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Search Results for " cnv "

Targets Recommended: Sodium Channel

11

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2342	Raxatrigine CNV1014802,CNV 1014802,GSK-1014802,CNV-1014802	Sodium Channel	Membrane transporter/Ion channel
	Raxatrigine (CNV 1014802) 是有效的钠离子通道 Nav1.7抑制剂。
T41192	CNV Dopamine	Others	Others
	CNV Dopamine is a carboxynitroveratryl (CNV)-caged dopamine; releases dopamine upon ultraviolet light stimulation (365 nm). Induces dopaminergic currents upon photolysis in brain slices expressing wild-type or GFP-labeled D2receptors. Displays no decrease in current (rundown) with UV light flash duration of up to 100 ms. Pharmacologically inactive prior to photolysis.
T71239	CNV-2197944	Others	Others
	CNV-2197944 is a novel, small molecule, state-dependent calcium channel blocker, designed to selectively inhibit highly active Cav2.2 channels.
T71237	SC 46944	Others	Others
	SC 46944 is a highly potent human renin inhibitor.
T2141	Mecamylamine hydrochloride 盐酸美加明,Inversine,Mevasin	AChR	Neuroscience
	Mecamylamine hydrochloride (Mevasin) 是一种易穿过血脑屏障的烟碱拮抗剂，用作高血压的神经节阻滞剂，具有抗神经疾病作用。
T14992	Raxatrigine hydrochloride GSK-1014802 hydrochloride,CNV1014802 (hydrochloride)	Others	Others
	Raxatrigine hydrochloride is a state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor.
T80459	ω-Conotoxin CnVIIA	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	ω-Conotoxin CnVIIA为含27个氨基酸的神经肽类毒素，具有N型钙电流阻滞活性。
T67746	IMS2186	Others	Others
	IMS2186 是一种抗脉络膜新生血管 (CNV) 试剂，可以使癌细胞周期阻滞在 G2/M 期，由此产生抗增殖和抗血管生成作用。IMS2186 能够减少眼睛渗漏和病变细胞的数量，并且无眼内毒性。
T75156	Bevasiranib	Others	Others
	Bevasiranib 是一种siRNA，可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用，而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。
T75156L	Bevasiranib sodium	Others	Others
	Bevasiranib sodium 是一种siRNA，可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用，而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。
T70329	SH-11037	Others	Others
	SH-11037 is a novel potent seh inhibitor, effectively blocking key angiogenic properties of human retinal endothelial cells (hrecs), inhibiting choroidal sprouting and significantly suppressing cnv lesion volume

化合物

Cat.No: T2342

Synonym: CNV1014802,CNV 1014802,GSK-1014802,CNV-1014802

Target: Sodium Channel

Cat.No: T41192

Target: Others

Cat.No: T71239

Target: Others

Cat.No: T71237

Target: Others

Mecamylamine hydrochloride

Cat.No: T2141

Synonym: 盐酸美加明,Inversine,Mevasin

Target: AChR

Raxatrigine hydrochloride

Cat.No: T14992

Synonym: GSK-1014802 hydrochloride,CNV1014802 (hydrochloride)

Target: Others

ω-Conotoxin CnVIIA

Cat.No: T80459

Target: Calcium Channel

Cat.No: T67746

Target: Others

Cat.No: T75156

Target: Others

Bevasiranib sodium

Cat.No: T75156L

Target: Others

Cat.No: T70329

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04722	DcR1/TRAILR3 Protein, Human, Recombinant (His) TRAILR3,TRID,DCR1,TRAIL-R3,CD263,DCR1-TNFR,tumor necrosis fa...	Human	HEK293 Cells
	TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC.
TMPK-00893	PGF Protein, Human, Recombinant (hFc) PlGF,SHGC-10760,PGFL,PGF,D12S1900,PlGF-2	Human	HEK293 Cells
	Placental growth factor (PGF) is another member of the VEGF family of cytokines with pro-angiogenic and pro-inflammatory effects. Retinal inhibition of PGF in combination with VEGF-A prevents vascular leakage and CNV possibly via modulating their own expression in mononuclear phagocytes. PGF-related, optimized strategies to target inflammation-mediated angiogenesis may help to increase efficacy and reduce non-responders in the treatment of wet AMD patients.

重组蛋白

DcR1/TRAILR3 Protein, Human, Recombinant (His)

Cat.No: TMPY-04722

Species: Human

Expression System: HEK293 Cells

PGF Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00893

Species: Human

Expression System: HEK293 Cells

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