479
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Cat. No. | Product Name | ||
---|---|---|---|
L5300 | 线粒体靶向库 | 812 compounds | |
812 种具有潜在或确定线粒体靶向活性的化合物,以促进针对线粒体的药物研究; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0146 |
Ac-DEVD-CHO
|
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Ac-DEVD-CHO 是一种特异性 Caspase-3 抑制剂(Ki: 230 pM)。Ac-DEVD-CHO在 SLNT 诱导的细胞凋亡中有抑制作用。 | |||
TQ0146L |
Ac-DEVD-CHO acetate
Caspase-3 Inhibitor I,N-acetyl-asp-glu-val-asp-al,Ac-DEVD-CHO acetate (169332-60-9 free base),乙酰基-天冬氨酰-谷氨酰-缬氨酰-天冬氨醛 |
Caspase | Apoptosis; Proteases/Proteasome |
Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) 是 Caspase-3 的特异性抑制剂。 | |||
T41069 |
CHO-C-PEG2-C-CHO
CHO-C-PEG2-C-CHO |
Others | Others |
CHO-C-PEG2-C-CHO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T21617 |
MG-115
Z-LL-Nva-CHO |
Proteasome | Proteases/Proteasome; Ubiquitination |
MG-115 (Z-LL-Nva-CHO) 是一种有效且可逆的蛋白酶体抑制剂,对20S 和26S 蛋白酶体的 Ki 值分别为 21 nM 和 35 nM。MG-115 特异性抑制蛋白酶体的胰凝乳蛋白酶样活性,诱导 p53 依赖性细胞凋亡。 | |||
T80531 |
Ac-AAVALLPAVLLALLAP-DEVD-CHO
DEVD-CHO-CPP 32 |
Caspase | Apoptosis; Proteases/Proteasome |
DEVD-CHO-CPP 32(Ac-AAVALLPAVLLALLAP-DEVD-CHO)是一种高效且可逆的caspase-3抑制剂。 | |||
T80624 |
Ac-VAD-CHO
Ac-Val-Ala-Asp-CHO |
Caspase | Apoptosis; Proteases/Proteasome |
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO)是一款caspase抑制剂,能够阻止缺氧细胞内MMP的降解以及细胞色素c的释出。 | |||
T39722 |
CHO-CH2-PEG1-CH2-Boc
CHO-CH2-PEG1-CH2-Boc |
Others | Others |
CHO-CH2-PEG1-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T78640 |
Z-LLF-CHO
Z-Leu-Leu-Phe-CHO |
Proteasome | Proteases/Proteasome; Ubiquitination |
Z-LLF-CHO(Z-Leu-Leu-Phe-CHO)为垂体多催化蛋白酶复合物所具有的胰凝乳蛋白酶样活性提供有效抑制,具有Ki值为460 nM。此外,Z-LLF-CHO同样作为NF-κB核转位的抑制剂。 | |||
T83205 |
Ac-DNLD-CHO
Ac-Asp-Asn-Leu-Asp-CHO |
Caspase | Apoptosis; Proteases/Proteasome |
Ac-DNLD-CHO(Ac-Asp-Asn-Leu-Asp-CHO)是一种有效的Caspase-3/7抑制剂,具有较低的IC50(分别为9.89, 245 nM)和Kiapp(分别为0.68、55.7 nM)。该化合物在研究caspase介导的细胞凋亡过程中具有重要应用价值,适用于神经退行性疾病和病毒感染疾病的相关研究。 | |||
T2154 |
MG-132
Z-LLL-al,Z-Leu-Leu-Leu-CHO |
Apoptosis; Proteasome; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination |
MG-132 (Z-Leu-Leu-Leu-al) 是一种 26S 蛋白酶体抑制剂 (IC50=100 nM),具有细胞渗透性、可逆性。MG-132 可作为自噬激活剂,可诱导凋亡。 | |||
T80735 |
Z-Gly-Pro-Phe-Leu-CHO
Z-GPFL-CHO |
Proteasome | Proteases/Proteasome; Ubiquitination |
Z-Gly-Pro-Phe-Leu-CHO(Z-GPFL-CHO)是一种具有高选择性和高效率的四肽醛类蛋白酶体抑制剂,优先抑制支链氨基酸(Ki为1.5 µM),对小中性氨基酸的Ki值为2.3 µM,胰凝乳蛋白酶样活性的Ki值为40.5 µM,对肽基-谷氨酰肽水解活性的IC50为3.1 µM。 | |||
T78586L |
Ac-IETD-CHO TFA
Ac-IETD-CHO TFA(191338-86-0 Free base ) |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Ac-IETD-CHO TFA 是一种 granzyme B 和 caspase-8 抑制剂,通过阻断 caspase3 前体裂解抑制 caspase8 活性。Ac-IETD-CHO TFA 抑制 Fas 介导的细胞凋亡(Apoptosis)。 | |||
T41236 |
Z-FY-CHO
|
Others | Others |
Z-FY-CHO (Z-Phe-Tyr-CHO) 是一种特异且有效的组织蛋白酶 L (CTSL) 抑制剂。 | |||
T36350 |
Cho-Arg (trifluoroacetate salt)
|
Others | Others |
Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the cav... | |||
T36368 |
2H-Cho-Arg (trifluoroacetate salt)
|
Others | Others |
2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and t... | |||
T29233 |
Z-LLNle-CHO
|
||
Z-LLNle-CHO is a cell permeable inhibitor of gamma-secretase. Z-LLNle-CHO induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response. | |||
T6583 |
MG-101
ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101,钙蛋白酶抑制剂I |
Cysteine Protease; Proteasome | Proteases/Proteasome; Ubiquitination |
MG-101 (Calpain inhibitor I) 是一种有效的半胱氨酸蛋白酶抑制剂,能够抑制钙蛋白酶I (Ki:190 pM),钙蛋白酶II (Ki:220 pM),组织蛋白酶B (Ki:150 pM)和组织蛋白酶L (Ki:500 pM)。 | |||
T19883 |
Ac-YVAD-CHO
L 709049,L-709049,L709049 |
||
L 709049是一种生物活性化合物,它是白细胞介素-1β转化酶( Caspase-1)的选择性抑制剂。 Caspase 抑制剂可干扰细胞凋亡的启动,具有多种临床应用前景。 | |||
T80513 |
YVAD-CHO
|
||
YVAD-CHO为白细胞介素-1β转换酶(ICE,caspase 1)的抑制剂,能够在一定程度上减缓面神经损伤小鼠运动神经元死亡速率。 | |||
T17281 |
Z-Ile-Leu-aldehyde
Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII |
Others | Others |
Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch. | |||
T38240 |
2,6-Dichlorodiphenylamine
|
Antibacterial | Microbiology/Virology |
2,6-Dichlorodiphenylamine 是双氯芬酸钠的一种结构类似物,显示出抗白色念珠菌活性。2,6-Dichlorodiphenylamine 是非选择性抗炎剂,为COX 的抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50分别为 4 和 1.3 nM。 | |||
T80093 |
IETD-CHO TFA
|
Caspase | Apoptosis; Proteases/Proteasome |
IETD-CHO TFA (Caspase-8-IN-1) 是一种高效的 caspase-8 抑制剂。 | |||
T80076 |
Ac-ESMD-CHO
|
Casein Kinase | Metabolism; Stem Cells |
Ac-ESMD-CHO是一种抑制caspase-3和caspase-7的化合物。该化合物能有效阻止caspase-3前体肽(CPP32)在Glu-Ser-Met-Asp(ESMD)位点发生的蛋白水解切割作用。 | |||
T78586 |
Ac-IETD-CHO
|
Apoptosis | Apoptosis |
Ac-IETD-CHO是一种针对granzyme B和caspase 8的有效可逆抑制剂,能够阻止Fas介导的(Apoptosis)、出血和肝衰竭,并且能够抑制细胞毒性T淋巴细胞引发的细胞死亡。 | |||
T80467 |
Boc-AEVD-CHO
|
Caspase | Apoptosis; Proteases/Proteasome |
Boc-AEVD-CHO是一种Caspase 8抑制剂,适用于细胞凋亡以及免疫和炎症疾病研究。 | |||
T78622 |
Ac-VDVAD-CHO
|
Casein Kinase | Metabolism; Stem Cells |
Ac-VDVAD-CHO为caspase-2/3抑制剂,其IC50值分别为46 nM和15 nM。 | |||
T8566 |
AA92593
|
Others | Others |
AA92593 是一种选择性的 OPN4 (melanopsin)竞争性拮抗剂。 | |||
T3306 |
PF-04418948
PF 04418948,PF04418948 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
PF-04418948 是一种可口服的,选择性的前列腺素EP2受体拮抗剂,IC50为16 nM。 | |||
T80537 |
Ac-AAVALLPAVLLALLAP-LEHD-CHO
|
Caspase | Apoptosis; Proteases/Proteasome |
