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Search Results for " cox "

Targets Recommended: COX COX

347

抑制剂 & 化合物

136

天然产物

1

化合物库

13

重组蛋白

28

同位素标记化合物

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Cat. No.	Product Name
L4710	非甾体类抗炎化合物库		530 compounds
	530 种非甾体类的抗炎相关化合物，可用于高通量和高内涵筛选；

化合物库

非甾体类抗炎化合物库

Cat.No: L4710

Compounds: 530

Cat. No.	Product Name	Target	Signaling Pathways
T10033	COX-2-IN-1	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-1 是一个强效的 COX-2 抑制剂，其 IC50 值为 3.9 μM。
T10032	COX-2-IN-2	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-2 是选择性的，诱导型的 COX2 抑制剂，IC50 值为0.24 μM。COX-2-IN-2 是具有抗炎和止痛活性的抗炎物。
T77618	COX-2-IN-34	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-34 是一种选择性的、口服有效的 COX-2 抑制剂，在小鼠实验过程中显示出抗炎活性且无胃溃疡毒性。
T6574	Lumiracoxib Prexige,罗美昔布,COX-189	COX	Immunology/Inflammation; Neuroscience
	Lumiracoxib (Prexige) 是强选择性有口服活性的 COX-2抑制剂，Ki 值为 0.06 μM。它是非选择性非甾体抗炎试剂，具有抗炎和解热活性，可用于骨关节炎和骨癌研究。
T62061	COX-2-IN-6	COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	COX-2-IN-6 是一种具有有效性、选择性且可口服的环氧化酶-2 (COX-2) 抑制剂，对 COX-2 具有抑制作用，IC50 为 0.84 μM，Ki 为 69 nM。COX-2-IN-6 对 COX-2 驱动的 PGE2 合成具有抑制作用，IC50 为 0.60 μM。COX-2-IN-6 可用于预防结直肠癌。
T7207	FK 3311 N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺,FK-3311,COX-2 Inhibitor V	COX	Immunology/Inflammation; Neuroscience
	FK 3311 (COX-2 Inhibitor V) 是一种细胞渗透性和口服磺胺类药物，可作为 COX-2 抑制剂和非甾体抗炎药。
T13263	COX/5-LO-IN-1 Atreleuton analog	COX	Immunology/Inflammation; Neuroscience
	COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.
T78705	COX-2-IN-30	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-30 是苯磺酰胺衍生的口服活性 COX/5-LOX 双重抑制剂，其 IC50 值为 COX 同源物为 49 nM、5-LOX 同源物为 10.4 μM。此化合物还能纳摩尔级别 Ki 值抑制 hCA IX 与 hCA XII 亚型。COX-2-IN-30 具备镇痛、抗炎、致溃疡作用，不引发急性胃部反应。
T63480	COX-2-IN-26	Others	Others
	COX-2-IN-26 是有效的、口服具有活力的、选择性的 COX-2 抑制剂，能够作用于 COX-1 (IC50: 10.61 μM)、COX-2 (IC50: 0.067 μM)、15-LOX (IC50: 1.96 μM)。COX-2-IN-26 具有抗炎作用，具有胃肠道安全性。
T63646	COX-2-IN-9	Others	Others
	COX-2-IN-9 是选择性的、有效的、口服具有活力的 COX-2 抑制剂 (IC50: 10.17 μM)。COX-2-IN-9 的 COX-2 选择性比 Celecoxib 高。COX-2-IN-9 表现出良好的体内抗炎活性和低致溃疡效果。
T0432	Diclofenac diethylamine	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Diclofenac diethylamine 是非选择性抗炎剂，通过活化 caspase 级联反应来诱导神经干细胞凋亡。它是一种COX 抑制剂，在 CHO 细胞中，对人COX-1和COX-2的IC50值分别为 4 和 1.3 nM。它对绵羊COX-1和COX-2的IC50值分别为 5.1 μM 和0.84 μM。
T78706	COX-2-IN-31	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-31（化合物7b）是一种COX/5-LOX双重抑制剂，口服活性显著，对COX-2的IC50为60 nM，对5-LOX的IC50为0.9 μM。此外，COX-2-IN-31对跨膜蛋白hCA IX和hCA XII具有抑制作用，其Ki值分别为48.9 nM和5.8 nM，显示出镇痛和抗炎的生物活性。
T60457	COX-2-IN-11	Others	Others
	COX-2-IN-11 (compound 7b2) 是COX-2的有效的选择性抑制剂。COX-2-IN-11 在炎症性疾病的研究方面具有潜力。
T61760	COX-2-IN-18	Others	Others
	COX-2-IN-18 (Compound 3) is a highly effective COX-2 inhibitor with strong inhibitory activity against COX-2 (IC 50 = 0.775 μM). Its potency is comparable to the reference drug Celecoxib (IC 50 = 0.153 μM). This compound, COX-2-IN-18, shows promise in the field of cancer research [1].
T60978	COX-2-IN-7	Others	Others
	COX-2-IN-7 (compound 4a) 是口服有效的COX-2 选择性抑制剂，其选择性高于 Celecoxib，IC50值为6.585 uM。COX-2-IN-7 在体内具有良好的抗炎和低致溃疡活性。
T79130	COX-2-IN-32	NF-κB	NF-κB
	COX-2-IN-32（Compound 2f）为一种抑制iNOS和COX-2的化合物，能够降低NF-κB表达，并抑制LPS诱导的RAW264.7巨噬细胞中NO产生，显示出抗炎活性（IC50: 11.2 μM）。
T7670	Mavacoxib	COX	Immunology/Inflammation; Neuroscience
	Mavacoxib 是口服长效环氧合酶 2 选择性抑制剂，是长效的非甾体类抗炎药，用于犬退化性关节病相关的炎疼及痛症的研究。
T79760	COX-2-IN-35	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-35（化合物7），作为选择性COX-2抑制剂，表现出4.37 nM的IC50，并展现抗炎活性。
T63348	COX-2-IN-23	Others	Others
	COX-2-IN-23 是 COX-2 的选择性抑制剂，它对 COX-2 和 COX-1 的IC50值分别为 0.28 和 20.14 μM。COX-2-IN-23 表现出抗炎作用以及低致溃疡效果。
T62175	COX-2-IN-8	Others	Others
	COX-2-IN-8 (compound 6a) 是一种有效的、选择性的、口服具有活力的 COX-2 抑制剂 (IC50: 6.585 μM)。COX-2-IN-8 的 COX-2 选择性比 Celecoxib 高。COX-2-IN-8 在体内表现出良好的抗炎活性和低致溃疡效果。
T61264	COX-2-IN-19	Others	Others
	COX-2-IN-19 (Compound 24) is a highly potent inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 1.76 μM. Notably, COX-2-IN-19 exhibits robust in vivo anti-inflammatory activity [1].
T61821	COX-2-IN-16	Others	Others
	COX-2-IN-16 (compound 2b)为一种口服活性高、选择性强的COX-2抑制剂，其IC50为102 μM，能有效抑制NO产生并具备抗炎活性。
T61714	COX-2-IN-13	Others	Others
	COX-2-IN-13 (compound 13e) is a highly potent and selective inhibitor of COX-2, demonstrating a remarkable IC50 value of 0.98 μM. It exhibits strong anti-inflammatory activity and has shown favorable results in vivo acute toxicity studies [1].
T63215	COX-2-IN-22	Others	Others
	COX-2-IN-22 是一种能够透过血脑屏障的 COX-2 抑制剂 (IC50: 8.6 μM)，也对AChE (IC50: 2.8 μM)、BChE (IC50: 6.3 μM)、β-Secretase (IC50: 15.3 μM)、LOX-5 (IC50: 13.9 μM) 和 DPPH (IC50: 6.8 μM)表现出抑制作用。
T62259	COX-2-IN-21	Others	Others
