930
123
4
314
36
Cat. No. | Product Name | ||
---|---|---|---|
L7200 | 钙通道分子库 | 140 compounds | |
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L9700 | 内质网应激化合物库 | 193 compounds | |
193 个内质网应激相关的化合物集合,可用于高通量和高内涵筛选; | |||
L7110 | 抗高血压化合物库 | 678 compounds | |
678 种高血压相关的小分子,用于高通量和高内涵筛选; | |||
L5300 | 线粒体靶向库 | 812 compounds | |
812 种具有潜在或确定线粒体靶向活性的化合物,以促进针对线粒体的药物研究; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40923 |
Calcium lactate
Lactic acid calcium,Hemicalcium L-lactate,Lactate calcium,乳酸钙,Conclyte calcium |
Others | Others |
Calcium lactate (Conclyte calcium) 被饮料工业用作强化果汁的钙源。Calcium lactate 促进豆芽生长和植酸降解。 | |||
T0411 |
Gluconate Calcium
Calcium D-gluconate,Gluconic acid hemicalcium salt,Calcium gluconate,葡萄糖酸钙 |
Others | Others |
Gluconate Calcium (Gluconic acid hemicalcium salt) 是矿物质补充剂, 由葡糖酸和石灰或碳酸钙中和制成。 | |||
T1673 |
Acamprosate calcium
calcium acetylhomotaurinate,N-Acetylhomotaurine Calcium,Alcomed,阿坎酸钙,Sobriol,Campral EC,Calcium N-acetylhomotaurinate |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Acamprosate calcium (Campral EC) 是 GABA 受体激动剂和谷氨酸能系统调节剂,用于治疗酒精依赖。 | |||
T1530 |
Mitiglinide calcium hydrate
KAD-1229 calcium hydrate,米格列奈钙,Mitiglinide calcium,S-21403 calcium hydrate |
Potassium Channel | Membrane transporter/Ion channel |
Mitiglinide calcium hydrate (S-21403 calcium hydrate) 是一种 ATP 敏感的 K+通道 (KATPchannel) 拮抗剂, 属于促胰岛素化合物。它对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性,在 2 型糖尿病中有研究价值。 | |||
T3131 |
Fosfomycin calcium
Phosphomycin calcium salt,Fosmicin,磷霉素钙 |
Antibacterial; Antibiotic | Microbiology/Virology |
Fosfomycin calcium (Phosphomycin calcium salt) 是一种能透过血脑屏障的广谱抗生素,不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性,包括耐多药、广泛耐药和耐全药细菌。 | |||
T3608 |
Carbasalate calcium
Rheomin,Omegin,Alcacyl,Iromin,卡巴匹林钙,Solupsan,Carbasalate Calcium |
Platelet aggregation | Others |
Carbasalate calcium (Rheomin) 是抗炎和解热剂,可用于研究疼痛的缓解。 | |||
T5030 |
Zofenopril calcium
SQ26991,佐芬普利钙,Zofenopril (calcium) |
RAAS; Reactive Oxygen Species | Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB |
Zofenopril calcium (SQ26991) 是一种抗氧化剂和血管紧张素转化酶 (ACE) 抑制剂。 | |||
T22321 |
edetate calcium disodium
EDTA calcium disodium,乙二胺四乙酸二钠钙 |
Others | Others |
Edetate calcium disodium(EDTA calcium disodium) 是一种螯合剂,主要用于治疗严重的铅中毒。 | |||
T1510 |
Rosuvastatin calcium
ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium,瑞舒伐他汀钙 |
Potassium Channel; HMG-CoA Reductase; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Rosuvastatin calcium (ZD4522) 是肝羟甲基戊二酰辅酶 A 还原酶的选择性和竞争性抑制剂,具有抗血脂活性。它降低成熟 hERG 的表达以及热休克蛋白 70 与 hERG 蛋白的相互作用,还降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go 相关基因电流,延迟心脏复极化,来延长动作电位持续时间和校正 QT 间期间隔。 | |||
T7871 |
Calcium D-saccharate tetrahydrate
D-Glucaric acid calcium salt,葡萄糖二酸鈣,Calcium D-saccharate tetrahydrate,D-Saccharic acid calcium salt |
Others | Others |
Calcium D-saccharate tetrahydrate (Calcium D-saccharate tetrahydrate) 是一种氧化的非环状己糖。它可以抑制癌细胞的癌变和增殖。 | |||
T13591 |
Calcium polystyrene sulfonate
Poly(styrenesulfonic acid) calcium salt,聚苯乙烯磺酸钙 |
Others | Others |
Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt) 是一种离子交换树脂。 Calcium polystyrene sulfonate 可降低血钾水平,可用于治疗慢性肾病患者高钾血症的研究。 | |||
T0148L |
Folinic Acid Calcium Salt Pentahydrate
Folinic acid,亚叶酸钙五水合物,Leucovorin Calcium Pentahydrate,Leucovorin calcium salt pentahydrate |
Others; Antifolate | Cell Cycle/Checkpoint; Others |
Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate) 是一种还原型叶酸,是一种解毒剂,通常与甲氨蝶呤 (MTX) 联用,以降低 MTX 诱导的毒性。 | |||
T0170 |
Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, calcium salt (9CI)
phosphonomycin calcium,Fosfomycin calcium,磷霉素钙,phosphomycin calcium |
Antibiotic | Microbiology/Virology |
Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, calcium salt (9CI) (phosphonomycin calcium)是一种抗生素,用于治疗敏感菌株引起的尿路感染和肠道感染。 | |||
T6498 |
Fenoprofen calcium hydrate
Feprona dihydrate,Fenoprofen calcium salt dihydrate,Progesic dihydrate,非诺洛芬钙二水合物 |
Apoptosis; Others; COX | Apoptosis; Immunology/Inflammation; Neuroscience; Others |
Fenoprofen calcium hydrate (Progesic dihydrate) 是一非甾体类抗炎症化合物。 | |||
T5939 |
Calcium dobesilate
|
Apoptosis; Others | Apoptosis; Others |
Calcium dobesilate 具有血管保护特性,部分通过改善 HG 诱导的炎症来保护内皮细胞,用于慢性静脉疾病、糖尿病视网膜病变以及痔疮发作等研究。 | |||
T40857 |
Calcium ionophore II
Calcium ionophore II,N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide |
Others | Others |
Calcium ionophore II (N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide) 是一种亲脂性离子载体,可用于制备钙离子选择性电极。 | |||
T6497 |
Fenoprofen Calcium
|
Others; COX | Immunology/Inflammation; Neuroscience; Others |
Fenoprofen Calcium 是一种非甾体类抗炎药,可治疗关节炎。 | |||
T7593 |
Levomefolate calcium
左旋甲状腺素钙,L-5-甲基四氢叶酸钙 |
Antifolate | Cell Cycle/Checkpoint |
Levomefolate calcium 是一种人工形式的叶酸。它是叶酸的一种辅酶形式,是膳食补充剂中生物利用度更高的替代品。 | |||
T0184 |
Fenoprofen calcium dihydrate
|
COX | Immunology/Inflammation; Neuroscience |
Fenoprofen calcium dihydrate 是一种丙酸衍生物,用作非甾体抗炎剂。 | |||
T10101 |
Calcium channel-modulator-1
|
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Calcium channel-modulator-1是钙离子通道调节剂(IC50:0.8 μM),具有阻塞主动脉收缩的专业化。 | |||
T7598 |
Calcium N5-methyltetrahydrofolate
5-甲基四氢叶酸钙,N5-甲基四氢叶酸钙,NSC173328 |
Others; Antifolate | Cell Cycle/Checkpoint; Others |
Calcium N5-methyltetrahydrofolate (NSC-173328) 是左旋叶酸的钙盐,用于治疗心血管疾病、乳腺癌和结肠直肠癌。 | |||
T9259 |
Alpha-calcium ketoglutarate monohydrate
|
Others | Others |
Alpha-calcium ketoglutarate monohydrate 是 α-酮戊二酸的钙盐形式,参与生物体内的三羧酸循环。 | |||
T6587 |
Mitiglinide Calcium
KAD-1229,米格列奈钙,S21403,米格列奈 |
ATPase; Potassium Channel | Membrane transporter/Ion channel |
