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Search Results for " calcitonin gene-related peptide receptor "

Targets Recommended: CGRP Receptor

24

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1040	Calcitonin (salmon) 鲑降钙素,Calcitonin salmon,Salmon calcitonin	CGRP Receptor	GPCR/G Protein; Neuroscience
	Calcitonin (salmon) 是一种阿米林和卡西宁受体的双激动剂，是一种钙调节激素，能够刺激骨的生成并能抑制骨吸收。
T17194	Ubrogepant MK-1602	CGRP Receptor	GPCR/G Protein; Neuroscience
	Ubrogepant (MK-1602) 是新型的、口服有效的降钙素基因相关肽受体拮抗剂。Ubrogepant 有潜力用于急性偏头痛的相关研究。
T12293L	Olcegepant BIBN-4096,BIBN 4096BS	CGRP Receptor	GPCR/G Protein; Neuroscience
	Olcegepant (BIBN-4096) 是一种选择性的降钙素基因相关肽1 (CGRP1) 受体拮抗剂，IC50=0.03 nM，Ki=14.4 pM。
T8682	Vazegepant hydrochloride Vazegepant HCl	CGRP Receptor	GPCR/G Protein; Neuroscience
	Vazegepant hydrochloride (Vazegepant HCl) 是一种用于偏头痛的鼻用 gepant，是一种高度亲和性CGRP 受体拮抗剂 (hCGRPKi=0.023 nM)。它可能有助于有效管理 COVID-19 相关肺部炎症。
T4610	Rimegepant BMS 927711,BMS-927711,BMS927711,BHV-3000	CGRP Receptor	GPCR/G Protein; Neuroscience
	Rimegepant (BMS 927711) 是一种有效的降钙素基因相关肽 (CGRP) 受体拮抗剂 (Ki=0.027 nM，IC50=0.14 nM)。Rimegepant 可同时用于偏头痛急性发作治疗及预防性治疗。
T6590	MK-3207 Hydrochloride MK-3207 HCl	CGRP Receptor	GPCR/G Protein; Neuroscience
	MK-3207 Hydrochloride (MK-3207 HCl) 是口服具有活力的CGRP receptor 拮抗剂，IC50=0.12 nM，Ki=0.024 nM。
TP1200	CGRP (83-119), rat TFA Calcitonin Gene Related Peptide(83-119), rat TFA	Others	Others
	CGRP (83-119), rat TFA (Calcitonin Gene Related Peptide(83-119), rat TFA) 是一种由 37 个氨基酸组成的神经肽降钙素家族，通过降钙素受体样受体起作用。
TP1134L	HCGRP-(8-37) acetate HCGRP-(8-37) acetate (119911-68-1 free base)	CGRP Receptor	GPCR/G Protein; Neuroscience
	HCGRP-(8-37) acetate 是一种人降钙素基因相关肽 (hCGRP) 片段醋酸盐，也是 CGRP 受体的拮抗剂。
T38734	Vazegepant Zavegepant,BHV-3500,BMS-742413	CGRP Receptor	GPCR/G Protein; Neuroscience
	Vazegepant (Zavegepant) 是一种可口服且具有选择的降钙素基因相关肽 CGRP 受体拮抗剂，可缓解疼痛，可用于研究偏头疼。
T26682	Atogepant MK 8031,MK8031. Atogepant,MK-8031	Others	Others
	Atogepant is an antagonist of calcitonin gene-related peptide receptor.
T39522	HTL22562	Others	Others
	HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine.
TP1203	CGRP(83-119), rat Calcitonin Gene Related Peptide (CGRP) (83-119), rat
	Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor.
T12293	Olcegepant hydrochloride BIBN-4096 hydrochloride,BIBN4096BS hydrochloride	Others	Others
	Olcegepant hydrochloride is a potent and selective non-peptidethe calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (with IC50 of 0.03 nM for human CGRP).
TP2044	α-CGRP(human) α-CGRP (human)
	Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.
T26796	BI-44370	Others	Others
	BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.
T70248	4991W93	Others	Others
	4991W93 is a 5HT(1B/1D) receptor partial agonist, inhibiting electrically induced plasma extravasation, blocking neurogenic plasma protein extravasation, inhibiting release of calcitonin gene-related peptide.
T16093	Telcagepant MK-0974	Others	Others
	Telcagepant is an orally active antagonist of calcitonin gene-related peptide (CGRP) receptor (Kis: 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively).
T76363	[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat
	[Tyr22]CalcitoninGene Related Peptide, (22-37), rat 是一种大鼠降钙素基因相关肽 (CGRP) 的 22-37 片段，靶向CGRP 受体和腺苷酸环化酶。降钙素 (calcitonin) 主要由甲状腺 C 细胞产生，而 CGRP 则分泌并储存在神经系统中。
TP1625	Adrenomedullin (11-50), rat
	Adrenomedullin 11-50 rat is a peptide fragment of adrenomedullin that possesses systemic vasodilator activity at the level of calcitonin gene-related peptide-1 (CGRP1) receptor activation. Adrenomedullin and its peptide may be used in bone growth studies.
TP2049	CRSP-1
	Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin recept
T73703	(3R,5R,6S)-Atogepant	Others	Others
	(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) 是Atogepant 的异构体.Atogepant 是降钙素基因相关肽受体 (CGRP) 拮抗剂。Atogepant 可用于研究偏头痛。
T37413	Calcitonin (salmon) (trifluoroacetate salt)	Others	Others
	Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and ...
T76678	Eptinezumab
	Eptinezumab为人源化单克隆抗体，主要通过与降钙素基因相关肽(CGRP)结合，进而阻止其与受体相结合，用于成人偏头痛的预防。
TP2049L	CRSP-1 acetate(697327-12-1 Free base)
	CRSP-1 acetate(697327-12-1 Free base) 是一种内源性中枢降钙素(CT)受体激动剂，其刺激cAMP形成的效力是CT的350倍（ED50值分别为0.2和71nM）。CRSP-1 acetate 对降钙素基因相关肽 (CGRP) 和肾上腺髓质素受体没有活性。CRSP-1 acetate 抑制多核破骨细胞的形成，其体外功效与CT相似。CRSP-1 acetate 抑制自由进食大鼠的食物摄入并升高体温，并显着降低体内血浆钙水平。

