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Search Results for " comt "

Targets Recommended: Endogenous Metabolite

18

抑制剂 & 化合物

7

天然产物

1

化合物库

1

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name
L9830	抗帕金森病化合物库		857 compounds
	857 种帕金森病相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

抗帕金森病化合物库

Cat.No: L9830

Compounds: 857

Cat. No.	Product Name	Target	Signaling Pathways
T75389	Catechol O-methyltransferase COMT	Endogenous Metabolite	Metabolism
	Catechol O-methyltransferase (COMT) 是是调节褪黑激素合成的关键酶，可调节参与调节植物的生长发育，可被具有特定结构的肝素低聚糖抑制。
T16398	Opicapone BIA 9-1067	Transferase	Metabolism
	Opicapone (BIA 9-1067) 是第三代儿茶酚-O-甲基转移酶 (COMT)抑制剂，能够降低细胞 ATP 含量，IC50=98 μM。它有用于帕金森病和运动波动的研究潜力。
T7831	Nitecapone	Others; Transferase	Metabolism; Others
	Nitecapone 是一个具有口服活性的、短效的儿茶酚-O-甲基转移酶(COMT)的抑制剂。它具有胃肠道保护和抗氧化活性，能够清除活性氧和一氧化氮，防止脂质过氧化。
T60658	hMAO-B/MB-COMT-IN-2	Others	Others
	hMAO-B/MB-COMT-IN-2 是MAO-B/MB-COMT 的双重抑制剂，对hMAO-B 和MB-COMT 的IC50值分别为 4.27 μM 和 2.69 μM。hMAO-B/MB-COMT-IN-2 保护细胞免受氧化损伤，可用于神经退行性疾病，如帕金森病 (PD) 等的研究。
T60489	hMAO-B/MB-COMT-IN-1	Others	Others
	hMAO-B/MB-COMT-IN-1 是 MAO-B/MB-COMT 的双重抑制剂，对 hMAO-B 的IC50值为 2.5 μM，对MB-COMT 的IC50值为 3.84 μM。hMAO-B/MB-COMT-IN-1 能保护细胞免受氧化损伤，可用于神经退行性疾病，如帕金森病 (PD)等的研究。
T2216	Entacapone OR-611,恩他卡朋	Transferase	Metabolism
	Entacapone (OR-611) 是可逆的、具有口服活性的、外周作用的儿茶酚-O-甲基转移酶抑制剂。它对大鼠脑、红细胞和肝脏 COMT 有抑制作用。它对 COMT 的选择性优于其他儿茶酚胺代谢酶。它抑制 FTO 去甲基化活性，可用于研究代谢紊乱。它可用于研究帕金森病。
T6708	Tolcapone Tasmar,Ro 40-7592,托卡朋	Apoptosis; Beta Amyloid; Transferase	Apoptosis; Metabolism; Neuroscience
	Tolcapone (Ro 40-7592) 是一种选择性，具有口服活性的外周和中枢COMT 抑制剂，在肝脏中对 COMT 的IC50为 773 nM。它还是一种 α-syn 和 Aβ42 寡聚和原纤维形成的有效抑制剂，可诱导氧化应激导致神经母细胞瘤细胞凋亡和抑制肿瘤生长。
T4983	Isoetharine mesylate salt Isoetarine mesilate,异丙肾上腺素甲磺酸盐	Others; Adrenergic Receptor	GPCR/G Protein; Neuroscience; Others
	Isoetharine mesylate salt (Isoetarine mesilate) 是一种 β-肾上腺素能受体激动剂。它还是能够上调 CYP450 表达的孕烷 X 受体(PXR) 激活剂。
T23109	3,5-Dinitrocatechol	Transferase	Metabolism
	3,5-Dinitrocatechol 是儿茶酚-O-甲基转移酶的有效抑制剂，IC50为 12 nM。它可用于制备钼 (VI)- 3,5-Dinitrocatechol 配合物。
T24030	Entacapone acid AG1290,AG 1290,AG-1290,恩他卡朋酸	Transferase	Metabolism
	Entacapone acid (AG 1290) 是一种选择性和可逆的儿茶酚-O-甲基转移酶 (COMT) 抑制剂。
T11207	Entacapone sodium salt	Others	Others
	Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.Entacapone sodium salt is a specific, potent, peripherally acting catech...
T26106	Ro 41-0960 Ro-41-0960,Ro41-0960	Others	Others
	Ro 41-0960 is used as a reversible and orally-active COMT-inhibitor.
T27162	DHMPA	Others	Others
	DHMPA is an inhibitor of catechol-O-methyltransferase (COMT), it also reduces tissue norepinephrine and blood pressure.
T16279	Nebicapone BIA 3-202	Others	Others
	Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of CO
T36207	Methylspinazarin	Others	Others
	Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg. \|1. Chimura, H., Sawa, T., Takita, T., et al. Methylspinazarin and dihydromethylspinazarin, gate...
T10119	3-O-Methyltolcapone Ro 40-7591	Transferase	Metabolism
	3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of Parkinson's disease.
T70608	cis-Entacapone	Others	Others
	cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone. It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.
T29029	U-0521	Others	Others
	U-0521, an inhibitor of catechol-O-methyltransferase (COMT), enhances the availability and utilization of levodopa in the brain.