Mitiglinide Calcium (KAD-1229) 是一种 ATP 敏感的 K+通道拮抗剂,具有促胰岛素的作用。Mitiglinide Calcium 对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性。Mitiglinide Calcium 在 2 型糖尿病的研究中具有价值。 | |||
T77710 |
Calcium Channel antagonist 2
WAY-327363 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Calcium Channel antagonist 2是一种 calcium channel 拮抗剂 (IC50=5-20 μM),可用于研究像疼痛和糖尿病等由于 Ca2+ 通道造成的疾病。 | |||
T8238 |
Fosamprenavir Calcium Salt
福沙那伟钙,Diallyl Trisulfide,GW433908G |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fosamprenavir Calcium Salt (GW433908G) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药,具有改善的溶解性和抗HIV 感染作用。 | |||
T2534 |
Pitavastatin calcium
P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104 |
Apoptosis; Mitophagy; Endogenous Metabolite; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Pitavastatin calcium (NK-104) 是一种羟甲基戊二酰-CoA 还原酶抑制剂。它在 HepG2 细胞中抑制乙酸合成胆固醇的IC50为 5.8 nM。它是高效的肝细胞低密度脂蛋白胆固醇受体诱导剂。具有抗癌活性。 | |||
TQ0020 |
AMG 837 calcium hydrate
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
AMG 837 calcium hydrate 是口服有效的 GPR40/FFA1部分激动剂,抑制 [3H]AMG 837 与人类 FFA1受体的特异性结合,pIC50为 8.13。AMG 837 calcium hydrate 可增强啮齿动物的胰岛素分泌并降低葡萄糖水平。 | |||
TQ0045 |
2-Hydroxy atorvastatin calcium salt
|
Drug Metabolite | Metabolism |
2-Hydroxy atorvastatin calcium salt 是 Atorvastatin 钙盐的羟基代谢物,Atorvastatin 是一种有效的 HMG-CoA 还原酶抑制剂 (IC50 = 8 nM)。 | |||
T35350 |
Calcium gluconate monohydrate
Calciofon,Calcium gluconate anhydrous,Calcium D-gluconate,Glucobiogen,Calcarea gluconica |
Others | Others |
Calcium gluconate (Calcarea gluconica, Calcium gluconate anhydrous, Calcium D-gluconate, Calciofon, Glucobiogen)是维持正常神经、肌肉和心脏功能所必需的元素或矿物质。葡萄糖钙可维持体内钙平衡,口服可阻止骨质疏松。 | |||
T78613 |
Selnoflast calcium
RO-7486967 calcium |
NOD-like Receptor (NLR) | Immunology/Inflammation |
Selnoflast calcium (example 6) 作为一种NLRP3抑制剂。 | |||
T64679 |
Calcium chloride
|
Others | Others |
Calcium chloride 常用于细胞培养研究,如用作 DMEM 培养基中的钙补充剂,也可以用于制备合成盐水溶液。 | |||
T30689 |
Calcium decanoate
Calcium bis(caprate),Decanoic acid, calcium salt,Calcium caprate |
Others | Others |
Calcium decanoate is a biochemical. | |||
T30690 |
Calcium dextrofolinate
Calcium (6R)-folinate |
Others | Others |
Calcium dextrofolinate is a calcium salt of a derivative of Folic Acid. | |||
T25832 |
Moveltipril
Moveltipril calcium,MC-838,Altiopril calcium |
RAAS | Endocrinology/Hormones |
Moveltipril (Moveltipril calcium) 是一种强效血管紧张素转换酶(ACE)抑制剂。 | |||
T84520 |
Palmitic acid calcium
Calcium palmitate |
Others | Others |
Palmitic acid calcium,一种长链饱和脂肪酸,广泛存在于动物和植物中。它能在小鼠颗粒细胞诱导葡萄糖调节蛋白78 (GRP78) 和CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达,可用于建立细胞脂肪变性模型。 | |||
T60254 |
Calcium glycerophosphate
|
Phosphorylase | Metabolism |
Calcium glycerophosphate(CaGP)是肠道碱性磷酸酶 F3 的抑制剂 (intestinal alkaline phosphatase F3)。Calcium glycerophosphate 可作为全肠外营养溶液中钙和磷的来源。 | |||
T11386 |
Gemcabene calcium
PD-72953 calcium |
Others | Others |
Gemcabene calcium , a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) andexerting anti-inflammatory activity, lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP). | |||
T77711 |
Calcium Channel antagonist 4
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Calcium Channel antagonist 4 是一种电压门控钙通道抑制剂(IC50 : 5-20μM)。 | |||
T30692 |
Calcium lignosulfonate
Lignin calcium sulfonate,Lignosulfonic acid, calcium salt,Caswell No. 146 |
Others | Others |
Calcium lignosulfonate is a granulating agent for limestone and ores, compaction aid for coal and metal wastes and also dispersing agent for gypsum and clay slurries. | |||
T77712 |
Calcium Channel antagonist 3
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Calcium Channel antagonist 3 是一种电压门控钙通道抑制剂(IC50 : 5-20μM)。 | |||
T30694 |
Calcium phosphate, dibasic
Calcium hydrogen phosphate,Calcium hydrogenorthophosphate |
Others | Others |
Dicalcium phosphate is the calcium phosphate with the formula CaHPO4 and its dihydrate. The "di" prefix in the common name arises because the formation of the HPO42– anion involves the removal of two protons from phosphoric acid, H3PO4. It is al | |||
T30691 |
Calcium diglutamate
Calcium di-L-glutamate,Glutamic acid, calcium salt (2:1), L- |
Others | Others |
Calcium diglutamate(CDG), calcium acid salt of glutamic acid. As a soluble source of calcium ions, this chemical is used as a first-aid treatment for exposure to hydrofluoric acid. | |||
T23832 |
Bucloxic acid calcium salt
Bucloxic acid calcium,CB 804 calcium,Calcium esfar |
Others | Others |
Bucloxic acid calcium salt 是一种吡唑类衍生物,Bucloxic acid 的钙盐。它是一种抗炎药,具有镇痛和解热作用;也可用于慢性肾小球肾病的研究。 | |||
T21363 |
Atorvastatin calcium trihydrate
CI-981,atorvastatin, calcium salt,CI981,Atorvastatin,CI 981 |
Others | Others |
Atorvastatin is used to inhibits HMG-CoA reductase for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. | |||
T19896 |
Phenylbutazone calcium
DA 241,P 241,DA-241,Phenylbutazone calcium salt,DA241 |
Others | Others |
Phenylbutazone calcium is a calcium derivative of phenylbutazone that has anti-inflammatory effects. | |||
T34032 |
Phosphoethanolamine calcium
|
Others | Others |
Phosphoethanolamines (phosphoethanolamines, calcium EAP) are important components of the human cell membrane structure, which help to maintain the integrity of the cell membrane and improve cell function. | |||
T36732 |
Ciprostene (calcium salt)
|
Others | Others |
Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 μg/kg/min and 60 ng/ml, respectively. | |||
T23848 |
Calcium Fusarate
|
Others | Others |
Calcium Fumarate is an inhibitor of dopamine beta-hydroxylase. It also inhibited cell proliferation and DNA synthesis. | |||