Ac-AAVALLPAVLLALLAP-LEHD-CHO 是半胱天冬酶4、5和9的抑制剂,能够对Neocarzinostatin处理的MCF-7细胞展现保护效果。 | |||
T78619 |
Z-Pro-Pro-CHO
|
Prolyl Endopeptidase (PREP) | Metabolism; Proteases/Proteasome |
Z-Pro-Pro-CHO为一种有效的脯氨酰寡肽酶抑制剂,其具有针对人类及曼氏血吸虫脯氨酰寡肽酶的较低半抑制浓度(IC50),分别为0.16 μM和0.01 μM。 | |||
T80532 |
Ac-AAVALLPAVLLALLAP-YVAD-CHO
|
Caspase | Apoptosis; Proteases/Proteasome |
Ac-AAVALLPAVLLALLAP-YVAD-CHO为具备细胞穿透能力的caspase-1抑制剂,展现出抗肿瘤活性。 | |||
T73852 |
Ac-YVAD-CHO acetate
|
Others | Others |
Ac-YVAD-CHO(L-709049)醋酸盐是一种高效、可逆、特异的四肽白介素1β转化酶(ICE)抑制剂,小鼠和人类的Ki值分别为3.0 nM和0.76 nM。它同时也能抑制caspase-1,从而抑制成熟IL-lβ的产生。 | |||
T80536 |
Ac-AAVALLPAVLLALLAP-LEVD-CHO
|
Caspase | Apoptosis; Proteases/Proteasome |
Ac-AAVALLPAVLLALLAP-LEVD-CHO是一caspase-4抑制剂,可穿透细胞膜,并表现出抗肿瘤特性。 | |||
T73683 |
AC-VEID-CHO TFA
|
||
AC-VEID-CHO (TFA) 是一种源自多肽的半胱天冬酶抑制剂,针对Caspase-6、Caspase-3和Caspase-7展示出优异的抑制效果,其IC50值分别为16.2 nM、13.6 nM和162.1 nM。该化合物常用于研究阿尔茨海默病、亨廷顿病等神经退行性疾病。 | |||
T0432 |
Diclofenac diethylamine
|
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Diclofenac diethylamine 是非选择性抗炎剂,通过活化 caspase 级联反应来诱导神经干细胞凋亡。它是一种COX 抑制剂,在 CHO 细胞中,对人COX-1和COX-2的IC50值分别为 4 和 1.3 nM。它对绵羊COX-1和COX-2的IC50值分别为 5.1 μM 和0.84 μM。 | |||
T1671 |
Mirabegron
YM178,米拉贝隆 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Mirabegron (YM178) 是选择性的肾上腺素受体激动剂,EC50=22.4 nM。 | |||
T9927 |
Panitumumab
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Panitumumab 是一种重组全人源 IgG2 单克隆抗体,可与表皮生长因子(EGFR)结合,具有抗肿瘤活性。 | |||
T8991 |
BMS986187
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BMS986187 是一种有效的δ-阿片受体选择性正变构调节剂 (PAM),其 EC50= 0.03 μM,pKB= 6.02 (~1 μM)。BMS986187 对 μ 受体无明显 PAM 活性 (EC50=3 μM)。 | |||
T2667 |
PIK-75
|
Apoptosis; DNA-PK; PI3K | Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
PIK75 是一种可逆的DNA-PK 和p110α-选择性的抑制剂,抑制 DNA-PK、p110α 和 p110γ,IC50分别为 2、5.8 和 76 nM。它诱导凋亡,抑制 p110α 效果比抑制 p110β 高 200 多倍,p110β的IC50为 1.3 μM。 | |||
T6470 |
Diclofenac Potassium
双氯芬酸钾,CGP-45840B,Cataflam,Voltfast |
Apoptosis; Others; COX | Apoptosis; Immunology/Inflammation; Neuroscience; Others |
Diclofenac Potassium (CGP-45840B) 是一种非甾体抗炎药,用于减轻炎症并在某些情况下作为镇痛剂减轻疼痛。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。它是一种COX 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM 和0.84 μM。 | |||
T1555 |
Diclofenac sodium
GP 45840,双氯芬酸钠 |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Diclofenac sodium (GP 45840) 是一种非选择性抗炎剂,是 COX 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。 | |||
T0196 |
Diclofenac
双氯芬酸,奥尔芬,Diclofenacum,Voltaren |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Diclofenac (Diclofenacum) 是一种具有抗炎活性的非甾体苯乙酸衍生物,是 COX 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。 | |||
T1566 |
Aripiprazole
阿立哌唑,OPC-14597 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Aripiprazole (OPC-14597) 是血清素受体 5-HT1A 和多巴胺 D2 受体的部分激动剂,还用作突触后拮抗剂和血清素受体 5-HT2A 的拮抗剂。 | |||
T6905 |
Netupitant
Ro 67-31898/000,奈妥吡坦,CID 6451149 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Netupitant (CID 6451149) 是一种高效选择性、可口服的神经激肽 1 受体 (NK1) 拮抗剂,具有止吐作用,在 CHO 细胞中对 hNK1的 Ki 值为 0.95 nM。 | |||
T6140 |
SB-334867 free base
SB334867A free base,SB-334867,SB 334867,SB334867 |
OX Receptor | GPCR/G Protein; Neuroscience |
SB-334867 free base (SB334867A free base) 是一种选择性 orexin-1(OX1) 受体拮抗剂,对 OX2有选择性,pKb 为7.4,对 5-HT2B、5-HT2C 的选择性是 100 倍,pKi 值分别为 5.4 和 5.3。它减少乙醇消耗,还抑制吗啡诱导的体内运动活动敏感性的获得。 | |||
T23386 |
SR 142948
|
Neurotensin Receptor | GPCR/G Protein |
SR 142948 是一种神经降压素 (NT) 受体拮抗剂。 | |||
T2287 |
PIK-75 hydrochloride
PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75 |
Apoptosis; DNA-PK; PI3K | Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
PIK-75 hydrochloride (PIK-75 HCl) 是一种可逆的 DNA-PK 和 p110α-选择性抑制剂,抑制 DNA-PK,p110α和 p110γ,可诱导凋亡。 | |||
TP2500 |
Cholecystokinin (26-33) free acid
CCK (26-33) free acid |
cholecystokinin | GPCR/G Protein |
Cholecystokinin (26-33) free acid 是胆囊收缩素 (CCK) 的一部分, 是脊椎动物中枢神经系统中存在的 CCKB 型受体的高选择性配体,可诱导大鼠轻度味觉厌恶条件反射。 | |||
T35941 |
DC-Chol hydrochloride
Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate |
Beta Amyloid | Neuroscience |
DC-Chol hydrochloride(DC-Cholesterol hydrochloride) 在适当的实验条件下能抑制 Aβ40 纤维的形成且以剂量依赖性的方式显著抑制氧化hCT的淀粉样蛋白形成。DC-Chol hydrochloride可诱导改善和平衡的免疫力,能够促进乙型肝炎疫苗的研究。 | |||
T2227 |
Hemicholinium 3
半胆碱基-3,Hemicholinium-3,Hemicholine |
Others; AChE | Neuroscience; Others |
Hemicholinium 3 是一种竞争性的、高亲和力的胆碱转运蛋白 (HACU) 抑制剂,Ki=25 nM。它是一种神经肌肉阻滞剂,能够抑制乙酰胆碱 (ACh)的合成和释放。它抑制Epibatidine 诱发的收缩和 [3H] 乙酰胆碱释放,IC50分别为 897 nM 和 693 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5214 |
Cholesteryl linoleate
CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester,胆甾烯基亚油酸酯 |
Others; Endogenous Metabolite | Metabolism; Others |
Cholesteryl linoleate 是低密度脂蛋白和动脉粥样硬化病变中主要的胆固醇酯。它存在于 LDL 中的胆固醇酯,利用 LDL 受体相关蛋白转移到表达 15-脂氧合酶的巨噬细胞和 CHO 细胞的质膜,被氧化形成胆固醇亚油酸氢过氧化物。 | |||
T2968 |
Hyodeoxycholic acid
NSC 60672,猪去氧胆酸,α-Hyodeoxycholic Acid,HDCA |
FXR; Endogenous Metabolite; GPCR19 | GPCR/G Protein; Metabolism |
Hyodeoxycholic acid (NSC 60672) 是由肠道菌群在小肠中形成的次级胆汁酸,是TGR5(GPCR19)的激动剂, CHO 细胞中的EC50=31.6 µM。它已用于研究高胆固醇血症的治疗。 | |||
T7628 |
3b-Hydroxy-5-cholenoic acid
|
Endogenous Metabolite | Metabolism |
3b-Hydroxy-5-cholenoic acid 是内源性的单羟基胆酸的一种,大量崔乃在于患有肝胆管状发育不全的儿童体内。 | |||
TN2215 |
