。在动物体内,它在大鼠发作后的海马区具有神经保护作用,且显著减少创伤后的细胞凋亡,并在诱发的大鼠创伤性脑损伤之前和之后改善神经学恢复情况。 | |||
TQ0146L |
Ac-DEVD-CHO acetate
Caspase-3 Inhibitor I,N-acetyl-asp-glu-val-asp-al,Ac-DEVD-CHO acetate (169332-60-9 free base),乙酰基-天冬氨酰-谷氨酰-缬氨酰-天冬氨醛 |
Caspase | Apoptosis; Proteases/Proteasome |
Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) 是 Caspase-3 的特异性抑制剂。 | |||
T7374 |
2-HBA
|
Caspase; NADPH | Apoptosis; Metabolism; Proteases/Proteasome |
2-HBA 是姜黄素的合成类似物,是通过 Keap1-Nrf2-ARE 途径催化解毒反应的酶的间接诱导剂。 | |||
T10580 |
BOC-D-FMK
|
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Boc-D-FMK 是一种可渗透细胞,不可逆的泛半胱天冬酶抑制剂。它抑制 TNF-α 诱导的细胞凋亡的IC50值为 39 µM。 | |||
T10384 |
Farudodstat
ASLAN003 |
Apoptosis; Dehydrogenase; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Farudodstat (ASLAN003) 是一种具有口服活性的二氢乳清酸脱氢酶 (DHODH) 抑制剂,对人 DHODH 酶的IC50为 35 nM。它通过激活 AP-1 转录因子来抑制蛋白质合成,可以诱导凋亡,并在急性髓样白血病异种移植小鼠中大大延长其生存期。 | |||
T1724 |
SCR7 pyrazine
SCR7,SCR7 吡嗪 |
Apoptosis; DNA/RNA Synthesis; CRISPR/Cas9 | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
SCR7 pyrazine (SCR7) 是一种 DNA 连接酶 IV 抑制剂,以连接酶 IV 依赖的方式阻断非同源末端连接。它也是 CRISPR/Cas9的增强子,可提高 Cas9 介导的同源性定向修复的效率。它诱导细胞凋亡,具有抗癌活性。 | |||
T6090 |
Belnacasan
VX-765 |
Caspase | Apoptosis; Proteases/Proteasome |
Belnacasan (VX-765) 是一种 IL 转换酶 (ICE)/caspase-1 抑制剂,是 VRT-043198 的口服生物活性前药。Belnacasan 可以修饰 Caspase-1 的活性位点并导致 Caspase-1 阻断,从而与动物模型中炎症疾病的组织保护相关。 | |||
T3103 |
L67
DNA Ligase Inhibitor |
DNA; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
L67 (DNA Ligase Inhibitor) 是一种竞争性人类 DNA 连接酶抑制剂,抑制 DNA 连接酶 I 和 III,IC50为10μM。 | |||
T9118 |
KEA1-97
|
Apoptosis; Others; Caspase | Apoptosis; Others; Proteases/Proteasome |
KEA1-97 是一种选择性硫氧还蛋白-半胱天冬酶 3相互作用干扰剂,IC50为10 μM。它在不影响硫氧还蛋白活性的情况下, 破坏硫氧还蛋白与 caspase 3 的相互作用,激活半胱天冬酶,诱导细胞凋亡。 | |||
T16104 |
ML-9
|
Myosin; Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
ML-9 是 Akt 激酶的一种选择性强效抑制剂,可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子1(STIM1) 活性。它通过刺激自噬小体的形成并抑制其降解来诱导自噬。它抑制 MLCK,PKA 和 PKC 活性,Ki 值分别为 4、32 和 54 μM。 | |||
T6993 |
Tauroursodeoxycholate sodium
牛磺熊脱氧胆酸钠,Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,牛磺熊去氧胆酸钠,Sodium Tauroursodeoxycholate (TUDC) |
Apoptosis; ERK; Caspase | Apoptosis; MAPK; Proteases/Proteasome |
Tauroursodeoxycholate sodium (TUDC) 是一种内质网应激抑制剂。Tauroursodeoxycholate sodium (TUDC) 抑制ERK,显著降低凋亡分子表达,如caspase-3和caspase-12。 | |||
T22119 |
NS3694
|
Apoptosis | Apoptosis |
NS3694 是一种凋亡抑制剂,可抑制凋亡小体形成和半胱天冬酶活化。 | |||
T1979 |
AVN-944
VX-944 |
Dehydrogenase | Metabolism |
AVN-944 (VX-944) 是一种选择性的、非竞争性 IMPDH 抑制剂,对IMPDH1和IMPDH2的Ki=为6-10nM。 | |||
T2065 |
Bioymifi
DR5 Activator |
Apoptosis; TNF | Apoptosis |
Bioymifi (DR5 Activator) 是一种 TRAIL 受体DR5激活剂,与DR5的胞外结构域结合,Kd 为 1.2 μM,它可诱导 DR5 聚集,导致细胞凋亡。 | |||
T0432 |
Diclofenac diethylamine
|
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Diclofenac diethylamine 是非选择性抗炎剂,通过活化 caspase 级联反应来诱导神经干细胞凋亡。它是一种COX 抑制剂,在 CHO 细胞中,对人COX-1和COX-2的IC50值分别为 4 和 1.3 nM。它对绵羊COX-1和COX-2的IC50值分别为 5.1 μM 和0.84 μM。 | |||
T0300 |
Pargyline
Pargylamine,Paragyline,优降宁 |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Pargyline (Pargylamine) 是不可逆的单胺氧化酶抑制剂,对MAO-A 和MAO-B 的Ki 分别为 13 μM 和 0.5 μM,具有降压和抗癌作用。 | |||
T0282 |
Q-VD-OPH
Quinoline-Val-Asp-Difluorophenoxymethylketone |
Caspase; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Q-VD-OPH (Quinoline-Val-Asp-Difluorophenoxymethylketone) 是一种具有强效抗凋亡特性的泛半胱天冬酶抑制剂。它可抑制 HIV 感染,能透过血脑屏障。 | |||
T6258 |
Zibotentan
ZD4054 |
Apoptosis; Endothelin Receptor | Apoptosis; GPCR/G Protein |
Zibotentan (ZD4054) 是一种选择性的,具有口服活性的内皮素 A (ETA) 受体拮抗剂,Ki 为 13 nM。它具有抗癌作用,可研究去势抵抗性前列腺癌。 | |||
T6738 |
Z-FA-FMK
|
SARS-CoV; Cysteine Protease | Microbiology/Virology; Proteases/Proteasome |
Z-FA-FMK 是一种广谱的卤代甲基酮抑制剂,可抑制冠状病毒蛋白酶3CL,Ki 为 25.7 μM。它可以不可逆地抑制半胱氨酸蛋白酶,也可以抑制效应半胱天冬酶。 | |||
T8478 |
SC-43
|
Apoptosis; Phosphatase; STAT | Apoptosis; JAK/STAT signaling; Metabolism; Stem Cells |
SC-43 是一种具有口服活性的SHP-1 (PTPN6)激动剂。它是Sorafenib 的衍生物,可抑制STAT3的磷酸化并诱导细胞凋亡,具有抗纤维化和抗癌作用。 | |||
T17011 |
TCH-165
|
Proteasome | Proteases/Proteasome; Ubiquitination |
TCH-165 是一种蛋白酶体组装的小分子调节剂,可增加游离 20S 水平,进而增强 IDP 蛋白水解。 | |||
T16522 |
Phenoxodiol
脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E |
Apoptosis; IAP; Caspase; Topoisomerase; p53 | Apoptosis; DNA Damage/DNA Repair; Proteases/Proteasome |
Phenoxodiol (Idronoxil) 是合成genestein 的类似物,激活线粒体caspase 系统,抑制XIAP,使癌细胞对fas 介导的凋亡敏感。它在细胞周期的G1/S 期诱导细胞周期阻滞,通过独立于p53的方式上调p21WAF1。它通过稳定可分裂复合物抑制DNA 拓扑异构酶II,从而阻止DNA 复制。 | |||
T15771 |
Lobaplatin
D-19466,络铂 |
DNA Alkylation | DNA Damage/DNA Repair |
Lobaplatin (D-19466) 是一种铂 (II) 复合物的非对映混合物,是一种有前途的抗肿瘤化疗药物,在多种肿瘤类型的患者中具有活性。 | |||
T5104 |
BTSA1
|
Apoptosis; BCL | Apoptosis |
BTSA1 是一种有口服活性的 BAX 激活剂,IC50为 250 nM,EC50为 144 nM。它以高亲和力和特异性与 N 末端激活位点结合,并诱导 BAX 发生构象变化,从而导致BAX 介导的细胞凋亡。 | |||
T1578 |
Pargyline hydrochloride
优降宁盐酸盐,Pargylamine hydrochloride |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Pargyline hydrochloride (Pargylamine hydrochloride) 是不可逆的单胺氧化酶抑制剂,可作用于 MAO-A (Ki=13 μM) 和 MAO-B (Ki=0.5 μM) ,具有降压和抗癌作用。 | |||
T6761 |
Ossirene
AS101 |
IL Receptor; Caspase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Ossirene (AS101) 是一种免疫调节抑制剂,是一种新型 IL-1beta 转化酶抑制剂,可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化,有效抑制Caspase-1。 | |||
T1266 |
Terfenadine
(±)-Terfenadine,特非那定,MDL-991 |
Apoptosis; Potassium Channel; 5-HT Receptor; Caspase; Na+/Ca2+ Exchanger; HER; AChR; Histamine Receptor | Angiogenesis; Apoptosis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Terfenadine ((±)-Terfenadine) 是一种hERG 开放通道抑制剂,IC50为 204 nM。它也是一种 H1 组胺受体拮抗剂,通过调节Ca2+稳态在黑素瘤细胞中起到有效的细胞凋亡诱导作用。 Terfenadine 诱导 ROS 依赖性细胞凋亡,同时激活Caspase-4,-2,-9。 | |||
T11793 |
KY-05009
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
KY-05009 是 ATP 竞争性的、有效的 TNIK 抑制剂,Ki 为 100 nM。KY-05009抑制人肺腺癌细胞中 TGF-β1 诱导的上皮-间质转化。KY-05009 还抑制TNIK 的蛋白表达和Wnt 靶基因的转录活性,并诱导癌细胞凋亡,显示抗癌活性。 | |||
T0196 |
Diclofenac
双氯芬酸,奥尔芬,Diclofenacum,Voltaren |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Diclofenac (Diclofenacum) 是一种具有抗炎活性的非甾体苯乙酸衍生物,是 COX 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。 | |||
T0859 |
Fenbufen
芬布芬,CL-82204,Lederfen |
ATPase; Caspase; COX | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome |
Fenbufen (Lederfen) 是一种非甾体抗炎药,主要用于治疗骨关节炎、强直性脊柱炎和肌腱炎的炎症。它还可用于缓解背痛、扭伤和骨折,具有 caspases 的抑制活性。它对 COX-1和 COX-2具有抑制活性,其 IC50分别为 3.9 μM 和 8.1 μM。 | |||
T38562 |
AKN-028
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
AKN-028 是酪氨酸激酶 FLT3的抑制剂,可剂量依赖性的诱导 FLT3的自磷酸化。 | |||
T2503 |
PAC-1
Procaspase activating compound 1 |
Apoptosis; Caspase; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome |
PAC-1 (Procaspase activating compound 1) 是一种 procaspase-3激活剂,诱导癌细胞凋亡,EC50为 2.08 μM,可用于研究淋巴瘤、黑色素瘤、实体瘤、乳腺癌和胸癌等治疗的试验。 | |||
T6826 |
Emricasan
PF 03491390,恩利卡生,IDN-6556 |
Influenza Virus; Caspase | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Emricasan (IDN-6556) 是一种泛的 caspase 抑制剂,具有不可逆性。Emricasan 具有抗炎和抗凋亡活性,可以用于治疗感染和肝衰竭等。Emricasan 还可以抑制 Zika 病毒感染。 | |||
T2085 |
PQ401
IGF-1R Inhibitor II |
Apoptosis; IGF-1R | Apoptosis; Tyrosine Kinase/Adaptors |
PQ401 (IGF-1R Inhibitor II) 是一种IGF-IR 抑制剂。在 MCF-7 细胞中,它抑制 IGF-I 刺激的 IGF-IR 自磷酸化,可有效抑制 IGF-I 刺激的 MCF-7 细胞生长。它诱导 caspase 介导的细胞凋亡,有用于乳腺癌和其他对 IGF-I 敏感的癌症的研究潜力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S2076 |
Senkyunolide I
|
Others; Caspase | Apoptosis; Others; Proteases/Proteasome |
Senkyunolide I 是从川芎中分离得到的一种天然产物,具有神经保护作用,与其抗氧化和抗凋亡特性有关。 | |||
T5S2283 |
Sesamolin
|
p38 MAPK; Caspase; JNK | Apoptosis; MAPK; Proteases/Proteasome |
Sesaminol 是从Justicia orbiculata 中分离得到的一种天然产物,抑制脂质过氧化,具有神经保护作用和抗氧化活性。它通过抑制JNK、p38 MAPKs 和caspase-3磷酸化,抑制MAPK 的级联反应。 | |||
T13815 |
Penicillic acid
|
Apoptosis; Caspase; Antibacterial; Antibiotic | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Penicillic acid,一种由多种Aspergillus和Penicillium物种合成的polyketide mycotoxin,通过阻碍caspase-8的自我处理作用,抑制Fas ligand引发的apoptosis。此外,体外研究表明,Penicillic acid在rat alveolar macrophages中显示出cytotoxic特性。 | |||
T2532 |
Tauroursodeoxycholate
Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA |
Apoptosis; ERK; P450; Caspase; Endogenous Metabolite | Apoptosis; MAPK; Metabolism; Proteases/Proteasome |
Tauroursodeoxycholate (UR 906) 是一种天然的高度亲水性的三级胆汁酸。Tauroursodeoxycholate 可用于原发性胆汁性肝硬化 (PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症的研究。 | |||