	COX-2-IN-21 (Compound 5c) 一种口服具有活力的、选择性的 COX-2 抑制剂 (IC50: 0.039 μM)。COX-2-IN-21 具有良好的抗炎潜力。
T63336	COX-2-IN-29	Others	Others
	COX-2-IN-29 是口服具有活力的 COX-2 的选择性抑制剂 (IC50: 0.005 μM)。
T62142	COX-2-IN-17	Others	Others
	COX-2-IN-17 是一种有效的、具有血脑屏障通透性的 COX-2(环氧化酶 -2) 抑制剂 (IC50: 0.02 μM)，具有抗炎和镇痛活性。
T78754	COX-2-IN-33	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-33（化合物5f）作为一种COX-2抑制剂（IC50=45.5 nM），同样具备潜在抗炎作用。该化合物能抑制促炎细胞因子的生成，同时确保胃部安全。
T64109	COX-2-IN-28	Others	Others
	COX-2-IN-28 是一种有效的、选择性的 COX-2 抑制剂，能够作用于 COX-2 (IC50: 0.054 μM)、15-LOX (IC50: 2.14 μM)、COX-1 (IC50: 13.21 μM)。
T63943	COX-2-IN-10	Others	Others
	COX-2-IN-10 是 COX-2 的有效抑制剂。COX-2-IN-10 对 IL-6、TNF-α 和 IL-1β 的产生表现出抑制作用。COX-2-IN-10 能够浓度依赖性地抑制 PGE2 的产生，其 IC50 值为 2.54 μM。COX-2-IN-10 在 mRNA 和蛋白水平上抑制 iNOS 和 COX-2 的表达。
T61711	COX-2-IN-14	Others	Others
	COX-2-IN-14 (compound 2a) is a highly potent and selective inhibitor of COX-2 (cyclooxygenase-2), with strong binding affinity at the active site of COX-2 co-crystal. Demonstrating remarkable in vivo anti-inflammatory activity, COX-2-IN-14 effectively reduces ear edema and myeloperoxidase (MPO) activity in mice [1].
T60566	COX-2-IN-12	Others	Others
	COX-2-IN-12 (compound 3b) 是一种有效的选择性COX-2抑制剂，IC50值为 19.98 μM。COX-2-IN-12 是一种抗炎剂，并且在体内急性毒性研究中显示出安全性。
T64063	COX-2-IN-24	Others	Others
	COX-2-IN-24是一种口服具有活力的 COX-2 抑制剂 (IC50: 0.17 μM)，具有抗炎和低致溃疡作用。
T60464	COX-2-IN-20	Others	Others
	COX-2-IN-20 (Compound 5d) 是一种选择性口服活性的COX-2抑制剂（IC 50 = 17.9 nM），具有抗炎活性。
T0458	Indomethacin Indocin,Indometacine,吲哚美辛,Indomethacine,Indometacin	Phospholipase; COX; PDE; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; Neuroscience
	Indomethacin (Indometacin) 是一种可透过血脑屏障的，非选择性的COX1和COX2抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的IC50值分别为 18 nM 和 26 nM。它通过干扰溶酶体的正常功能来破坏自噬流，是一种非甾体抗炎药。
T62350	XO/COX/LOX-IN-1	Others	Others
	XO/COX/LOX-IN-1 是一种黄嘌呤氧化酶/环氧酶/脂氧合酶 XO/COX/LOX 的有效抑制剂。XO/COX/LOX-IN-1 能够用于研究炎症、癌症以及代谢性疾病。
T60403	COX-2/NO-IN-1	Others	Others
	COX-2/NO-IN-1 是一种具有口服活性的一氧化氮合酶 (iNOS) 和 NO（IC 50 为 3.52 μM）抑制剂，并抑制 COX-2 的表达。 COX-2/NO-IN-1 具有抗炎作用，可减少肾脏组织的病理损伤[1]。
T62103	COX-2/PI3K-IN-1	Others	Others
	COX-2/PI3K-IN-1 (compound 5d) 是一种 PI3K 的有效抑制剂 (IC50: 1.14 nM)。COX-2/PI3K-IN-1 是一种 COX-2 的选择性抑制剂 (Ki: 3.24 nM)。COX-2/PI3K-IN-1 显示出抗炎和抗癌效果。
T79592	COX-1/2-IN-4	COX	Immunology/Inflammation; Neuroscience
	COX-1/2-IN-4 为COX-1与COX-2酶的抑制剂，其IC50值分别为0.239 μM与0.191 μM。此化合物在对COLO205与B16F1癌细胞系表现出中等程度的抗癌活性，对应IC50值分别为30.79 μM与74.15 μM。
T6737	Zaltoprofen CN100,扎托布洛芬,Soleton	COX	Immunology/Inflammation; Neuroscience
	Zaltoprofen (Soleton) 是一种非甾体类抗炎剂，具有强大的抗炎作用和对炎性疼痛的止痛作用。它是可口服的COX-2抑制剂，对COX-1和COX-2的IC50值分别为 1.3 和 0.34 μM。
T9472	Rebamipide mofetil	COX	Immunology/Inflammation; Neuroscience
	Rebamipide mofetil 是 Rebamipide 的口服活性前药，是一种粘膜保护剂。
T60630	COX/5-LOX-IN-1	Others	Others
	COX/5-LOX-IN-1 (compound 6b) 是有效的COX/5-LOX 双重抑制剂，具有用于炎症性疾病研究的潜力。COX/5-LOX-IN-1 对于 COX-1、COX-2 和 5-LOX 酶的IC50值分别为 1.07、0.55 和 0.28 μM。
T0448	(S)-(+)-Ibuprofen 左旋布洛芬,Dexibuprofen,(S)-Ibuprofen,(S)-(+)-布洛芬	BCL; Thrombin; Cysteine Protease; COX; PPAR	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome
	(S)-(+)-Ibuprofen (Dexibuprofen) 是 Ibuprofen 的 S(+)-对映异构体，能够有效的抑制COX-1(IC50:2.1 μM)和COX-2(IC50:1.6 μM)，。它具有抗癌、退热、止痛，抗炎的效果。
T61674	COX-2/5-LOX-IN-1	Others	Others
	COX-2/5-LOX-IN-1 (compound 3a), a benzothiophen-2-yl pyrazole carboxylic acid derivative, is a potent and dual inhibitor of COX-2 / 5-LOX. It exhibits superior analgesic and anti-inflammatory properties compared to Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 displays strong inhibitory activity against COX-1, COX-2, and 5-LOX, with IC50 values of 12.13 μM, 0.4 μM, and 4.96 μM, respectively [1].
T79360	COX-2/15-LOX-IN-2	Lipoxygenase	Metabolism
	COX-2/15-LOX-IN-2 作为一种效能高的双重抑制剂，对COX-2和15-LOX的IC50值分别为0.065 μM和1.86 μM，显示出显著的抗氧化活性。
T6470	Diclofenac Potassium 双氯芬酸钾,CGP-45840B,Cataflam,Voltfast	Apoptosis; Others; COX	Apoptosis; Immunology/Inflammation; Neuroscience; Others
	Diclofenac Potassium (CGP-45840B) 是一种非甾体抗炎药，用于减轻炎症并在某些情况下作为镇痛剂减轻疼痛。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。它是一种COX 抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM 和0.84 μM。
T0778	Phenacetin 非那西丁,Acetophenetidin	COX	Immunology/Inflammation; Neuroscience
	Phenacetin (Acetophenetidin) 是一种非阿片类解热化合物，可用于缓解疼痛的研究。它是一种选择性的COX-3抑制剂，能作为人肝微粒体和大鼠体内 CYP1A2 的探针。
T60992	COX-1/2-IN-3	Others	Others
	COX-1/2-IN-3 (Compound 7a) 是COX-1和COX-2 的双重抑制剂。COX-2-IN-3 具有低毒性的抗炎活性。
T61196	COX-1/2-IN-1	Others	Others
	COX-1/2-IN-2 是一种有效的 COX1/2抑制剂。COX-1/2-IN-2 对 COX-1 和 COX-2 均有明显抑制作用，IC50分别为 13.9 ± 3.21 μM 和 6.4±0.74 μM。
T61865	COX-1/2-IN-2	Others	Others
	COX-1/2-IN-2 是一种有效的 COX1/2抑制剂。COX-1/2-IN-2 对 COX-1 和 COX-2 抑制剂均有明显抑制作用，IC50分别为 9.7±0.09 μM 和 4.6±1.45 μM。