T36367 |
RK-682 (calcium salt)
|
Others | Others |
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the... | |||
T78072 |
Prohexadione calcium
BX-112 |
Others | Others |
Prohexadione (BX-112) calcium为植物生长调节剂,其作用机制为抑制赤霉素生物合成。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0148 |
Folinic acid calcium
亚叶酸钙,Wellcovorin,Calcium folinate,Leucovorin Calcium,Folinic acid calcium salt |
DNA/RNA Synthesis; Endogenous Metabolite; Antifolate | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Folinic acid calcium (Leucovorin Calcium) 是叶酸的活性代谢物,是一种解毒剂,通常与甲氨蝶呤 (MTX) 联用,以降低 MTX 诱导的毒性。 | |||
T6431 |
Levoleucovorin Calcium
左亚叶酸钙,Calcium Levofolinate,CL307782 |
Others; Antifolate | Cell Cycle/Checkpoint; Others |
Levoleucovorin Calcium (CL307782) 是一种亚叶酸的钙盐,在癌症化疗中用作辅助剂。 | |||
T11665 |
Ionomycin calcium
SQ23377 calcium,罗红霉素钙盐(链霉菌属载体) |
Apoptosis; Calcium Channel; Antibacterial; Antibiotic; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Ionomycin calcium (SQ23377 calcium) 是选择性钙离子载体,也是一种由 Streptomyces conglobatus 产生的抗生素。它对二价阳离子具有高度特异性,还诱导蛋白激酶 C 激活。Ionomycin 促进细胞凋亡。 | |||
T8148 |
Mupirocin calcium hydrate
莫匹罗星钙,Mupirocin calcium |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Mupirocin calcium hydrate 是从Pseudomonas fluorescens 中分离得到的,一种有口服活性的抗生素。它可逆地抑制异亮氨酸转移RNA,并抑制细菌蛋白和RNA 的合成起到抗菌作用。 | |||
T5216 |
Calcium L-Threonate
L-苏糖酸钙,L-Threonic acid Calcium Salt |
Others; Endogenous Metabolite | Metabolism; Others |
L-Threonic acid Calcium Salt 是一种抗骨质疏松症,能够刺激抗坏血酸的吸收,常用于钙补充剂。 | |||
T4713 |
Phosphorylcholine chloride calcium salt tetrahydrate
Phosphocholine chloride calcium salt tet,胆碱磷酸氯化钙四水,CalciuM Phosphorylcholine Tetrahydrate |
Others; Endogenous Metabolite | Metabolism; Others |
Phosphorylcholine chloride calcium salt tetrahydrate (Phosphocholine chloride calcium salt tet) 是内源性代谢产物的一种。 | |||
T5082 |
Calcium 2-hydroxy-4-(methylthio)butanoate
羟基蛋氨酸钙,calcium hydroxymethionine,2-Hydroxy-4-(methylthio)butyric acid calcium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Calcium 2-hydroxy-4-(methylthio)butanoate (Calcium 2-hydroxy-4-(calcium hydroxymethionine)) 是内源性代谢产物的一种。 | |||
T3551 |
D-Pantothenic acid hemicalcium salt
泛酸钙,D-Pantothenic Acid Calcium,D-泛酸半钙,Calpanate,Calcium D-pantothenate,Vitamin B5 calcium salt,Calcium pantothenate,Calcium D-Panthotenate |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
D-Pantothenic acid hemicalcium salt (Calcium pantothenate) 是一种水溶性维生素,能够减少苹果汁中的棒曲霉素。 | |||
T8267 |
Aspartic acid calcium
天冬氨酸钙,Calcium L-aspartate,Aspartic acid (calcium) |
Others | Others |
Aspartic acid calcium (Calcium L-aspartate) 是一种钙和 L-Aspartic acid (L-天冬氨酸) 连接的螯合物。其中L-Aspartic acid 是一种氨基酸,是体内蛋白质的结构单元。 | |||
T4987 |
NSC 42196
Calcium α-D-heptagluconate hydrate,葡庚糖酸钙水合物,Calcium glucoheptonate |
Others; Endogenous Metabolite | Metabolism; Others |
NSC 42196 (Calcium glucoheptonate) 是内源性代谢产物的一种。 | |||
T10664 |
Calcium 2-oxoglutarate
|
Others; Tyrosinase | Others; Proteases/Proteasome |
Calcium 2-oxoglutarate is an intermediate in the production of GTP or ATP in the Krebs cycle. It is a reversible inhibitor of tyrosinase (IC50: 15 mM). | |||
T3827 |
Rhein-8-glucoside calcium
大黄酸-8-O-β-D-葡萄糖苷,Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt |
Phosphatase; Antibacterial | Metabolism; Microbiology/Virology |
Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt 是一种从 Saussurea lappa 根的 EtOH 提取物中,分离得到的蒽醌类 hPTP1B 抑制剂,IC50值为11.5 μM,具有抗菌作用。 | |||
T8206 |
Cycleanine
|
Others | Others |
Cycleanine 是一种高效血管选择性Ca- 拮抗剂,具有缓解疼痛、肌肉松弛和抗炎作用。它还具有有效的抗菌、抗真菌、抗疟原虫和细胞毒活性。 | |||
TN2322 |
Yangambin
|
Calcium Channel; PAFR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素,是选择性PAF 受体拮抗剂,通过调控Ca2+通道抑制 Ca2+流入,导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少,具有降压作用。 | |||
TN1008 |
Psoralenoside
|
CaMK; Calcium Channel; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Psoralenoside 是源于补骨脂中的苯并呋喃苷,具有抗肿瘤、抗菌、促进成骨细胞增殖和雌激素样活性。它对组胺 H1、钙调素和电压门控 l 型钙通道具有较高的亲和力。 | |||
T6S1418 |
Praeruptorin C
|
Antioxidant; Calcium Channel | Membrane transporter/Ion channel; Metabolism; oxidation-reduction |
Praeruptorin C 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.7。 | |||
T3802 |
Ligustroflavone
女贞苷,Nuezhenoside |
Others; CaSR | GPCR/G Protein; Others |
Ligustroflavone (Nuezhenoside) 是一种潜在的钙敏感受体拮抗剂,提取自 Ligustrum lucidum,对糖尿病性骨质疏松症小鼠有保护作用。 | |||
T8787 |
Drotaverine hydrochloride
|
PDE | Metabolism |
Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂,也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂,可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果,但无抗胆碱能的效果。 | |||
T0728 |
Ethosuximide
Zarontin,乙琥胺 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Ethosuximide (Zarontin) 是一种抗癫痫药物,可改善多种神经退行性疾病模型的表型,且阻断低电压激活的 T 型钙通道。 | |||
T3904 |
Gomisin J
|
Calcium Channel; AMPK | Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Gomisin J 是在五味子中发现的小分子量木脂素,具有血管舒张活性,在非酒精性脂肪性肝病方面有研究潜力。 它通过激活 AMPK、LKB1 和 Ca2+/钙调蛋白依赖性蛋白激酶 II 以及抑制 HepG2 细胞中的胎球蛋白 A 来调节脂肪生成酶和脂肪分解酶以及炎症分子的表达,从而抑制脂质积累。 | |||
T5723 |
Menthol
薄荷脑,DL-Menthol |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Menthol (DL-Menthol) 是从薄荷或薄荷油中得到的一种天然产物,具有调味和局部麻醉特性。它通过抑制神经元细胞膜的 Ca++电流,刺激冷感受器,从而产生清凉的感觉。 | |||
T15027 |
Cyclopiazonic acid
环匹阿尼酸,环二氮酸 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM),源于A. flavus,是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA),是植物细胞死亡的有效诱导剂。 | |||
T4S1422 |
Praeruptorin E
白花前胡素 E,白花前胡素E |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Praeruptorin E 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.2。 | |||
TQ0302 |
Thapsigargin
毒胡萝卜素 |