T9503 |
PHYTOSPHINGOSINE
|
Apoptosis | Apoptosis |
Phytosphingosine 是具有抗癌作用的一种磷脂。在癌细胞中,它通过 caspase 8 的激活和 Bax 转位诱导细胞凋亡。 | |||
T2A2481 |
Taurochenodeoxycholic Acid
Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸 |
Apoptosis; TNF; Caspase; Endogenous Metabolite | Apoptosis; Metabolism; Proteases/Proteasome |
Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一,可诱导细胞凋亡,具有明显的抗炎和免疫调节作用。 | |||
T7982 |
3,6-Dihydroxyflavone
|
Others | Others |
3,6-Dihydroxyflavone 是一种抗癌剂。它能够提高细胞内氧化应激和脂质过氧化。它是能够根据剂量和时间依赖性地降低细胞活力,并活化半胱天冬酶级联、切割聚 (ADP-核糖) 聚合酶 (PARP) 诱导细胞凋亡。 | |||
TN2215 |
Taurochenodeoxycholic acid sodium
牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡,具有抗炎和免疫调节作用。 | |||
T2698 |
Asperosaponin VI
Akebia saponin D,Asperosaponin Ⅵ,川续断皂苷 VI |
Apoptosis; Others; Caspase | Apoptosis; Others; Proteases/Proteasome |
Asperosaponin VI (Akebia saponin D) 是一种来自续断壁的皂苷组分。它通过增加 Bcl-2/Bax 比值,降低活性 caspase-3 表达,以及增强 p-Akt 和 p-CREB,从而抑制缺氧诱导的心肌细胞凋亡。它通过 BMP-2/p38 和 ERK1/2 信号途径诱导成骨细胞分化。 | |||
T3S1227 |
Aristolactam I
Aristolactam,Aristololactam I,马兜铃内酰胺I,Aristololactum |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Aristolactam I (Aristololactum) 是马兜铃酸 I (AA-I) 的主要代谢产物,参与导致肾损伤的过程。它具有细胞毒性,通过诱导半胱天冬酶 3 依赖性途径中的细胞凋亡介导。 | |||
T21936 |
M50054
2,2′-亚甲基双(1,3-环己二酮) |
Caspase | Apoptosis; Proteases/Proteasome |
M50054 是一种有效的细胞凋亡抑制剂,可用于研究抗 Fas 抗体引起的肝炎和化疗引起的脱发。它抑制 Etoposide 诱导的 U937 细胞 caspase-3 活化,IC50为 79 μg/mL。 | |||
T2S0500 |
Ilexsaponin A
毛冬青皂苷A,毛冬青皂苷甲,Ilexsaponin A1 |
Others | Others |
Ilexsaponin A (Ilexsaponin A1)1 是分离自冬凌草的根中,利用抗凋亡途径减轻缺血再灌注引起的心肌损伤。它能够减少心肌梗塞的大小,减少 LDH,AST 和 CK-MB 的血清水平,促进细胞活力并抑制缺氧/复氧心肌细胞的凋亡。 | |||
T5574 |
Guggulsterone
Guggulsterone E&Z,香胶甾酮 |
Apoptosis; FXR; Akt; Caspase; JNK; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Guggulsterone (Guggulsterone E&Z) E&Z 是来自Commiphora wightii 树中树胶脂的植物甾醇。 它通过下调抗细胞凋亡基因产物 ,调节细胞周期蛋白,激活caspases,JNK,抑制Akt,抑制多种肿瘤细胞的生长并诱导细胞凋亡。它是法尼醇 X 受体拮抗剂,可降低 CDCA 诱导的 FXR 活化。 | |||
T5A2461 |
Bufotalin
蟾蜍他灵,Bufotaline,蟾毒它灵,蟾蜍他灵 |
Apoptosis; Others; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Others |
Bufotalin (Bufotaline) 是一种从蟾酥中分离的类固醇内酯,可诱导癌细胞凋亡,也诱导内质网应激的激活,具有强大的抗肿瘤活性。 | |||
TN1405 |
Arnicolide D
山金车内酯 D,山金车内酯D |
Akt; Caspase; PI3K; STAT; mTOR | Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯,以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期,激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。 | |||
T5S2358 |
Dehydrocorydaline
Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
T3384 |
Wedelolactone
蟛蜞菊内酯,IKK Inhibitor II |
Apoptosis; NF-κB; Lipoxygenase; Caspase | Apoptosis; Metabolism; NF-κB; Proteases/Proteasome |
Wedelolactone (IKK Inhibitor II) 是来自旱莲草的一种天然产物,通过阻断 IκBα 的磷酸化和降解来抑制细胞中 NF-κB 介导的基因转录,具有抗癌,抗炎和抗氧化活性。 | |||
T2S2362 |
Dehydrocorydaline nitrate
去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱 |
BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome |
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。 | |||
T10990 |
Dehydrocorydaline chloride
盐酸脱氢紫堇碱,13-Methylpalmatine chloride |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline chloride (13-Methylpalmatine chloride) 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达;激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
T2764 |
(S)-10-Hydroxycamptothecin
10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡,可研究肝癌、胃癌、结肠癌和白血病。 | |||
T1079 |
Metronidazole
Flagyl,Metronidazol,甲硝唑,Anagiardil |
Apoptosis; NADPH; Hydrogenase; Antibacterial; Antibiotic; Parasite; Antifection | Apoptosis; Metabolism; Microbiology/Virology |
Metronidazole (Metronidazol) 是一种合成的硝基咪唑衍生物,一种抗生素和抗原虫剂,具有口服活性和血脑屏障渗透性。Metronidazole 可用于治疗或预防厌氧菌引起的系统或局部感染。 | |||
T5S1805 |
5,7-Dihydroxychromone
5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮 |
Others; Virus Protease; PARP; Caspase; Nrf2 | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome |
5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物,通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3,caspase-9以及切割的PARP 表达。 | |||
T2959 |
Ginsenoside Rh2