化合物

Cat.No: T10033

Target: COX

Cat.No: T10032

Target: COX

Cat.No: T77618

Target: COX

Cat.No: T6574

Synonym: Prexige,罗美昔布,COX-189

Target: COX

Cat.No: T62061

Target: COX, Prostaglandin Receptor

Cat.No: T7207

Synonym: N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺,FK-3311,COX-2 Inhibitor V

Target: COX

COX/5-LO-IN-1

Cat.No: T13263

Synonym: Atreleuton analog

Target: COX

Cat.No: T78705

Target: COX

Cat.No: T63480

Target: Others

Cat.No: T63646

Target: Others

Diclofenac diethylamine

Cat.No: T0432

Target: Apoptosis, COX

Cat.No: T78706

Target: COX

Cat.No: T60457

Target: Others

Cat.No: T61760

Target: Others

Cat.No: T60978

Target: Others

Cat.No: T79130

Target: NF-κB

Cat.No: T7670

Target: COX

Cat.No: T79760

Target: COX

Cat.No: T63348

Target: Others

Cat.No: T62175

Target: Others

Cat.No: T61264

Target: Others

Cat.No: T61821

Target: Others

Cat.No: T61714

Target: Others

Cat.No: T63215

Target: Others

Cat.No: T62259

Target: Others

Cat.No: T63336

Target: Others

Cat.No: T62142

Target: Others

Cat.No: T78754

Target: COX

Cat.No: T64109

Target: Others

Cat.No: T63943

Target: Others

Cat.No: T61711

Target: Others

Cat.No: T60566

Target: Others

Cat.No: T64063

Target: Others

Cat.No: T60464

Target: Others

Cat.No: T0458

Synonym: Indocin,Indometacine,吲哚美辛,Indomethacine,Indometacin

Target: Phospholipase, COX, PDE, Autophagy

XO/COX/LOX-IN-1

Cat.No: T62350

Target: Others

COX-2/NO-IN-1

Cat.No: T60403

Target: Others

COX-2/PI3K-IN-1

Cat.No: T62103

Target: Others

Cat.No: T79592

Target: COX

Cat.No: T6737

Synonym: CN100,扎托布洛芬,Soleton

Target: COX

Rebamipide mofetil

Cat.No: T9472

Target: COX

COX/5-LOX-IN-1

Cat.No: T60630

Target: Others

(S)-(+)-Ibuprofen

Cat.No: T0448

Synonym: 左旋布洛芬,Dexibuprofen,(S)-Ibuprofen,(S)-(+)-布洛芬

Target: BCL, Thrombin, Cysteine Protease, COX, PPAR

COX-2/5-LOX-IN-1

Cat.No: T61674

Target: Others

COX-2/15-LOX-IN-2

Cat.No: T79360

Target: Lipoxygenase

Diclofenac Potassium

Cat.No: T6470

Synonym: 双氯芬酸钾,CGP-45840B,Cataflam,Voltfast

Target: Apoptosis, Others, COX

Cat.No: T0778

Synonym: 非那西丁,Acetophenetidin

Target: COX

Cat.No: T60992

Target: Others

Cat.No: T61196

Target: Others

Cat.No: T61865

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1723	Hamaudol	COX	Immunology/Inflammation; Neuroscience
	Hamaudol 是从防风中分离出的一种色酮，有抗炎作用，可用于缓解疼痛的研究。它抑制环加氧酶COX-1和COX-2的活性，IC50值分别为 0.30 和 0.57 mM。
T6S0077	Byakangelicol	COX	Immunology/Inflammation; Neuroscience
	Byakangelicol 是一种分离自白芷的白三醇，能够抑制环加氧酶-2的表达及活性，从而减少白细胞介素-1β诱导的 A549 细胞中前列腺素 E2 的释放。它可用于研究气道炎症。
T3883	Roburic acid	COX	Immunology/Inflammation; Neuroscience
	Roburic acid 是秦艽中的一种四环三萜类天然产物，作为COX 抑制剂，对 COX-1 和 COX-2 的IC50值分别为 5 和 9 μM。
T4S0590	Columbin	Phospholipase; COX; Parasite	Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	Columbin 是有口服活性的二萜呋喃内酯，选择性抑制COX-1和COX-2，EC50值为 327 μM 和 53.1 μM，具有抗炎和抗锥虫体作用。
T6S0413	Pectolinarigenin 柳穿鱼黄素,Pectolinaringenin	Others; Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience; Others
	Pectolinarigenin (Pectolinaringenin) 是 COX-2/5-LOX 的双重抑制剂，可抑制炎症病变中类花生酸的形成，具有抗炎活性。
TQ0288	Hexahydrocurcumin	Reactive Oxygen Species; ROS; COX	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Hexahydrocurcumin 是一种选择性口服活性COX-2抑制剂，对 COX-1 无活性，是姜黄素的主要代谢产物之一，。它具有抗氧化，抗癌和抗炎作用。
T3399	Psoralidin	Others; Estrogen/progestogen Receptor; Reactive Oxygen Species; Lipoxygenase; Gamma-secretase; Akt; COX; Antibacterial	Cytoskeletal Signaling; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Psoralidin 是COX-2和5-LOX 的抑制剂，有抗癌，抗菌和抗炎作用。它显著下调NOTCH1信号传导，还极大地诱导活化氧产生。
T3824	Jaceosidin	Apoptosis; BCL; COX; UGT	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物，可激活Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。它能够降低炎性因子水平，激活 NF-κB，抑制COX-2的表达，具有抗癌和抗炎作用。
TN2139	Regaloside B 鸦胆子苦醇,王百合苷 B	NOS; COX; NO Synthase	Immunology/Inflammation; Neuroscience
	Regaloside B 是从麝香百合中分离出来的一种苯丙烷，可抑制iNOS 和COX-2的表达，具有抗炎活性。
T5758	sphondin 6-甲氧基当归素,牛防风素,牛防风素	COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Sphondin 具有抗惊厥、抗炎和抗增殖活性，对 IL-1beta 诱导的 A549 细胞中 COX-2 蛋白水平和 PGE(2) 释放的增加具有抑制作用。