Taurochenodeoxycholic acid sodium
牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡,具有抗炎和免疫调节作用。 | |||
T3742 |
3-Methylcatechol
3-甲基苯邻二酚,3-Methylpyrocatechol,2,3-Toluenediol,3-甲基邻苯二酚,2,3-dihydroxytoluene |
Others | Others |
3-Methylcatechol (2,3-Toluenediol) 是由 Pseudomonas putidaMC2 产生,能够用作化学合成中的分子砌块。 | |||
T19124 |
3-Oxocholic acid
3-Ketocholic acid |
Endogenous Metabolite | Metabolism |
3-Oxocholic acid(3-Ketocholic acid) 是胆汁酸的代谢产物,也是产气荚膜梭菌在肠道中由胆汁降解的主要产物。33-Oxocholic acid 是一种主要存在于哺乳动物的胆汁中类固醇酸。 | |||
TN2349 |
Taurodeoxycholate sodium salt
Sodium taurodeoxylate,牛磺脱氧胆酸钠 |
Endogenous Metabolite | Metabolism |
Taurodeoxycholate sodium salt (Sodium taurodeoxylate) 是胆盐相关的阴离子洗涤剂,用于分离膜蛋白,包括线粒体内膜蛋白。它还可以抑制各种炎症反应。 | |||
T40646 |
Lipoteichoic acid
|
Complement System | Immunology/Inflammation |
Lipoteichoic acid 是 Staphylococcus aureus 细胞壁的聚合物,通过诱导 C3 和抑制 CD55 来激活补体系统,通过 IGF-1 途径减少脂肪沉积。 | |||
T6805 |
Choline bitartrate
2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium,酒石酸氢胆碱 |
Others; AChR | Neuroscience; Others |
Choline bitartrate (2-hydroxyethyl(trimethyl)azanium) 是一种存在于食物中的营养胆碱,可影响肝脏疾病、动脉粥样硬化和神经系统疾病等疾病。它是神经递质乙酰胆碱的前体,作为甲基供体参与各种代谢过程和脂质代谢。 | |||
T6751 |
Acetylcholine iodide
Acetylcolina |
Others | Others |
Acetylcholine iodide (Acetylcolina) 是一种在中枢和外周神经系统中常见的神经递质。 | |||
TN3651 |
Cichoriin
|
Others | Others |
Cichoriin 对SARS-CoV-2有明显活性,是治疗重症COVID-19的潜在候选物质。 | |||
T4717 |
25-Hydroxycholesterol
25-羟基胆固醇,25-羟基胆甾醇 |
Others; Endogenous Metabolite; HMG-CoA Reductase | Metabolism; Others |
25-Hydroxycholesterol 是胆固醇的代谢产物,由巨噬细胞响应 Toll 样受体激活而分泌。它有效抑制 B 细胞产生 IgA,EC50约为 65 nM。 | |||
T5240 |
Cholestenone
胆甾烯酮,4-胆甾烯-3-酮,(+)-4-Cholesten-3-one |
Others; Endogenous Metabolite | Metabolism; Others |
Cholestenone 是胆固醇的中间氧化产物,主要在肝脏中代谢。它能够会导致细胞长期功能缺陷。它在膜中具有很高的流动性,会影响胆固醇的翻转和外排。 | |||
T2962 |
5α-Cholestan-3β-ol
Dihydrocholesterol,Zymostanol,5α-Cholestanol,5alpha-Cholestanol,NSC 18188,Beta-Cholestanol,二氢胆甾醇 |
Others; Endogenous Metabolite | Metabolism; Others |
Dihydrocholesterol 是衍生化的类固醇化合物的一种,抑制胆固醇吸收。 | |||
TJA2398 |
Taurodeoxycholic acid sodium hydrate
Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt,牛磺猪去氧胆酸 |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate) 通过阻断钙介导的凋亡通路和 Caspase-12的活化来阻止细胞凋亡。它可用于原发性胆汁性肝硬化、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤积和肌萎缩侧索硬化症。 | |||
T2S0142 |
4-Hydroxylonchocarpin
异补骨脂色烯查耳酮,Isobavachromene |
Others | Others |
Isobavachromene is a natural product from Psoralea corylifolia | |||
T5077 |
Deoxycholic acid sodium salt
脱氧胆酸钠,Sodium deoxycholate,Sodium Desoxycholate |
Endogenous Metabolite; GPCR19 | GPCR/G Protein; Metabolism |
Deoxycholic acid sodium salt (Sodium deoxycholate) 是 G 蛋白偶联胆汁酸受体TGR5的激活剂。 | |||
T9510 |
1,2-Distearoyl-sn-glycero-3-phosphorylcholine
DSPC,L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL,1,2-Distearoyl-sn-glycero-3-PC,二硬脂酰磷脂酰胆碱 |
Others | Others |
1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) 是一种脂质纳米颗粒(LNP) 系统中的脂质成分,可用于合成脂质体。 | |||
T4136 |
Lapachol
Bethabarra wood,CI75490,黄钟花醌,Greenhartin,Tecomin |
Others; Influenza Virus; Antibacterial; Parasite; Antifungal | Microbiology/Virology; Others |
Lapachol (CI75490) 是从Tabebuia avellanedae 中分离得到的一种萘醌。它具有具有抗菌、抗炎、镇痛、抗肿瘤和抗生素特性。 | |||
T4727 |
Taurolithocholic acid sodium salt
牛磺石胆酸钠,Sodium taurolithocholate |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Taurolithocholic acid sodium salt (Sodium taurolithocholate) 是抑胆剂和 Ca2+激动剂,可抑制放射性配体与毒蕈碱 M1 结合。 | |||
T75319 |
Taurodeoxycholic acid
Taurodeoxychloic acid |
Apoptosis; Calcium Channel; Caspase | Apoptosis; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome |
Taurodeoxycholic acid (Taurodeoxychloic acid) 是脱氧胆酸的胆汁酸牛磺酸共轭物,是一种人体代谢物,可稳定线粒体膜,减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid具有神经保护活性,可用于研究 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 。 | |||
T1317 |
Cinchonidine
奎宁树,α-Quinidine,辛可尼丁,L-Cinchonidine |
5-HT Receptor; Serotonin Transporter; Parasite | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Cinchonidine (L-Cinchonidine) 是在金鸡纳和角蒿中发现的一种生物碱,有抗疟活性。 它是用于有机化学中不对称合成的砌块,是血清素转运蛋白的弱抑制剂。 | |||
TQ0274 |
27-Hydroxycholesterol
27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol |
Estrogen/progestogen Receptor; Liver X Receptor | Endocrinology/Hormones; Metabolism |
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) 是一种有效的、选择性的雌激素受体调节剂和肝X 受体激动剂。 | |||
T6S0659 |
Rhynchophylline
钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin |
Calcium Channel; NF-κB | Membrane transporter/Ion channel; Metabolism; NF-κB |
Rhynchophylline (Mitrinermine) 是一种生物碱类化合物,从钩藤中分离得到,具有很高的生物活性,被广泛用于抗炎、神经保护等方面的研究。 | |||
T4713 |
Phosphorylcholine chloride calcium salt tetrahydrate
Phosphocholine chloride calcium salt tet,胆碱磷酸氯化钙四水,CalciuM Phosphorylcholine Tetrahydrate |
Others; Endogenous Metabolite | Metabolism; Others |
Phosphorylcholine chloride calcium salt tetrahydrate (Phosphocholine chloride calcium salt tet) 是内源性代谢产物的一种。 | |||
T5072 |
Glycocholic acid hydrate
|
Others; Endogenous Metabolite | Metabolism; Others |
Glycocholic acid hydrate 是内源性代谢产物的一种。 | |||
T8712 |
1-Palmitoyl-sn-glycero-3-phosphocholine
1-十六酰-SN-丙三醇-磷酸胆碱,1-Hexadecanoyl-sn-glycero-3-phosphocholine |
Others | Others |
