386
91
2
1
12
22
Cat. No. | Product Name | ||
---|---|---|---|
L3100 | 造血毒性小分子库 | 101 compounds | |
101 种生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L4900 | 心血管毒性化合物库 | 131 compounds | |
131 种心血管毒性化合物的独特集合,可用于毒理学研究; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0074 |
Mag Beads COOH High capacity (2.8 μm)
羧基磁珠 (2.8 μm) |
Suspension in bottle |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18868 |
Val-Cit
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Val-Cit 是一种可切割的 ADC 接头,用于合成抗体-药物偶联物。 | |||
T18867 |
Val-Cit-PAB-MMAE
|
Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related |
Val-Cit-PAB-MMAE 是 ADC 的药物-接头偶联物。它包含 ADC 接头(肽 Val-Cit-PAB)和有效的微管蛋白抑制剂 MMAE。 | |||
T17983 |
Fmoc-Val-Cit-PAB-MMAE
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
Fmoc-Val-Cit-PAB-MMAE 由 ADC 接头 (Fmoc-Val-Cit-PAB) 和强效微管蛋白抑制剂 (MMAE) 组成。 它是一种用于 ADC 的药物-接头偶联物。 | |||
T17693 |
Boc-Val-Cit-PAB
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Boc-Val-Cit-PAB 是一种可切割的 ADC 接头,用于抗体-药物偶联物的合成。 | |||
T17213 |
Val-cit-PAB-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Val-cit-PAB-OH 是可降解ADC 连接剂。 | |||
T17691 |
Boc-Val-Cit-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Boc-Val-Cit-OH 是一种可切割的 ADC 接头,用于合成抗体-药物偶联物。 | |||
T4678 |
Fmoc-Val-Cit-PAB
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Fmoc-Val-Cit-PAB 是一种可降解的抗体-药物偶联的连接剂。 | |||
T7767 |
FMoc-Val-Cit-PAB-PNP
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Fmoc-Val-Cit-PAB-PNP 是一种可降解的 ADC 连接剂,可用于合成抗体偶联药物。 | |||
T18321 |
Mc-Val-Cit-PAB-Cl
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Mc-Val-Cit-PAB-Cl 是一种可切割的 ADC 接头,可用于偶联 MMAE 和抗体以形成抗体-MC-vc-MMAE。 | |||
T40303 |
5-A-RU-PABC-Val-Cit-Fmoc
|
Others | Others |
5-A-RU-PABC-Val-Cit-Fmoc 是 5-A-RU 的前体物质之一。5-A-RU 是一种小分子粘膜相关的 MAIT 激活剂,是细菌合成核黄素的前体物质。 | |||
T5149 |
MC-Val-Cit-PAB
N-[6-(2,5-二氢-2,5-二氧代-1H-吡咯-1-基)-1-氧代己基]-L-缬氨酰-N5-(氨基甲酰基)-N-[4-(羟甲基)苯基]-L-鸟氨酰胺 |
Others; AChR; ADC Linker | Antibody-drug Conjugate/ADC Related; Neuroscience; Others |
MC-Val-Cit-PAB 是一种组织蛋白酶可裂解的 ADC 接头,用于制备抗体-药物偶联物。 | |||
T17692 |
Boc-Val-Cit-PAB-PNP
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Boc-Val-Cit-PAB-PNP 是一种可切割的 ADC 接头,用于合成抗体-药物偶联物。 | |||
T18267 |
Mal-PEG1-Val-Cit-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Mal-PEG1-Val-Cit-OH是一种在抗体药物偶联体(ADCs)[1]合成中使用的可裂解单元聚乙二醇(PEG)连接器。 | |||
T3503 |
MC-Val-Cit-PABC-PNP
Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate,马来酰亚胺基己酰-L-缬氨酸-L-瓜氨酸对氨基苄醇 对硝基苯基碳酸脂 |
Others; AChR; ADC Linker | Antibody-drug Conjugate/ADC Related; Neuroscience; Others |
MC-Val-Cit-PABC-PNP 是一种组织蛋白酶可裂解的 ADC 肽接头,可用于合成抗体偶联药物。 | |||
T39765 |
Mal-PEG1-Val-Cit-PAB-PNP
Mal-PEG1-Val-Cit-PAB-PNP |
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Mal-PEG1-Val-Cit-PAB-PNP is an ADC linker employed in the synthesis of ADCs, enabling cleavage. | |||
T39748 |
DBCO-PEG4-Val-Cit-PAB-MMAF
DBCO-PEG4-Val-Cit-PAB-MMAF |
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
DBCO-PEG4-Val-Cit-PAB-MMAF is a chemical compound that comprises a cleavable 4 unit polyethylene glycol antibody-drug conjugate (ADC) linker known as DBCO-PEG4-Val-Cit-PAB, and a highly effective inhibitor of tubulin polymerization called MMAF. This compound serves as a valuable component in the synthesis of ADCs. | |||
T77847 |
MC-Val-Cit-PAB-Exatecan
MC-Val-Cit-PAB-DX8951 |
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) 是一种抗体-活性分子偶联物(ADC)的关键部分,由 DNA 拓扑异构酶 I 抑制剂 DX-8951 和组织蛋白酶敏感的连接子共同构成。 | |||
T39307 |
Azido-PEG4-Val-Cit-PAB-MMAE
Azido-PEG4-Val-Cit-PAB-MMAE |
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
Azido-PEG4-Val-Cit-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor), connected through the cleavable linker Azido-PEG4-Val-Cit-PAB-OH. | |||
T77876 |