T6S2023	Harpagoside	Others; COX; NO Synthase	Immunology/Inflammation; Neuroscience; Others
	Harpagoside 是从爪钩草中分离出来的一种天然产物，可抑制COX-1和COX-2活性，并抑制 NO 的产生。
T8240	Cis-5-Dodecenoic Acid	Others	Others
	Cis-5-Dodecenoic Acid 是一种单不饱和脂肪酸，具有 C12 链作为主链，C5 位具有顺式双键。
T5S0045	Isofraxidin 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶	MMP; ERK; p38 MAPK; TLR; COX	Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。
T3747	syringaldehyde Syringic aldehyde,丁香醛,Springaldehyde	COX	Immunology/Inflammation; Neuroscience
	syringaldehyde 是可从厚朴和木薯中分离得到的黄酮类多酚，具有抗氧化、抗高血糖和抗炎活性，可适度抑制COX-2活性，IC50为 3.5 μg/mL。
TQ0180	Chebulagic acid	SARS-CoV; Influenza Virus; Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	Chebulagic acid 是从 Terminalia chebula Retz 中分离出来的一种 COX-LOX 双重抑制剂，有抗炎和抗感染作用。它抑制 SARS-CoV-2病毒的复制，EC50值为 9.76 μM。它还是 M2(S31N)抑制剂和抗流感病毒剂。
T3877	Esculentoside A	NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Esculentoside A 是一种三萜皂苷，从商陆根部分离得到。它在具有抗炎活性，对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。
T5431	[10]-Shogaol 10-姜烯酚,10-Shogaol	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	[10]-Shogaol (10-Shogaol) 是一种从生姜中提取的抗氧化剂，用于皮肤细胞增殖和迁移增强剂。它抑制 COX-2，IC50值为 7.5 μM，可能有降血脂和胰岛素增敏作用。
T5430	[8]-Shogaol 8-SHOGAOL,8-姜烯酚	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	[8]-Shogaol 是生姜中的一种刺激性酚类天然产物，可诱导人白血病细胞凋亡，抑制 COX-2的IC50为17.5 μM，具有抗血小板活性，IC50为5 μM。
T7052	Gnetol	Tyrosinase; COX; HDAC; AChR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Gnetol 是从买麻藤的根中分离出来的一种酚类。它是酪氨酸酶抑制剂，对鼠酪氨酸酶的 IC50为 4.5 μM，可抑制黑色素的生物合成。它有效抑制 COX-1和 HDAC，具有抗氧化、抗增殖、抗癌和保肝活性，还具有浓度依赖性的 α-淀粉酶、α-葡萄糖苷酶和脂肪形成活性。
T0443	Salicin Salicoside,水杨甙,Salicine,水杨苷,D-(−)-Salicin	COX	Immunology/Inflammation; Neuroscience
	Salicin (Salicine) 是天然的COX 抑制剂。
T2972	Rutaecarpine Rutacarpine,吴茱萸次碱,Rhetine,Rutecarpine	COX	Immunology/Inflammation; Neuroscience
	Rutaecarpine (Rhetine) 是从槐木中提取的一种生物碱，是 COX-2的抑制剂，IC50值为0.28 μM。
T8255	(±)-Catechin (±)-Catechin hydrate,儿茶素	ROS; COX	Immunology/Inflammation; Neuroscience
	(±)-Catechin ((±)-Catechin hydrate) hydrate 是 Catechin 的外消旋体，是从云南红豆杉中提取的一种天然产物，具有抗肿瘤、抗肥胖、抗糖尿病、抗心血管、抗感染、保肝和神经保护作用。
T3866	Macelignan 安五脂素,Anwuligan,(+)-Anwulignan	Others; COX	Immunology/Inflammation; Neuroscience; Others
	Macelignan (Anwuligan) 是一种从肉豆蔻中分离得到的木脂素，具有抗炎、抗癌、抗糖尿病和神经保护活性。
T6S1572	Sauchinone	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。
TN3500	beta-Amyrone β-Amyron,β-香树脂酮	COX; AChR; PPAR; Antifection	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性，EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。
T3342	Xanthohumol	Apoptosis; Others; Influenza Virus; COX; Acyltransferase; HSV	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; Others
	Xanthohumol 是从啤酒花中分离到的黄酮类化合物，可抑制 COX-1 和 COX-2 活性，具有抗肿瘤，抗血管生成的作用，还具有抗多种病毒的活性。
T7113	Paradol 姜酮酚,6-paradol,必理通,[6]-Gingerone	COX	Immunology/Inflammation; Neuroscience
	Paradol ([6]-Gingerone) 是一种姜科植物中发现的酚类天然产物，具有抗癌、抗炎、抗氧化和神经保护作用。在小鼠皮肤癌变中，可结合到环氧合酶(COX-2) 活性位点。
T2778	(+)-Catechin Hydrate 一水合儿茶素,(+)-水合儿茶素	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	(+)-Catechin hydrate 是来自茶树的抗氧化类黄酮，可抑制环加氧酶-1，IC50为 1.4 μM。它是一种自由基清除剂，可防止多种生物系统中自由基介导的损害。
T0649	Salicylic acid 2-Hydroxybenzoic acid,水杨酸	Apoptosis; Mitophagy; COX; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; Neuroscience
	Salicylic acid (2-Hydroxybenzoic acid) 是一种从柳树皮中提取的天然产物，是一种抗炎活性环加氧酶抑制剂，抑制COX-2活性。
T2826	Asaraldehyde Asarylaldehyde,2,4,5-trimethoxy-Benzaldehyde,Asaronaldehyde,细辛醛	COX	Immunology/Inflammation; Neuroscience
	Asaraldehyde (2,4,5-trimethoxy-Benzaldehyde) 是COX-2抑制剂，能够明显降低环加氧酶 II (COX-2) 的活性(IC50:100 μg/mL)。
T4643	TFAP N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	COX; Endogenous Metabolite	Immunology/Inflammation; Metabolism; Neuroscience
	TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) 是环氧酶 1 的一种选择性抑制剂，IC50值为 0.8 μM。
T6S1543	Dehydrodiisoeugenol 去氢二异丁香酚,脱氢二异丁香酚	Others; NF-κB; COX; Antibacterial	Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Others
	Dehydrodiisoeugenol 是从Myristica fragrans Houtt 中分离得到的天然产物，具有抗炎和抗菌作用。它抑制 LPS 刺激的小鼠巨噬细胞中NF-κB 活化和环氧合酶 (COX)-2 基因的表达。