1-Palmitoyl-sn-glycero-3-phosphocholine (1-Hexadecanoyl-sn-glycero-3-phosphocholine) 是一种用于荧光探针设计的磷酸胆碱。 | |||
T10085 |
20(S)-Hydroxycholesterol
20α-Hydroxycholesterol |
Smo | Stem Cells |
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂。 | |||
T19189 |
Allocholic acid
|
Others | Others |
Allocholic acid 是一种胆汁酸,在脊椎动物中发现,在肝脏再生和致癌过程中会重新出现,也是成熟嗅觉系统的特定性刺激物。 | |||
T8714 |
1-Stearoyl-sn-glycero-3-phosphocholine
1-硬脂酰-SN-甘油-3-磷酰胆碱,1-stearoyl-lysophosphatidylcholine,L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROY |
Others | Others |
1-Stearoyl-sn-glycero-3-phosphocholine (L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROY) 是一种用于脂质代谢研究的化学物质。 | |||
T2965 |
Deoxycholic acid
Cholorebic,去氧胆酸,脱氧胆酸,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic |
Endogenous Metabolite; GPCR19 | GPCR/G Protein; Metabolism |
Deoxycholic acid (Cholanoic Acid) 是 G 蛋白偶联胆汁酸受体 TGR5的激活剂。 | |||
TN7235 |
4-methoxylonchocarpin
|
TNF; NF-κB | Apoptosis; NF-κB |
4-methoxylonchocarpin 是从Abrus precatorius 的根中分离出来的以一种有效的抗炎化合物。4-methoxylonchocarpin 通过抑制LPS 与巨噬细胞的TLR4结合来抑制NF-κB 激活TNF 表达,抑制TNBS 引起的小鼠结肠炎。 | |||
T13505 |
3α,12β-Dihydroxycholanoic acid
Lagodeoxycholic acid |
Endogenous Metabolite | Metabolism |
3α,12β-Dihydroxycholanoic acid (Lagodeoxycholic acid) 是一种广泛存在于动物体内的胆汁酸。 | |||
T0760 |
Cholesterol
Cholesterin,Cholesteryl alcohol,胆固醇 |
Estrogen Receptor/ERR; MRP; Endogenous Metabolite; ROR | Endocrinology/Hormones; Immunology/Inflammation; Metabolism |
Cholesterol (Cholesteryl alcohol) 属于天然产物,是哺乳动物中的主要固醇,是一种雌激素相关受体 α (ERRα) 的激动剂。Cholesterol 广泛存在于动物的细胞膜,也是合成几种重要荷尔蒙及胆酸的材料。 | |||
T5352 |
GLYCODEOXYCHOLIC ACID
|
Others; Endogenous Metabolite | Metabolism; Others |
Glycodeoxycholic Acid 是内源性代谢产物的一种,是一种存在于黑链霉菌、布氏锥虫和隐单胞菌中的天然产物,可诱导阻塞性胆汁淤积症患者的肝细胞坏死和自噬。 | |||
T2744 |
Methyl Cholate
胆酸甲酯,Cholic acid methyl ester |
Others | Others |
Methyl Cholate 是胆酸的甲酯形式。其中胆酸是一种由肝脏产生的主要胆汁酸,由胆固醇合成。Methyl Cholate 具有抗炎抗肿瘤活性。 | |||
T31964 |
Glycolithocholic acid
Lithocholic acid glycine conjugate,甘氨石胆酸,Lithocholylglycine |
Endogenous Metabolite | Metabolism |
Glycolithocholic acid (Lithocholic acid glycine conjugate) 属于内源性代谢产物,是甘氨酸结合的次级胆汁酸。它可用于诊断非酒精性脂肪性肝炎,溃疡性结肠炎和原发性硬化性胆管炎。 | |||
T2963 |
Cholic Acid
Cholanic acid,胆汁酸,Cholate,Colalin |
Endogenous Metabolite | Metabolism |
Cholic Acid (Cholate) 是肝脏产生的主要胆汁酸,与牛磺酸或甘氨酸缀合,有助于脂肪吸收和胆固醇排泄。 | |||
TN7024 |
Hyocholic acid
|
Others | Others |
Hyocholic acid 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN7024,CAS号为 547-75-1。 | |||
T8092 |
Taurohyodeoxycholic acid sodium salt
Sodium taurohyodeoxycholate hydrate |
Caspase | Apoptosis; Proteases/Proteasome |
Taurohyodeoxycholic acid sodium salt (Sodium taurohyodeoxycholate hydrate) 通过阻断钙介导的细胞凋亡途径以及 Caspase-12 活化来防止细胞凋亡 | |||
T74293 |
Allolithocholic acid
|
Others | Others |
Allolithocholic acid 是一种类固醇酸,在正常血清和粪便中可发现。该化合物促进脂肪与甾醇在肠道及肝脏的排泄、吸收与运输。 | |||
TN5173 |
Trichorabdal A
|
Antifection | Microbiology/Virology |
Trichorabdal A 是一种二萜化合物,分离自 Rabdosia trichocarpa,抗肿瘤作用强大。 | |||
T8040 |
Cholesterol myristate
胆甾烯基豆蔻酸酯,Cholesteryl myristate,胆固醇肉豆蔻酸,Cholesteryl tetradecanoate |
Others; Potassium Channel; GABA Receptor; Endogenous Metabolite; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience; Others |
Cholesterol myristate (Cholesteryl myristate) 是粗吻海龙中的一种类固醇,可与多种离子通道结合,例如nAChR、GABAA 受体和内向整流钾离子通道。 | |||
T22293 |
Chondroitine sulfate
Chondroitine sulfate (From cattle) |
Others | Others |
Chondroitine sulfate 是软骨的重要结构成分,已被用作治疗关节不适的膳食补充剂。 | |||
T1039 |
Choline chloride
Biocolina,Biocoline,Hepacholine,氯化胆碱 |
AChR | Neuroscience |
Choline chloride (Biocoline) 是一种必需营养素,可激活 α7 烟碱受体,具有抗炎、镇痛的活性。对动脉粥样硬化、神经系统疾病和肝脏疾病等具有影响。 | |||
T19161 |
7α-Hydroxycholesterol
|
Others | Others |
7α-Hydroxycholesterol 是一种由酶促氧化和非酶促氧化形成的胆固醇氧化物,可用作脂质过氧化的生物标志物。 | |||
T2202 |
Lithocholic acid
3α-Hydroxy-5β-cholanic acid,石胆酸 |
Apoptosis; Others; FXR; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism; Others |
Lithocholic acid (3α-Hydroxy-5β-cholanic acid) 是由鹅去氧胆酸盐通过细菌作用形成的胆汁酸,通常与甘氨酸或牛磺酸结合,被用作利胆剂。 它作为清洁剂溶解脂肪以供吸收,并且本身被吸收。 | |||
T5234 |
Glycoursodeoxycholic acid
Ursodeoxycholylglycine,甘氨熊胆酸,GUDCA |
Others; Endogenous Metabolite | Metabolism; Others |
Glycoursodeoxycholic acid (Ursodeoxycholylglycine) 是一种酰基甘氨酸和胆汁酸-甘氨酸缀合物,是熊去氧胆酸的代谢物。 | |||
T4779 |
4-Methylcatechol
p-Methylcatechol,3,4-二羟基甲苯,Homocatechol,4-methylbenzene-1,2-diol,3,4-Dihydroxytoluene |
Others; Endogenous Metabolite | Metabolism; Others |
4-Methylcatechol (3,4-Dihydroxytoluene) 是 p-toluate 的代谢物,它是 Catechol 2,3-Dioxygenase 的自杀性底物抑制剂。 | |||
T1221 |
Acetylcholine chloride
ACh chloride,Pilofrin,氯化乙酰胆碱 |
Calcium Channel; Endogenous Metabolite; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Acetylcholine chloride (Pilofrin) 是一种神经递质,是胆碱能激动剂,通过刺激烟碱乙酰胆碱受体调节多巴胺能神经元活性,在体外抑制 p53 突变肽的聚集。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01693 |
Butyrylcholinesterase Protein, Human, Recombinant (His)
CHE1,E1,butyrylcholinesterase,CHE2 |
Human | HEK293 Cells |
Butyrylcholinesterase Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.5 kDa and the accession number is P06276. | |||
TMPY-03006 |
CHODL Protein, Rat, Recombinant (hFc)
chondrolectin |
Rat | HEK293 Cells |
CHODL Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is D3ZI86. | |||
