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Search Results for " ck1 "

Targets Recommended: Casein Kinase

24

抑制剂 & 化合物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T60005	CK1-IN-3	Casein Kinase	Metabolism; Stem Cells
	CK1-IN-3 是酪蛋白激酶 1 抑制剂，可用于治疗或预防与 circadiantiazol 节律相关的疾病、炎症性疾病的研究。
T5393	CK1-IN-1 PUN51207	p38 MAPK; Casein Kinase	MAPK; Metabolism; Stem Cells
	CK1-IN-1 (PUN51207) 是一种酪蛋白激酶 1 抑制剂，对 CK1δ、CK1ε和p38σ MAPK 的IC50值为 15 nM、16 nM 和73 nM。
T79145	CK1-IN-2	Casein Kinase	Metabolism; Stem Cells
	CK1-IN-2 (compound Nr.4) 作为CK1抑制剂展现出高效性，其对CK1a、CK1d、CK1e、p38a的IC50值依次为123、19.8、26.8、74.3 nM。
T9175	Casein Kinase inhibitor A51	Apoptosis; Casein Kinase	Apoptosis; Metabolism; Stem Cells
	Casein Kinase inhibitor A51 是一种具有口服活性的酪蛋白激酶 1α (CK1α) 抑制剂，具有抗癌活性，可诱导白血病细胞凋亡 (apoptosis)，可用于研究颈部癌、急性髓系白血病、乳腺癌和前列腺癌。
T8987	Epiblastin A	Casein Kinase	Metabolism; Stem Cells
	Epiblastin A 是 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂，能够抑制 CK1α (IC50:8.9 µM)、 CK1δ (IC50:0.5 µM)、CK1 ɛ (IC50:4.7 µM)。它能够抑制 CK1 诱导外胚层干细胞重编程为胚胎干细胞。
T22884	JW 67	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	JW 67 是典型 Wnt 信号通路的抑制剂，IC50为 1.17 μM。它影响由 β- 连环蛋白/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物，快速降低活性 β- 连环蛋白，随后下调Wnt 靶基因。它也抑制结直肠癌细胞生长。
T19913	CKI-7 CKI 7 2HCl,CKI-7 dihydrochloride,N-(2-氨基乙基)-5-氯异喹啉-8-磺酰胺二盐酸盐,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl	ROCK; SGK; Casein Kinase; CDK; S6 Kinase	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	CKI-7 是一种有效且 ATP 竞争性的酪蛋白激酶 1 抑制剂，IC50为 6 μM，Ki 为 8.5 μM。它选择性抑制 Cdc7激酶，还抑制 SGK，S6K1以及 MSK1。
TP1971	Pseudo RACK1
	Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide i
T61843	CK156	Others	Others
	CK156 is a potent inhibitor of death-associated protein kinase (DAPK), demonstrating high selectivity. In the DRAK1 NanoBRET assay, CK156 exhibits IC50 values of 182 nM, 34 μM, and 39 μM for DRAK1, CK2a1, and CK2a2, respectively. This compound is valuable for studying autoimmune and inflammatory diseases [1].
T71654	APcK110	Others	Others
	APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3 proliferation than the clinically used Kit inhibitors imatinib and dasatinib and at least as potent as cytarabine. APcK110 inhibits the phosphorylation of Kit, Stat3, Stat5, and Akt in a dose-dependent fashion, showing activity of APcK110 on Kit and its downstream signaling path...
T27030	CK176 HIV-1 inhibitor-34,HIV-1 inhibitor 34,CK 176,CK-176,HIV-1 inhibitor34	Others	Others