Py-MAA-Val-Cit-PAB-MMAE
AAJ8D6-PY-Val-Cit-MMAE |
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) 是一款ADC Linker,专用于合成抗体药物偶联物Zapadcine-3a (ADC)。Zapadcine-3a 对抗多种肿瘤表现出高效的活性,其作用机理为定位TRAILR2并通过肿瘤细胞内的溶酶体被摄取,进而针对性释放致死的小分子,从而特异性消灭TRAILR2阳性的肿瘤细胞,并能够有效地治愈肿瘤。 | |||
T38739 |
Mal-PEG2-Val-Cit-PABA-PNP
Mal-PEG2-Val-Cit-PABA-PNP |
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Mal-PEG2-Val-Cit-PABA-PNP is a cleavable linker compound employed in the synthesis of antibody-drug conjugates (ADCs). | |||
T39447 |
Azide-PEG1-Val-Cit-PABC-OH
Azide-PEG1-Val-Cit-PABC-OH |
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Azide-PEG1-Val-Cit-PABC-OH is a one-unit PEG cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs). | |||
T33243 |
MC-Val-Cit-PAB-VX765
Belnacasan-conjugate,VX765-conjugate,MC-Val-Cit-PABC-VX765 |
Others | Others |
MC-VAL-CIT-PAB-VX765 or MC-VAL-CIT-PABC-VX765 is a VX765 derivative that can be conjugated to antibodies, proteins, or polymers for targeted drug delivery. MC-Val- CIT -PAB is a cathepsin cleavable ADC connector, which has been widely used in the preparat | |||
T39579 |
Mal-(CH2)5-Val-Cit-PAB-Eribulin
Mal-(CH2)5-Val-Cit-PAB-Eribulin |
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
Mal-(CH2)5-Val-Cit-PAB-Eribulin is a potent antitumor ADC drug-linker conjugate that utilizes Eribulin, an anti-microtubule agent, connected through the Mal-(CH2)5-Val-Cit-PAB linker. | |||
T18320 |
MC-Val-Cit-PAB-carfilzomib iodide
MC-Val-Cit-PAB-carfilzomib |
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-Val-Cit-PAB-carfilzomib is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADC), comprising the irreversible proteasome inhibitor carfilzomib, connected through the ADC linker MC-Val-Cit-PAB. | |||
T18324 |
MC-Val-Cit-PAB-duocarmycin chloride
MC-Val-Cit-PAB-duocarmycin |
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity. | |||
T38747 |
Fmoc-Val-D-Cit-PAB
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Fmoc-Val-D-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC). | |||
T38746 |
Fmoc-D-Val-Cit-PAB
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC). | |||
T38748 |
Fmoc-D-Val-D-Cit-PAB
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Fmoc-D-Val-D-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC). | |||
T18323 |
MC-Val-Cit-PAB-dimethylDNA31
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-Val-Cit-PAB-dimethylDNA31 is a drug-linker conjugate employed in antibody-drug conjugates (ADCs) that exhibits robust antitumor efficacy. This conjugate utilizes the ADC linker, MC-Val-Cit-PAB, to link to the potent antitumor agent dimethylDNA31. Notably, dimethylDNA31 also demonstrates significant bactericidal activity against both persister and stationary-phase Staphylococcus aureus. | |||
T17814 |
DBCO-Val-Cit-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
DBCO-Val-Cit-OH, a cleavable linker compound, finds utility in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T39328 |
SuO-Glu-Val-Cit-PAB-MMAE
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
SuO-Glu-Val-Cit-PAB-MMAE is a chemical compound comprising a cleavable ADC linker, SuO-Glu-Val-Cit-PAB, and a potent tubulin inhibitor known as MMAE. It is utilized in the synthesis of antibody-drug conjugates (ADCs). | |||
T18736 |
SuO-Val-Cit-PAB-MMAE
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
SuO-Val-Cit-PAB-MMAE is an ADC (antibody-drug conjugate) linker comprising the anti-mitotic monomethyl auristatin E (MMAE, a tubulin inhibitor) connected through the SuO-Val-Cit-PAB peptide. | |||
T17816 |
DBCO-Val-Cit-PABC-PNP
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
DBCO-Val-Cit-PABC-PNP is a cleavable linker for antibody-drug conjugate (ADC) synthesis[1]. | |||
