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Search Results for " ch1 "

Targets Recommended: PARP

3

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T79667	YCH1899	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	YCH1899为一种口服活性PARP抑制剂，其对PARP1/2的IC50均低于0.001 nM。该化合物对Olaparib和Talazoparib耐药的Capan-1细胞株(Capan-1/OP及Capan-1/TP细胞)表现出显著抗增殖能力，IC50分别为0.89 nM和1.13 nM。在大鼠体内，YCH1899展现优良的药代动力学属性。
T14879	CB 300919	Others	Others
	CB 300919 is a quinazoline-based antitumor agent with high activity in the CH1 human ovarian tumor xenograft and has continuous exposure (96 h) growth inhibition (IC50: 2 nM).
T73566	OHM1	Others	Others
	OHM1 是HIF1α CTAD 的类似物，抑制其与 p300/CBP 的结合。OHM1 靶向 CH1 结构域，亲和力为 0.53 μM。

化合物

Cat.No: T79667

Target: PARP

Cat.No: T14879

Target: Others

Cat.No: T73566

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00355	Major allergen I polypeptide chain 1 Protein, Feline, Recombinant (His & Myc) Allergen Cat-1,Allergen Fel d I-A,AG4,Major allerge...	Feline	E. coli
	Major allergen I polypeptide chain 1 Protein, Feline, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 15.3 kDa and the accession number is P30438.
TMPY-03464	ECH1 Protein, Human, Recombinant (His) enoyl CoA hydratase 1, peroxisomal,HPXEL	Human	E. coli
	ECH1 is a member of the hydratase/isomerase superfamily. ECH1 shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. ECH1 contains a C-terminal peroxisomal targeting sequence and localizes to peroxisomes. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans, 5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-de...
TMPJ-00893	IgG2a Protein, Rat, Recombinant Ig γ-2A chain C region,Ig gamma-2A chain C...	Rat	HEK293 Cells
	Immunoglobulin G (IgG) is a type of antibody composed of four peptide chains—two identical heavy chains and two identical light chains arranged in a Y-shape typical of antibody monomers.There are four IgG subclasses (IgG1, 2, 3, and 4) in humans, named in order of their abundance in serum. The IgG2a isotype was able to interact very efficiently with FcgammaR, and share approximately 64-78% amino acid sequence identity with IgG1 and IgG2b in the heavy chain constant region domains, CH1, CH2 and C...

重组蛋白

Major allergen I polypeptide chain 1 Protein, Feline, Recombinant (His & Myc)

Cat.No: TMPH-00355

Species: Feline

Expression System: E. coli

ECH1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03464

Species: Human

Expression System: E. coli

IgG2a Protein, Rat, Recombinant

Cat.No: TMPJ-00893

Species: Rat

Expression System: HEK293 Cells

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