T5759	S-(+)-Marmesin (+)-Marmesin,异紫花前胡内酯,(S)-Marmesin,marmesin	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	S-(+)-Marmesin (marmesin) 是一种从木橘成熟树皮中分离得到的香豆素，具有 COX-2/5-LOX 双重抑制活性。
T1468	Lornoxicam Ro 13-9297,Chlortenoxicam,TS110,氯诺昔康	COX; Endogenous Metabolite	Immunology/Inflammation; Metabolism; Neuroscience
	Lornoxicam (Chlortenoxicam) 是一种新型非甾体抗炎药，是高活性 COX-1 和 COX-2 抑制剂，IC50 分别为 5 和 8 nM。
T2856	(-)-Epicatechin L-Epicatechin,表儿茶素,Epicatechin,(-)-Epicatechol,表儿茶精	Ferroptosis; COX; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	(-)-Epicatechin (Epicatechin) 是一种 COX-1 的抑制剂，通过阻断 NF-κB 的 p65 亚基的核定位来抑制 IL-1β 诱导的 iNOS 表达。
TQ0169	Inulicin 1-O-Acetylbritannilactone,旋覆花内酯	FAK; NF-κB; COX; Src	Angiogenesis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Inulicin (1-O-Acetylbritannilactone) 是从欧亚旋覆花中提取的一种天然产物，可抑制 VEGF 介导的Src 和FAK 活化，抑制NF-κB 活化和易位，以及抑制 LPS 诱导的PGE2产生和COX-2表达。
T3S0645	N-trans-Feruloyltyramine Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺	Others; COX	Immunology/Inflammation; Neuroscience; Others
	N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱，是COX1和COX2的抑制剂，具有抗氧化和抗炎活性。
TN1377	α-Spinasterol Α-波菜甾醇,alpha-Spinasterol,菠甾醇	COX; Antibacterial; TRP/TRPV Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	α-Spinasterol 是一种从Spinacia oleracea 分离的瞬时受体电位香草酸 1 拮抗剂，具有抗菌、抗炎、抗抑郁、抗氧化和抗伤害作用。它抑制COX-1和COX-2活性，IC50值分别为 16.17 μM 和 7.76 μM。
T3744	Veratric acid Veratrumenoic acid,藜芦酸,3,4-Dimethoxybenzoic acid	Reactive Oxygen Species; COX	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Veratric acid (3,4-Dimethoxybenzoic acid) 是从蔬菜和水果中得到的一种可口服多酚，具有抗氧化、保护心血管和抗炎活性。当细胞受到 UVB 辐射时，它能够减少上调的 COX-2 表达，降低 PGE2 和 IL-6 水平。
T8293	γ-Tocopherol D-gamma-生育酚,γ-生育酚,(+)-γ-Tocopherol	COX	Immunology/Inflammation; Neuroscience
	γ-Tocopherol ((+)-γ-Tocopherol) 是有效的环氧合酶抑制剂，是存在于玉米油和大豆中的维生素 E，具有抗炎特性和抗癌活性。
T6S0722	Isoorientin Homoorientin,Luteolin-6-C-glucoside,异荭草苷;异荭草素,异荭草素	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	Isoorientin (Homoorientin) 是一种 COX-2抑制剂，IC50值为 39 μM，具有抗氧化活性。
T2S2335	Dehydroevodiamine DHED,去氢吴茱萸碱	Others; NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB; Others
	Dehydroevodiamine (DHED) 是从吴茱萸中分离出的一种喹唑啉生物碱，可抑制 LPS 诱导的小鼠巨噬细胞中iNOS、COX-2、PGE2和NF-κB 的表达，对豚鼠心室肌细胞具有抗心律失常作用。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
T5727	CAFESTOL 咖啡醇,咖啡油醇	ERK; NF-κB; COX; PGE Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Cafestol 是咖啡特有的一种二萜，可靶向 AP-1 抑制ERK，有化学预防、抗肿瘤、保肝、抗氧化和抗炎作用。它通过抑制NF-kB 活化途径强烈的抑制 PGE2的产生，还抑制 LGE 激活的 RAW264.7 细胞中的PGE2产生和环氧合酶(COX-2)的 mRNA 表达。
T0822	Catechin Catechinic acid,D-Catechin,(+)-Catechin,Cianidanol,儿茶素,Catechuic acid	Apoptosis; Influenza Virus; COX; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	Catechin (Cianidanol) 属于天然酚类，是一种抗氧化剂，可以抑制环加氧酶-1 (COX-1) (IC50=1.4 μM)。Catechin 具有抗肿瘤、抗氧化、抗菌等多种生物活性。
T5S2360	Corydaline Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline	P450; Virus Protease; Opioid Receptor; AChE	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Corydaline (Corydalin) 是从 Corydalis yanhusuo 提取的一种异喹啉生物碱，是一种新型促动力植物药的主要活性成分之一。它促进胃排空和小肠转运，促进胃的调节，具有抗乙酰胆碱酯酶、抗过敏和镇痛活性。
TN1373	α-Humulene Alpha-caryophyllene,ALPHA-律草烯	TNF; NOS; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	α-Humulene (Alpha-caryophyllene) 是 Tanacetum vulgareL. 精油的主要成分，显示出抗炎作用，IC50=15±2 μg/mL。它抑制 iNOS 和COX-2表达。
T0065	Acetaminophen 对乙酰氨基酚,醋氨酚,4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol	COX; Endogenous Metabolite; Histone Acetyltransferase	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Neuroscience
	Acetaminophen (APAP) 是一种 COX 抑制剂，抑制 COX-1 和 COX-2 (IC50=113.7/25.8 μM)。Acetaminophen 具有解热镇痛活性，以及较弱的抗炎活性。
T0877	Gallic acid 3,4,5-Trihydroxybenzoic acid,Gallate,没食子酸,Benzoic acid	Apoptosis; Ferroptosis; Reactive Oxygen Species; ROS; COX; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Gallic acid (Benzoic acid) 属于天然多羟基酚类，可以抑制 COX-2 的自由基清除作用。Gallic acid 具有抗氧化、抗炎、抗肿瘤、抗菌等多种生理活性。
T3918	Ginsenoside Rb3 人参皂苷 Rb3,Gypenoside IV,人参皂苷Rb3	NF-κB; COX; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB
	Ginsenoside Rb3 (Gypenoside IV) 是从三七中提取的一种天然产物。它在 293T 细胞系中抑制 TNFα 诱导的NF-κB 转录活性，IC50为 8.2 μM。它还抑制COX-2和iNOSmRNA 的诱导。
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天然产物