T18511 |
OPSS-Val-Cit-PAB-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
OPSS-Val-Cit-PAB-OH is an ADC linker utilized for the synthesis of antibody-drug conjugates (ADCs) [1]. | |||
T17531 |
BCN-PEG3-Val-Cit
|
Others | Others |
BCN-PEG3-Val-Cit is a PEG-based linker commonly employed in PROTAC synthesis[1]. Additionally, it serves as a cleavable 3 unit PEG linker in the production of antibody-drug conjugates (ADCs)[2]. | |||
T18677 |
SC-Val-Cit-PAB
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
SC-Val-Cit-PAB is a cleavable ADC linker for antibody-drug conjugates (ADCs). | |||
T18307 |
MC(C5)-Val-Cit
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
MC(C5)-Val-Cit is a cleavable ADC linker employed in ADCs synthesis [1]. | |||
T18315 |
MC-Sq-Cit-PAB-Dolastatin10
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-Sq-Cit-PAB-Dolastatin10 is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Dolastatin10 (a tubulin polymerization inhibitor) connected through the MC-Sq-Cit-PAB ADC linker. | |||
T17478 |
Azido-PEG1-Val-Cit-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Azido-PEG1-Val-Cit-OH is a one-unit cleavable PEG ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T28621 |
RTI-55
ß CIT,ß-CIT,RTI 55,ßCIT |
Others | Others |
RTI-55 is an inhibitor of non-selective dopamine reuptake. | |||
T18753 |
TCO-PEG1-Val-Cit-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
TCO-PEG1-Val-Cit-OH is a cleavable 1-unit polyethylene glycol (PEG) linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T18301 |
Mal-Phe-C4-Val-Cit-PAB
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Mal-Phe-C4-Val-Cit-PAB is a cleavable antibody-drug conjugate (ADC) linker featuring a Maleimide functional group. It is employed in the synthesis of ADCs. | |||
T18299 |
Mal-PEG8-Val-Cit-PAB-MMAE
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
Mal-PEG8-Val-Cit-PAB-MMAE is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T18512 |
OPSS-Val-Cit-PAB-PNP
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
OPSS-Val-Cit-PAB-PNP is a cleavable linker employed in ADC (antibody-drug conjugates) synthesis [1]. | |||
T18328 |
MC-Val-Cit-PAB-rifabutin
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-Val-Cit-PAB-rifabutin is a drug-linker conjugate designed for antibody-drug conjugates (ADC), featuring the potent antitumor agent rifabutin (a DNA-dependent RNA polymerase inhibitor) connected through the MC-Val-Cit-PAB ADC linker. This configuration endows it with significant antitumor activity. | |||
T17356 |
Acid-propionylamino-Val-Cit-OH
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Acid-propionylamino-Val-Cit-OH is a cleavable linker commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T17788 |
DBCO-(PEG2-Val-Cit-PAB)2
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
DBCO-(PEG2-Val-Cit-PAB)2 is a dual cleavable ADC linker for antibody-drug conjugates (ADCs). | |||
T18330 |
MC-Val-Cit-PAB-vinblastine
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-Val-Cit-PAB-vinblastine is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), featuring vinblastine (a microtubule protein inhibitor) connected through the MC-Val-Cit-PAB ADC linker. | |||
T18327 |
MC-Val-Cit-PAB-Retapamulin
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-Val-Cit-PAB-Retapamulin is a drug-linker conjugate for antibody-drug conjugates (ADC) that exhibits potent antitumor activity. This compound utilizes Retapamulin, a ribosome inhibitor, connected through the ADC linker MC-Val-Cit-PAB. | |||
T18326 |
MC-Val-Cit-PAB-MMAF
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavable linker, MC-Val-Cit-PAB. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN7247 |