TMPY-04905 |
Zika virus (ZIKV) (strain Zika SPH2016) ZIKV-E (Stem/anchor domain of flavivirus envelope glycoprotein E) protein (Fc)
|
ZIKV | HEK293 Cells |
Zika virus (ZIKV) (strain Zika SPH2016) ZIKV-E (Stem/anchor domain of flavivirus envelope glycoprotein E) protein (Fc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 36.7 kDa and the accession number is ALU33341.1. | |||
TMPY-02941 |
CHODL Protein, Rat, Recombinant (His)
chondrolectin |
Rat | HEK293 Cells |
CHODL Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is D3ZI86. | |||
TMPY-02408 |
CHODL Protein, Mouse, Recombinant (His)
3110074E07Rik,MT75,PRED12,chondrolectin |
Mouse | HEK293 Cells |
CHODL Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.4 kDa and the accession number is EDK98299.1. | |||
TMPK-01188 |
CHODL Protein, Human, Recombinant (hFc)
PRED12,C21orf68,CHODL,MT75,Chondrolectin,3... |
Human | HEK293 Cells |
chondrolectin (CHODL) is commonly overexpressed in the majority of lung cancers, indicating a possible correlation between CHODL and metastasis of lung cancer cells. the expression of CHODL is significantly decreased in HCC clinical samples and in HCC cell lines. Overexpression of CHODL in SMMC7721 cells with a lentiviral vector increased SMMC7721 cell migration and invasion. | |||
TMPH-03234 |
Acetylcholinesterase Protein, Rat, Recombinant (His)
AChE,EC:3.1.1.7 |
Rat | E. coli |
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Acetylcholinesterase Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 68.9 kDa and the accession number is P37136. | |||
TMPH-03702 |
MTA/SAH nucleosidase Protein, Vibrio cholerae serotype O1, Recombinant (His & Myc)
5'-deoxyadenosine nucleosidase,5'-methylthioadenosine nucleo... |
Vibrio cholerae | E. coli |
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. MTA/SAH nucleosidase Protein, Vibrio cholerae serotype O1, Recombinant (His & Myc) is expressed in E. coli expression system wit... | |||
TMPH-03703 |
Zot Protein, Vibrio cholerae serotype O1, Recombinant (His)
Zona occludens toxin,Zonular occludens toxin,zot |
Vibrio cholerae | E. coli |
Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens). Zot Protein, Vibrio cholerae serotype O1, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 48.4 kDa and the accession number is P38442. | |||
TMPH-00390 |
MOMP Protein, Chlamydia trachomatis, Recombinant (His & Myc)
ompA,Major outer membrane porin, serovar B |
Chlamydia trachomatis | E. coli |
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan.; Permits diffusion of specific solutes through the outer membrane. M... | |||
TMPH-02413 |
Lymphocytic choriomeningitis virus (LCMV) (strain Armstrong) GPC Protein (His & SUMO)
GPC,Pre-glycoprotein polyprotein GP complex |
LCMV | E. coli |
Lymphocytic choriomeningitis virus (LCMV) (strain Armstrong) GPC Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 42.4 kDa and the accession number is P09991. | |||
TMPH-03644 |
Hydrophobin-2/HFB2 Protein, Trichoderma reesei, Recombinant (His & SUMOstar)
Hydrophobin-2,hfb2,Hydrophobin II |
Hypocrea jecorina | P. pastoris (Yeast) |
Responsible for spore hydrophobicity and protection. Hydrophobin-2/HFB2 Protein, Trichoderma reesei, Recombinant (His & SUMOstar) is expressed in yeast with N-6xHis-SUMOSTAR tag. The predicted molecular weight is 23.2 kDa and the accession number is P79073. | |||
TMPY-00647 |
Chorionic Gonadotropin/CGA Protein, Human, Recombinant (His)
CG-α,FSH alpha,glycoprotein hormones, alpha polypeptide,FSHA... |
Human | HEK293 Cells |
Chorionic Gonadotropin/CGA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11.6 kDa and the accession number is P01215. | |||
TMPY-02923 |
Chorionic Gonadotropin/CGA Protein, Human, Recombinant (mFc)
HCG,GPHa,CG-ALPHA,glycoprotein hormones, alpha polypeptide,g... |
Human | HEK293 Cells |
Chorionic Gonadotropin/CGA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 36.6 kDa and the accession number is P01215. | |||
TMPY-01742 |
Acetylcholinesterase Protein, Mouse, Recombinant (His)
Acre,Chrne,acetylcholinesterase (Yt blood group) |
Mouse | HEK293 Cells |
Acetylcholinesterase, also known as ACHE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). ACHE appears to be a potential therapeutic target at muscle injuries including organophosphate myopathy. It is an externally oriented membrane-bound enzyme and ... | |||
TMPH-03182 |
DTE Protein, Pseudomonas cichorii, Recombinant (His & Myc)
Ketose 3-epimerase,D-ribulose 3-epimerase,DTE,D-tagatose 3-e... |
Pseudomonas cichorii | E. coli |
Catalyzes the epimerization of various ketoses at the C(3) position. It is able to interconvert D-tagatose and D-ribulose to D-sorbose and D-xylulose, respectively. The enzyme is also able to accept other ketopentoses such as D-psicose with lower efficiency. DTE Protein, Pseudomonas cichorii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 40.1 kDa and the accession number is O50580. | |||
TMPH-00220 |
Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His)
Hepato-ferredoxin,FDX1,Ferredoxin-1,Adrenodoxin, mitocho... |
Bovine | E. coli |
Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Adrenodoxin, mitochondrial Protein, Bov... | |||
