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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T30806 |
CFLZ-567
|
Others | Others |
CFLZ-567 is a key intermediate for making carfilzomib. | |||
T21342 |
CFLZ-171 TFA salt
|
Others | Others |
CFLZ-171 is a key intermediate for the synthesis of carfilzomib. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03607 |
Cofilin Protein, Human, Recombinant (His)
CFL,HEL-S-15,cofilin 1 (non-muscle) |
Human | E. coli |
CFL1, also known as n-cofilin, is a member of the ADF/Cofilin family. This family comprises three genes: CFL1, CFL2 and DSTN (destrin). ADF/Cofilin family members bind G-actin monomers and depolymerize actin filaments through two mechanisms: severing and increasing the off-rate for actin monomers from the pointed end. Cofilin also binds with other proteins such as myosin, tropomyosin, α-actinin, gelsolin and scruin. These proteins compete with cofilin for actin binding. Сofilin also plays a... |