Limocitrin 3-O-sophoroside
Limocitrinyle-3-O-β-D-sophoroside |
||
Limocitrin 3-O-sophoroside 是一种可用于生物研究的化合物。 | |||
TQ0216 |
Ercalcitriol
1α,25-Dihydroxy Vitamin D2 |
Others | Others |
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) 是维生素 D2 的活性代谢物。 Ercalcitriol 作为维生素 D 的生理活化形式,通过调节正常细胞和转化细胞中的导管素抗菌肽 (CAMP) 和防御素 β-4 (DEFB4) 基因来增强免疫力,从而对抗病原体感染。 | |||
T8061 |
Citronellal
(±)-Citronellal,香茅醛 |
Others | Others |
Citronellal ((±)-Citronellal) 是多种芳香植物精油的单萜烯,具有促进睡眠、安定和抗伤害的作用。它可以降低机械伤害感受,且部分通过 NO-cGMP-ATP 敏感型 K⁺渠道通道介导的。 | |||
T8069 |
Triethyl citrate
|
Others | Others |
Triethyl citrate 是一种柠檬酸酯,可在纤维素塑料基纳米复合材料中,作为增塑剂使用。 | |||
T1591 |
Ancitabine hydrochloride
NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C |
Others; DNA/RNA Synthesis; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
Ancitabine hydrochloride (NSC 145668 HCl) 是一种天然的抗白血病药物。 | |||
T4525 |
Citraconic acid
2-Methylmaleic Acid,柠康酸,Cis-Methylbutenedioic Acid |
Endogenous Metabolite | Metabolism |
Citraconic acid (2-Methylmaleic Acid) 是由马来酸在2-位具有甲基取代基的二羧酸。 | |||
T4S0758 |
Isoquercitrin-7-O-gentiobioside
槲皮素-3-O-Β-D-葡萄糖-7-O-Β-D-龙胆双糖苷,Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside,Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden |
Others | Others |
Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden (Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside) 是一种黄酮,来源于 Quercetin 中。 | |||
T2852 |
Citropten
Limettin,Citroptene,Limetin,5, 7-Dimethoxycoumarin,柠美内脂,5,7-二甲氧基香豆素,5,7-Dimethoxycoumarin |
Others | Others |
Citropten 是一种香豆素,分离自佛手柑油中,对 A2058 人黑色素瘤细胞株具有抗增殖作用。 | |||
T1508 |
Decitabine
Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA Methyltransferase | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Decitabine (Deoxycytidine) 是脱氧胞苷类似物,一种 DNA 甲基转移酶抑制剂,具有口服活性。Decitabine 具有抗肿瘤活性和抗代谢活性。Decitabine 诱导细胞周期阻滞和凋亡。 | |||
T5257 |
L-Homocitrulline
高瓜氨酸,Homo-L-citrulline,Homocitrulline |
Others; Endogenous Metabolite | Metabolism; Others |
L-Homocitrulline (Homocitrulline) 是一种代谢物,可在尿素循环障碍患者的尿液中大量检测到。在某些情况下,由于尿素循环的鸟氨酸供应耗尽而导致的氨甲酰磷酸酯的积累可能是 L-Homocitrulline 和高精氨酸合成增强的原因。 | |||
T5087 |
DL-Isocitric acid trisodium salt
异柠檬酸三钠盐,Isocitric acid trisodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
DL-Isocitric acid trisodium salt 是内源性代谢产物的一种。 | |||
T0256 |
Citric acid trilithium salt tetrahydrate
Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate |
Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells |
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。 | |||
T11589 |
Hydroxycitric acid tripotassium hydrate
柠檬酸钾一水合物,三水合钾柠檬酸,Potassium citrate monohydrate |
ATP Citrate Lyase; HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) 是一种藤黄果的主要活性成分,也是一种柠檬酸的衍生物。它可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ,并具有减肥作用。它有效抑制结石形成,并抑制HIF,具有抗氧化,抗炎和抗肿瘤活性。 | |||
T1226 |
Bacitracin
Albac,Ziba-RX,杆菌肽 |
Antibacterial; Antibiotic | Microbiology/Virology |
Bacitracin (Ziba-RX) 是一种用于葡萄球菌感染的多肽抗生素。它通过与焦磷酸十一癸烯基结合,起抑制细胞壁生物合成作用。 | |||
T8057 |
Citronellyl acetate
|
Apoptosis; Others | Apoptosis; Others |
Citronellyl acetate 是一种植物次生代谢产物,具有杀菌、杀幼虫、杀菌和驱虫杀虫作用,以及抗伤害活性。它在人肝癌细胞中具有促凋亡活性。 | |||
T11590 |
(-)-Hydroxycitric acid
Garcinia acid,(-)-羟基柠檬酸 |
ATP Citrate Lyase | Metabolism |
(-)-Hydroxycitric acid (Garcinia acid) 是Garcinia cambogia 果皮中的主要酸。它是 ATP 柠檬酸裂解酶的竞争性抑制剂,能够抑制脂肪酸的合成,减少脂肪生成,控制食物摄入,从而减轻体重。 | |||
T3154 |
Citral
Geranialdehyde,alpha-Citral,柠檬醛,geranial |
Others | Others |
Citral 是一种单萜,从柠檬草精油中获得,具有抗疼痛、抗炎作用。 | |||
T4813 |
L-Citrulline
|
Endogenous Metabolite | Metabolism |
L-Citrulline 是一种氨基酸,源自于精氨酸-瓜氨酸途径获得的 l-精氨酸,或脯氨酸、谷氨酰胺和谷氨酸盐的分解代谢过程中产生的鸟氨酸。 | |||
TN2151 |
Rhamnocitrin
|
Others | Others |
Rhamnocitrin 是一种分离自黄芪(沙源子)中的类黄酮,具有抗氧化,抗炎和抗动脉粥样硬化活性。它是 DPPH 的清除剂(IC50:28.38 mM)。 | |||
TN1124 |
Neoeriocitrin