Apoptosis; SARS-CoV; Calcium Channel | Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Thapsigargin 属于天然产物,是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂,也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。 | |||
T3013 |
Catharanthine tartrate
Catharanthine hemitartrate,酒石酸长春质碱 |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Catharanthine tartrate (Catharanthine hemitartrate) 是长春花中的一种生物碱,可抑制电压门控 L 型钙离子通道,具有抗肿瘤和降血压活性。 | |||
T2782 |
Catharanthine
(+)-3, 4-Didehydrocoronaridine,长春质碱,(+)-3,4-Didehydrocoronaridine |
Calcium Channel; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Catharanthine ((+)-3,4-Didehydrocoronaridine) 是长春花中的一种生物碱,可抑制电压门控 L 型钙离子通道,具有抗肿瘤和降血压活性。 | |||
T8118 |
Bekanamycin
Kanamycin B,卡那霉素,卡那霉素 B |
Antibacterial; Antibiotic | Microbiology/Virology |
Bekanamycin (Kanamycin B) 是一种提取自 Streptomyces kanamyceticus 的氨基糖苷类抗生素,抑制一系列革兰氏阳性和阴性细菌。 | |||
T10024 |
1-Octanol
Octanol,正辛醇 |
Calcium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
1-Octanol (Octanol) 是一种饱和脂肪醇,是一种 T 型钙通道抑制剂,对天然 T 电流的IC50为 4 μM。它是一种具有类似柴油特性的极具吸引力的生物燃料。 | |||
T6S1500 |
Ginsenoside Rf
人参皂苷 Rf,Ginsenoside-Rf,Panaxoside Rf |
Calcium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
Ginsenoside Rf (Panaxoside Rf) 是人参根的微量成分,可抑制 N 型 Ca2+通道。 | |||
T3S1916 |
Heteroclitin D
异型南五味子丁素,异南五味子丁素;异型南五味子丁素 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Heteroclitin D 是异形南五味子中的一种木脂素,可抑制 L 型钙通道,具有抗脂质过氧化作用。 | |||
T4727 |
Taurolithocholic acid sodium salt
牛磺石胆酸钠,Sodium taurolithocholate |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Taurolithocholic acid sodium salt (Sodium taurolithocholate) 是抑胆剂和 Ca2+激动剂,可抑制放射性配体与毒蕈碱 M1 结合。 | |||
TN7108 |
Urolithin C
|
Apoptosis; Calcium Channel; Reactive Oxygen Species; IGF-1R; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Tyrosine Kinase/Adaptors |
Urolithin C 属于多酚类,是鞣花酸的肠道微生物代谢产物,具有胰岛素分泌的葡萄糖依赖性激活活性。Urolithin C 是 L 型 Ca2+通道开放剂,可增强 Ca2+的流入。它通过线粒体介导的途径诱导细胞凋亡,并刺激活性氧的形成。 | |||
T5645 |
Nerol
Cis-Geraniol,橙花醇,Neryl alcohol |
Apoptosis; Reactive Oxygen Species; Mitochondrial Metabolism; Endogenous Metabolite; Antifungal | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Nerol (Neryl alcohol) 是橙花油的一种单萜, 它通过增强 Ca2+和ROS 来触发线粒体功能障碍并诱导凋亡,具有抗真菌活性。它可减轻哺乳动物心脏中哇巴因引发的心律失常的严重程度。 | |||
T5701 |
OPHIOPOGONIN D
麦冬皂苷 D,麦冬皂苷D |
RAAS; Calcium Channel; NF-κB; PPAR | DNA Damage/DNA Repair; Endocrinology/Hormones; Membrane transporter/Ion channel; Metabolism; NF-κB |
Ophiopogonin D 是从麦冬的块茎中分离的一种天然产物,是罕见的天然存在的 C29甾体糖苷。它是一种 CYP2J3 诱导剂,用于炎症和心血管疾病的相关研究。 | |||
T4S1419 |
(±)-Praeruptorin A
Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A |
p38 MAPK; Calcium Channel; Akt | Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
(±)-Praeruptorin A 是来自白花前胡的干燥根中的一种主要成分,用于研究伴有厚痰和呼吸困难的咳嗽,非天生性咳嗽和上呼吸道感染。它是顺式-内酯 (CKL) 的二酯化产物,可作为 Ca2+-反流阻滞剂,用于高血压的研究。 | |||
T8288 |
14-Deoxyandrographolide
去氧穿心莲内酯,14-去氧穿心莲内酯 |
Apoptosis; Others | Apoptosis; Others |
14-Deoxyandrographolide 是穿心莲中的一种天然产物,是一种钙通道阻断剂,具有保肝功效。它通过诱导 TNFRSF1A 的释放,使肝细胞对 TNF-α 介导的凋亡脱敏。 | |||
T1221 |
Acetylcholine chloride
ACh chloride,Pilofrin,氯化乙酰胆碱 |
Calcium Channel; Endogenous Metabolite; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Acetylcholine chloride (Pilofrin) 是一种神经递质,是胆碱能激动剂,通过刺激烟碱乙酰胆碱受体调节多巴胺能神经元活性,在体外抑制 p53 突变肽的聚集。 | |||
T1135 |
Vitamin D3
维生素D3,Cholecalciferol,Colecalciferol |
Endogenous Metabolite | Metabolism |
Vitamin D3 (Cholecalciferol) 是维生素 D 的一种天然存在形式,代谢激活后可以诱导细胞分化和癌细胞增殖。 | |||
T5S2059 |
Glaucine
|
Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Glaucine 是从海罂粟中分离的一种生物碱,具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂,具有抗氧化和抗病毒活性。 | |||
T4590 |
(+)-Kavain
醉椒素,Kavain,L-KAWAIN,(R)-KAWAIN |
Calcium Channel; GABA Receptor; Sodium Channel; Monoamine Transporter | Membrane transporter/Ion channel; Metabolism; Neuroscience |
(+)-Kavain ((R)-KAWAIN) 是从卡瓦胡椒中提取的一种主要的卡瓦内酯,可通过电压依赖性的 Na+和 Ca2+通道相互作用,减弱血管平滑肌的收缩,具有抗惊厥作用。它可与α4β2δ GABAA 受体结合,加强 GABA 的功效,用于炎症疾病研究。 | |||
T3915 |
Ginsenoside Ro
人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V |
Calcium Channel; Reductase; Prostaglandin Receptor | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism |
Ginsenoside Ro (Chikusetsusaponin V) 能降低 TXA2产量,较弱降低 COX-1 和 TXAS 活性,具有 Ca2+拮抗剂的抗血小板作用,IC50为 155 μM。 | |||
T2996 |
Tetrandrine
NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素 |
Potassium Channel; Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Tetrandrine (Sinomenine A) 是来自粉防己的一种双苯基异喹啉生物碱,可抑制电压门控钙离子通道 (ICa) 和 Ca2+激活的钾离子通道。 | |||
T7056 |
Dronedarone
决奈达隆,SR 33589 |
P450; Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; AChR; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Dronedarone (SR 33589) 是一种胺碘酮类似物,对治疗心房颤动可能有效。它是CYP3A4的底物和中度抑制剂。它是多种离子电流的有效阻滞剂,通过非竞争性结合到肾上腺素能受体显示出抗肾上腺素能的效果。 | |||
T2878 |
Ginsenoside Rd
Panaxoside Rd,Sanchinoside Rd,人参皂苷Rd,人参皂苷 Rd,Gypenoside VIII |
P450; Calcium Channel; NF-κB; COX; Endogenous Metabolite | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
Ginsenoside Rd (Gypenoside VIII) 抑制 TNFα 诱导的NF-κB 转录活性,还抑制COX-2和iNOSmRNA 的表达。它抑制CYP2D6、CYP1A2、CYP3A4和CYP2C9,也抑制Ca2+内流,有可能抑制或阻止肿瘤生长。 | |||
T6856 |
Halofuginone
卤夫酮,常山酮,Tempostatin,empostatin,RU-19110 |
Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Stem Cells |
Halofuginone (RU-19110) 是Febrifugine 的衍生物,是一种竞争性脯氨酰-tRNA 合成酶抑制剂。它也是肺血管扩张剂,可激活Kv 通道并阻断电压门控、受体操作和存储操作的钙离子通道。它具有抗炎、抗癌、抗疟疾和抗纤维化作用。 | |||
T3377 |
L-Phenylalanine
L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine |
Calcium Channel; Endogenous Metabolite; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
L-Phenylalanine (3-Phenyl-L-alanine) 是分离自大肠杆菌的必需氨基酸,是 NMDARs(KB573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂,用于食品香料和药品的生产中。它是一种电压依赖性 α2δ 亚基 Ca2+通道拮抗剂,Ki 为 980 nM。 | |||