20(S)-Rh2,20S-Ginsenoside Rh2,人参皂苷Rh2,20(S)-Ginsenoside Rh2,人参皂苷 Rh2 |
Apoptosis; EGFR; Caspase; Endogenous Metabolite | Angiogenesis; Apoptosis; JAK/STAT signaling; Metabolism; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Ginsenoside Rh2 (20(S)-Ginsenoside Rh2) 诱导caspase-8和caspase-9活化。它以多途径方式诱导癌细胞凋亡。 | |||
TJA2398 |
Taurodeoxycholic acid sodium hydrate
Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt,牛磺猪去氧胆酸 |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate) 通过阻断钙介导的凋亡通路和 Caspase-12的活化来阻止细胞凋亡。它可用于原发性胆汁性肝硬化、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤积和肌萎缩侧索硬化症。 | |||
T1152 |
Albendazole
SKF-62979,阿苯达唑 |
HIF/HIF Prolyl-Hydroxylase; Microtubule Associated; Antibiotic; Parasite | Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Microbiology/Virology |
Albendazole (SKF-62979) 是一种广谱抗寄生虫剂,具有高效,低宿主毒性的特点。 它用于研究人类和动物的胃肠道寄生虫。 | |||
T7727 |
Se-Methylselenocysteine
Se MSC,SeMCys,MSeC,L-硒甲基硒代半胱氨酸,Se-MSC,SeMSC |
BCL; IAP; Caspase | Apoptosis; Proteases/Proteasome |
Se-Methylselenocysteine (Se-MSC) 是具有口服活性的甲基硒前体,具有强大的抗氧化活性和抗癌活性。Se-Methylselenocysteine 可诱导细胞凋亡。 | |||
T8296 |
5,7,4'-Trimethoxyflavone
5,7,4'-三甲氧基黄酮,芹菜素三甲醚,4',5,7-三甲氧基黄酮,4',5,7-Trimethoxyflavone |
Apoptosis; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) 是从泰国著名的药用植物 Kaempferia parviflora 中分离出来的一种天然产物。它以浓度依赖性方式显著有效抑制 SNU-16 人胃癌细胞的增殖,诱导细胞凋亡。 | |||
T5558 |
Chelidonic acid
Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid |
NF-κB; Caspase | Apoptosis; NF-κB; Proteases/Proteasome |
Chelidonic acid (Jervaic acid) 是从白屈菜中分到的酸类物质,用作温和的镇痛剂、抗菌剂和中枢神经系统镇静剂。它是谷氨酸脱羧酶抑制剂,Ki 值为 1.2 μM。它可能通过抑制 NF-κB 和caspase-1来降低 IL-6 的产生抗炎作用。 | |||
T2881 |
Crustecdysone
Commisterone,B-ecdysone,Commisterone,20-Hydroxyecdysone,Ecdysterone,B-ecdysone,β-蜕皮甾酮,Hydroxyecdysone,羟基蜕皮激素 |
Others; Caspase; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism; Others; Proteases/Proteasome |
Crustecdysone (Hydroxyecdysone) 是来源于露水草的一种蜕皮激素,可调节昆虫的蜕皮或蜕皮过程。它是 Ecdysone 的活性代谢物,通过 20E 核受体复合物 EcR-USP 抑制半胱天冬酶活性并诱导自噬,在心血管系统中具有调节或保护作用。 | |||
T2163 |
Dihydrocapsaicin
CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide |
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素,是TRPV1的选择性激动剂,同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。 | |||
T2851 |
Daphnetin
7,8-Dihydroxycoumarin,Daphnetol,瑞香素 |
EGFR; PKA; PKC; Parasite; Autophagy | Angiogenesis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Daphnetin (7,8-Dihydroxycoumarin) 是从 Genus Daphne 中分离得到的香豆素衍生物,有抗氧化、抗炎、抗疟疾和解热作用,可用于凝血功能障碍、类风湿性关节炎等疾病的相关研究。 | |||
TN1086 |
Dehydrotrametenolic acid
Dehydroeburicoic acid,去氢齿孔酸,松苓新酸 |
Apoptosis; TNF; NOS; Caspase; NO Synthase | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Dehydrotrametenolic acid (Dehydroeburicoic acid) 是从茯苓的菌核中分离的一种甾醇,具有抗肿瘤活性、抗炎和抗糖尿病作用。它通过 caspase-3途径诱导细胞凋亡。 | |||
T4085 |
Paris saponin VII
重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII |
Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位,增加凋亡相关蛋白的表达,并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬,可研究白血病。 | |||
T3914 |
Saikosaponin C
柴胡皂苷C,柴胡皂苷 C |
Beta Amyloid; Caspase | Apoptosis; Neuroscience; Proteases/Proteasome |
Saikosaponin C 是一种柴胡中的活性成分,能够抑制 Aβ1-40 和 Aβ1-42 的释放,抑制异常 tau 蛋白的磷酸化,但对 BACE1 的活性和表达无作用。它在阿尔滋海默症中主要靶作用于amyloid beta 和tau 蛋白。 | |||
T8092 |
Taurohyodeoxycholic acid sodium salt
Sodium taurohyodeoxycholate hydrate |
Caspase | Apoptosis; Proteases/Proteasome |
Taurohyodeoxycholic acid sodium salt (Sodium taurohyodeoxycholate hydrate) 通过阻断钙介导的细胞凋亡途径以及 Caspase-12 活化来防止细胞凋亡 | |||
T5S2083 |
Puerarin 6''-O-Xyloside
|
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Puerarin 6''-O-Xyloside 是从葛根中分离得到的一种天然产物,可诱导线粒体介导的细胞凋亡通路,有抗炎和抗癌活性。 | |||
T2S0410 |
Euphorbia factor L1
Euphorbiasteroid,大戟因子L1,大戟因子 L1 |
Apoptosis; P-gp | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
Euphorbia factor L1 (Euphorbiasteroid) 可降低 Bcl-2,PI3K,AKT 和 mTOR 蛋白和 mRNA 水平,上调 caspase-9 and caspase-3 蛋白水平。它可诱导自噬,具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。 | |||
TN1880 |
Lucidenic acid B
