Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10896L |
CSRM617 hydrochloride
CSRM617 hydrochloride(787504-88-5 Free base) |
Apoptosis; Others; Androgen Receptor | Apoptosis; Endocrinology/Hormones; Others |
CSRM617 hydrochloride 是转录因子ONECUT2(OC2,雄激素受体 AR 的主要调节剂) 的选择性小分子抑制剂,在 SPR 测定中Kd 为 7.43 uM,直接与 OC2-HOX 结构域结合。CSRM617 hydrochloride 通过裂解 Caspase-3 和 PARP 诱导细胞凋亡 (apoptosis)。CSRM617 hydrochloride 在小鼠的前列腺癌模型中具有良好的耐受性。 | |||
T10896 | CSRM617 | Others | Others |
CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the |