化合物

Catechol O-methyltransferase

Cat.No: T75389

Synonym: COMT

Target: Endogenous Metabolite

Cat.No: T16398

Synonym: BIA 9-1067

Target: Transferase

Cat.No: T7831

Target: Others, Transferase

hMAO-B/MB-COMT-IN-2

Cat.No: T60658

Target: Others

hMAO-B/MB-COMT-IN-1

Cat.No: T60489

Target: Others

Cat.No: T2216

Synonym: OR-611,恩他卡朋

Target: Transferase

Cat.No: T6708

Synonym: Tasmar,Ro 40-7592,托卡朋

Target: Apoptosis, Beta Amyloid, Transferase

Isoetharine mesylate salt

Cat.No: T4983

Synonym: Isoetarine mesilate,异丙肾上腺素甲磺酸盐

Target: Others, Adrenergic Receptor

3,5-Dinitrocatechol

Cat.No: T23109

Target: Transferase

Entacapone acid

Cat.No: T24030

Synonym: AG1290,AG 1290,AG-1290,恩他卡朋酸

Target: Transferase

Entacapone sodium salt

Cat.No: T11207

Target: Others

Cat.No: T26106

Synonym: Ro-41-0960,Ro41-0960

Target: Others

Cat.No: T27162

Target: Others

Cat.No: T16279

Synonym: BIA 3-202

Target: Others

Methylspinazarin

Cat.No: T36207

Target: Others

3-O-Methyltolcapone

Cat.No: T10119

Synonym: Ro 40-7591

Target: Transferase

Cat.No: T70608

Target: Others

Cat.No: T29029

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0525	Flopropione 夫洛丙酮,Phloropropiophenone	5-HT Receptor; Transferase	GPCR/G Protein; Metabolism; Neuroscience
	Flopropione (Phloropropiophenone) 是一种解痉剂，用作 5-HT1A 受体拮抗剂，也是儿茶酚-O-甲基转移酶抑制剂。
T2765	Rosmarinic acid Labiatenic acid,迷迭香酸,Rosemary acid	Apoptosis; IκB/IKK; MAO; Endogenous Metabolite; Transferase; Monoamine Oxidase	Apoptosis; Metabolism; Neuroscience; NF-κB
	Rosmarinic acid (Labiatenic acid) 广泛存在植物中，具有抗氧化、抗炎和抗菌活性。它抑制 MAO-A，MAO-B 和 COMT，IC50分别为 50.1，184.6 和 26.7 μM。
TN2437	Serotonin 5-羟基色胺,5-hydroxytryptamine,血清素,五羟色胺,5-HT	Others; 5-HT Receptor; Endogenous Metabolite; Transferase	GPCR/G Protein; Metabolism; Neuroscience; Others
	Serotonin (5-hydroxytryptamine) 是 CNS 中的单胺神经递质和内源性5-HT 受体激动剂。它也是儿茶酚 O-甲基转移酶(COMT) 的抑制剂，Ki 值为 44 μM。
T2209	Serotonin hydrochloride 5-HT hydrochloride,5-羟基色胺盐酸盐,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride	5-HT Receptor; Endogenous Metabolite; Transferase	GPCR/G Protein; Metabolism; Neuroscience
	Serotonin hydrochloride (Serotonin HCl) 是一种内源性 5-HT 受体激动剂、CNS 中的单胺神经递质和儿茶酚 O-甲基转移酶 (COMT) 抑制剂，Ki 值为 44 μM。
TN7057	rosmarinate acid (R)-rosmarinic acid,rosmarinic acid,迷迭香素,Rosemary acid	MAO; Endogenous Metabolite; Transferase	Metabolism; Neuroscience
	Rosmarinate acid(Rosemary acid) 抑制 MAO-A、MAO-B 和 COMT 酶，IC50 分别为 50.1、184.6 和 26.7 μM。