Lucidenicacid B |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Lucidenic acid B (Lucidenicacid B) 是从灵芝中提取得到的天然化合物,可诱导caspase-9 和 caspase-3 的活化和 PARP 的裂解,可通过线粒体介导诱导人白血病细胞凋亡 。 Lucidenic acid B通过灭活MAPK / ERK信号转导途径和降低NF-kappaB和AP-1的结合活性来抑制PMA诱导的人肝癌细胞侵袭。。Lucidenic acid B 对细胞周期和坏死细胞没有影响。 | |||
TN2175 |
Salvianolic acid F
丹酚酸F,丹酚酸 F |
Caspase | Apoptosis; Proteases/Proteasome |
The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6. | |||
T3857 |
magnolin
木兰脂素,(+)-Magnolin,木兰苷 |
ERK | MAPK |
Magnolin 是辛夷的一种主要成分,靶向作用于ERK1和ERK2,IC50值分别为 87 和 16.5 nM,可抑制Ras/ERKs/RSK2信号通路。它在体内外降低肾脏氧化应激,抑制 caspase-3 活性,并增加 Bcl-2 表达,具有抗炎和抗氧化作用。 | |||
T3892 |
Isoacteoside
异麦角甾苷,Isoverbascoside |
NF-κB | NF-κB |
Isoacteoside 具有抗炎作用,通过作用于 caspase-1、丝裂原活化蛋白激酶(c-Jun N-末端激酶、p38、细胞外信号调节蛋白激酶)和核因子-kappa B 途径介导。 | |||
T16791 |
Rottlerin
Mallotoxin,NSC 56346,粗糠柴苦素,NSC 94525 |
CaMK; Apoptosis; Others; HIV Protease; PKA; PKC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Neuroscience; Others; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Rottlerin (NSC-56346) 是一种从Mallotus Philippinensis 中得到的天然产物, 是 PKC 的特异性抑制剂,抑制HIV-1整合和狂犬病病毒感染。它通过活化 caspase 3 诱导细胞凋亡. | |||
T3240 |
Citronellol
dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Citronellol ((±)-β-Citronellol) 是一种单萜类化合物,从头状天竺葵中分离到。它可通过上调 TNF-α,RIP1/RIP3 的活性,下调 caspase-3/caspase-8 的活性,以及增加活性氧 (ROS) 的聚集来诱导肿瘤细胞的坏死性凋亡。 | |||
T3S0335 |
Soyasaponin Bb
Soyasaponin I,大豆皂苷Bb |
NF-κB; Caspase | Apoptosis; NF-κB; Proteases/Proteasome |
Soyasaponin Bb (Soyasaponin I) 是一种分离自菜豆科中的大豆皂苷,可用作醛糖还原酶差异抑制剂。 | |||
T4S1335 |
Daphnoretin
Dephnoretin,西瑞香素,Thymelol |
Influenza Virus; Caspase; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome |
Daphnoretin (Thymelol) 是从了哥王中提取得到的一种天然产物,具有抗癌和抗病毒活性。它通过在 G2/M 期连续阻断细胞并激活 caspase-3 通路导致 HOS 细胞死亡。 | |||
T7452 |
2-methoxycinnamaldehyde
2'-甲氧基肉桂醛,O-methoxycinnamaldehyde |
Apoptosis; Others | Apoptosis; Others |
2-methoxycinnamaldehyde 是一种肉桂中的天然产物。它能通过使线粒体膜电位 (ΔΨm) 损失 、激活 caspase-3 和 caspase-9,来抑制细胞增殖和诱导细胞凋亡,具有抗肿瘤活性。它还能抑制血小板衍生生长因子诱导的 HASMC 迁移。 | |||
T75319 |
Taurodeoxycholic acid
Taurodeoxychloic acid |
Apoptosis; Calcium Channel; Caspase | Apoptosis; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome |
Taurodeoxycholic acid (Taurodeoxychloic acid) 是脱氧胆酸的胆汁酸牛磺酸共轭物,是一种人体代谢物,可稳定线粒体膜,减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid具有神经保护活性,可用于研究 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 。 | |||
TN1711 |
Gossypetin
|
Antioxidant; p38 MAPK; MAPK; Antibacterial | MAPK; Microbiology/Virology; oxidation-reduction |
Gossypetin 是一种可从Rhodiola rosea Linn.中提取的六羟基化的类黄酮,是一种有效的 MKK3 和 MKK6 抑制剂,可强烈减弱 MKK3/6-p38 信号传导途径。Gossypetin 具有抗突变、抗动脉粥样硬化、抗氧化以及细胞保护和抗菌作用,它通过下调溶酶体酪蛋白酶 K 的活性和诱导肌动蛋白环破骨细胞中的自噬相关蛋白来抑制骨吸收。 | |||
T6S1597 |
Mulberroside A
桑皮苷 A,桑皮苷A |
TNF; Tyrosinase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Mulberroside A 是桑中的一种主要活性成分,可降低TNF-α、IL-1β和IL-6的表达,抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化 。它抑制蘑菇酪氨酸酶,具有抗炎和抗细胞凋亡作用。 | |||
T3771 |
Methyl protodioscin
山药,Smilax saponin B,NSC-698790 |
Apoptosis | Apoptosis |
Methyl protodioscin (Smilax saponin B) 是一种甾二糖苷,能诱导细胞周期阻滞,具有抗肿瘤活性。 | |||
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Cat. No. | Product Name | Species | Expression System |
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TMPY-01824 |
Caspase-14 Protein, Human, Recombinant (His)
caspase 14, apoptosis-related cysteine peptidase,AR... |
Human | E. coli |
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Casp... | |||
TMPY-02831 |
Caspase-7 Protein, Human, Recombinant (His)
ICE-LAP3,LICE2,MCH3,CASP-7,caspase 7, apoptosis-rel... |
Human | E. coli |
Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are r... | |||
TMPH-01057 |
Caspase-8 Protein, Human, Recombinant (His)
Caspase-8,CAP4,Apoptotic cysteine protease,FLICE,FA... |
Human | E. coli |
Caspase-8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.9 kDa and the accession number is Q14790. | |||
TMPH-01056 |
Caspase-3 Protein, Human, Recombinant (His)
SCA-1,Protein Yama,CASP-3,Cysteine protease CPP32,CPP32,SREB... |
Human | E. coli |
Caspase-3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P42574. | |||
TMPJ-01256 |
Caspase-10 Protein, Human, Recombinant (His)
