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Search Results for " cll "

Targets Recommended: Apoptosis CDK

22

抑制剂 & 化合物

2

天然产物

20

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T14919	CDKI-73	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	CDKI-73 是一种具有口服活性的 CDK9抑制剂，其对 CDK9、CDK1 和 CDK2 的Ki 值分别为 4 nM、4 nM 和 3 nM。CDKI-73 可下调 RNA 聚合酶 II 的磷酸化。CDKI-73 也是一种 Rab11 的抑制剂。
T6588	Mitoxantrone 米托蒽醌,mitozantrone	Topoisomerase; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair
	Mitoxantrone (mitozantrone) 是一种拓扑异构酶 II (Topo II) 的抑制剂，一种蛋白激酶 C (PKC) 的抑制剂 (IC50=8.5 μM)。Mitoxantrone 具有抗肿瘤活性，可以治疗急性髓系白血病、肝细胞癌、乳腺癌等。
T3626	Acalabrutinib ACP-196,阿可替尼	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Acalabrutinib (ACP-196) 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK 抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
T4209	TAK-659 hydrochloride TAK-659	VEGFR; FLT; Tyrosine Kinases; JAK; Syk	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TAK-659 hydrochloride (TAK-659) 是可逆的、高效的、选择性的、口服有效的 SYK/FLT3 双抑制剂，对 SYK 和 FLT3 作用的IC50值分别为 3.2 nM、4.6 nM。它能诱导肿瘤细胞死亡，却不作用于非肿瘤细胞，对慢性淋巴细胞白血病具有潜在的研究价值。
T4976	Umbralisib TGR-1202,RP5264,TGR 1202,TGR1202	PI3K	PI3K/Akt/mTOR signaling
	Umbralisib (TGR 1202) 是一种PI3Kδ抑制剂，IC50=22.2 nM，EC50=24.3 nM。它同时可抑制CK1ε，EC50=6.0 μM。
T2558	Cladribine 2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA	Apoptosis; Adenosine deaminase	Apoptosis; Metabolism
	Cladribine (2CdA) 是一种嘌呤核苷类似物，是具有口服活性的腺苷脱氨酶抑制剂。它能作为 DNA 合成的抑制剂，可阻断受损 DNA 的修复。它可抑制 DNA 甲基化，具有抗淋巴瘤活性，可研究血液恶性肿瘤和多发性硬化。
T0158	Mitoxantrone dihydrochloride 米托蒽醌二盐酸盐,盐酸米托蒽醌,Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride	Topoisomerase; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair
	Mitoxantrone dihydrochloride (NSC-301739) 是一种拓扑异构酶 II 的抑制剂；也可抑制蛋白激酶C (PKC)，IC50值为8.5 μM。
T75943	TAT-cyclo-CLLFVY TFA
	TAT-cyclo-CLLFVY TFA 是一种 HIF-1异二聚化的环肽抑制剂，可抑制癌细胞中的缺氧信号传导。TAT-cyclo-CLLFVY TFA 破坏 HIF-1α/HIF-1β蛋白相互作用，IC50为 1.3 μM。
TP2046L	TAT-cyclo-CLLFVY acetate(1446322-66-2 Free base)
	TAT-cyclo-CLLFVY acetate(1446322-66-2 Free base) 是一种选择性 HIF-1 二聚化抑制剂。 TAT-cyclo-CLLFVY acetate 阻断重组 HIF-1α 与 HIF-1β 的蛋白质-蛋白质相互作用，但不阻断 HIF-2α 与 HIF-1β (IC50 = 1.3 μM)。 TAT-cyclo-CLLFVY acetate 在体外抑制缺氧诱导的 HIF-1 活性，并降低骨肉瘤和乳腺癌细胞中 VEGF 和 CAIX 的表达。 TAT-cyclo-CLLFVY acetate 减少缺氧 HUVEC 的管状化。
TP2046	TAT-cyclo-CLLFVY
	Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cance
T14847	B I09	Others; IRE1	Cell Cycle/Checkpoint; Others