T2946 |
Tanshinone IIA sulfonate sodium
丹参酮IIA磺酸盐,丹参酮IIA-磺酸钠,Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium |
CaMK; P450; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) 是从丹参中提取的丹参酮IIA 的水溶性衍生物,是SOCE 抑制剂,用于心血管疾病的研究。 | |||
T0928 |
L-Ascorbic acid
维生素C,Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,抗坏血酸,L-Ascorbate |
Apoptosis; Calcium Channel; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB |
L-Ascorbic acid (Vitamin C) 属于天然产物,是一种强效的还原剂和抗氧化剂。L-Ascorbic acid 具有抗细菌感染、解毒反应和胶原蛋白形成的作用。L-Ascorbic acid 被用于治疗坏血病。 | |||
T3524 |
Halofuginone hydrobromide
卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐 |
Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells |
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。 | |||
T6674 |
L-Ascorbic acid sodium salt
(+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,抗坏血酸钠,Sodium L-ascorbate,维生素C钠 |
Apoptosis; Others; Calcium Channel; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Others |
L-Ascorbic acid sodium salt (Vitamin C sodium salt) 是一种电子供体,是一种内源性抗氧化剂。它还是一种胶原沉积促进剂和弹性生成抑制剂。它选择性抑制 Cav3.2 通道(Cav3.2 channels),IC50为 6.5 μM。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05153 |
TROP-2 Protein, Cynomolgus, Rhesus, Recombinant (His)
tumor-associated calcium signal transducer 2 |
Cynomolgus,Rhesus | HEK293 Cells |
TROP-2 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.7 kDa and the accession number is XP_001114599.1. | |||
TMPY-02667 |
TROP-2 Protein, Mouse, Recombinant (His)
Ly97,TROP2,tumor-associated calcium signal transduc... |
Mouse | HEK293 Cells |
TROP-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.4 kDa and the accession number is Q8BGV3. | |||
TMPY-01357 |
S100A9 Protein, Human, Recombinant (His)
MRP14,P14,LIAG,CFAG,CGLB,CAGB,NIF,MIF,S100 calcium ... |
Human | Baculovirus Insect Cells |
S100A9 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 14.6 kDa and the accession number is P06702. | |||
TMPY-01262 |
TROP-2 Protein, Human, Recombinant (His)
TROP2,M1S1,GA733-1,TROP-2,GA7331,tumor-associated calciu... |
Human | HEK293 Cells |
TROP-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.4 kDa and the accession number is P09758. | |||
TMPY-01356 |
S100A8 Protein, Human, Recombinant (His)
60B8AG,MRP-8,MA387,NIF,L1Ag,S100 calcium binding pr... |
Human | Baculovirus Insect Cells |
S100A8 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 12.2 kDa and the accession number is P05109. | |||
TMPH-01279 |
CRACR2B Protein, Human, Recombinant (His)
CRACR2B,EFCAB4A,EF-hand calcium-binding domain-cont... |
Human | E. coli |
Plays a role in store-operated Ca(2+) entry (SOCE). | |||
TMPY-02955 |
CABP5 Protein, Human, Recombinant (His)
calcium binding protein 5,CABP3 |
Human | E. coli |
CABP3, also known as CABP5, belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of CABP3 gene is retina-specific. The mouse homolog of CABP3 has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of CABP3 gene is unknown. Study of the transcripts and genomic structure r... | |||
TMPH-01951 |
S100A7A Protein, Human, Recombinant (His)
Protein S100-A7A,S100A7A,S100 calcium-binding prote... |
Human | P. pastoris (Yeast) |
May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases. S100A7A Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 13.2 kDa and the accession number is Q86SG5. | |||
TMPY-02222 |
S100A3 Protein, Human, Recombinant (His & MBP)
S100 calcium binding protein A3,S100E |
Human | E. coli |
S100A3 Protein, Human, Recombinant (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 55.3 kDa and the accession number is P33764. | |||
TMPY-05152 |
TROP-2 Protein, Rat, Recombinant (His)
tumor-associated calcium signal transducer 2 |
Rat | HEK293 Cells |
TROP-2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.5 kDa and the accession number is A0A0G2JSJ1. | |||
TMPY-02463 |
S100A5 Protein, Mouse, Recombinant (His)
S100 calcium binding protein A5,S100D9 |
Mouse | E. coli |
S100A5 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.3 kDa and the accession number is P63084. | |||
TMPY-03335 |
S100A3 Protein, Mouse, Recombinant (His)
S100E,S100 calcium binding protein A3 |
Mouse | E. coli |
S100A3 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14 kDa and the accession number is P62818. | |||
TMPY-03699 |
S100A13 Protein, Mouse, Recombinant (His)
S100 calcium binding protein A13,S100A13 |
Mouse | E. coli |
S100A13 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.3 kDa and the accession number is P97352. | |||
TMPY-01931 |
S100A5 Protein, Human, Recombinant (His)
S100D,S100 calcium binding protein A5 |
Human | E. coli |
S100A5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.2 kDa and the accession number is B48219. | |||
TMPY-01476 |
S100A13 Protein, Human, Recombinant
protein S100-A13,OTTHUMP00000034802,S100 calcium-bi... |
Human | E. coli |
S100A13 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.6 kDa and the accession number is Q99584. | |||
TMPH-01029 |
CAPN1 Protein, Human, Recombinant (His)
CANPL1,CAPN1,Calpain-1 catalytic subunit,Micromolar-calpain,... |
Human | E. coli |
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. CAPN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.9 kDa and the accession number is P07384. | |||
TMPH-01031 |
CAPN2 Protein, Human, Recombinant (His)
Calpain-2 catalytic subunit,Millimolar-calpain,Calpain-2 lar... |
Human | E. coli |
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. CAPN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82... | |||