CASP10,FAS-Associated Death Domain Protein Interleukin-1B-Co... |
Human | E. coli |
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca... | |||
TMPH-01055 |
Caspase-1 Protein, Human, Recombinant (HA)
Interleukin-1 beta convertase,Interleukin-1 beta-converting ... |
Human | E. coli |
Caspase-1 Protein, Human, Recombinant (HA) is expressed in E. coli expression system with C-HA tag. The predicted molecular weight is 11.4 kDa and the accession number is P29466. | |||
TMPH-01236 |
DFFB Protein, Human, Recombinant (His)
DNA fragmentation factor 40 kDa subunit,Caspase-act... |
Human | E. coli |
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. | |||
TMPH-01738 |
NLRP1 Protein, Human, Recombinant (GST)
Caspase recruitment domain-containing protein 7,Nuc... |
Human | E. coli |
NLRP1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 42.9 kDa and the accession number is Q9C000. | |||
TMPH-00289 |
NOD2 Protein, Bovine, Recombinant (His & KSI)
Caspase recruitment domain-containing protein 15,Nu... |
Bovine | E. coli |
NOD2 Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 36.8 kDa and the accession number is Q6E804. | |||
TMPJ-01059 |
CRADD Protein, Human, Recombinant
Caspase and RIP Adapter with Death Domain,RAIDD,RIP... |
Human | E. coli |
Death Domain-Containing Protein CRADD (CRADD) is widely expressed in most tissues, with particularly high expression in the adult heart, testis, liver, skeletal muscle, fetal liver, and kidney. CRADD contains one CARD domain that mediates the interaction with caspase-2, and one death domain involved in the binding of RIP protein. CRADD functions as an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. CRADD induces cell apoptosis/cell death in numero... | |||
TMPH-01315 |
CASR Protein, Human, Recombinant (GST)
CAP4,MCH5,Caspase-8,CASP-8,CASP8,FADD-homologous IC... |
Human | E. coli |
CASR Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 93.6 kDa and the accession number is P41180. | |||
TMPH-00951 |
PYCARD Protein, Human, Recombinant (His & Myc)
Caspase recruitment domain-containing protein 5,PYD... |
Human | HEK293 Cells |
PYCARD Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 26.7 kDa and the accession number is Q9ULZ3. | |||
TMPH-00950 |
PYCARD Protein, Human, Recombinant (E. coli, His & Myc)
Target of methylation-induced silencing 1,PYCARD,Caspase... |
Human | E. coli |
PYCARD Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 29.1 kDa and the accession number is Q9ULZ3. | |||
TMPY-00817 |
Granzyme B/GZMB Protein, Human, Recombinant (His)
CGL1,CTLA1,CSP-B,CTSGL1,HLP,SECT,CSPB,granzyme B (granzyme 2... |
Human | HEK293 Cells |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G... | |||
TMPY-02078 |
HtrA2/Omi Protein, Human, Recombinant (His)
PARK13,OMI,HtrA serine peptidase 2,PRSS25 |
Human | E. coli |
Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor... | |||
TMPY-02700 |
BCL2 Protein, Human, Recombinant (His)
Bcl-2,PPP1R50,B-cell CLL/lymphoma 2 |
Human | E. coli |
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins... | |||
TMPJ-00358 |
DR6 Protein, Mouse, Recombinant (hFc & His)
BM-018,CD358,DR6,Tnfrsf21,Tumor necrosis factor receptor sup... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragm... | |||
TMPY-02213 |
RAIDD Protein, Human, Recombinant (His)
RAIDD,MRT34,CASP2 and RIPK1 domain containing adaptor with d... |
Human | E. coli |
Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the ... | |||
TMPH-02521 |
PYCARD Protein, Mouse, Recombinant (His & Myc)
Pycard,PYD and CARD domain-containing protein,Apoptosis-asso... |
Mouse | E. coli |
Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved ... | |||
TMPJ-00718 |
AIF Protein, Human, Recombinant (His)
AIF,Apoptosis-Inducing Factor 1 Mitochondrial,PDCD8,Programm... |
Human | E. coli |
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces pa... | |||
TMPJ-00697 |
NOL3 Protein, Human, Recombinant (GST)
Nop30,Myp,NOP,Apoptosis Repressor With CARD,Nucleolar Protei... |
Human | E. coli |
Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing.Isoform 2 may inhibit apoptosis.It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. | |||
TMPK-00277 |
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)
TRAIL R2,TNFRSF10B,TRICK2,KILLER,DR5,TRAIL receptor 2,Fas-li... |
Human | HEK293 Cells |
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. | |||
TMPJ-00215 |
Fas/CD95 Protein, Mouse, Recombinant (hFc)
CD95,Apoptosis-mediating surface antigen FAS,TNFRSF6,Fas,Tum... |
Mouse | HEK293 Cells |
Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which... | |||
TMPJ-00696 |
NOL3 Protein, Human, Recombinant
Apoptosis Repressor With CARD,Nucleolar Protein of 30 kDa,Nu... |
Human | E. coli |
Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex ... | |||
TMPY-01775 |
AIM2 Protein, Human, Recombinant (GST)
absent in melanoma 2,PYHIN4 |
Human | Baculovirus Insect Cells |
AIM2, Absent In Melanoma 2 is a member of the interferon-inducible HIN-200 protein family that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytoplasmic DNA by means of its oligonucleotide/oligosaccharide-binding domain and interacts with ASC (apoptosis-associated speck-like protein containing a CARD) through its pyrin domain to activate caspase-1. In response to foreign cytoplasmic DNA, AIM2 forms an inflammasome, resulting... | |||
TMPK-00276 |
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)
ZTNFR9,DR5TRICK2B,DR5,TRAIL receptor 2,TRICKB,TNFRSF10B,TRIC... |
Human | HEK293 Cells |
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. | |||
TMPJ-00770 |
Granzyme B/GZMB Protein, Mouse, Recombinant (His)
Gzmb,Cytotoxic cell protease 1,Fragmentin-2,CTLA-1,Granzyme ... |
Mouse | HEK293 Cells |
Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. | |||
TMPJ-00483 |
DFF45 Protein, Human, Recombinant (His)
DNA Fragmentation Factor Subunit Alpha,DFF45,H13,ICAD,DFFA,D... |
Human | E. coli |
DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression. | |||
TMPY-03572 |
PTRH2 Protein, Human, Recombinant (His)
PTH 2,PTH2,peptidyl-tRNA hydrolase 2,CGI-147,CFAP37,BIT1,PTR... |
Human | E. coli |
PTH2, also known as PTRH2, is a mitochondrial protein that belongs to the PTH2 family. PTH 2 is released during apoptosis from the mitochondria to the cytoplasm. The natural substrate for PTH 2 may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. When in the cytoplasm, PTRH2 regulates the function of 2 transcriptional regulators, TLE5 and TLE1, thus promoting caspase-independent cell death. | |||
TMPY-04003 |
UNC5B Protein, Rat, Recombinant (hFc)
unc-5 homolog B (C. elegans) |
Rat | HEK293 Cells |
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular we... | |||
TMPK-00555 |
CDH17 Protein, Cynomolgus, Recombinant (His)
Cdh17,HPT-1,FLJ26931,LI-cadherin,BILL-cadherin,P130,Cadherin... |
Cynomolgus | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Cynomolgus, Recombinant (His) is expressed i... | |||
TMPK-00948 |
CDH17 Protein, Human, Recombinant (hFc)
Cdh17,cadherin-16,FLJ26931,Cadherin-17,HPT-1,P130,CDH16,LI-c... |
Human | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Human, Recombinant (hFc) is expressed in HEK... | |||
TMPK-01224 |
CDH17 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated
P130,BILL-cadherin,LI-cadherin,MGC138218,FLJ26931,CDH16,Cadh... |
Mouse | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein (Primary Amine Labeling), Mouse, Recombinant ... | |||
TMPK-00949 |
CDH17 Domain 7 Protein, Human, Recombinant (hFc)
CDH16,P130,MGC142024,Cdh17,FLJ26931,Cadherin-17,MGC138218,ca... |
Human | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 7 Protein, Human, Recombinant (hFc) is express... | |||
TMPH-00023 |
Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & Myc)
Outer membrane protein Omp38,Outer membrane protein OmpA,omp... |
Acinetobacter baumannii | E. coli |
Functions as a porin. Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor). Binds peptidoglycan, contributes to cell wall maintenance (Probable). Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & Myc) is expressed in E. coli expression system with N-1... | |||
TMPY-00507 |