	B I09是一种 IRE-1 RNase 抑制剂，IC50为1230 nM，对人 WaC3细胞中 XBP1 mRNA 的剪接和 LPS 刺激的 B 细胞中 xbp -1的表达有抑制作用。B I09可用于 CLL 细胞模拟XBP-1缺陷的研究。
T76794	Ulocuplumab BMS 936564,MDX 1338	Apoptosis; CXCR	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation
	Ulocuplumab (BMS-936564) 是一种完全人抗 CXCR4 的 IgG4 抗体。Ulocplumab 在急性髓系白血病 (AML)，非霍奇金淋巴瘤 (NHL) 和多发性骨髓瘤移植模型中展现出抗肿瘤活性。Ulocplumab 对 CXCL12 介导的慢性淋巴细胞白血病 (CLL) 细胞在 CXCR4 激活下的迁移有抑制作用，诱导癌细胞凋亡 (apoptosis)，。
T9744	MP07-66	Phosphatase	Metabolism
	MP07-66 是 FTY720 的一种类似物，没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。
T16157	MT-802	BTK; PROTACs	Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors
	MT-802 是一种基于Cereblon 配体的、BTK 的降解剂，其 DC50=1 nM。它具有研究 C481S 突变型慢性淋巴细胞白血病的潜力。
T10483	Lisaftoclax Bcl-2/Bcl-xl inhibitor 1,APG-2575	BCL	Apoptosis
	Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) 是一种双重 Bcl-2 和 Bcl-xl 抑制剂(IC50：2 nM 和 5.9 nM)，具有抗肿瘤活性。
T22553	Adaphostin 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Adaphostin (NSC-680410) 是 AG957 金刚烷酯，是一种 p210bcr/abl 抑制剂，可诱导 T 淋巴细胞白血病细胞系凋亡。它增加了 CLL B 细胞内活性氧的水平，对慢性和急性髓系白血病细胞具有显著的选择性活性。
T76909	Apolizumab
	Apolizumab (Hu1D10)为人源化单克隆抗体，针对人类白细胞抗原-DR β链。该抗体能够介导慢性淋巴细胞白血病(CLL)细胞在体外的凋亡。
T36890	A 410099.1	Others	Others
	High affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells. Oost et al (2004) Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J.Med.Chem. 47 4417 PMID:15317454 \|Loeder et al (2009) A n...
T72527	Umbralisib sulfate TGR-1202 sulfate ; RP-5264 sulfate,TGR-1202 sulfate,RP-5264 sulfate	Others	Others
	Umbralisib (TGR-1202) sulfate 是一种口服有效、选择性的 PI3Kδ和酪蛋白激酶-1-ε (CK1ε) 双抑制剂，其 EC50分别为 22.2 nM 和 6.0 μM。 Umbralisib sulfate 显示出对慢性淋巴细胞白血病 (CLL) T 细胞独特的免疫调节作用。Umbralisib sulfate 可用于血液系统恶性肿瘤的研究。
T76729	Lucatumumab
	Lucatumumab (HCD122) 是一种全人抗 CD40拮抗剂单克隆抗体，可阻断 CD40/ CD40L 介导的信号通路。Lucatumumab 可有效介导抗体依赖性细胞介导的细胞毒性 (ADCC) 和肿瘤细胞清除，可用于顽固性淋巴瘤、慢性淋巴细胞白血病 (CLL) 和多发性骨髓瘤研究。
T72465	Umbralisib tosylate RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate	Others	Others
	Umbralisib (TGR-1202) tosylate是一种口服有效、具有选择性的PI3Kδ和酪蛋白激酶-1-ε (CK1ε) 双重抑制剂，EC50值分别为22.2 nM和6.0 μM。该化合物针对慢性淋巴细胞白血病 (CLL) 中的T细胞显示出独特的免疫调节作用，适用于血液系统恶性肿瘤的研究。
T63997	Mitoxantrone diacetate	Others	Others
	Mitoxantrone diacetate 是拓扑异构酶II (topoisomerase II) 的有效抑制剂。Mitoxantrone diacetate 也能够抑制蛋白激酶 C (PKC) (IC50: 8.5 μM)。Mitoxantrone diacetate 能够诱导 B-慢性淋巴细胞白血病 (B-CLL) 细胞凋亡 (apoptosis)。Mitoxantrone diacetate 表现出抗肿瘤作用，也具有抗正痘病毒 (orthopoxvirus) 效果，能够作用于牛痘 (EC50: 0.25 μM) 和猴痘 (EC50: 0.8 μM)。

