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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1576 |
Iopamidol
SQ-13396,Niopam,Iopamiron,Iopamiro,碘帕醇,B-15000,Isovue |
Others | Others |
Iopamidol (SQ-13396) 是一种 benzenedicarboxamide 化合物。它具有放射性不透明介质、环境污染物和异种生物的作用。 | |||
TQ0238 |
Lanabecestat
LY3314814,AZD3293 |
BACE | Neuroscience |
Lanabecestat (AZD3293) 是一种具有高效性和高渗透性、口服活性且可穿过血脑屏障的 BACE1 抑制剂(Ki:0.4 nM),Lanabecestat 可用于研究像阿尔茨海默症类的神经系统疾病。 | |||
T6249 |
Avagacestat
BMS-708163 |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Avagacestat (BMS-708163) 是一种有效的γ-secretase 抑制剂,抑制 Aβ42 (IC50:0.27 nM) 和 Aβ40 (IC50:0.30 nM) 的产生。它同时抑制 Notch 胞内结构域 (NICD) (IC50:0.84 nM) 和 CYP2C19 (IC50:20 nM) 。它可用于阿尔兹海默症的研究。 | |||
T13674 |
Elacestrant
依拉司群,RAD1901 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Elacestrant (RAD1901) 是一种具有口服活性的、选择性的雌激素受体 (ER) 降解剂 (SERD),能够作用于 ERα (IC50:48 nM)和 ERβ (IC50:870 nM)。 | |||
T13675 |
Elacestrant dihydrochloride
RAD1901 dihydrochloride |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) 是一种具有口服活性的的选择性雌激素受体 (ER) 降解剂 (SERD),能够作用于 ERα (IC50:48 nM) 和 ERβ (IC50:870 nM)。 | |||
T11175 |
Elenbecestat
E2609 |
Beta-Secretase; BACE | Neuroscience |
Elenbecestat (E2609) 是一种高效、有口服活性的,能透过 CNS 的 BACE-1抑制剂,它有用于阿尔茨海默病 (AD) 的研究潜力。 | |||
T14338 |
Atabecestat
RSC-385896,JNJ-54861911 |
BACE | Neuroscience |
Atabecestat (JNJ-54861911) 是一种具有口服活性和脑渗透性的 β-位淀粉样蛋白前体蛋白裂解酶 1 (BACE1) 抑制剂,减缓临床前阿尔茨海默病参与者的认知能力下降。Atabecestat 可用于研究阿尔茨海默氏病。 | |||
T13253 |
Umibecestat
CNP520 |
BACE | Neuroscience |
Umibecestat 是一种β-位点淀粉样前体蛋白裂解酶-1 (BACE-1) 抑制剂,对人 BACE-1 和小鼠 BACE-1 的 IC50 分别为 11 nM 和 10 nM,可用于阿尔茨海默病的研究。 | |||
T3633 |
Crenigacestat
LY3039478 |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Crenigacestat (LY3039478) 是一种口服具有活性的Notch 和γ-secretase 的抑制剂,其在多种肿瘤细胞中的IC50为 ∼1nM。 | |||
T6935 |
Nirogacestat
PF-03084014,PF-3084014,PF03084014,PF 03084014 |
Apoptosis; Gamma-secretase | Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells |
Nirogacestat (PF 03084014) 是一种具有口服活性的,可逆的,非竞争性的,选择性γ-secretase 抑制剂,IC50为 6.2 nM。它抑制 Notch 信号通路,可研究 Notch 受体依赖性肿瘤。 | |||
T7011 |
Verubecestat
MK-8931,维罗司他 |
Beta-Secretase; BACE | Neuroscience |
Verubecestat (MK-8931) 是一种高亲和力的、具有口服活性的BACE1和BACE2抑制剂,Ki 分别为 2.2 nM 和 0.38 nM。它可以有效降低 Aβ40,并具有潜力用于阿尔茨海默氏病。 | |||
T6125 |
Semagacestat
LY450139,塞美司他 |
Beta Amyloid; Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Semagacestat (LY450139) 是一种γ-secretase 抑制剂,抑制β-amyloid(Aβ42),Aβ38和Aβ40,IC50分别为 10.9,12 和 12.1 nM,可用于研究阿尔茨海默病。 | |||
T70800 |
Elenbecestat free base
|
Others | Others |
Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD. | |||
T24924 |
Umibecestat HCl (1387560-01-1 free base)
CNP 520,Umibecestat HCl,Umibecestat hydrochloride,CNP520,CNP-520 |
Others | Others |
Umibecestat is a beta-secretase inhibitor. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. | |||
T125754 |
Cesternoside A
|
Others | Others |
Cesternoside A 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125754,CAS号为 153120-71-9。 | |||
T69664 |
Umibecestat HCl
|
Others | Others |
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP‐transgenic mice | |||
T10014 |
(1α,1'S,4β)-Lanabecestat
(1α,1'S,4β)-AZD3293 |
Others | Others |
(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzymel (BACE1) inhibitor, and has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively. | |||
T11173 |
Elacestrant S enantiomer
RAD1901 S enantiomer |
Others | Others |
Elacestrant S enantiomer is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. | |||
T23874 |
CESTRIN
|
Others | Others |
CESTRIN is a cellulose synthase trafficking probe that acts by inhibiting cellulose deposition and interferes with the trafficking of cellulose synthase complexes and their associated proteins KORRIGAN1 and POM2/CSI1. | |||
T38266 |
Nirogacestat dihydrobromide
|
Others | Others |
Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs. Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID:20363853 | |||
T70807 |
Lanabecestat HCl
|
Others | Others |
Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Aβ40, Aβ42, and sAβPPβ. | |||
T14525 |
Begacestat
GSI-953 |
Beta Amyloid | Neuroscience |
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's disease. | |||
T11173L |
Elacestrant S enantiomer dihydrochloride
RAD1901 S enantiomer dihydrochloride,RAD-1901 S enantiomer dihydrochloride,RAD 1901 S enantiomer dihydrochloride |
Others | Others |
Elacestrant (RAD1901) dihydrochloride is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant S enantiomer dihydrochloride is an low activity enantiomer of elacestrant dihydrochloride. | |||
T25610 |
Lanabecestat camsylate
LY 3314814 camsylate,LY-3314814 camsylate,LY3314814 camsylate |
Others | Others |
Lanabecestat camsylate is used as a BACE1 Inhibitor. | |||
T70104 |
Verubecestat tosylate
|
Others | Others |
Verubecestat tosylate, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat tosylate is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat tosylate reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients. | |||
T71899 |
Verubecestat TFA
|
Others | Others |
Verubecestat TFA, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat TFA is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat TFA reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T75465 |
Mycestericin G
|
Others | Others |
Mycestericin G 是一种鞘氨醇样真菌代谢产物,具有免疫抑制活性。 | |||
T81735 |
Mycestericin C
|
||
Mycestericin C, 分离自 Mycelia sterilia ATCC 20349 的培养液, 能在小鼠同种异体混合淋巴细胞反应中抑制淋巴细胞的增殖。 |