UNC5B Protein, Human, Recombinant (hFc)
unc-5 homolog B (C. elegans),UNC5H2,p53RDL1 |
Human | HEK293 Cells |
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular ... | |||
TMPY-04133 |
UNC5B Protein, Human, Recombinant (His)
UNC5H2,p53RDL1,unc-5 homolog B (C. elegans) |
Human | HEK293 Cells |
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular ... | |||
TMPK-00950 |
CDH17 Domain 6-7 Protein, Human, Recombinant (hFc)
HPT-1,P130,MGC138218,LI-cadherin,FLJ26931,cadherin-16,Cdh17,... |
Human | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 6-7 Protein, Human, Recombinant (hFc) is expre... | |||
TMPK-01223 |
CDH17 Protein, Mouse, Recombinant (His)
CDH16,LI-cadherin,Cdh17,MGC138218,HPT-1,MGC142024,FLJ26931,B... |
Mouse | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Mouse, Recombinant (His) is expressed in HEK... | |||
TMPK-00473 |
CDH17 Protein, Rhesus macaque, Recombinant (His)
CDH16,Cdh17,MGC142024,Cadherin-17,cadherin-16,P130,MGC138218... |
Rhesus | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Rhesus macaque, Recombinant (His) is express... | |||
TMPK-00951 |
CDH17 Domain 5-7 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
FLJ26931,CDH16,LI-cadherin,MGC138218,cadherin-16,Cadherin-17... |
Human | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 5-7 Protein (Primary Amine Labeling), Human, R... | |||
TMPK-00162 |
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated
IL-1 β,IL-1β,IL-1 β/IL-1F2,IL-1 beta,IL1B,Interleukin-1 beta... |
Human | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with C... | |||
TMPK-00161 |
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi)
Interleukin-1 beta,IL-1 β,IL-1β,IL1F2,IL-1BETA,Interleukin-1... |
Human | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with C-His-Avi tag. ... | |||
TMPK-00952 |
CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc)
BILL-cadherin,Cadherin-17,LI-cadherin,CDH16,cadherin-16,Cdh1... |
Human | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc) is exp... | |||
TMPK-00947 |
CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated
CDH16,Cdh17,P130,cadherin-16,HPT-1,LI-cadherin,Cadherin-17,B... |
Human | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated... | |||
TMPY-01927 |
ANP32A Protein, Human, Recombinant (His & GST)
MAPM,PP32,I1PP2A,C15orf1,LANP,HPPCn,PHAPI,acidic (leucine-ri... |
Human | E. coli |
acidic leucine-rich nuclear phosphoprotein 32 family member A, also known as acidic nuclear phosphoprotein pp32, Leucine-rich acidic nuclear protein, Mapmodulin, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, Putative HLA-DR-associated protein I, PHAPI and ANP32A, is a nucleus, cytoplasm and endoplasmic reticulum. ANP32A / LANP is expressed in all tissues tested. It is highly expressed in kidney and skeletal muscle, moderate levels of expression is in brain, placenta and panc... | |||
TMPK-00953 |
CDH17 Domain 6-7 Protein, Human, Recombinant (mFc)
Cdh17,CDH16,MGC138218,BILL-cadherin,HPT-1,cadherin-16,MGC142... |
Human | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 6-7 Protein, Human, Recombinant (mFc) is expre... | |||
TMPK-00515 |
IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His)
Interleukin-1 β,IL-1 beta,IL1B,IL1F2,IL-1BETA,IL-1β,IL-1 β,I... |
Cynomolgus | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The p... | |||
TMPH-02687 |
Granzyme A/GZMA Protein, Mouse, Recombinant (His)
CTLA-3,Granzyme A,Autocrine thymic lymphoma granzyme-like se... |
Mouse | E. coli |
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Granz... | |||
TMPJ-01329 |
ATG5 Protein, Human, Recombinant
ASP,APG5L,Apoptosis-specific protein,Autophagy protein 5,APG... |
Human | E. coli |
ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic cells. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 plays an impor... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0127 |
Diclofenac-d4
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Diclofenac-d4 是 Diclofenac 的氘代化合物。Diclofenac 的 CAS 号为 15307-86-5。Diclofenac 是一种具有抗炎活性的非甾体苯乙酸衍生物,是COX抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。 |