化合物

Cat.No: T14919

Target: Apoptosis, CDK

Cat.No: T6588

Synonym: 米托蒽醌,mitozantrone

Target: Topoisomerase, PKC

Cat.No: T3626

Synonym: ACP-196,阿可替尼

Target: BTK

TAK-659 hydrochloride

Cat.No: T4209

Synonym: TAK-659

Target: VEGFR, FLT, Tyrosine Kinases, JAK, Syk

Cat.No: T4976

Synonym: TGR-1202,RP5264,TGR 1202,TGR1202

Target: PI3K

Cat.No: T2558

Synonym: 2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA

Target: Apoptosis, Adenosine deaminase

Mitoxantrone dihydrochloride

Cat.No: T0158

Synonym: 米托蒽醌二盐酸盐,盐酸米托蒽醌,Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride

Target: Topoisomerase, PKC

TAT-cyclo-CLLFVY TFA

Cat.No: T75943

TAT-cyclo-CLLFVY acetate(1446322-66-2 Free base)

Cat.No: TP2046L

TAT-cyclo-CLLFVY

Cat.No: TP2046

Cat.No: T14847

Target: Others, IRE1

Cat.No: T76794

Synonym: BMS 936564,MDX 1338

Target: Apoptosis, CXCR

Cat.No: T9744

Target: Phosphatase

Cat.No: T16157

Target: BTK, PROTACs

Cat.No: T10483

Synonym: Bcl-2/Bcl-xl inhibitor 1,APG-2575

Target: BCL

Cat.No: T22553

Synonym: 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410

Target: Bcr-Abl

Cat.No: T76909

Cat.No: T36890

Target: Others

Umbralisib sulfate

Cat.No: T72527

Synonym: TGR-1202 sulfate ; RP-5264 sulfate,TGR-1202 sulfate,RP-5264 sulfate

Target: Others

Cat.No: T76729

Umbralisib tosylate

Cat.No: T72465

Synonym: RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate

Target: Others

Mitoxantrone diacetate

Cat.No: T63997

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1480	Cephaeline 吐根鹼,吐根酚碱	Virus Protease; Influenza Virus; HIF	Angiogenesis; Chromatin/Epigenetic; Microbiology/Virology
	Cephaeline 对受保护的原代 CLL 细胞具有高度活性（相对 IC50 为 35nM），并通过抑制 HIF-1α± 和扰乱细胞内氧化还原稳态发挥作用。
TN1564	Delphinidin 3-glucoside chloride Delphinidin-3-O-glucoside chloride	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Delphinidin 3-glucoside chloride (Delphinidin-3-O-glucoside chloride) 是从 Hibiscus sabdariffa 提取物中发现的膳食酚类物质。Delphinidin 3-glucoside chloride 具有抗氧化活性，可诱导 B 细胞慢性淋巴细胞性白血病 (B CLL) 的促凋亡作用，抑制 EGFR，抑制血小板聚集。Delphinidin 3-glucoside chloride 具有抗肿瘤活性，通过调节 pAKT/IRF1/HOTAIR 通路发挥作用。