化合物

Calcitonin (salmon)

Cat.No: TP1040

Synonym: 鲑降钙素,Calcitonin salmon,Salmon calcitonin

Target: CGRP Receptor

Cat.No: T17194

Synonym: MK-1602

Target: CGRP Receptor

Cat.No: T12293L

Synonym: BIBN-4096,BIBN 4096BS

Target: CGRP Receptor

Vazegepant hydrochloride

Cat.No: T8682

Synonym: Vazegepant HCl

Target: CGRP Receptor

Cat.No: T4610

Synonym: BMS 927711,BMS-927711,BMS927711,BHV-3000

Target: CGRP Receptor

MK-3207 Hydrochloride

Cat.No: T6590

Synonym: MK-3207 HCl

Target: CGRP Receptor

CGRP (83-119), rat TFA

Cat.No: TP1200

Synonym: Calcitonin Gene Related Peptide(83-119), rat TFA

Target: Others

HCGRP-(8-37) acetate

Cat.No: TP1134L

Synonym: HCGRP-(8-37) acetate (119911-68-1 free base)

Target: CGRP Receptor

Cat.No: T38734

Synonym: Zavegepant,BHV-3500,BMS-742413

Target: CGRP Receptor

Cat.No: T26682

Synonym: MK 8031,MK8031. Atogepant,MK-8031

Target: Others

Cat.No: T39522

Target: Others

CGRP(83-119), rat

Cat.No: TP1203

Synonym: Calcitonin Gene Related Peptide (CGRP) (83-119), rat

Olcegepant hydrochloride

Cat.No: T12293

Synonym: BIBN-4096 hydrochloride,BIBN4096BS hydrochloride

Target: Others

Cat.No: TP2044

Synonym: α-CGRP (human)

Cat.No: T26796

Target: Others

Cat.No: T70248

Target: Others

Cat.No: T16093

Synonym: MK-0974

Target: Others

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat

Cat.No: T76363

Adrenomedullin (11-50), rat

Cat.No: TP1625

Cat.No: TP2049

(3R,5R,6S)-Atogepant

Cat.No: T73703

Target: Others

Calcitonin (salmon) (trifluoroacetate salt)

Cat.No: T37413

Target: Others

Cat.No: T76678

CRSP-1 acetate(697327-12-1 Free base)

Cat.No: TP2049L

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03280	RAMP3 Protein, Human, Recombinant (hFc) receptor (G protein-coupled) activity modifying pro...	Human	HEK293 Cells
	RAMP3 belongs to the RAMP family. Members of this family are single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. They are required to transp...
TMPY-02839	Adrenomedullin Protein, Human, Recombinant (hFc) AM,PAMP,adrenomedullin	Human	HEK293 Cells
	Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been report...
TMPK-01491	HLA-A*02:01&B2M&HBV (FLLTRILTI) Monomer Protein, Human, MHC (His & Avi), Biotinylated MHC,HBV,Hepatitis B virus	Human	HEK293 Cells
	Hepatitis B virus (HBV), is the leading cause of liver diseases infecting an estimated 240 million persons worldwide. The HBV prevalence rates are variables between different countries, with an high level of endemicity in the south-eastern part of Europe. Seven main HBV-D subgenotypes have been described until now (D1-D7).
TMPK-01501	HLA-A*02:01&B2M&HBV (FLLTRILTI) Tetramer Protein, Human, MHC (His & Avi) MHC,Hepatitis B virus,HBV	Human	HEK293 Cells
	Hepatitis B virus (HBV), is the leading cause of liver diseases infecting an estimated 240 million persons worldwide. The HBV prevalence rates are variables between different countries, with an high level of endemicity in the south-eastern part of Europe. Seven main HBV-D subgenotypes have been described until now (D1-D7).
TMPK-01505	HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Monomer Protein, Human, MHC (His & Avi), Biotinylated E7,MHC,HPV16	Human	HEK293 Cells
	HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KDEL) to the HPV16 E7-specific affibody.
TMPK-01492	HLA-A*02:01&B2M&HBV (FLLTRILTI) Monomer Protein, Human, MHC (His & Avi) Hepatitis B virus,HBV,MHC	Human	HEK293 Cells
	Hepatitis B virus (HBV), is the leading cause of liver diseases infecting an estimated 240 million persons worldwide. The HBV prevalence rates are variables between different countries, with an high level of endemicity in the south-eastern part of Europe. Seven main HBV-D subgenotypes have been described until now (D1-D7).
TMPK-01504	HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Tetramer Protein, Human, MHC (His & Avi) MHC,HPV16,E7	Human	HEK293 Cells
	HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KDEL) to the HPV16 E7-specific affibody.
TMPK-01506	HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Monomer Protein, Human, MHC (His & Avi) HPV16,E7,MHC	Human	HEK293 Cells
	HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KDEL) to the HPV16 E7-specific affibody.

重组蛋白

RAMP3 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03280

Species: Human

Expression System: HEK293 Cells

Adrenomedullin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02839

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HBV (FLLTRILTI) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01491

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HBV (FLLTRILTI) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01501

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01505

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HBV (FLLTRILTI) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01492

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01504

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01506

Species: Human

Expression System: HEK293 Cells

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