|
AChE | Neuroscience |
Neoeriocitrin 是一种有效的乙酰胆碱酯酶抑制剂,分离于自百日草,在 MC3T3-E1 中显示出对增殖和成骨分化的活性。 | |||
T6S0325 |
Glycitein
黄豆黄素,Glycetein |
Apoptosis; Others | Apoptosis; Others |
Glycitein (Glycetein) 是一种大豆异黄酮,可研究抗氧化和细胞凋亡。 | |||
T12045 |
(-)-Hydroxycitric acid lactone
藤黄内酯,Garcinia lactone |
ATP Citrate Lyase | Metabolism |
(-)-Hydroxycitric acid lactone (Garcinia lactone) 是一种有效的 ATP-柠檬酸裂解酶抑制剂,能够催化柠檬酸盐线粒体外裂解为草酰乙酸和乙酰辅酶 A,限制了脂肪酸合成所需乙酰辅酶 A 单位的可用性。它是一种减肥药,是一种广受欢迎的减肥食品补充剂。 | |||
T0185 |
Escitalopram
Seroplex,依他普仑,S-(+)-Citalopram,艾司西酞普兰,(S)-Citalopram |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Escitalopram (Seroplex) 是一种外消旋 Citalopram 的 S-对映体,是一种选择性 5-羟色胺再摄取抑制剂,Ki=0.89 nM,比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性,是一种研究抑郁症的抗抑郁药。 | |||
T0136 |
Citicoline
CDP-Choline,Citicholine,尼古林,cytidine 5'-diphosphocholine,cytidine diphosphate-choline |
Apoptosis; Dopamine Receptor; Endogenous Metabolite | Apoptosis; GPCR/G Protein; Metabolism; Neuroscience |
Citicoline (CDP-Choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体,有神经保护作用。 | |||
T12952 |
Sodium citrate dihydrate
Citric acid trisodium salt dihydrate,Trisodium citrate dihydrate,二水合柠檬酸钠 |
Antibacterial | Microbiology/Virology |
Sodium citrate dihydrate (Trisodium citrate dihydrate) 是一种抗凝血剂,也用为缓冲剂和食品防腐剂。 | |||
TN4931 |
L-Citronellol
(S)-(-)-beta-Citronellol,(S)-(-)-β-Citronellol |
Antifungal | Microbiology/Virology |
L-Citronellol ((S)-(-)-beta-Citronellol) 是一种从天竺葵中分离到的小分子化合物,具有抗真菌活性, 会对真菌膜产生影响。L-Citronellol 在对念珠菌酵母菌作用时与两性霉素B具有协同作用。 | |||
T1330 |
Acitretin
阿曲汀,Ro 10-1670,Etretin |
Apoptosis; Retinoid Receptor; Autophagy | Apoptosis; Autophagy; Metabolism |
Acitretin (Ro 10-1670) 是一种维甲酸,可用于银屑病和阿尔兹海默症的研究。 | |||
T0529 |
Dulcite
Galactitol,Dulcitol,Euonymit,NSC 1944,D-Galactitol,Melampyrit,半乳糖醇 |
Endogenous Metabolite | Metabolism |
Dulcite (D-Galactitol) 是一种具有微甜味的糖醇,其是半乳糖的代谢分解产物。 | |||
TN3194 |
6''-O-xylosyl-glycitin
|
Others | Others |
6''-O-xylosyl-glycitin 是从 Pueraria thunbergiana Benth 的花中分离出来的。 | |||
T6S0221 |
Eriocitrin
eriodictyol 7-rutinoside,圣草次甙,Eriodictyol-7-O-Rutinoside,Eriodictioside,圣草次甙;圣草次苷,Eriodictyol glycoside |
Apoptosis; Carbonic Anhydrase | Apoptosis; Metabolism |
Eriocitrin (Eriodictyol-7-O-Rutinoside) 是从柠檬中分离出来的一种黄酮类天然产物,是强效的抗氧化剂。它通过激活线粒体涉及的内在信号传导途径来触发细胞凋亡。它通过上调 p53、cyclin A、cyclin D3 和 CDK6 使 S 期细胞周期停滞,从而抑制肝癌细胞的增殖。 | |||
T5669 |
Citric acid monohydrate
|
Others | Others |
Citric acid monohydrate 是一种存在于柑橘类水果中的三羧酸。柠檬酸因其抗氧化特性而被用作药物制剂中的赋形剂。它保持活性成分的稳定性并用作防腐剂。 | |||
T3240 |
Citronellol
dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Citronellol ((±)-β-Citronellol) 是一种单萜类化合物,从头状天竺葵中分离到。它可通过上调 TNF-α,RIP1/RIP3 的活性,下调 caspase-3/caspase-8 的活性,以及增加活性氧 (ROS) 的聚集来诱导肿瘤细胞的坏死性凋亡。 | |||
T3237 |
Lecithin
Phospholutein,卵磷脂,L-α-磷脂酰胆碱,L-α-Phosphatidylcholine,Phosphatidylcholines |
Others; Endogenous Metabolite | Metabolism; Others |
Lecithin (L-α-Phosphatidylcholine) 被认为是安全的常规磷脂源。磷脂能够改变动物细胞膜的脂肪酸组成和微观结构。 | |||
T8266 |
(R)-Citronellol
D-Citronellol,(R)-(+)-β-Citronellol,(R)-3,7-二甲基-6-辛烯醇 |
Others; Endogenous Metabolite | Metabolism; Others |
(R)-Citronellol ((R)-(+)-β-Citronellol) 是一种存在于天竺葵精油中的醇单萜。它抑制肥大细胞的脱颗粒,并且不影响咖啡因的苦味感。它能够用于装饰性化妆品,盥洗用品以及非化妆品中。 | |||
T13750 |
L-Fucitol
L-岩藻糖醇,1-Deoxy-D-galactitol |
Others | Others |
L-Fucitol (1-Deoxy-D-galactitol) 是一种糖醇,从肉豆蔻 (Nutmeg) 中分离得到。 | |||
TN1299 |
Desmethylglycitein
4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone |
PI3K; CDK; PKC | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物,具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂,抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2,抑制 CDK1 和 CDK2 活性。 | |||
T2820 |
Glycitin
黄豆黄苷,Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside |
Others; Influenza Virus; Antibacterial | Microbiology/Virology; Others |