天然产物

Cat.No: TN1480

Synonym: 吐根鹼,吐根酚碱

Target: Virus Protease, Influenza Virus, HIF

Delphinidin 3-glucoside chloride

Cat.No: TN1564

Synonym: Delphinidin-3-O-glucoside chloride

Target: Apoptosis, EGFR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02092	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His) HECL,CLL-1,CD303,PRO34150,DCAL-2,CLL1,DLEC...	Human	HEK293 Cells
	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 41~45 kDa and the accession number is EAW96132.1.
TMPY-02700	BCL2 Protein, Human, Recombinant (His) Bcl-2,PPP1R50,B-cell CLL/lymphoma 2	Human	E. coli
	BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins...
TMPY-06865	CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (His) D230024O04,C-type lectin domain family 12, member A,Micl,	Mouse	HEK293 Cells
	CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.12 kDa and the accession number is NP_808354.1.
TMPK-01003	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His, Avi), Biotinylated DCAL2,CD371,CLEC12A,CLL-1,MICL,CD303,HECL,PRO34150,...	Human	HEK293 Cells
	CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His, Avi), Bi...
TMPK-00548	CLEC12A/MICL/CLL-1 Protein, Cynomolgus, Recombinant (His) CD371,HECL,CLECSF11,CLEC12A,CD303,CLL-1,PRO34150,DL...	Cynomolgus	HEK293 Cells
	CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Cynomolgus, Recombinant (His) is ...
TMPK-01004	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, hFc) DCAL2,HECL,DCAL-2,DLEC,CLECSF11,CLEC12A,CD371,MICL,CLL	Human	HEK293 Cells
	CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, hF...
TMPK-01005	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His), FITC-Labeled DCAL-2,HECL,CLL-1,CLECSF7,CD371,CLEC12A,PRO34150,MI...	Human	HEK293 Cells
	CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His), FITC-La...
TMPK-01002	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc & Avi), Biotinylated HECL,DCAL-2,CD303,CLECSF7,DCAL2,CLECSF11,CLL1,C...	Human	HEK293 Cells
	CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc & Avi), B...
TMPY-06866	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc) CLECSF11,MICL,CLECSF7,DLEC,C-type lectin domain family 12, m...	Human	HEK293 Cells
	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.38 kDa and the accession number is EAW96132.1.
TMPK-00995	CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (aa 65-267, His) HECL,CLL1,CD371,CLL-1,CLEC12A,MICL,DCAL-2,...	Mouse	HEK293 Cells
	CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (aa 65-267, Hi...
TMPK-01006	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, His) CLECSF7,CLL-1,PRO34150,CLL1,DLEC,CLEC12A,D...	Human	HEK293 Cells
	CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, Hi...
TMPY-06881	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (Avi & Fc), Biotinylated MICL,PRO34150,CLL1,DCAL-2,CD303,CLL-1,CD37...	Human	HEK293 Cells
	CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (Avi & Fc), Biotinylated is expressed in HEK293 mammalian cells with AVI and Fc tag. The predicted molecular weight is 51.61 kDa and the accession number is EAW96132.1.
TMPY-02430	BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx) BCL5,ZNF51,B-cell CLL/lymphoma 6,LAZ3,ZBTB27,BCL6A	Human	E. coli
	The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon...
TMPH-01851	PSIP1 Protein, Human, Recombinant (His & SUMO) Lens epithelium-derived growth factor,PC4 and SFRS1-interact...	Human	E. coli
	PSIP1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 76.1 kDa and the accession number is O75475.
TMPJ-01386	STUB1 Protein, Human, Recombinant Carboxy Terminus of Hsp70-Interacting Protein,STIP1 Homology...	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation....
TMPH-02246	TGS1 Protein, Human, Recombinant (His & SUMO) CLL-associated antigen KW-2,Cap-specific guanine-N2...	Human	E. coli
	Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
TMPY-04272	FcRH2/FCRL2 Protein, Human, Recombinant (His) IFGP4,FCRH2,CD307b,SPAP1,SPAP1B,Fc receptor like 2,SPAP1C,FC...	Human	HEK293 Cells
	Fc receptor-like 2 (FCRL2) is highly expressed on B-cell chronic lymphocytic leukemia (B-CLL) cells and could possibly influence disease pathogenesis. FCRL2 has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in CLL (B-cell chronic lymphocytic leukemia).
TMPK-00234	CD84 Protein, Human, Recombinant (His & Avi) CD84,DKFZp781E2378,Hly9-beta,Hly9-β,CD84 molecule,SLAMF5,LY9...	Human	HEK293 Cells
	Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5 B lymphocytes in peripheral blood, lymphoid organs and bone marrow. The main feature of the disease is accumulation of the malignant cells due to decreased apoptosis. CD84 belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells.
TMPY-04686	SHISA3 Protein, Human, Recombinant (mFc) shisa family member 3,hShisa3	Human	HEK293 Cells
	SHISA3(high)CLL are characterized by a restrained activation of Wnt signaling and sensibility to lenalidomide-induced apoptosis. SHISA3 promoter hypermethylation might increase the risk of LSCC through regulation of gene expression and is a potential diagnostic and prognostic biomarker for LSCC. Shisa3 is a novel tumor suppressor identified in lung cancer. SHISA3 gene is epigenetically inactivated in a substantial fraction of CRC, and its hypermethylation is of prognostic significance in predict...
TMPY-03748	BCL2L12 Protein, Human, Recombinant (GST) BCL2-like 12 (proline rich)	Human	E. coli
	BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. BCL2L12 is a recently identified gene belonging to the BCL2 family, members of which are implicated in hematologic malignancies, including chronic lymphocytic leukemia (CLL). BCL2L12 can be considered as a new independent prog...

