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Search Results for " chop "

Targets Recommended: Apoptosis AMPK Autophagy

16

抑制剂 & 化合物

5

天然产物

1

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6854	GSK621	Apoptosis; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	GSK621 是一种特异性AMPK 激动剂，对 AML 细胞系的IC50值为13-30 μM。它可诱导自噬和凋亡，还可诱导eiF2α磷酸化。
T13416	ZX-29	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	ZX-29 是一种选择性ALK 抑制剂，对ALK、ALK L1196M 和ALK G1202R 的IC50分别为 2.1 nM、1.3 nM 和 3.9 nM。它还可诱导保护性自噬并具有抗肿瘤作用。它通过诱导内质网应激来诱导细胞凋亡，并克服了由ALK 突变引起的细胞抗性。
T0456	Cinchophen 2-苯基-4-喹啉羧酸,辛可芬,Cinconal	COX	Immunology/Inflammation; Neuroscience
	Cinchophen (Cinconal) 是口服具有活性的非甾体抗炎试剂，具有抗菌活性。它可用于研究关节炎和某些肝脏疾病。
T34720	Stichoposide Stichoposide A,Holotoxins	Others	Others
	Stichoposide is a triterpene glycoside.
T125852	Isorhynchophyllic acid	Others	Others
	Isorhynchophyllic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125852。
T25911	Oxycinchophen Magnophenyl,Sintofene,Reumartril,Chinoxone	Others	Others
	Oxycinchophen 是一种喹啉类的有机物，抗风湿病的化合物。它已被用于研究 P- 选择素拮抗活性，DHOD 抑制活性，以及抗炎药对血管平滑肌的作用。
T124429	Trichophydine	Others	Others
	Trichophydine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124429。
T12009	Telomerase-IN-1	Telomerase	DNA Damage/DNA Repair
	Telomease-IN-1是一种端粒酶抑制剂（IC50：0.19μM）。Telomease-IN-1通过ER 过度反应（EOR）的内质网应激（ERS）激活hTERT 的表达，然后诱导ERS，导致细胞凋亡。Telomease-IN-1通过表达下游信号分子包括CHOP（CAAT /增强子结合蛋白同源蛋白））和线粒体凋亡途径，导致细胞增殖受到抑制。Telomease-IN-1对端粒酶具有较高的抑制活性，对SMMC-7721细胞具有较高的抗增殖能力，对人正常肝细胞无明显毒性作用。Telomease-IN-1 在异种移植肿瘤模型表现出抗肿瘤活性。
T69106	Avarol	Others	Others
	Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheimer's disease.
T26709	Azadirone	Others	Others
	Azadirone is a limonoid tetranortriterpene. Azadirone can sensitize cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR4 and DR5 signaling, down-regulation of cell survival prot
T22104	ML-291	Others	Others
	ML291 is a sufonamidebenzamide compound that induces the unfolded protein response (UPR) and overwhelms the adaptive capacity of UPR, resulting in apoptosis in various solid cancer models. It activates the PERK/eIF2a/CHOP apoptotic pathway of UPR and reduces leukemic cell burden [1].
T84520	Palmitic acid calcium Calcium palmitate	Others	Others
	Palmitic acid calcium，一种长链饱和脂肪酸，广泛存在于动物和植物中。它能在小鼠颗粒细胞诱导葡萄糖调节蛋白78 (GRP78) 和CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达，可用于建立细胞脂肪变性模型。
T63665	EIF2α activator 1	Others	Others
	EIF2α activator 1（Compound 40）为真核生物起始因子2α（eIF2α）磷酸化的激活剂，能够提高EIF2α下游蛋白ATF和CHOP的表达水平。该化合物对K562细胞和PBMC细胞展现出抗增殖活性，其IC50值分别为4.00 μM和19.3 μM。
T74844	Antiproliferative agent-23	Others	Others
	Antiproliferative agent-23，一种微管去稳定剂(MDA)，通过扰乱微管蛋白-微管系统来发挥作用。该化合物通过降低Bcl-2蛋白水平、提高Bax和Cyt c蛋白水平以及激活半胱天冬酶级联反应和线粒体依赖途径来诱导细胞凋亡。此外，Antiproliferative agent-23还能在A549/CDDP细胞（顺铂耐药癌细胞系）中通过PERK/ATF4/CHOP信号通路激活ROS介导的内质网应激，展现出抗肿瘤活性。
T85207	1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol 1,2-Palmitin-3-caprylin	Others	Others
	1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol 是一种三酰基甘油，其结构特征在于 sn-1 和 sn-2 位置上连接有棕榈酸，在 sn-3 位置上连接有辛酸。棕榈酸，一种广泛存在于动植物体中的长链饱和脂肪酸，已知能够在小鼠颗粒细胞中诱导葡萄糖调节蛋白 78 (GRP78) 与 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。辛酸，作为一种具有微弱腐臭味的油性液体，不仅应用于酯类香料与染料的制备中，还被认为是一种有效的震颤抑制剂。
T36570	KUS121	Others	Others
	KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, an inducer of ER stress, in HeLa cells when used at concentrations of 20, 50, and 50 μM, respectively. KUS121 (100 μM) inhibits ATP depletion and cell death induced by oxygen-glucose deprivation (OGD) in rat primary cortical neurons in anin vitromodel of cerebral ischemia.2It red...