TMPY-02216 |
S100P Protein, Human, Recombinant
MIG9,S100 calcium binding protein P |
Human | E. coli |
S100P Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 10.4 kDa and the accession number is P25815. | |||
TMPY-04944 |
S100P Protein, Human, Recombinant, Biotinylated
MIG9,S100 calcium binding protein P |
Human | E. coli |
S100P Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 10.4 kDa and the accession number is P25815. | |||
TMPJ-01189 |
S100A15A Protein, Mouse, Recombinant
Protein S100-A15A,S100 calcium-binding protein A7A,... |
Mouse | E. coli |
Members of the S100 protein family are involved in calcium- or zinc-dependent cellular functions and regulate immune-mechanisms, cell proliferation and differentiation. Some S100 members have been established as tumor markers because they are dysregulated during carcinogenesis. Psoriasin (S100A7) and koebnerisin (S100A15) are highly homologous proteins that have been first described in psoriasis, which is characterized by disturbed epidermal maturation and chronic inflammation. Several studies s... | |||
TMPY-01783 |
SMOC1 Protein, Human, Recombinant (His)
OAS,SPARC related modular calcium binding 1 |
Human | HEK293 Cells |
SPARC-related modular calcium-binding protein 1, also known as secreted modular calcium-binding protein 1 and SMOC1, is a member of the SPARC family. SMOC1 is widely expressed in many tissues with a strongest signal in ovary. It contains two EF-hand domains, one Kazal-like domain and two thyroglobulin type-1 domains. Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) through paracrine or autocri... | |||
TMPH-02128 |
SMOC1 Protein, Human, Recombinant (GST & His)
SMOC1,Secreted modular calcium-binding protein 1,SP... |
Human | E. coli |
Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation. | |||
TMPY-04415 |
CAMKI Protein, Human, Recombinant
calcium/calmodulin-dependent protein kinase I,CAMKI |
Human | E. coli |
CAMKI Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 41.5 kDa and the accession number is B0YIY3. | |||
TMPY-00086 |
Reticulocalbin 3/RCN3 Protein, Rat, Recombinant (His)
reticulocalbin 3, EF-hand calcium binding domain |
Rat | HEK293 Cells |
Reticulocalbin 3/RCN3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.4 kDa and the accession number is I6L9G5. | |||
TMPY-00910 |
S100A2 Protein, Human, Recombinant (hFc)
S100L,CAN19,S100 calcium binding protein A2 |
Human | HEK293 Cells |
S100A2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.6 kDa and the accession number is P29034. | |||
TMPY-01346 |
Psoriasin/S100A7 Protein, Human, Recombinant
S100 calcium binding protein A7,PSOR1,S100A7c |
Human | E. coli |
Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role... | |||
TMPY-01879 |
S100A14 Protein, Human, Recombinant (His)
S100 calcium binding protein A14,BCMP84,S100A15 |
Human | E. coli |
S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from theneural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of in... | |||
TMPY-03020 |
S100B Protein, Mouse, Recombinant (hFc)
AI850290,S100 calcium binding protein B,Bpb |
Mouse | HEK293 Cells |
S100B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39 kDa and the accession number is P50114. | |||
TMPY-00998 |
S100A2 Protein, Human, Recombinant
S100L,CAN19,S100 calcium binding protein A2 |
Human | E. coli |
S100A2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11 kDa and the accession number is P29034. | |||
TMPY-03181 |
Reticulocalbin 3/RCN3 Protein, Human, Recombinant (His)
RLP49,reticulocalbin 3, EF-hand calcium binding dom... |
Human | HEK293 Cells |
Reticulocalbin 3/RCN3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q96D15. | |||
TMPY-04373 |
CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST)
calcium/calmodulin-dependent protein kinase II alph... |
Human | Baculovirus Insect Cells |
Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca2+homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII... | |||
TMPY-01339 |
S100A6 Protein, Human, Recombinant (His)
2A9,PRA,CABP,CACY,S100 calcium binding protein A6,5... |
Human | Baculovirus Insect Cells |
S100A6 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 12 kDa and the accession number is P06703. | |||
TMPY-02532 |
S100A1 Protein, Mouse, Recombinant (His)
AI266795,S100a,S100 calcium binding protein A1,S100 |
Mouse | E. coli |
S100A1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.5 kDa and the accession number is P56565. | |||
TMPY-02710 |
CANT1 Protein, Human, Recombinant (His)
SCAN1,SCAN-1,DBQD,SHAPY,calcium activated nucleotid... |
Human | HEK293 Cells |
CANT1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q8WVQ1-1. | |||
TMPH-03766 |
ATP2A2 Protein, Human, Recombinant (C-His)
SR Ca(2+)-ATPase 2,Calcium pump 2,SERCA2,ATP2A2,Sar... |
Human | E. coli |
ATP2A2 Protein, Human, Recombinant (C-His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 55.2 kDa and the accession number is P16615. | |||
TMPY-01094 |
S100A6 Protein, Mouse, Recombinant
2A9,PRA,5B10,S100 calcium binding protein A6,Cacy,C... |
Mouse | E. coli |
S100A6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 10 kDa and the accession number is P14069. | |||
TMPY-02975 |
CANT1 Protein, Human, Recombinant (hFc)
SCAN1,DBQD,SCAN-1,SHAPY,calcium activated nucleotid... |
Human | HEK293 Cells |
CANT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.3 kDa and the accession number is Q8WVQ1-1. | |||
TMPH-00780 |
CACNA1C Protein, Guinea Pig, Recombinant (His)
CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent L-type ca... |
Guinea pig | E. coli |