Cat.No: TN1723

Target: COX

Cat.No: T6S0077

Target: COX

Cat.No: T3883

Target: COX

Cat.No: T4S0590

Target: Phospholipase, COX, Parasite

Pectolinarigenin

Cat.No: T6S0413

Synonym: 柳穿鱼黄素,Pectolinaringenin

Target: Others, Lipoxygenase, COX

Hexahydrocurcumin

Cat.No: TQ0288

Target: Reactive Oxygen Species, ROS, COX

Cat.No: T3399

Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial

Cat.No: T3824

Target: Apoptosis, BCL, COX, UGT

Cat.No: TN2139

Synonym: 鸦胆子苦醇,王百合苷 B

Target: NOS, COX, NO Synthase

Cat.No: T5758

Synonym: 6-甲氧基当归素,牛防风素,牛防风素

Target: COX, Prostaglandin Receptor

Cat.No: T6S2023

Target: Others, COX, NO Synthase

Cis-5-Dodecenoic Acid

Cat.No: T8240

Target: Others

Cat.No: T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶

Target: MMP, ERK, p38 MAPK, TLR, COX

Cat.No: T3747

Synonym: Syringic aldehyde,丁香醛,Springaldehyde

Target: COX

Chebulagic acid

Cat.No: TQ0180

Target: SARS-CoV, Influenza Virus, Lipoxygenase, COX

Esculentoside A

Cat.No: T3877

Target: NF-κB, COX

Cat.No: T5431

Synonym: 10-姜烯酚,10-Shogaol

Target: Antioxidant, COX

Cat.No: T5430

Synonym: 8-SHOGAOL,8-姜烯酚

Target: Apoptosis, COX

Cat.No: T7052

Target: Tyrosinase, COX, HDAC, AChR

Cat.No: T0443

Synonym: Salicoside,水杨甙,Salicine,水杨苷,D-(−)-Salicin

Target: COX

Cat.No: T2972

Synonym: Rutacarpine,吴茱萸次碱,Rhetine,Rutecarpine

Target: COX

Cat.No: T8255

Synonym: (±)-Catechin hydrate,儿茶素

Target: ROS, COX

Cat.No: T3866

Synonym: 安五脂素,Anwuligan,(+)-Anwulignan

Target: Others, COX

Cat.No: T6S1572

Target: ERK, p38 MAPK, NF-κB

Cat.No: TN3500

Synonym: β-Amyron,β-香树脂酮

Target: COX, AChR, PPAR, Antifection

Cat.No: T3342

Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV

Cat.No: T7113

Synonym: 姜酮酚,6-paradol,必理通,[6]-Gingerone

Target: COX

(+)-Catechin Hydrate

Cat.No: T2778

Synonym: 一水合儿茶素,(+)-水合儿茶素

Target: Antioxidant, COX

Cat.No: T0649

Synonym: 2-Hydroxybenzoic acid,水杨酸

Target: Apoptosis, Mitophagy, COX, Endogenous Metabolite, Autophagy

Cat.No: T2826

Synonym: Asarylaldehyde,2,4,5-trimethoxy-Benzaldehyde,Asaronaldehyde,细辛醛

Target: COX

Cat.No: T4643

Synonym: N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide

Target: COX, Endogenous Metabolite

Dehydrodiisoeugenol

Cat.No: T6S1543

Synonym: 去氢二异丁香酚,脱氢二异丁香酚

Target: Others, NF-κB, COX, Antibacterial

Cat.No: T5759

Synonym: (+)-Marmesin,异紫花前胡内酯,(S)-Marmesin,marmesin

Target: Lipoxygenase, COX

Cat.No: T1468

Synonym: Ro 13-9297,Chlortenoxicam,TS110,氯诺昔康

Target: COX, Endogenous Metabolite

(-)-Epicatechin

Cat.No: T2856

Synonym: L-Epicatechin,表儿茶素,Epicatechin,(-)-Epicatechol,表儿茶精

Target: Ferroptosis, COX, Endogenous Metabolite

Cat.No: TQ0169

Synonym: 1-O-Acetylbritannilactone,旋覆花内酯

Target: FAK, NF-κB, COX, Src

N-trans-Feruloyltyramine

Cat.No: T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺

Target: Others, COX

Cat.No: TN1377

Synonym: Α-波菜甾醇,alpha-Spinasterol,菠甾醇

Target: COX, Antibacterial, TRP/TRPV Channel

Cat.No: T3744

Synonym: Veratrumenoic acid,藜芦酸,3,4-Dimethoxybenzoic acid

Target: Reactive Oxygen Species, COX

Cat.No: T8293

Synonym: D-gamma-生育酚,γ-生育酚,(+)-γ-Tocopherol

Target: COX

Cat.No: T6S0722

Synonym: Homoorientin,Luteolin-6-C-glucoside,异荭草苷;异荭草素,异荭草素

Target: Antioxidant, COX

Dehydroevodiamine

Cat.No: T2S2335

Synonym: DHED,去氢吴茱萸碱

Target: Others, NF-κB, COX, PGE Synthase, NO Synthase

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: T5727

Synonym: 咖啡醇,咖啡油醇

Target: ERK, NF-κB, COX, PGE Synthase

Cat.No: T0822

Synonym: Catechinic acid,D-Catechin,(+)-Catechin,Cianidanol,儿茶素,Catechuic acid

Target: Apoptosis, Influenza Virus, COX, Endogenous Metabolite

Cat.No: T5S2360

Synonym: Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline

Target: P450, Virus Protease, Opioid Receptor, AChE

Cat.No: TN1373

Synonym: Alpha-caryophyllene,ALPHA-律草烯

Target: TNF, NOS, COX

Cat.No: T0065

Synonym: 对乙酰氨基酚,醋氨酚,4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol

Target: COX, Endogenous Metabolite, Histone Acetyltransferase

Cat.No: T0877

Synonym: 3,4,5-Trihydroxybenzoic acid,Gallate,没食子酸,Benzoic acid

Target: Apoptosis, Ferroptosis, Reactive Oxygen Species, ROS, COX, Endogenous Metabolite

