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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9394 |
CHIKV-IN-2
|
Dehydrogenase | Metabolism |
CHIKV-IN-2 基孔肯雅病毒的选择性抑制剂,具有强大的细胞抗病毒活性 (EC90=270 nM) 以及能够改善肝微粒体稳定性。它能够抑制细胞靶二氢乳清酸脱氢酶的活性。 | |||
T61675 |
CHIKV-IN-3
|
||
CHIKV-IN-3 是一种有效的针对 CHIKV-122508和 CHIKV-6708的低通道抑制剂,其 EC50值分别为 1.55 和 0.14 μM。CHIKV-IN-3 作用于宿主细胞以干扰病毒复制。CHIKV-IN-3 表现出极小的细胞毒性 (CC50> 100 μM)。预防作用。 | |||
T8498 |
EIDD-1931
Beta-d-N4-hydroxycytidine |
Virus Protease; HCV Protease; SARS-CoV; Topoisomerase | DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
EIDD-1931 (Beta-d-N4-hydroxycytidine) 是一种核苷类抗病毒试剂 ,可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。 | |||
T10835L1 |
Cletoquine hydrochloride
Cletoquine hydrochloride( 4298-15-1 Free base) |
Influenza Virus; Parasite | Microbiology/Virology |
Cletoquine hydrochloride 是 Hydroxychloroquine 的主要活性代谢产物。Cletoquine hydrochloride 也是一种 Chloroquine 衍生物,具有抗基孔肯雅热病毒 (CHIKV) 的能力。Cletoquine hydrochloride 具有抗疟作用。 | |||
T10835L |
Cletoquine oxalate
Desethylhydroxychloroquine oxalate |
Others | Others |
Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disea | |||
T38861 |
Tat-beclin 1
|
||
Tat-beclin 1, a peptide derived from the autophagy protein beclin 1, is a powerful inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a negative regulator of autophagy. Tat-beclin 1 effectively reduces the buildup of polyglutamine expansion protein aggregates and inhibits the replication of various pathogens, such as HIV-1, in laboratory experiments. In addition, it has demonstrated the ability to decrease mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV). | |||
T36880 |
NHC-diphosphate
|
Others | Others |
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1]. Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and ... | |||
T76058 |
Tat-beclin 1 TFA
|
||
Tat-beclin 1 TFA是一种来源于自噬蛋白区域(beclin 1)的肽,有效诱导自噬(autophagy)并与GAPR-1 (GLIPR2)发生相互作用,具有显著的自噬负调控作用。该化合物能有效减少体外聚谷氨酰胺扩增蛋白聚集体的积累,并抑制HIV-1等多种病原体的复制。同时,Tat-beclin 1 TFA能显著降低感染基孔肯雅病(CHIKV)或西尼罗河病毒(WNV)小鼠的死亡率。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10835 |
Cletoquine
Desethylhydroxychloroquine |
Parasite; Antifection | Microbiology/Virology |
Cletoquine 是 Hydroxychloroquine 的主要活性代谢物。 Cletoquine 具有对抗基孔肯雅病毒 (CHIKV) 的能力。 Cletoquine 具有抗疟作用,并具有治疗自身免疫性疾病的潜力。 | |||
TN3500 |
beta-Amyrone
β-Amyron,β-香树脂酮 |
COX; AChR; PPAR; Antifection | DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience |
beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性,EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04865 |
Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His)
|
CHIKV | Baculovirus Insect Cells |
Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 39.8 kDa and the accession number is A5Y7Y5. | |||
TMPK-01151 |
MXRA8 Protein, Human, Recombinant (His)
Asp3,Limitrin,Adipocyte-specific 3,DICAM,Adipocyte-specific ... |
Human | HEK293 Cells |
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 36.70 kDa and the accession number is Q9BRK3-1. | |||
TMPK-01166 |
MXRA8 Protein, Mouse, Recombinant (His)
Asp3,DICAM,Adipocyte-specific protein 3,Adipocyte-specific 3... |
Mouse | HEK293 Cells |
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 37.11 kDa and the accession number is Q9DBV4. | |||
TMPH-00385 |
Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His)
P1234,Non-structural polyprotein,Polyprotein P1234 |
CHIKV | E. coli |
Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is Q8JUX6. |