Glycitin (Glycitein 7-O-β-glucoside) 是一种从豆类中分离出来的天然异黄酮,有抗菌,抗病毒和雌激素作用,还有促进骨髓基质细胞和成骨细胞的增殖和抑制骨转换的生物学功能。 | |||
T8013 |
(S)-(-)-Citronellal
(S)-(-)-3,7-Dimethyl-6-Octenal,(-)-香茅醛,(-)-Citronellal |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-(-)-Citronellal ((S)-(-)-3,7-Dimethyl-6-Octenal) 是存在于Corymbia citriodora 和Cymbopogon nardus 中的一种单萜类化合物。 | |||
T7921 |
β-Cyclocitral
beta-Cyclocitral,β-环柠檬醛 |
Others | Others |
β-Cyclocitral 是 β-胡萝卜素的挥发性氧化衍生物,是微囊藻特有的掠食性动物防御信号。它是一种强大的驱虫剂。它是主要的挥发性萜类化合物之一,可以上调防御基因的表达,从而增强过量光照 (EL) 的适应性。 | |||
T2871 |
Quercitrin
Sophoretin,3-rhamnosyl quercetin,Quercetin 3-rhamnoside,Xanthaurine,槲皮苷,Meletin |
Reactive Oxygen Species; S6 Kinase; Autophagy | Autophagy; Immunology/Inflammation; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling |
Quercitrin (3-rhamnosyl quercetin) 是苦荞麦中的一种天然产物,具有抗炎作用,有用于心血管疾病的研究潜力。 | |||
TN7238L |
Sanguinarine citrate
Sanguinarium citrate,Sanguinarin citrate,Pseudochelerythrine citrate |
Antibiotic | Microbiology/Virology |
Sanguinarine citrate (Pseudochelerythrine chloride) 是一种来源于 Sanguinaria Canadensis 的生物碱,具有抗菌、抗炎和镇痛活性,可用于治疗口腔炎、牙龈出血和喉炎等口腔炎症疾病 。 | |||
T1208 |
Citicoline sodium
Citicoline sodium salt,CDP-choline,胞磷胆碱钠 |
Apoptosis; Others; Endogenous Metabolite | Apoptosis; Metabolism; Others |
Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体,有神经保护作用。 | |||
T5S0636 |
Citric acid
柠檬酸,Citro,Citretten |
Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic | Apoptosis; Metabolism; Microbiology/Virology; Others |
Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。 | |||
T3766 |
(-)-vibo-Quercitol
(-)-Viburnitol,(-)-VIBO-栎醇 |
Others | Others |
(-)-vibo-Quercitol ((-)-Viburnitol) 是一种羧基糖胺糖苷酶抑制剂。 | |||
T2757 |
Myricitrin
杨梅苷,Myricetrin,Myricitrine |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Myricitrin (Myricitrine) 是从杨梅根皮中分离出来的类黄酮化合物,具有镇痛作用。它是主要的抗氧化剂。 | |||
T6316 |
Calcitriol
Topitriol,Rocaltrol,Calcijex,RO215535,骨化三醇,1,25-Dihydroxyvitamin D3 |
Endogenous Metabolite | Metabolism |
Calcitriol (1,25-Dihydroxyvitamin D3) 是一种维他命 D 的代谢物,一种维他命 D 受体 (VDR) 的激动剂 (IC50=0.4 nM)。Calcitriol 增加肠道对钙和磷的吸收,并与甲状旁腺激素一起增加了骨吸收。 | |||
T20819 |
Ammonium iron(III) citrate
柠檬酸铁铵,柠檬酸铁 (III) 铵,Ferric ammonium citrate |
Others; Ferroptosis | Apoptosis; Others |
Ammonium iron(III) citrate (Ferric ammonium citrate) 是一种非运铁蛋白结合的铁的生理形式,会引起的细胞内铁超负荷从而导致细胞铁死亡,能增强蛋白质产生。 | |||
TN3670 | Citromycin | Antifection | Microbiology/Virology |
Citromycin, an antibiotic, has weakly cytotoxic. | |||
TN1263 |
3''-O-Galloylmyricitrin
|
Others | Others |
3''-O-Galloylmyricitrin is a natural product | |||
TN2934 |
3''-Galloylquercitrin
|
Others | Others |
1. 3''-Galloylquercitrin possesses the activity for PTK inhibition. <br/> | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02483 |
ATP citrate lyase/ACLY Protein, Human, Recombinant (His)
ATPCL,ACL,ATP citrate lyase,CLATP |
Human | Baculovirus Insect Cells |
ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, show... | |||
TMPY-00085 |
Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc)
CTR,CTR1,CT-R,calcitonin receptor,CRT |
Human | HEK293 Cells |
Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.1 kDa and the accession number is P30988-2. | |||
TMPY-00066 |
Procalcitonin/CALCA Protein, Human, Recombinant (His)
KC,CGRP,CALC1,Procalcitonin,CT,calcitonin-... |
Human | HEK293 Cells |
Procalcitonin/CALCA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.2 kDa and the accession number is P01258-1. | |||
TMPH-00400 |
DHAK Protein, Citrobacter freundii, Recombinant (His & SUMO)
Dihydroxyacetone kinase,dhaK,Glycerone kinase,DHA kinase |
Citrobacter freundii | E. coli |