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur... | |||
TMPY-00912 |
S100A6 Protein, Human, Recombinant
5B10,PRA,S100 calcium binding protein A6,CACY,CABP,... |
Human | E. coli |
S100A6 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 10.2 kDa and the accession number is P06703. | |||
TMPY-02135 |
S100A16 Protein, Human, Recombinant
S100F,DT1P1A7,S100 calcium binding protein A16,MGC1... |
Human | E. coli |
S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting with specific target proteins. S100A16 expression was found to be astrocyte-specific. The S100A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S100A16 in the apo state has be... | |||
TMPY-04381 |
CAMK1D Protein, Human, Recombinant (GST)
calcium/calmodulin-dependent protein kinase ID,CaMK... |
Human | Baculovirus Insect Cells |
CAMK1D Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 69 kDa and the accession number is Q8IU85-1. | |||
TMPH-02308 |
CACNA2D1 Protein, Human, Recombinant (His & SUMO)
MHS3,Voltage-dependent calcium channel subunit alph... |
Human | E. coli |
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. | |||
TMPH-03357 |
S100A4 Protein, Rat, Recombinant (His & Myc)
P9K,Metastasin,Placental calcium-binding protein,S1... |
Rat | E. coli |
S100A4 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.6 kDa and the accession number is P05942. | |||
TMPY-00997 |
S100A1 Protein, Human, Recombinant
S100-α,S100A,S100 calcium binding protein A1,S100,S... |
Human | E. coli |
S100A1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 10.5 kDa and the accession number is A0A0S2Z4H2. | |||
TMPY-00909 |
S100A1 Protein, Human, Recombinant (hFc)
S100 calcium binding protein A1,S100-alpha,S100A,S1... |
Human | HEK293 Cells |
S100A1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.1 kDa and the accession number is A0A0S2Z4H2. | |||
TMPY-04111 |
S100A4 Protein, Mouse, Recombinant (His)
Capl,FSp1,pk9a,Mts1,metastasin,S100 calcium binding... |
Mouse | E. coli |
S100A4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 13.8 kDa and the accession number is P07091. | |||
TMPH-03090 |
SCP alpha chain Protein, Penaeus sp., Recombinant (His & Myc & SUMO)
Sarcoplasmic calcium-binding protein, alpha-B and -... |
Penaeus | E. coli |
Like parvalbumins, SCP's seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution. SCP alpha chain Protein, Penaeus sp., Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 42.0 kDa and the accession number is P02636. | |||
TMPY-04080 |
S100A4 Protein, Mouse, Recombinant
PeL98,18A2,42a,Capl,pk9a,FSp1,metastasin,S100 calcium |
Mouse | HEK293 Cells |
S100A4 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 11.7 kDa and the accession number is P07091. | |||
TMPY-01331 |
S100A11 Protein, Human, Recombinant
S100C,HEL-S-43,S100 calcium binding protein A11,MLN... |
Human | E. coli |
S100A11 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 24 and 12 kDa and the accession number is P31949. | |||
TMPY-01875 |
SCGN Protein, Human, Recombinant (His)
SEGN,SECRET,DJ501N12.8,CALBL,secretagogin, EF-hand calci... |
Human | E. coli |
Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes ... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIH-0511 |
Sacubitril-d4 calcium salt
AHU-377-d4 calcium salt |
||
Sacubitril-d4 calcium salt 是 Sacubitril calcium salt 的氘代化合物。 | |||
T19551 |
Rosuvastatin D6 Calcium
|
Others | Others |
Rosuvastatin D6 Calcium is deuterium labeled Rosuvastatin, which is a competitive HMG-CoA reductase inhibitor(IC50 of 11 nM). | |||
TMIH-0504 |
Rosuvastatin-d6 Calcium Salt
|
||
Rosuvastatin-d6 Calcium Salt 是 Rosuvastatin Calcium Salt 的氘代化合物。Rosuvastatin Calcium Salt 的 CAS 号为 147098-20-2。Rosuvastatin calcium 是肝羟甲基戊二酰辅酶 A 还原酶的选择性和竞争性抑制剂,具有抗血脂活性。它降低成熟 hERG 的表达以及热休克蛋白 70 与 hERG 蛋白的相互作用,还降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go相关基因电流,延迟心脏复极化,来延长动作电位持续时间和校正 QT 间期间隔。 | |||
TMIJ-0151 |
Atorvastatin-d5 Calcium Salt
|
||
Atorvastatin-d5 Calcium Salt 是 Atorvastatin Calcium Salt 的氘代化合物。Atorvastatin Calcium Salt 的 CAS 号为 134523-00-5。 | |||
TMIJ-0150 |
para-Hydroxy Atorvastatin-d5 Calcium Salt
|
||
para-Hydroxy Atorvastatin-d5 Calcium Salt 是 para-Hydroxy Atorvastatin Calcium Salt 的氘代化合物。para-Hydroxy Atorvastatin Calcium Salt 的 CAS 号为 214217-88-6。 | |||
TMIJ-0152 |
ortho-Hydroxy Atorvastatin-d5 Calcium Salt
|
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ortho-Hydroxy Atorvastatin-d5 Calcium Salt 是 ortho-Hydroxy Atorvastatin Calcium Salt 的氘代化合物。ortho-Hydroxy Atorvastatin Calcium Salt 的 CAS 号为 265989-47-7。 | |||
T40376 |
L-Phenylalanine-15N
L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是 15N 标记的 L-Phenylalanine。L-Phenylalanine 是从大肠杆菌中分离出来的一种必需氨基酸。 L-Phenylalanine 广泛用于食品香精和药物的生产。 | |||
T10439 |
Azelnidipine D7
CS-905 D7 |
Others | Others |
Azelnidipine D7 is a deuterium-labeled Azelnidipine. Azelnidipine is an L-type calcium channel blocker. | |||
TMIH-0087 |
Amlodipine-d4 Maleate (Racemic)
|
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Amlodipine-d4 Maleate (Racemic) 是 Amlodipine Maleate (Racemic) 的氘代化合物。Amlodipine Maleate (Racemic) 的 CAS 号为 88150-47-4。Amlodipine maleate是一种具有口服活性的二氢吡啶类钙通道阻滞剂,通过阻滞电压依赖性L型钙通道,从而抑制钙离子内流。Amlodipine maleate可用于研究高血压和癌症。 | |||
TMIJ-0246 |
Tetracaine-d6
|
||
Tetracaine-d6 是 Tetracaine 的氘代化合物。Tetracaine 的 CAS 号为 94-24-6。 | |||
T12222 |
Nifedipine-d6
硝苯地平 D6,Nifedipine D6,BAY-a-1040 D6 |
Others | Others |
Nifedipine D6 is deuterium labeled nifedipine which is a potent blocker of calcium channel. | |||
T12625 |
(R)-Lercanidipine-d3 hydrochloride
(R)-Lercanidipine D3 hydrochloride |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
