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Search Results for " cgrp receptor "

Targets Recommended: CGRP Receptor CGRP Receptor

30

抑制剂 & 化合物

2

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8682	Vazegepant hydrochloride Vazegepant HCl	CGRP Receptor	GPCR/G Protein; Neuroscience
	Vazegepant hydrochloride (Vazegepant HCl) 是一种用于偏头痛的鼻用 gepant，是一种高度亲和性CGRP 受体拮抗剂 (hCGRPKi=0.023 nM)。它可能有助于有效管理 COVID-19 相关肺部炎症。
T17194	Ubrogepant MK-1602	CGRP Receptor	GPCR/G Protein; Neuroscience
	Ubrogepant (MK-1602) 是新型的、口服有效的降钙素基因相关肽受体拮抗剂。Ubrogepant 有潜力用于急性偏头痛的相关研究。
T12293L	Olcegepant BIBN-4096,BIBN 4096BS	CGRP Receptor	GPCR/G Protein; Neuroscience
	Olcegepant (BIBN-4096) 是一种选择性的降钙素基因相关肽1 (CGRP1) 受体拮抗剂，IC50=0.03 nM，Ki=14.4 pM。
TP1040	Calcitonin (salmon) 鲑降钙素,Calcitonin salmon,Salmon calcitonin	CGRP Receptor	GPCR/G Protein; Neuroscience
	Calcitonin (salmon) 是一种阿米林和卡西宁受体的双激动剂，是一种钙调节激素，能够刺激骨的生成并能抑制骨吸收。
T4610	Rimegepant BMS 927711,BMS-927711,BMS927711,BHV-3000	CGRP Receptor	GPCR/G Protein; Neuroscience
	Rimegepant (BMS 927711) 是一种有效的降钙素基因相关肽 (CGRP) 受体拮抗剂 (Ki=0.027 nM，IC50=0.14 nM)。Rimegepant 可同时用于偏头痛急性发作治疗及预防性治疗。
T6590	MK-3207 Hydrochloride MK-3207 HCl	CGRP Receptor	GPCR/G Protein; Neuroscience
	MK-3207 Hydrochloride (MK-3207 HCl) 是口服具有活力的CGRP receptor 拮抗剂，IC50=0.12 nM，Ki=0.024 nM。
T13453	CGRP antagonist 1	CGRP Receptor	GPCR/G Protein; Neuroscience
	CGRP antagonist 1是高效 CGRP 受体拮抗剂，Ki 值分别为 35nM，IC50 值为 57 nM。CGRP antagonist 1可用于研究心血管疾病和神经血管疾病。
TP1323	CGRP 8-37 (rat)	CGRP Receptor	GPCR/G Protein; Neuroscience
	CGRP 8-37 (rat) 是 CGRP receptor 拮抗剂，是一种可作用于大鼠的 CGRP片段，具有潜在的抗伤害作用，可诱导动脉松弛。
TP1134L	HCGRP-(8-37) acetate HCGRP-(8-37) acetate (119911-68-1 free base)	CGRP Receptor	GPCR/G Protein; Neuroscience
	HCGRP-(8-37) acetate 是一种人降钙素基因相关肽 (hCGRP) 片段醋酸盐，也是 CGRP 受体的拮抗剂。
TP1200	CGRP (83-119), rat TFA Calcitonin Gene Related Peptide(83-119), rat TFA	Others	Others
	CGRP (83-119), rat TFA (Calcitonin Gene Related Peptide(83-119), rat TFA) 是一种由 37 个氨基酸组成的神经肽降钙素家族，通过降钙素受体样受体起作用。
T38734	Vazegepant Zavegepant,BHV-3500,BMS-742413	CGRP Receptor	GPCR/G Protein; Neuroscience
	Vazegepant (Zavegepant) 是一种可口服且具有选择的降钙素基因相关肽 CGRP 受体拮抗剂，可缓解疼痛，可用于研究偏头疼。
TP1257L	Adrenomedullin (AM) (22-52), human acetate Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）	CGRP Receptor	GPCR/G Protein; Neuroscience
	Adrenomedullin (AM) (22-52), human acetate 是猫后肢血管床中 CGRP 受体和肾上腺髓质素受体的拮抗剂。
T75978	β-CGRP, human TFA
	β-CGRP, human TFA (Human β-CGRP TFA) 是一种降钙素肽，通过降钙素受体样受体CRLR 与RAMP 的复合物起作用，在细胞体系中，对 CRLR/RAMP1 和 CRLR/RAMP2 的IC50值分别为 1 nM 和 300 nM。
TP1134	HCGRP-(8-37) Human α-CGRP (8-37)
	Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist
T70820	MK-8825	Others	Others
	MK-8825 is a CGRP receptor antagonist.
T39522	HTL22562	Others	Others
	HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine.
T16093	Telcagepant MK-0974	Others	Others
	Telcagepant is an orally active antagonist of calcitonin gene-related peptide (CGRP) receptor (Kis: 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively).
T12293	Olcegepant hydrochloride BIBN-4096 hydrochloride,BIBN4096BS hydrochloride	Others	Others
	Olcegepant hydrochloride is a potent and selective non-peptidethe calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (with IC50 of 0.03 nM for human CGRP).
T76363	[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat
	[Tyr22]CalcitoninGene Related Peptide, (22-37), rat 是一种大鼠降钙素基因相关肽 (CGRP) 的 22-37 片段，靶向CGRP 受体和腺苷酸环化酶。降钙素 (calcitonin) 主要由甲状腺 C 细胞产生，而 CGRP 则分泌并储存在神经系统中。
TP2044	α-CGRP(human) α-CGRP (human)
	Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.
TP1203	CGRP(83-119), rat Calcitonin Gene Related Peptide (CGRP) (83-119), rat
	Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor.
T26796	BI-44370	Others	Others
	BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.
T30537	BMS-694153 BMS694153,BMS 694153	Others	Others
	BMS-694153 is a potent and selective CGRP receptor antagonist.This compound is unstable in powder form and other related salt forms are recommended.
T73703	(3R,5R,6S)-Atogepant	Others	Others
	(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) 是Atogepant 的异构体.Atogepant 是降钙素基因相关肽受体 (CGRP) 拮抗剂。Atogepant 可用于研究偏头痛。
T21558	MK-3207	Others	Others
	MK-3207是口服生物相容性的CGRP 受体拮抗剂，IC50和 Ki 分别为 0.12 nM 和 0.024 nM，对 AM1，AM2，CTR 和 AMY3 的抑制性较弱。MK-3207可用于偏头痛研究。
T76678	Eptinezumab
	Eptinezumab为人源化单克隆抗体，主要通过与降钙素基因相关肽(CGRP)结合，进而阻止其与受体相结合，用于成人偏头痛的预防。
TP1131	β-CGRP, human TFA (101462-82-2 free base) CGRP-II (Human) (TFA),Human β-CGRP (TFA),β-CGRP, human TFA
	β-CGRP,human tissue is one of the calcitonin peptide, through complex behavior of calcitonin receptor like receptor (CRLR) - and receptor activity - modifying proteins (increased), and 1 and 300 - nM CRLR IC50s/RAMP1 and CRLR/RAMP2 cells.
T75934	AC 187 TFA
	AC 187 TFA 是一种有效且具有口服活性的胰淀素受体 (amylin receptor) 拮抗剂，IC50为 0.48 nM，Ki 为 0.275 nM。AC 187 TFA 对胰淀素受体的选择性高于降钙素和 CGRP 受体。AC 187 TFA 具有神经保护作用。
TP2049	CRSP-1
	Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin recept
TP2049L	CRSP-1 acetate(697327-12-1 Free base)
	CRSP-1 acetate(697327-12-1 Free base) 是一种内源性中枢降钙素(CT)受体激动剂，其刺激cAMP形成的效力是CT的350倍（ED50值分别为0.2和71nM）。CRSP-1 acetate 对降钙素基因相关肽 (CGRP) 和肾上腺髓质素受体没有活性。CRSP-1 acetate 抑制多核破骨细胞的形成，其体外功效与CT相似。CRSP-1 acetate 抑制自由进食大鼠的食物摄入并升高体温，并显着降低体内血浆钙水平。

