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Search Results for " carotegrast methyl hcl "
Targets Recommended: Others

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Cat. No. Product Name Target Signaling Pathways
T70944 Carotegrast methyl HCl

Others Others
Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the α4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM300 dose-dependently inhibited lymphocyte homing to Peyer's patches and increased the peripheral lymphocyte count in the same dose range. AJM300 dose-dependently prevented the development of experimental colitis in mice.
T70942 AM-8508

Others Others
AM-8508 is a potent and selective PI3Kδ inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM ). AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.

化合物

Carotegrast methyl HCl
Cat.No: T70944
Synonym:
Target: Others
AM-8508
Cat.No: T70942
Synonym:
Target: Others
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