	CK176 is a capsid targeted inhibitor of HIV-1 replication. CK176 shows an 11-fold improvement over I-XW-053 in blocking HIV-1 replication in primary human peripheral blood mononuclear cells (PBMCs).
T2449	D4476 D 4476,Casein Kinase I Inhibitor	Apoptosis; Casein Kinase; ALK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	D4476 (Casein Kinase I Inhibitor) 是一种选择性和细胞渗透性的CK1抑制剂，在体外实验的IC50值为0.3 μM。
T2440	IC261 SU-5607	Apoptosis; Casein Kinase; CDK	Apoptosis; Cell Cycle/Checkpoint; Metabolism; Stem Cells
	IC261 (SU-5607) 是一种选择性的，ATP 竞争性的CK1抑制剂，可触发有丝分裂检查点控制。对Ckiδ、Ckiε、 Ckiα1 和Cdk5的IC50值分别为 1 μM、1 μM 、16 μM 和4.5mM。
T6745	5-Iodotubercidin 5-碘代杀结核菌素,5-ITu,NSC 113939	Adenosine Receptor	GPCR/G Protein; Neuroscience
	5-Iodotubercidin (NSC-113939) 是一种 ATP 类似物，有效抑制腺苷激酶，IC50为 26 nM。它可以激活磷酸化酶和糖原合成酶，在离体肝细胞中启动糖原合成。它也抑制 CK1、胰岛素受体酪氨酸激酶、磷酸化酶激酶、PKA、CK2、PKC 和 Haspin 。
T4645	TA-01	p38 MAPK; Casein Kinase; Autophagy	Autophagy; MAPK; Metabolism; Stem Cells
	TA01 是一种心源性抑制剂，有效抑制CK1和p38 MAPK，其对 CK1ε，CK1δ 和 p38 MAPK 的IC50值分别为 6.4 nM，6.8 nM 和 6.7 nM。
T21915	TBCA Casein Kinase II Inhibitor III, TBCA	Casein Kinase	Metabolism; Stem Cells
	TBCA (Casein Kinase II Inhibitor III, TBCA) 是高选择性的酪蛋白激酶II CK2 抑制剂，IC50 为 110 nM，Ki 为 77 nM。TBCA 对 CK1、DYRK1A 和其它 27 个激酶表现出选择性。
T23224	(R)-DRF053 dihydrochloride	Others	Others
	cdk/CK1 inhibitor,potent and ATP-competitive
T16141	MRT00033659	Others	Others
	MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.
T2695	TBB Casein Kinase II Inhibitor I,NSC 231634,4,5,6,7-tetrabromobenzotriazole	GSK-3; Casein Kinase; CDK	Cell Cycle/Checkpoint; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	TBB (NSC-231634) 是一种高选择性的 ATP/GTP 竞争性酪蛋白激酶 2 (CK2) 抑制剂，可抑制大鼠肝脏 CK2，IC50值为0.15 μM。
T10829	CKI-7 free base CKI-7	Casein Kinase	Metabolism; Stem Cells
	CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.
T83684	Myelin Basic Protein Peptide (mouse, bovine) TFA Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu,MBP Peptide
	Myelin基础蛋白(MBP)肽是PKC的肽底物，相比PKA、酪蛋白激酶1(CK1)、CK2、磷酸化酶激酶及钙/钙调蛋白依赖性蛋白激酶(CaMKII)，它对PKC有选择性。MBP肽已用于监测原发性人类肾动脉平滑肌细胞中的PKC活性。
T14069	A-3 hydrochloride	CaMK; Casein Kinase; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Neuroscience; Stem Cells; Tyrosine Kinase/Adaptors
	A-3 hydrochloride 是一种细胞可渗透的、可逆的、ATP 竞争性非选择性拮抗剂。它抑制 PKA 、酪蛋白激酶 II 和肌球蛋白轻链激酶，Ki 值分别为4.3 µM、5.1 µM 和7.4 µM。它还抑制 PKC 和酪蛋白激酶 I 的活性，Ki 分别为 47 µM 和 80 µM。
T16507	PF-5006739	Casein Kinase	Metabolism; Stem Cells
	PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selecti
T10298L	AMG-548	p38 MAPK	MAPK
	AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM

化合物

Cat.No: T60005

Target: Casein Kinase

Cat.No: T5393

Synonym: PUN51207

Target: p38 MAPK, Casein Kinase

Cat.No: T79145

Target: Casein Kinase

Casein Kinase inhibitor A51

Cat.No: T9175

Target: Apoptosis, Casein Kinase

Cat.No: T8987

Target: Casein Kinase

Cat.No: T22884

Target: Wnt/beta-catenin

Cat.No: T19913

Synonym: CKI 7 2HCl,CKI-7 dihydrochloride,N-(2-氨基乙基)-5-氯异喹啉-8-磺酰胺二盐酸盐,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl

Target: ROCK, SGK, Casein Kinase, CDK, S6 Kinase

Cat.No: TP1971

Cat.No: T61843

Target: Others

Cat.No: T71654

Target: Others

Cat.No: T27030

Synonym: HIV-1 inhibitor-34,HIV-1 inhibitor 34,CK 176,CK-176,HIV-1 inhibitor34

Target: Others

Cat.No: T2449

Synonym: D 4476,Casein Kinase I Inhibitor

Target: Apoptosis, Casein Kinase, ALK, Autophagy

Cat.No: T2440

Synonym: SU-5607

Target: Apoptosis, Casein Kinase, CDK

5-Iodotubercidin

Cat.No: T6745

Synonym: 5-碘代杀结核菌素,5-ITu,NSC 113939

Target: Adenosine Receptor

Cat.No: T4645

Target: p38 MAPK, Casein Kinase, Autophagy

Cat.No: T21915

Synonym: Casein Kinase II Inhibitor III, TBCA

Target: Casein Kinase

(R)-DRF053 dihydrochloride

Cat.No: T23224

Target: Others

Cat.No: T16141

Target: Others

Cat.No: T2695

Synonym: Casein Kinase II Inhibitor I,NSC 231634,4,5,6,7-tetrabromobenzotriazole

Target: GSK-3, Casein Kinase, CDK

CKI-7 free base

Cat.No: T10829

Synonym: CKI-7

Target: Casein Kinase

Myelin Basic Protein Peptide (mouse, bovine) TFA

Cat.No: T83684

Synonym: Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu,MBP Peptide

A-3 hydrochloride

Cat.No: T14069

Target: CaMK, Casein Kinase, PKA, PKC

Cat.No: T16507

Target: Casein Kinase

Cat.No: T10298L

Target: p38 MAPK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00566	CCL18 Protein, Human, Recombinant (His) PARC,CCL18,CKb7,DC-CK1,c...	Human	P. pastoris (Yeast)
	CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) a...
TMPY-04865	Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His)	CHIKV	Baculovirus Insect Cells
	Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 39.8 kDa and the accession number is A5Y7Y5.
TMPY-04375	Casein Kinase 1 alpha Protein, Human, Recombinant (GST) CKIa,casein kinase 1, alpha 1,cas...	Human	Baculovirus Insect Cells
	Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are use...
TMPY-02761	Rack1 Protein, Human, Recombinant (His & MBP) PIG21,Gnb2-rs1,H12.3,RACK	Human	E. coli
	The scaffolding protein, Rack1, is a seven-WD-domain-containing protein that has been implicated in binding to integrin beta subunit cytoplasmic domains and to members of two kinase families (src and protein kinase C, PKC) that mediate integrin bidirectional signaling.Rack1 may link protein kinase C directly to integrins and participate in the regulation of integrin functions.Rack1 regulates the localization of an essential PCP protein and acts as a molecular switch to promote PCP signaling.
TMPY-03405	SPOCK1 Protein, Human, Recombinant (aa 21-429, His) SPOCK,sparc/osteonectin, cwcv and kazal-like domain...	Human	Baculovirus Insect Cells
	Osteonectin, also known as SPOCK1, is an extracellular heparan/chondroitin sulfate proteoglycan. Members of this family are known as testicans, also called SPOCKs. They are characterized structurally by an N-terminal testican-specific domain, a follistatin-like region, a calcium-binding domain, a thyroglobulin-like domain, and an acidic C-terminal domain with two putative glycosaminoglycan attachment sites. SPOCKs are enriched in brain and have been shown to regulate neuronal attachment and outg...
TMPJ-00870	NCK1 Protein, Human, Recombinant (His) SH2/SH3 Adaptor Protein NCK-α,SH2/SH3 Adaptor Prote...	Human	E. coli
	Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing...
TMPH-03364	RBCK1 Protein, Rat, Recombinant (His & Myc) Heme-oxidized IRP2 ubiquitin ligase 1 homolog,RING-...	Rat	E. coli
	RBCK1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 65.1 kDa and the accession number is Q62921.
TMPH-01860	PCK1 Protein, Human, Recombinant (His) Serine-protein kinase PCK1,PCK	Human	E. coli
	PCK1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 73.2 kDa and the accession number is P35558.
TMPY-04484	ACK1 Protein, Human, Recombinant (GST) ACK-1,ACK1,p21c...	Human	Baculovirus Insect Cells
	ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell migration via phosphorylation of BCAR1. The ACK1 protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. ACK1 integrates signals from plethora of liga...
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO) S-phase kinase-associated protein 2,SKP2,F-box protein Skp2,...	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB...
TMPY-04402	CSNK1G1 Protein, Human, Recombinant (His & GST) CK1γ1,casein kinase 1, g...	Human	Baculovirus Insect Cells
	Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are serine / threonine-selective enzymes that function as regulators ofsignal transductionpathways in most eukaryotic cell types. Casein has been used as a substrate since the earliest days of research on protein phosphorylation. Casein kinase activity associated with the endopla...

重组蛋白

CCL18 Protein, Human, Recombinant (His)

Cat.No: TMPY-00566

Species: Human

Expression System: P. pastoris (Yeast)

Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His)

Cat.No: TMPY-04865

Species: CHIKV

Expression System: Baculovirus Insect Cells

Casein Kinase 1 alpha Protein, Human, Recombinant (GST)

Cat.No: TMPY-04375

Species: Human

Expression System: Baculovirus Insect Cells

Rack1 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPY-02761

Species: Human

Expression System: E. coli

SPOCK1 Protein, Human, Recombinant (aa 21-429, His)

Cat.No: TMPY-03405

Species: Human

Expression System: Baculovirus Insect Cells

NCK1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00870

Species: Human

Expression System: E. coli

RBCK1 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03364

Species: Rat

Expression System: E. coli

PCK1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01860

Species: Human

Expression System: E. coli

ACK1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04484

Species: Human

Expression System: Baculovirus Insect Cells

SKP2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02131

Species: Human

Expression System: E. coli

CSNK1G1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04402

Species: Human

Expression System: Baculovirus Insect Cells

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