化合物

Cat.No: T6854

Target: Apoptosis, AMPK, Autophagy

Cat.No: T13416

Target: ALK

Cat.No: T0456

Synonym: 2-苯基-4-喹啉羧酸,辛可芬,Cinconal

Target: COX

Cat.No: T34720

Synonym: Stichoposide A,Holotoxins

Target: Others

Isorhynchophyllic acid

Cat.No: T125852

Target: Others

Cat.No: T25911

Synonym: Magnophenyl,Sintofene,Reumartril,Chinoxone

Target: Others

Cat.No: T124429

Target: Others

Telomerase-IN-1

Cat.No: T12009

Target: Telomerase

Cat.No: T69106

Target: Others

Cat.No: T26709

Target: Others

Cat.No: T22104

Target: Others

Palmitic acid calcium

Cat.No: T84520

Synonym: Calcium palmitate

Target: Others

EIF2α activator 1

Cat.No: T63665

Target: Others

Antiproliferative agent-23

Cat.No: T74844

Target: Others

1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol

Cat.No: T85207

Synonym: 1,2-Palmitin-3-caprylin

Target: Others

Cat.No: T36570

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5A2461	Bufotalin 蟾蜍他灵,Bufotaline,蟾毒它灵,蟾蜍他灵	Apoptosis; Others; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Others
	Bufotalin (Bufotaline) 是一种从蟾酥中分离的类固醇内酯，可诱导癌细胞凋亡，也诱导内质网应激的激活，具有强大的抗肿瘤活性。
TN1465	Cannabigerol	NOS; 5-HT Receptor; ROS	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cannabigerol 是一种植物大麻素，是一种高亲和力 α2-肾上腺素能受体激动剂、中度亲和力 5-HT1A 受体拮抗剂和低亲和力 CB1/CB2受体拮抗剂。它可降低眼压，有潜力治疗青光眼。
T6S0657	Isorhynchophylline IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline	Others	Others
	Isorhynchophylline (7-Isorhyncophylline) 是一种分离自钩藤中的生物碱类化合物，具有舒张血管、降血压、保护神经免于局部缺血造成损伤的作用。
T6S0659	Rhynchophylline 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel; NF-κB	Membrane transporter/Ion channel; Metabolism; NF-κB
	Rhynchophylline (Mitrinermine) 是一种生物碱类化合物，从钩藤中分离得到，具有很高的生物活性，被广泛用于抗炎、神经保护等方面的研究。
T6S1315	Oroxylin A 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy	Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮，具有较强的抗癌作用。

天然产物

Cat.No: T5A2461

Synonym: 蟾蜍他灵,Bufotaline,蟾毒它灵,蟾蜍他灵

Target: Apoptosis, Others, Reactive Oxygen Species

Cat.No: TN1465

Target: NOS, 5-HT Receptor, ROS

Isorhynchophylline

Cat.No: T6S0657

Synonym: IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline

Target: Others

Rhynchophylline

Cat.No: T6S0659

Synonym: 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

Cat.No: T6S1315

Synonym: 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc) Ubiquilin-1,UBQLN1,Protein linking IAP with cytoskeleton 1	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its in...

重组蛋白

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02282

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T40141	Palmitic acid-13C16 sodium Palmitic acid-13C16 sodium
	Palmitic acid-13C16 sodium, a 13C-labeled form of the naturally occurring saturated fatty acid Palmitic acid sodium, is prevalent in animals and plants. This compound can trigger the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells.
T40980	Palmitic acid-13C2 Palmitic acid-13C2
	Palmitic acid-13C2 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
T39423	Palmitic acid-13C sodium
	Sodium palmitate-13C is the 13C-labeled variant of palmitic acid, a long-chain saturated fatty acid prevalent in animals and plants. This compound has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in mouse granulosa cells.

同位素标记化合物

Palmitic acid-13C16 sodium

Cat.No: T40141

Synonym: Palmitic acid-13C16 sodium

Palmitic acid-13C2

Cat.No: T40980

Synonym: Palmitic acid-13C2

Palmitic acid-13C sodium

Cat.No: T39423

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