TMPY-04586 |
Chorionic Gonadotropin/CGA Protein, Human, Recombinant
FSH alpha,glycoprotein hormones, alpha polypeptide,LHA,CG-AL... |
Human | HEK293 Cells |
Chorionic Gonadotropin/CGA Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 10.2 kDa and the accession number is P01215. | |||
TMPJ-00744 |
Toxin B Protein, Vibriocholerae, Recombinant
Cholera enterotoxin γ chain,Choleragenoid,... |
Vibrio cholerae | E. coli |
Cholera toxin is protein complex secreted by the bacterium Vibrio cholerae. It is responsible for the massive, watery diarrhea characteristic of cholera infection. Cholera enterotoxin subunit B (CTXB) pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. | |||
TMPH-03614 |
DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO)
DNA photolyase,Deoxyribodipyrimidine photo-lyase,phr,phrA,Ph... |
Synechococcus | E. coli |
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 74.3 kDa and the accession number is P05... | |||
TMPH-00026 |
Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His)
Equinatoxin-2,EqTII,DELTA-AITX-Aeq1a,Equinatoxin II,DELTA-ac... |
Actinia equina | E. coli |
Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.9 kDa and the accession number is P61914. | |||
TMPH-00017 |
acpS Protein, Acholeplasma laidlawii, Recombinant (His & Myc)
Holo-ACP synthase,Holo-[acyl-carrier-protein] synthase,acpS,... |
Acholeplasma laidlawii | E. coli |
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. acpS Protein, Acholeplasma laidlawii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.9 kDa and the accession number is A9NHV3. | |||
TMPH-00389 |
OmcB Protein, Chlamydia trachomatis, Recombinant (His & SUMO)
Large cysteine-rich periplasmic protein OmcB,Cysteine-rich o... |
Chlamydia trachomatis | E. coli |
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan. OmcB Protein, Chlamydia trachomatis, Recombinant (His & SUMO) is expressed in E... | |||
TMPH-00392 |
Small-CRP Protein, Chlamydia trachomatis, Recombinant (His & SUMO)
omcA,Small cysteine-rich outer membrane protein OmcA,9 kDa c... |
Chlamydia trachomatis | E. coli |
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the large cysteine-rich periplasmic protein and the major outer membrane porin. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan. Small-CRP Protein, Chlamydia trachomatis, Recombinant (His & SUMO) is... | |||
TMPH-02244 |
Trichohyalin Protein, Human, Recombinant (His & Myc)
TCHH,Trichohyalin |
Human | E. coli |
Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing dur... | |||
TMPH-03615 |
Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO)
rnj,Ribonuclease J |
Synechocystis | E. coli |
An RNase that has 5'-3' exonuclease and possibly endoonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 86.4 kDa and the accession number is P54123. | |||
TMPH-03605 |
CHOD Protein, Streptomyces sp., Recombinant (GST)
choA,Cholesterol isomerase,CHOD,<... |
Streptomyces | E. coli |
Bifunctional enzyme that catalyzes the oxidation of the 3-beta-hydroxy group of cholesterol and the isomerization of the double bond of the resulting product. CHOD Protein, Streptomyces sp., Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 81.9 kDa and the accession number is P12676. | |||
TMPH-03645 |
Alpha-TCS Protein, Trichosanthes kirilowii, Recombinant (His)
rRNA N-glycosidase,EC:3.2.2.22,Ribosome-inactivating protein... |
Trichosanthes kirilowii | E. coli |
Inactivates eukaryotic 60S ribosomal subunits. Alpha-TCS Protein, Trichosanthes kirilowii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P09989. | |||
TMPH-03057 |
Chorismate synthase Protein, Neurospora crassa, Recombinant (His)
B7F21.10,NCU05420,aro-2,5-enolpyruvylshikimate-3-phosphate p... |
Neurospora crassa | E. coli |
Bifunctional enzyme that possesses chorismate synthase and intrinsic flavin reductase activity, it uses NADPH to reduce FMN. | |||
TMPH-02412 |
Lymphocytic choriomeningitis virus (LCMV) (strain WE) GPC Protein (His & Myc)
Pre-glycoprotein polyprotein GP complex,GPC |
LCMV | E. coli |
Lymphocytic choriomeningitis virus (LCMV) (strain WE) GPC Protein (His & Myc) is expressed in E. coli expression system with N-6xHis and C-Myc tag. The predicted molecular weight is 30.9 kDa and the accession number is P07399. | |||
TMPH-00393 |
pGP3-D Protein, Chlamydia trachomatis, Recombinant (His)
Proteins P-6/P-7,Virulence plasmid protein pGP3-D |
Chlamydia trachomatis | P. pastoris (Yeast) |
pGP3-D Protein, Chlamydia trachomatis, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 30.3 kDa and the accession number is P0CE18. | |||
TMPH-03613 |
NblA Protein, Synechococcus elongatus, Recombinant (His & Myc)
nblA,Phycobilisome degradation protein NblA |
Synechococcus elongatus | E. coli |
Involved in phycobilisome (PBS) degradation during nutrient deprivation. May mark the PBS for degradation by covalent association with PBS components or may disrupt the PBS via ionic interactions. NblA Protein, Synechococcus elongatus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.5 kDa and the accession number is P35087. | |||
TMPY-02309 |
CHODL Protein, Mouse, Recombinant (hFc)
3110074E07Rik,chondrolectin,MT75,PRED12 |