Catalyzes the phosphorylation of dihydroxyacetone. DHAK Protein, Citrobacter freundii, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.9 kDa and the accession number is P45510. | |||
TMPY-04120 |
Procalcitonin/CALCA Protein, Human, Recombinant (mFc)
Procalcitonin,CGRP,CGRP-I,calcitonin-relat... |
Human | HEK293 Cells |
Procalcitonin/CALCA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 39.2 kDa and the accession number is P01258-1. | |||
TMPH-03412 |
Citrate synthase Protein, Rickettsia australis, Recombinant (His & Myc)
gltA,Citrate synthase |
Rickettsia australis | E. coli |
Citrate synthase Protein, Rickettsia australis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.6 kDa and the accession number is P51039. | |||
TMPY-02413 |
Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant (His)
HEL-S-26,HEL-216,IDP,IDCD,PICD,IDH,isocitrate dehyd... |
Human | E. coli |
Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 48 kDa and the accession number is O75874. | |||
TMPY-04070 |
Citrate Synthase Protein, Human, Recombinant (His)
citrate synthase |
Human | Baculovirus Insect Cells |
Chondroitin sulphate (CS) glycosaminoglycan chains on cell and extracellular matrix proteoglycans (PGs) can no longer be regarded as merely hydrodynamic space fillers. Overwhelming evidence over recent years indicates that sulphation motif sequences within the CS chain structure are a source of significant biological information to cells and their surrounding environment. CS sulphation motifs have been shown to interact with a wide variety of bioactive molecules, e.g. cytokines, growth factors, ... | |||
TMPY-00317 |
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc)
CTR,calcitonin receptor,CRT,CTR1,CT-R |
Human | HEK293 Cells |
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.9 kDa and the accession number is P30988-1. | |||
TMPH-03097 |
Beta-elicitin cryptogein Protein, Phytophthora cryptogea, Recombinant (His & Myc)
Beta-elicitin cryptogein,CRY |
Phytophthora cryptogea | E. coli |
Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families. Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins. Might interact with the lipidic molecules of the plasma membrane. Beta-elicitin cryptogein Protein, Phytophthora cryptogea, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.3 kDa and the accession... | |||
TMPH-00553 |
Fructose 5-dehydrogenase [NADP(+)] Protein, Erwinia citreus, Recombinant (His & KSI)
Fructose 5-dehydrogenase [NADP(+)],5-ketofructose reductase ... |
Erwinia citreus | E. coli |
Fructose 5-dehydrogenase [NADP(+)] Protein, Erwinia citreus, Recombinant (His & KSI) is expressed in E. coli. | |||
TMPH-00401 |
LGTase Protein, Citrus unshiu, Recombinant (His & Myc)
Limonoid UDP-glucosyltransferase |
Citrus unshiu | Baculovirus Insect Cells |
LGTase Protein, Citrus unshiu, Recombinant (His & Myc) is expressed in Baculovirus. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14687 |
Deucravacitinib
BMS-986165 |
Tyrosine Kinases; JAK; IFNAR; Interleukin | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂,用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活,可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域,IC50为1.0 nM。 | |||
T11952 |
Maxacalcitol-D6
|
Others | Others |
Maxacalcitol-D6 is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.Maxacalcitol-D6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol). | |||
TMIJ-0137 |
Tofacitinib-d3 Citrate
|
||
Tofacitinib-d3 Citrate 是 Tofacitinib Citrate 的氘代化合物。Tofacitinib Citrate 的 CAS 号为 540737-29-9。Tofacitinib citrate是JAK1/2/3抑制剂,IC50分别为112,20 和 1 nM。它具有抗菌,抗真菌和抗病毒活性。 | |||
TMID-0242 |
Capecitabine-d11
|
||
Capecitabine-d11 是 Capecitabine 的氘代化合物。Capecitabine 的 CAS 号为 154361-50-9。Capecitabine 是一种可口服的前药,可由胸苷磷酸化酶催化转变为其活性代谢物 Fluorouracil。 | |||
TMIJ-0267 |
Upadacitinib-15N-d2