Ginsenoside Rb3

Cat.No: T3918

Synonym: 人参皂苷 Rb3,Gypenoside IV,人参皂苷Rb3

Target: NF-κB, COX, NO Synthase

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01736	COX-2 Protein, Human, Recombinant (His) GRIPGHS,PHS-2,hCox-2,COX-2,PGHS-2,prostagl...	Human	Baculovirus Insect Cells
	PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression ...
TMPH-01179	COX4I1 Protein, Human, Recombinant (His & SUMO) Cytochrome c oxidase polypeptide IV,COX4I1,Cytochro...	Human	E. coli
	COX4I1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-04807	Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc) VP4 Protein	CV	Baculovirus Insect Cells
	Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc) is expressed in Baculovirus insect cells with Fc tag. The predicted molecular weight is 32.6 kDa and the accession number is AAA50478.1.
TMPY-04908	Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc)	CV	Baculovirus Insect Cells
	Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc) is expressed in Baculovirus insect cells with Fc tag. The predicted molecular weight is 59.5 kDa and the accession number is AAA50478.1.
TMPH-01180	COX5A Protein, Human, Recombinant (GST) Cytochrome c oxidase polypeptide Va,Cytochrome c oxidase sub...	Human	E. coli
	COX5A Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPY-03511	COX5B Protein, Human, Recombinant (His) COXVB,cytochrome c oxidase subunit Vb	Human	E. coli
	Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nucl...
TMPY-03752	COX4NB Protein, Human, Recombinant (His) ER membrane protein complex subunit 8,C16orf4,FAM158B,NOC4,C...	Human	E. coli
	COX4NB Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O43402.
TMPH-02617	COX5A Protein, Mouse, Recombinant (His & SUMO) Cytochrome c oxidase subunit 5A, mitochondrial,COX5...	Mouse	E. coli
	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over t...
TMPH-03639	COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) Cytochrome c oxidase subunit VIIa-H,COX7A1,Cytochro...	Trachypithecus cristatus	HEK293 Cells
	N/A. COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 31.9 kDa and the accession number is Q9N234.
TMPY-02481	ACOX1 Protein, Human, Recombinant (His) PALMCOX,ACOX,SCOX,acyl-CoA oxidas...	Human	Baculovirus Insect Cells
	Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a...
TMPH-02825	ACOX1 Protein, Mouse, Recombinant (Myc) AOX,Peroxisomal fatty acyl-CoA oxidase,EC:1.3.3.6,Peroxisoma...	Mouse	E. coli
	Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.; Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length.; Is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.
TMPY-03658	ETHE1 Protein, Human, Recombinant (His) YF13H12,HSCO,ethylmalonic encephalopathy 1	Human	E. coli
	ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. ETHE1 can suppresses p53-induced apoptosis by preventing nuclear localization of RELA. Mutations in ETHE1 gene result in ethylmalonic encephalopathy. Ethylmalonic en...
TMPJ-00704	SCO1 Protein, Human, Recombinant (GST) Protein SCO1 Homolog Mitochondrial,SCOD1,SCO1	Human	E. coli
	Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4...

重组蛋白

COX-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01736

Species: Human

Expression System: Baculovirus Insect Cells

COX4I1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01179

Species: Human

Expression System: E. coli

Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc)

Cat.No: TMPY-04807

Species: CV

Expression System: Baculovirus Insect Cells

Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc)

Cat.No: TMPY-04908

Species: CV

Expression System: Baculovirus Insect Cells

COX5A Protein, Human, Recombinant (GST)

Cat.No: TMPH-01180

Species: Human

Expression System: E. coli

COX5B Protein, Human, Recombinant (His)

Cat.No: TMPY-03511

Species: Human

Expression System: E. coli

COX4NB Protein, Human, Recombinant (His)

Cat.No: TMPY-03752

Species: Human

Expression System: E. coli

COX5A Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02617

Species: Mouse

Expression System: E. coli

COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc)

Cat.No: TMPH-03639

Species: Trachypithecus cristatus

Expression System: HEK293 Cells

ACOX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02481

Species: Human

Expression System: Baculovirus Insect Cells

ACOX1 Protein, Mouse, Recombinant (Myc)

