Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35479 |
CRBN-6-5-5-VHL
|
PROTACs | PROTAC |
Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516 |