T9455	4-hydroxyestrone-4-methyl ether 4-Methoxy Estrone,4-甲氧基雌酮	Estrogen Receptor/ERR; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	4-hydroxyestrone-4-methyl ether (4-Methoxy Estrone) 是由COMT 催化的4-OHE1的甲基化反应。
T39198	5-Hydroxyferulic acid	Others	Others
	5-Hydroxyferulic acid is an important hydroxycinnamic acid compound and a metabolite in the phenylpropanoid pathway. It acts as a precursor for the biosynthesis of sinapic acid and functions as a non-esterified substrate for COMT.

天然产物

Cat.No: T0525

Synonym: 夫洛丙酮,Phloropropiophenone

Target: 5-HT Receptor, Transferase

Rosmarinic acid

Cat.No: T2765

Synonym: Labiatenic acid,迷迭香酸,Rosemary acid

Target: Apoptosis, IκB/IKK, MAO, Endogenous Metabolite, Transferase, Monoamine Oxidase

Cat.No: TN2437

Synonym: 5-羟基色胺,5-hydroxytryptamine,血清素,五羟色胺,5-HT

Target: Others, 5-HT Receptor, Endogenous Metabolite, Transferase

Serotonin hydrochloride

Cat.No: T2209

Synonym: 5-HT hydrochloride,5-羟基色胺盐酸盐,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride

Target: 5-HT Receptor, Endogenous Metabolite, Transferase

rosmarinate acid

Cat.No: TN7057

Synonym: (R)-rosmarinic acid,rosmarinic acid,迷迭香素,Rosemary acid

Target: MAO, Endogenous Metabolite, Transferase

4-hydroxyestrone-4-methyl ether

Cat.No: T9455

Synonym: 4-Methoxy Estrone,4-甲氧基雌酮

Target: Estrogen Receptor/ERR, Endogenous Metabolite

5-Hydroxyferulic acid

Cat.No: T39198

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05158	COMT Protein, Human, Recombinant (His) catechol-O-methyltransferase,HEL-S-98n	Human	Baculovirus Insect Cells
	COMT Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 31.5 kDa and the accession number is A0A140VJG8.

重组蛋白

COMT Protein, Human, Recombinant (His)

Cat.No: TMPY-05158

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T13181	Tolcapone D7 Ro 40-7592 D7	Transferase	Metabolism
	Tolcapone D7 is a deuterium-labeled Tolcapone. Tolcapone is a selective and orally active inhibitor of COMT.
TMID-0141	4-Methoxyestrone-1,2,16,16-d4
	4-Methoxyestrone-1,2,16,16-d4 是 4-Methoxyestrone 的氘代化合物。4-Methoxyestrone 的 CAS 号为 58562-33-7。4-hydroxyestrone-4-methyl ether 是由COMT催化的4-OHE1的甲基化反应。
T10118	3-O-Methyltolcapone D7 Ro 40-7591 D7	Transferase	Metabolism
	3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of P

同位素标记化合物

Cat.No: T13181

Synonym: Ro 40-7592 D7

Target: Transferase

4-Methoxyestrone-1,2,16,16-d4

Cat.No: TMID-0141

3-O-Methyltolcapone D7

Cat.No: T10118

Synonym: Ro 40-7591 D7

Target: Transferase

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