(R)-lercanidipine D3 hydrochloride is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride) is a calcium channel blocker. | |||
T10816 |
Cinnarizine D8
|
Others | Others |
Cinnarizine D8 is a deuterium-labeled Cinnarizine which is an antihistamine and a calcium channel blocker. | |||
T12243 |
Norverapamil-d7
D591 D7,(±)-Norverapamil D7 |
Others | Others |
Norverapamil D7 is a deuterium labeled Norverapamil . Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function . | |||
TMIH-0107 |
Barnidipine-d5
|
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Barnidipine-d5 是 Barnidipine 的氘代化合物。Barnidipine 的 CAS 号为 104713-75-9。Barnidipine 是一种二氢吡啶类钙通道阻滞剂,对 CaA 受体具有选择性作用。它是一种抗高血压药物,通过减少其血管扩张作用继发的外周血管阻力起作用。 | |||
T71303 |
Flufenamic Acid-d4
|
||
Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear... | |||
TMIJ-0095 |
Nimodipine-d7
|
||
Nimodipine-d7 是 Nimodipine 的氘代化合物。Nimodipine 的 CAS 号为 66085-59-4。Nimodipine 是一种具有口服活性,耐受性良好的光敏二氢吡啶钙拮抗剂。它可研究脑血管疾病。 | |||
TMIH-0002 |
(+/-)-Verapamil hydrochloride-d7
|
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(+/-)-Verapamil hydrochloride-d7 是 (+/-)-Verapamil hydrochloride 的氘代化合物。(+/-)-Verapamil hydrochloride 的 CAS 号为 152-11-4。Verapamil hydrochloride 是一种钙通道阻滞剂,是一种可口服的 P 糖蛋白 (P-gp) 抑制剂,可抑制CYP3A4,用于高血压、心律不齐和心绞痛的研究。 | |||
TMIJ-0187 |
Lercanidipine-13C-d3 HCl
|
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Lercanidipine-13C-d3 HCl 是 Lercanidipine HCl 的 13C 和氘代化合物。Lercanidipine HCl 的 CAS 号为 132866-11-6。Lercanidipine hydrochloride 是亲脂性二氢吡啶-钙通道阻滞剂,具有持久的降压作用和保护肾脏作用。 | |||
T11240 |
Ethacrynic acid D5
|
Others | Others |
Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by... | |||
TMIJ-0140 |
Felodipine-d5
|
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Felodipine-d5 是 Felodipine 的氘代化合物。Felodipine 的 CAS 号为 72509-76-3。Felodipine 是一种长效的 1, 4-二氢吡啶钙通道抑制剂,可跨越血脑屏障,可诱导自噬,具有抗高血压活性。它通过选择性作用于血管平滑肌,尤其是阻力血管来降低血压。 | |||
TMIJ-0285 |
Verapamil-d7 Hydrochloride
|
||
Verapamil-d7 Hydrochloride 是 Verapamil Hydrochloride 的氘代化合物。Verapamil Hydrochloride 的 CAS 号为 152-11-4。Verapamil hydrochloride 是一种钙通道阻滞剂,是一种可口服的 P 糖蛋白 (P-gp) 抑制剂,可抑制CYP3A4,用于高血压、心律不齐和心绞痛的研究。 | |||
TMIJ-0270 |
Pinaverium-d4 Bromide (Mixture of Diastereomers)
|
||
Pinaverium-d4 Bromide (Mixture of Diastereomers) 是 Pinaverium Bromide 的氘代化合物。Pinaverium Bromide 的 CAS 号为 53251-94-8。Pinaverium bromide 是一种具有解痉作用的钙通道阻滞剂,可有效缓解疼痛、腹泻和肠道不适。 | |||
TMID-0229 |
Cortisol-1,2-d2
|
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Cortisol-1,2-d2 是 Cortisol 的氘代化合物。Cortisol 的 CAS 号为 50-23-7。Hydrocortisone 是肾上腺皮质分泌的糖皮质激素。 | |||
TMIJ-0497 |
Lacidipine-d10
|
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Lacidipine-d10 是 Lacidipine 的氘代化合物。Lacidipine 的 CAS 号为 103890-78-4。Lacidipine 是一种L型钙离子通道阻断剂。 | |||
TMIH-0399 |
Norverapamil-d7 HCl
|
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Norverapamil-d7 HCl 是 Norverapamil HCl 的氘代化合物。Norverapamil HCl 的 CAS 号为 67812-42-4。Norverapamil hydrochloride是 Verapamil 的 N-去甲基代谢物,是L型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。 | |||
TMIJ-0077 |
Clevidipine-d7
|
||
Clevidipine-d7 是 Clevidipine 的氘代化合物。Clevidipine 的 CAS 号为 167221-71-8。Clevidipine butyrate 是一种二氢吡啶 L 型钙通道阻滞剂,IC50为7.1 nM。它对血管平滑肌有选择性,可用于降低血压。 | |||
TMIJ-0521 |
L-Lysine-4,4,5,5-d4 Hydrochloride
|
||
L-Lysine-4,4,5,5-d4 Hydrochloride 是 L-Lysine Hydrochloride 的氘代化合物。L-Lysine Hydrochloride 的 CAS 号为 657-27-2。L-lysine hydrochloride 是一种人类必需氨基酸,能增加钙吸收,减少糖尿病相关疾病和改善肠道健康,可用于疱疹的研究。 | |||
TMIJ-0193 |
Hydrocortisone-d4
|
||
Hydrocortisone-d4 是 Hydrocortisone 的氘代化合物。Hydrocortisone 的 CAS 号为 50-23-7。Hydrocortisone 是肾上腺皮质分泌的糖皮质激素。 | |||
TMIJ-0210 |
Bupivacaine-d9
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Bupivacaine-d9 是 Bupivacaine 的氘代化合物。Bupivacaine 的 CAS 号为 38396-39-3。Bupivacaine 是一种 NMDA 受体抑制剂。Bupivacaine 可以阻断钠、L-钙和钾通道。Bupivacaine 有效阻断 SCN5A 通道,IC50 为 69.5 μM。Bupivacaine 可用于慢性疼痛的研究。 | |||
TMIJ-0380 |
L-Lysine-13C6-15N2 Hydrochloride
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L-Lysine-13C6-15N2 Hydrochloride 是 L-Lysine Hydrochloride 的 13C 和 15 N 的标记化合物。L-Lysine Hydrochloride 的 CAS 号为 657-27-2。L-lysine hydrochloride 是一种人类必需氨基酸,能增加钙吸收,减少糖尿病相关疾病和改善肠道健康,可用于疱疹的研究。 | |||
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
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Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... | |||
TMIJ-0141 |
(S)-Amlodipine-d4
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(S)-Amlodipine-d4 是 (S)-Amlodipine 的氘代化合物。(S)-Amlodipine 的 CAS 号为 103129-82-4。Levamlodipine 是一种二氢吡啶钙通道阻滞剂,具有舒张血管的作用,可用于高血压和心绞痛的研究。 | |||
T35695 |
Oleic Acid-13C
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Oleic acid-13C is intended for use as an internal standard for the quantification of oleic acid by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.1,2 It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1 Oleic acid inhibits collagen-stimulated platelet aggregation by approximate... | |||
TMID-0299 |
Zonisamide-d4
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Zonisamide-d4 是 Zonisamide 的氘代化合物。Zonisamide 的 CAS 号为 68291-97-4。Zonisamide 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的Ki值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性,在癫痫、癫痫发作和帕金森病的研究中具有价值。 | |||
TMIJ-0252 |
Benazeprilat-d5
Benazepril EP Impurity C-d5 |
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Benazeprilat-d5 是 Benazeprilat 的氘代化合物。Benazeprilat 的 CAS 号为 86541-78-8。Benazeprilat(CGS 14831) 是一种具有口服活性的贝那普利活性代谢物。Benazeprilat 具有高效的抗血压活性,可与其他其他类别的化合物(包括噻嗪类利尿剂和钙通道阻滞剂)联合使用来减少与心血管风险和继发性终末器官损伤相关的疾病的发生。Benazeprilat 可能用于研究急性左心室衰竭。 |