重组蛋白

CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02092

Species: Human

Expression System: HEK293 Cells

BCL2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02700

Species: Human

Expression System: E. coli

CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06865

Species: Mouse

Expression System: HEK293 Cells

CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His, Avi), Biotinylated

Cat.No: TMPK-01003

Species: Human

Expression System: HEK293 Cells

CLEC12A/MICL/CLL-1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00548

Species: Cynomolgus

Expression System: HEK293 Cells

CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, hFc)

Cat.No: TMPK-01004

Species: Human

Expression System: HEK293 Cells

CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His), FITC-Labeled

Cat.No: TMPK-01005

Species: Human

Expression System: HEK293 Cells

CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPK-01002

Species: Human

Expression System: HEK293 Cells

CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-06866

Species: Human

Expression System: HEK293 Cells

CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (aa 65-267, His)

Cat.No: TMPK-00995

Species: Mouse

Expression System: HEK293 Cells

CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, His)

Cat.No: TMPK-01006

Species: Human

Expression System: HEK293 Cells

CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (Avi & Fc), Biotinylated

Cat.No: TMPY-06881

Species: Human

Expression System: HEK293 Cells

BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx)

Cat.No: TMPY-02430

Species: Human

Expression System: E. coli

PSIP1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01851

Species: Human

Expression System: E. coli

STUB1 Protein, Human, Recombinant

Cat.No: TMPJ-01386

Species: Human

Expression System: E. coli

TGS1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02246

Species: Human

Expression System: E. coli

FcRH2/FCRL2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04272

Species: Human

Expression System: HEK293 Cells

CD84 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00234

Species: Human

Expression System: HEK293 Cells

SHISA3 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04686

Species: Human

Expression System: HEK293 Cells

BCL2L12 Protein, Human, Recombinant (GST)

Cat.No: TMPY-03748

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0065	Acalabrutinib-d4
	Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。

同位素标记化合物

Acalabrutinib-d4

Cat.No: TMIH-0065

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