Mouse | HEK293 Cells |
CHODL Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is EDK98299.1. | |||
TMPY-01596 |
Butyrylcholinesterase Protein, Mouse, Recombinant (His)
C730038G20Rik,butyrylcholinesterase |
Mouse | HEK293 Cells |
Butyrylcholinesterase Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.7 kDa and the accession number is Q03311. | |||
TMPH-00388 |
Chaperonin GroEL Protein, Chlamydia trachomatis, Recombinant (His & SUMO)
Cpn60,mopA,60 kDa chaperonin,Chaperonin-60,Chaperonin GroEL,... |
Chlamydia trachomatis | E. coli |
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. Chaperonin GroEL Protein, Chlamydia trachomatis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.0 kDa and the accession number is P0C0... | |||
TMPH-03068 |
OV16 Protein, Onchocerca volvulus, Recombinant (His)
OV16,OV-16 antigen |
Onchocerca volvulus | E. coli |
OV16 Protein, Onchocerca volvulus, Recombinant (His) is expressed in E. coli. | |||
TMPH-00391 |
MOMP Protein, Chlamydia trachomatis serovar L2, Recombinant (His & SUMO)
ompA,Major outer membrane porin |
Chlamydia trachomatis serovar L2 | E. coli |
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan.; Permits diffusion of specific solutes through the outer membrane. M... | |||
TMPH-00265 |
Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO)
Ferrochelatase, mitochondrial,Protoheme ferro-lyase... |
Bovine | E. coli |
Catalyzes the ferrous insertion into protoporphyrin IX. Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Mycd tag. The predicted molecular weight is 58.1 kDa and the accession number is P22600. | |||
TMPH-00394 |
pGP3-D Protein, Chlamydia trachomatis, Recombinant (E. coli, His)
Proteins P-6/P-7,Virulence plasmid protein pGP3-D |
Chlamydia trachomatis | E. coli |
pGP3-D Protein, Chlamydia trachomatis, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.9 kDa and the accession number is P0CE18. | |||
TMPH-00757 |
Reticuline oxidase Protein, Eschscholzia californica, Recombinant (His)
BBE1,Tetrahydroprotoberberine synthase,Berberine bridge-form... |
Eschscholzia californica | E. coli |
Essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine. | |||
TMPY-01010 |
NGF Protein, Human, Recombinant
Beta-NGF,神经生长因子,β-NGF,NGFB,nerve growth factor (β polypeptid... |
Human | CHO Cells |
NGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 13.2 kDa and the accession number is P01138. | |||
TMPY-03565 |
Mannan Binding Lectin/MBL2 Protein, Human, Recombinant
MBPD,MBP-C,mannose-binding lectin (protein C) 2, soluble,COL... |
Human | CHO Cells |
Mannan Binding Lectin/MBL2 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 24 kDa and the accession number is P11226. | |||
TMPY-03145 |
IFN-beta Protein, Human, Recombinant
IFN-β,interferon, β1, fibroblast,IFNB,IFB,IFF,Interferon β,I... |
Human | CHO Cells |
IFN-beta Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 20 kDa and the accession number is P01574. | |||
TMPY-00467 |
NKG2D/CD314 Protein, Human, Recombinant (hFc)
D12S2489E,killer cell lectin-like receptor subfamily K, memb... |
Human | CHO Cells |
NKG2D/CD314 Protein, Human, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 46.5 kDa and the accession number is A0A024RAP8. | |||
TMPY-02638 |
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
transforming growth factor, beta 1,转化生长因子,transforming growt... |
Human,Rhesus,Cynomolgus,Canine | CHO Cells |
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.8 kDa and the accession number is A0A499FJK2. | |||
TMPY-01714 |
IFN gamma Protein, Human, Recombinant
IFI,interferon, γ,IFN γ,IFG,IFN gamma,interferon, gamma,干扰素,... |
Human | CHO Cells |
IFN gamma Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 16.7 kDa and the accession number is A0A7R8GUN6. | |||
TMPY-03142 |
IL-27 Protein, Human, Recombinant (His)
IL27p28,IL-27,白介素,IL27A,interleukin 27,p28,白细胞介素,IL-27A,IL30 |
Human | CHO Cells |
IL-27 Protein, Human, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is NP_005746.2&NP_663634.2. | |||
TMPY-01993 |
IL-13 Protein, Human, Recombinant
IL-13,P600,interleukin 13,ALRH,白介素,白细胞介素 |
Human | CHO Cells |
IL-13 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.5 kDa and the accession number is AAK53823.1. | |||
TMPY-02327 |
HGF Protein, Human, Recombinant
SF,hepatocyte growth factor (hepapoietin A,HGFB,F-TCF,F-TCFB... |
Human | CHO Cells |
HGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 79.7 kDa and the accession number is P14210-1. | |||
TMPY-03626 |
R-Spondin 1/RSPO1 Protein, Human, Recombinant
RSPO,R-spondin 1,CRISTIN3 |
Human | CHO Cells |
R-Spondin 1/RSPO1 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q2MKA7-1. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIH-0552 |
Tauroursodeoxycholic Acid-d4 Sodium Salt
|
||
Tauroursodeoxycholic Acid-d4 Sodium Salt 是 Tauroursodeoxycholic Acid Sodium Salt 的氘代化合物。Tauroursodeoxycholic Acid Sodium Salt 的 CAS 号为 14605-22-2。Tauroursodeoxycholate,又称 ursodoxicoltaurine,是一种高度亲水性的三级胆汁酸,在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式,而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病,如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。 | |||
TMIH-0145 |
Chenodeoxycholic Acid-d4
|
||