化合物

Vazegepant hydrochloride

Cat.No: T8682

Synonym: Vazegepant HCl

Target: CGRP Receptor

Cat.No: T17194

Synonym: MK-1602

Target: CGRP Receptor

Cat.No: T12293L

Synonym: BIBN-4096,BIBN 4096BS

Target: CGRP Receptor

Calcitonin (salmon)

Cat.No: TP1040

Synonym: 鲑降钙素,Calcitonin salmon,Salmon calcitonin

Target: CGRP Receptor

Cat.No: T4610

Synonym: BMS 927711,BMS-927711,BMS927711,BHV-3000

Target: CGRP Receptor

MK-3207 Hydrochloride

Cat.No: T6590

Synonym: MK-3207 HCl

Target: CGRP Receptor

CGRP antagonist 1

Cat.No: T13453

Target: CGRP Receptor

CGRP 8-37 (rat)

Cat.No: TP1323

Target: CGRP Receptor

HCGRP-(8-37) acetate

Cat.No: TP1134L

Synonym: HCGRP-(8-37) acetate (119911-68-1 free base)

Target: CGRP Receptor

CGRP (83-119), rat TFA

Cat.No: TP1200

Synonym: Calcitonin Gene Related Peptide(83-119), rat TFA

Target: Others

Cat.No: T38734

Synonym: Zavegepant,BHV-3500,BMS-742413

Target: CGRP Receptor

Adrenomedullin (AM) (22-52), human acetate

Cat.No: TP1257L

Synonym: Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）

Target: CGRP Receptor

β-CGRP, human TFA

Cat.No: T75978

Cat.No: TP1134

Synonym: Human α-CGRP (8-37)

Cat.No: T70820

Target: Others

Cat.No: T39522

Target: Others

Cat.No: T16093

Synonym: MK-0974

Target: Others

Olcegepant hydrochloride

Cat.No: T12293

Synonym: BIBN-4096 hydrochloride,BIBN4096BS hydrochloride

Target: Others

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat

Cat.No: T76363

α-CGRP(human)

Cat.No: TP2044

Synonym: α-CGRP (human)

CGRP(83-119), rat

Cat.No: TP1203

Synonym: Calcitonin Gene Related Peptide (CGRP) (83-119), rat

Cat.No: T26796

Target: Others

Cat.No: T30537

Synonym: BMS694153,BMS 694153

Target: Others

(3R,5R,6S)-Atogepant

Cat.No: T73703

Target: Others

Cat.No: T21558

Target: Others

Cat.No: T76678

β-CGRP, human TFA (101462-82-2 free base)

Cat.No: TP1131

Synonym: CGRP-II (Human) (TFA),Human β-CGRP (TFA),β-CGRP, human TFA

Cat.No: T75934

Cat.No: TP2049

CRSP-1 acetate(697327-12-1 Free base)

Cat.No: TP2049L

Cat. No.	Product Name	Target	Signaling Pathways
T21581L	AC 187 Acetate AC 187 Acetate (151804-77-2 Free base)	Amylin Receptor	GPCR/G Protein
	AC 187 Acetate 是胰淀素受体的强效拮抗剂。AC 187 对胰淀素受体的选择性高于降钙素和 CGRP 受体。
TP2167	β-CGRP, human acetate β-CGRP, human acetate (101462-82-2 free),CGRP-II (Human) (acetate),Human β-CGRP acetate	CGRP Receptor	GPCR/G Protein; Neuroscience
	β-CGRP, human acetate 是降钙素肽之一，通过受体活性修饰蛋白 (RAMP) 和降钙素受体样受体 (CRLR) 的复合物发挥作用（对于 CRLR/RAMP1 和 CRLR，IC50：1 nM 和 300 nM /RAMP2 在单元格中）。

天然产物

Cat.No: T21581L

Synonym: AC 187 Acetate (151804-77-2 Free base)

Target: Amylin Receptor

β-CGRP, human acetate

Cat.No: TP2167

Synonym: β-CGRP, human acetate (101462-82-2 free),CGRP-II (Human) (acetate),Human β-CGRP acetate

Target: CGRP Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03280	RAMP3 Protein, Human, Recombinant (hFc) receptor (G protein-coupled) activity modifying pro...	Human	HEK293 Cells
	RAMP3 belongs to the RAMP family. Members of this family are single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. They are required to transp...
TMPY-00371	STC1 Protein, Human, Recombinant (His) stanniocalcin 1,STC	Human	HEK293 Cells
	Stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. STC1 is a secreted glycoprotein hormone and involved in various types of human malignancies. Stanniocalcin-1 (STC1), which has myriad functions, including the maintenance of calcium homeostasis, the promotion of early wound healing, uncoupling respiration (aerobic glycolysis), reepithelialization in damaged tissues, the inhibition of vascular leakage, and the regulation of macrophage functions to keep e...
TMPY-02839	Adrenomedullin Protein, Human, Recombinant (hFc) AM,PAMP,adrenomedullin	Human	HEK293 Cells
	Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been report...

重组蛋白

RAMP3 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03280

Species: Human

Expression System: HEK293 Cells

STC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00371

Species: Human

Expression System: HEK293 Cells

Adrenomedullin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02839

Species: Human

Expression System: HEK293 Cells

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