Cat.No: TMPH-02825

Species: Mouse

Expression System: E. coli

ETHE1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03658

Species: Human

Expression System: E. coli

SCO1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00704

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11246	Etoricoxib-d4 MK-0663 D4,依托考昔 D4,L-791456 D4,Etoricoxib D4	Others	Others
	Etoricoxib D4 is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.Etoricoxib D4 is a deuterium labeled Etoricoxib.
T11754	Ketorolac-d5 Ketorolac D5	PPAR	DNA Damage/DNA Repair; Metabolism
	Ketorolac D5, a deuterium-labeled version of Ketorolac, is a non-steroidal anti-inflammatory agent that functions as a nonselective COX inhibitor. It exhibits IC50 values of 20 nM for COX-1 and 120 nM for COX-2.
T12800	(S)-(+)-Ibuprofen D3 (S)-Ibuprofen D3	COX	Immunology/Inflammation; Neuroscience
	(S)-(+)-Ibuprofen D3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen ,it is an inhibitor of COX-1 and COX-2 activity (IC50s of 2.1 μM and 1.6 μM).
T11655	Indomethacin-D4 Indometacin-D4,吲哚美辛-D4	CDK	Cell Cycle/Checkpoint
	Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.
T12227	Nimesulide D5	COX	Immunology/Inflammation; Neuroscience
	Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective inhibitor OF COX-2(IC50s of 70 nM-70 μM)
T11604	Ibuprofen-d3 Ibuprofen D3,(±)-Ibuprofen D3	Others	Others
	Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor (IC50s: 13 μM and 370 μM).
T12487	Piroxicam D3 吡罗昔康 D3,CP-16171 D3	Others	Others
	Piroxicam D3 is deuterium labeled Piroxicam. Piroxicam is a COX inhibitor(human monocyte COX-1 and COX-2 with IC50s of 47, 25 μM , respectively) .
TMIJ-0127	Diclofenac-d4
	Diclofenac-d4 是 Diclofenac 的氘代化合物。Diclofenac 的 CAS 号为 15307-86-5。Diclofenac 是一种具有抗炎活性的非甾体苯乙酸衍生物，是COX抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM，0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。
TMIH-0278	Iguratimod-d5
	Iguratimod-d5 是 Iguratimod 的氘代化合物。Iguratimod 的 CAS 号为 123663-49-0。Iguratimod 是一种抗风湿药，作为 COX-2 的抑制剂，IC50 为 20 μM (7.7 μg/mL)。它还抑制巨噬细胞迁移抑制因子 (MIF)，IC50值为 6.81 μM。
T12208	Nepafenac-d5 奈帕芬胺 D5,AHR-9434 D5,AL-6515 D5	Others	Others
	Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 .
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...
T11998	Meloxicam-d3 Meloxicam D4	Others	Others
	Meloxicam D4 is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity,(Target:COX-1; IC50: 36.6 μM ;(Target:COX-2; IC50: 0.49 μM).
T71212	Lornoxicam-d4
	Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e...
T71285	Metaxalone-d6
	Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone ...
TMIH-0472	Rac Loxoprofen sodium-d3
	Rac Loxoprofen sodium-d3 是 Rac Loxoprofen sodium 的氘代化合物。Rac Loxoprofen sodium 的 CAS 号为 68767-14-6。Loxoprofen 是一种非甾体类抗炎药，具有解热作用，可用于缓解疼痛的研究。它是非选择性COX抑制剂，对 COX-1 和 COX-2 的IC50分别为 6.5 和 13.5 μM。
TMIH-0290	Ketorolac-d5-P1
	Ketorolac-d5-P1 是 Ketorolac 的氘代化合物。Ketorolac 的 CAS 号为 74103-06-3。Ketorolac 是非甾体抗炎剂，是非选择性的COX抑制剂，对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。
TMIH-0291	Ketorolac-d5-P2
	Ketorolac-d5-P2 是 Ketorolac 的氘代化合物。Ketorolac 的 CAS 号为 74103-06-3。Ketorolac 是非甾体抗炎剂，是非选择性的COX抑制剂，对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。
T11995	Melatonin-d4 N-Acetyl-5-methoxytryptamine D5,Melatonin D5,褪黑素 D5	Others	Others
	Melatonin D5, a deuterium-labeled version of melatonin, is a hormone produced by the pineal gland, known for its role as a selective ATF-6 inhibitor that promotes apoptosis in human hepatoma cells via COX-2 downregulation. Additionally, it activates melatonin receptors and exhibits antioxidative and anti-inflammatory properties.
TMIJ-0211	Loxoprofen-d4
	Loxoprofen-d4 是 Loxoprofen 的氘代化合物。Loxoprofen 的 CAS 号为 68767-14-6。Loxoprofen 是一种非甾体类抗炎药，具有解热作用，可用于缓解疼痛的研究。它是非选择性COX抑制剂，对 COX-1 和 COX-2 的IC50分别为 6.5 和 13.5 μM。
TMID-0276	MAA-d3
	MAA-d3 是 MAA 的氘代化合物。MAA 的 CAS 号为 519-98-2。4-Methylamino antipyrine 是 Metamizole 的活性代谢产物，可用于疼痛和发烧的研究。Metamizole 是吡唑啉酮类非甾体抗炎药，可抑制COX。
TMIH-0281	Indobufen-d5
	Indobufen-d5 是 Indobufen 的氘代化合物。Indobufen 的 CAS 号为 63610-08-2。Indobufen 是一种血小板聚集抑制剂，是下调单核细胞中的组织因子，可逆抑制血小板环氧合酶 (Cox) 的活性和血栓素 A2 (TxA2) 的合成。
T35697	Lauric Acid-13C
	Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Lauric acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.2
T71288	Phenylbutazone-d9
	Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide). It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-in...
TMIJ-0274	Sulindac-d3
	Sulindac-d3 是 Sulindac 的氘代化合物。Sulindac 的 CAS 号为 38194-50-2。Sulindac 是一种非甾体类抗炎剂，可抑制COX-2的活性，也可抑制 COX-2 的过表达。它是一种亚磺酰基茚衍生物前药，具有潜在的抗肿瘤活性。
T35789	Palmitic acid-1-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 \|1. Santos, M.J., López-Jurado, M., Llopis, J., et a...
T35791	Palmitic acid-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ...
TMIJ-0224	Fenofibrate EP Impurity B-d6 Fenofibric Acid-d6
	Fenofibrate EP Impurity B-d6 是 Fenofibrate EP Impurity B 的氘代化合物。Fenofibrate EP Impurity B 的 CAS 号为 42017-89-0。Fenofibric acid 是 fenofibrate 的活性代谢物，是PPAR激动剂，对 PPARα、PPARγ 和 PPARδ 的EC50值分别为 22.4、1.47 和 1.06 µM。它抑制COX-2的活性，IC50值为 48 nM。
TMIJ-0207	(S)-Ketoprofen-d3
	(S)-Ketoprofen-d3 是 (S)-Ketoprofen 的氘代化合物。(S)-Ketoprofen 的 CAS 号为 22161-81-5。S-(+)-Ketoprofen 抑制COX-1和COX-2的IC50值分别为 1.9 和 27 nM。

同位素标记化合物

Cat.No: T11246

Synonym: MK-0663 D4,依托考昔 D4,L-791456 D4,Etoricoxib D4

Target: Others

Cat.No: T11754

Synonym: Ketorolac D5

Target: PPAR

(S)-(+)-Ibuprofen D3

Cat.No: T12800

Synonym: (S)-Ibuprofen D3

Target: COX

Indomethacin-D4

Cat.No: T11655

Synonym: Indometacin-D4,吲哚美辛-D4

Target: CDK

Cat.No: T12227

Target: COX

Cat.No: T11604

Synonym: Ibuprofen D3,(±)-Ibuprofen D3

Target: Others

Cat.No: T12487

Synonym: 吡罗昔康 D3,CP-16171 D3

Target: Others

Cat.No: TMIJ-0127

Cat.No: TMIH-0278

Cat.No: T12208

Synonym: 奈帕芬胺 D5,AHR-9434 D5,AL-6515 D5

Target: Others

Flufenamic Acid-d4

Cat.No: T71303

Cat.No: T11998

Synonym: Meloxicam D4

Target: Others

Cat.No: T71212

Cat.No: T71285

Rac Loxoprofen sodium-d3

Cat.No: TMIH-0472

Ketorolac-d5-P1

Cat.No: TMIH-0290

Ketorolac-d5-P2

Cat.No: TMIH-0291

Cat.No: T11995

Synonym: N-Acetyl-5-methoxytryptamine D5,Melatonin D5,褪黑素 D5

Target: Others

Cat.No: TMIJ-0211

Cat.No: TMID-0276

Cat.No: TMIH-0281

Lauric Acid-13C

Cat.No: T35697

Phenylbutazone-d9

Cat.No: T71288

Cat.No: TMIJ-0274

Palmitic acid-1-13C

Cat.No: T35789

Palmitic acid-13C

Cat.No: T35791

Fenofibrate EP Impurity B-d6

Cat.No: TMIJ-0224

Synonym: Fenofibric Acid-d6

(S)-Ketoprofen-d3

Cat.No: TMIJ-0207

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