Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3552 |
CPI-455
CPI-455 HCl |
Histone Demethylase | Chromatin/Epigenetic |
CPI-455 是一种特异性的泛KDM5抑制剂,对 KDM5A 的IC50为 10 nM。它介导 KDM5 抑制,提高 H3K4me3 的整体水平,有抗肿瘤作用。 | |||
T22299 |
CPI-455 HCl
|
Histone Demethylase | Chromatin/Epigenetic |
CPI-455 is a specific KDM5 inhibitor with IC50 value of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with target |