|
||
Upadacitinib-15N-d2 是 Upadacitinib 的 15N 和氘代化合物。Upadacitinib 的 CAS 号为 1310726-60-3。Upadacitinib 是高效选择性的,具有口服活性的JAK1抑制剂,IC50为43 nM,可用于多种自身免疫性疾病的研究。它对 JAK1 的选择性约为 JAK2 的 74 倍。 | |||
T70394 |
Deucravacitinib HCl
|
||
Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional resp... | |||
TMIH-0615 |
Zuclomiphene-d4 Citrate
cis-Clomiphene-d4 Citrate |
||
Zuclomiphene-d4 Citrate 是 Zuclomiphene Citrate 的氘代化合物。Zuclomiphene Citrate 的 CAS 号为 14158-66-8。 | |||
TMIH-0159 |
Citalopram-d6
|
||
Citalopram-d6 是 Citalopram 的氘代化合物。Citalopram 的 CAS 号为 59729-33-8。Citalopram (Lu 10-171) 是一种具有口服活性的、选择性的血清素再摄取抑制剂 (SSRI),是一种选择性5-羟色胺再摄取抑制剂,是一种 S(+)-对映体 (Escitalopram) 和 R(-)-对映体的外消旋混合物。Citalopram 具有抗抑郁活性,可增强血清素能神经传递,可用于研究老年痴呆。 | |||
T12363 |
Paricalcitol-D6
|
Others | Others |
Paricalcitol-D6 is the deuterated form of Paricalcitol, which is used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. | |||
T11934 |
Macitentan-d4
Macitentan D4,ACT-064992 D4 |
Endothelin Receptor | GPCR/G Protein |
Macitentan-d4 (ACT-064992 D4) 是一种 Macitentan 氘代物,可被当作非多肽 ETA 和 ETB (内皮素受体)双拮抗剂。Macitentan-d4 比 Macitentan 毒性更低,半衰期更长,可用于研究由内皮素受体介导介导的疾病。 | |||
T19088 |
13-cis Acitretin D3
Isoacitretin D3,13-cis Acitretin D3 |
Others | Others |
13-cis Acitretin D3 (Isoacitretin D3) is a deuterium-labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin is a second-generation, systemic retinoid. | |||
TMIH-0373 |
N-Desmethyl citalopram-d4 Oxalate
|
||
N-Desmethyl citalopram-d4 Oxalate 是 N-Desmethyl citalopram Oxalate 的氘代化合物。 | |||
T10351 |
Aprocitentan D4
ACT-132577 D4 |
Others | Others |
Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2s: 6.7 and 5.5). | |||
TMIH-0158 |
Citalopram-d6 Oxalate
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Citalopram-d6 Oxalate 是 Citalopram Oxalate 的氘代化合物。Citalopram Oxalate 的 CAS 号为 207559-01-1。 | |||
TMIH-0211 |
EN Clomiphene-d4 Citrate
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EN Clomiphene-d4 Citrate 是 EN Clomiphene Citrate 的氘代化合物。 | |||
TMIH-0157 |
Citalopram-d4 Oxalate
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Citalopram-d4 Oxalate 是 Citalopram Oxalate 的氘代化合物。Citalopram Oxalate 的 CAS 号为 207559-01-1。 | |||
TMIJ-0190 |
Gemcitabine EP Impurity C-13C-15N2
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Gemcitabine EP Impurity C-13C-15N2 是 Gemcitabine EP Impurity C 的 13C 和 15 N 的标记化合物。 | |||
TMIJ-0153 |
Dapagliflozin-13C6 (glucitol-13C6)
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Dapagliflozin-13C6 (glucitol-13C6) 是 Dapagliflozin 的 13C 的标记化合物。Dapagliflozin 的 CAS 号为 461432-26-8。Dapagliflozin竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可促进尿液中葡萄糖的排泄,在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导HIF1表达并减轻肾脏 IR 损伤。 | |||
TMIJ-0261 |
Baricitinib-d5
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Baricitinib-d5 是 Baricitinib 的氘代化合物。Baricitinib 的 CAS 号为 1187594-09-7。Baricitinib 是一种选择性,可口服的JAK1和JAK2抑制剂,IC50分别为5.9 nM 和 5.7 nM,具有潜在的抗炎、免疫调节和抗肿瘤活性。 | |||
T10663 |
Calcitriol-d6
Calcitriol D6,骨化三醇 D6 |
Others | Others |
Calcitriol D6 is the deuterated form of Calcitriol, which is the hormonally active form of vitamin D. Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor. | |||
T19305 |
Eldecalcitol-d6
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Others | Others |
Eldecalcitol is an orally active analogue of active vitamin D used in the treatment of osteoporosis. Eldecalcitol-d6 is the deuterium labeled Eldecalcitol. | |||
TMIH-0383 |
N-Despropyl Macitentan-d4
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N-Despropyl Macitentan-d4 是 N-Despropyl Macitentan 的氘代化合物。N-Despropyl Macitentan 的 CAS 号为 1103522-45-7。Aprocitentan 是一种 Macitentan 的主要活性代谢物。它是ETA/ETB的双重拮抗剂,其pA2值分别为 6.7 和 5.5,IC50分别为 3.4 nM 和 987 nM。 |