Chenodeoxycholic Acid-d4 是 Chenodeoxycholic Acid 的氘代化合物。 | |||
TMIH-0148 |
Cholic acid-d4
|
||
Cholic acid-d4 是 Cholic acid 的氘代化合物。 | |||
TMIJ-0197 |
Tauroursodeoxycholic-2,2,3,4,4-d5 Acid
|
||
Tauroursodeoxycholic-2,2,3,4,4-d5 Acid 是 Tauroursodeoxycholic Acid 的氘代化合物。Tauroursodeoxycholic Acid 的 CAS 号为 14605-22-2。Tauroursodeoxycholate,又称 ursodoxicoltaurine,是一种高度亲水性的三级胆汁酸,在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式,而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病,如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。 | |||
TMID-0058 |
Glycocholic acid-d4
|
||
Glycocholic acid-d4 是 Glycocholic acid 的氘代化合物。Glycocholic acid 的 CAS 号为 475-31-0。Glycocholic acid 是一种胆汁酸,具有抗肿瘤活性,能够靶向作用于耐药泵和非耐药泵通路。 | |||
TMIJ-0332 |
Taurolithocholic Acid-d5 Sodium Salt (Major)
|
||
Taurolithocholic Acid-d5 Sodium Salt (Major) 是 Taurolithocholic Acid Sodium Salt 的氘代化合物。Taurolithocholic Acid Sodium Salt 的 CAS 号为 6042-32-6。Taurolithocholic acid sodium salt 是抑胆剂和Ca2+激动剂,可抑制放射性配体与毒蕈碱 M1 结合。 | |||
TMIH-0182 |
Deoxycholic-2,2,4,4-d4 Acid
|
||
Deoxycholic-2,2,4,4-d4 Acid 是 Deoxycholic-2,2,4,4 Acid 的氘代化合物。 | |||
TMIJ-0198 |
Taurochenodeoxycholic Acid-d5 Sodium Salt
|
||
Taurochenodeoxycholic Acid-d5 Sodium Salt 是 Taurochenodeoxycholic Acid Sodium Salt 的氘代化合物。Taurochenodeoxycholic Acid Sodium Salt 的 CAS 号为 6009-98-9。Taurochenodeoxycholic acid sodium 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡,具有抗炎和免疫调节作用。 | |||
TMIJ-0199 |
Tauroursodeoxycholic-d4 Acid
Tauroursodiol-d4 |
||
Tauroursodeoxycholic-d4 Acid 是 Tauroursodeoxycholic Acid 的氘代化合物。Tauroursodeoxycholic Acid 的 CAS 号为 14605-22-2。Tauroursodeoxycholate,又称 ursodoxicoltaurine,是一种高度亲水性的三级胆汁酸,在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式,而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病,如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。 | |||
TMID-0294 |
Taurodeoxycholic Acid-d4 Sodium Salt
|
||
Taurodeoxycholic Acid-d4 Sodium Salt 是 Taurodeoxycholic Acid Sodium Salt 的氘代化合物。Taurodeoxycholic Acid Sodium Salt 的 CAS 号为 1180-95-6。Taurodeoxycholate sodium salt 是胆盐相关的阴离子洗涤剂,用于分离膜蛋白,包括线粒体内膜蛋白。它还可以抑制各种炎症反应。 | |||
TMID-0224 |
Cholesterol-d6
|
||
Cholesterol-d6 是 Cholesterol 的氘代化合物。Cholesterol 的 CAS 号为 57-88-5。Cholesterol 是哺乳动物中的主要固醇,占质膜结构成分的 20-25%。Cholesterol 在确定膜的流动性和渗透性特征以及转运蛋白和信号蛋白的功能中起着重要作用。Cholesterol 还是内源性雌激素相关受体 α 激动剂。 | |||
TMID-0225 |
Cholesterol-d6-1
|
||
Cholesterol-d6-1 是 Cholesterol 的氘代化合物。Cholesterol 的 CAS 号为 57-88-5。Cholesterol 是哺乳动物中的主要固醇,占质膜结构成分的 20-25%。Cholesterol 在确定膜的流动性和渗透性特征以及转运蛋白和信号蛋白的功能中起着重要作用。Cholesterol 还是内源性雌激素相关受体 α 激动剂。 | |||
T33348 |
Methyl-d9-choline
J2.078.736H |
||
Methyl -D9- choline is an isotopically labeled choline tracer. | |||
TMIH-0590 |
Ursodeoxycholic Acid-d4
|
||
Ursodeoxycholic Acid-d4 是 Ursodeoxycholic Acid 的氘代化合物。 | |||
TMIH-0257 |
Glycoursodeoxycholic Acid-d4
|
||
Glycoursodeoxycholic Acid-d4 是 Glycoursodeoxycholic Acid 的氘代化合物。Glycoursodeoxycholic Acid 的 CAS 号为 64480-66-6。Glycoursodeoxycholic acid 是一种酰基甘氨酸和胆汁酸-甘氨酸缀合物,是熊去氧胆酸的代谢物。 | |||
TMIH-0286 |
Isochenodeoxycholic Acid-d4
|
||
Isochenodeoxycholic Acid-d4 是 Isochenodeoxycholic Acid 的氘代化合物。Isochenodeoxycholic Acid 的 CAS 号为 566-24-5。 | |||
TMID-0223 |
Cholesterol-d7
|
||
Cholesterol-d7 是 Cholesterol 的氘代化合物。Cholesterol 的 CAS 号为 57-88-5。Cholesterol 是哺乳动物中的主要固醇,占质膜结构成分的 20-25%。Cholesterol 在确定膜的流动性和渗透性特征以及转运蛋白和信号蛋白的功能中起着重要作用。Cholesterol 还是内源性雌激素相关受体 α 激动剂。 | |||
TMIH-0254 |
Glycochenodeoxycholic Acid-d4
|
||
Glycochenodeoxycholic Acid-d4 是 Glycochenodeoxycholic Acid 的氘代化合物。 | |||
TMIH-0149 |
Choline-d4 Chloride
|
||
Choline-d4 Chloride 是 Choline Chloride 的氘代化合物。 | |||
TMID-0226 |
Cholesterol-d4
|
||
Cholesterol-d4 是 Cholesterol 的氘代化合物。Cholesterol 的 CAS 号为 57-88-5。Cholesterol 是哺乳动物中的主要固醇,占质膜结构成分的 20-25%。Cholesterol 在确定膜的流动性和渗透性特征以及转运蛋白和信号蛋白的功能中起着重要作用。Cholesterol 还是内源性雌激素相关受体 α 激动剂。 | |||
TMIJ-0304 |
Lithocholic Acid-d4
|
||
Lithocholic Acid-d4 是 Lithocholic Acid 的氘代化合物。Lithocholic Acid 的 CAS 号为 434-13-9。Lithocholic acid是由鹅去氧胆酸盐通过细菌作用形成的胆汁酸,通常与甘氨酸或牛磺酸结合,被用作利胆剂。 它作为清洁剂溶解脂肪以供吸收,并且本身被吸收。 | |||
TMID-0232 |
Choline-d13 Bromide (N,N,N-trimethyl-d9; 1,1,2,2-d4)
|
||
Choline-d13 Bromide (N,N,N-trimethyl-d9; 1,1,2,2-d4) 是 Choline Bromide 的氘代化合物。Choline Bromide 的 CAS 号为 1927-06-6。 | |||
TMID-0052 |
Taurocholic Acid-d4 Sodium
|
||
Taurocholic Acid-d4 Sodium 是 Taurocholic Acid Sodium 的氘代化合物。Taurocholic Acid Sodium 的 CAS 号为 145-42-6。Sodium taurocholate hydrate 具有显著的生物学效应,例如通过上调 VEGF-A 的表达抑制肝动脉结扎所致的胆道损伤。对免疫系统具有一定的调节作用。 | |||
TMIH-0255 |
Glycolithocholic-2,2,4,4-d4 Acid
|
||
Glycolithocholic-2,2,4,4-d4 Acid 是 Glycolithocholic-2,2,4,4 Acid 的氘代化合物。 | |||
TMID-0161 |
5-alpha-Cholestane-2,2,4,4-d4
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5-alpha-Cholestane-2,2,4,4-d4 是 5-alpha-Cholestane 的氘代化合物。5-alpha-Cholestane 的 CAS 号为 481-21-0。5α-Cholestane 属于一类称为胆甾烷类固醇的有机化合物。 | |||
T11655 |
Indomethacin-D4
Indometacin-D4,吲哚美辛-D4 |
CDK | Cell Cycle/Checkpoint |
Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. | |||
TMIJ-0127 |
Diclofenac-d4
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Diclofenac-d4 是 Diclofenac 的氘代化合物。Diclofenac 的 CAS 号为 15307-86-5。Diclofenac 是一种具有抗炎活性的非甾体苯乙酸衍生物,是COX抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。 |