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Search Results for " cd4 t cell "
Targets Recommended: Proteasome

22

抑制剂 & 化合物

1

天然产物

1

TargetMol 试剂盒

37

重组蛋白

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Cat. No. Product Name Form Specificity Of Inhibition
C0062 Mouse CD4+ T Cell Isolation Kit (negative selection)

小鼠 CD4+ T细胞分选试剂盒 (阴选)

Suspension in bo<em>t</em><em>t</em>le

TargetMol 试剂盒

小鼠 CD4+ T细胞分选试剂盒 (阴选)
Cat.No: C0062
Cat. No. Product Name Target Signaling Pathways
T12079 ML604440

Proteasome Proteases/Proteasome; Ubiquitination
ML604440 是一种特异性的、有效的、细胞可渗透的蛋白酶体 β1i (LMP2) 亚基抑制剂,能够破坏 MHC I 类细胞表面表达,IL-6 分泌以及 naïve T helper 向 17 T helper 细胞的分化。它可以改善实验性结肠炎和 EAE 疾病。
T30077 Anisperimus

LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195

Caspase Apoptosis; Proteases/Proteasome
Anisperimus (LF 15-0195) 是一种免疫抑制剂,通过促进 DISC 水平的 caspase-8 和 caspase-10 激活来增强激活诱导的 T 细胞死亡,通过促进表达 Foxp3 的调节性 CD4 T 细胞的发育来预防中枢神经系统自身免疫。
T81011 Tetanus Toxin (830–844)

Tetanus Toxin (830–844) 是具有生物活性的肽类化合物。它是破伤风毒素衍生的 TT830–844 CD4+ T 细胞表位,能与多种 HLA-DRB 分子结合。该 CD4+ T 细胞表位由于与广泛的 HLA-DRB 分子具有亲和力,有潜力在大范围人群中诱发 CD4+ T 细胞应答。
T72099 Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl

Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl (化合物 (CPF(LL)) 是一种 HIV-1抑制剂。Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl 能与 gp120相互作用以阻断 gp120与 CD4的结合,并保留 CD4依赖的 T 细胞功能。
T82179 HOXB7 8–25

MDM2 32-46

Others Others
HOXB7 8–25 (MDM2 32-46)为来源于MDM2的肽段,能够特异性诱导抗原和激活肿瘤反应性的CD4+ T细胞。
T80744 Zanolimumab

Anti-Human CD4 Recombinant Antibody

Zanolimumab(Anti-HumanCD4Recombinant Antibody)是靶向CD4的人源单克隆抗体,能有效地抑制T细胞受体(TCR)的信号转导。它在类风湿性关节炎、银屑病、黑色素瘤、皮肤及周围T细胞淋巴瘤的研究中有应用。
T77049 Keliximab

Keliximab (SB-210396) 是一种嵌合的人/猕猴IgG1抗CD4单克隆抗体,对可溶性CD4的Kd 值为 1.0 nM。Keliximab 阻断 T 细胞增殖并抑制IL-2的产生。Keliximab 可用于癌症研究。
T38687 Influenza Matrix Protein (61-72)

Influenza Matrix Protein (61-72) is a peptide derived from the matrix protein of influenza viruses and encompasses amino acids 61-72. This specific epitope, Influenza Matrix Protein (61-72), has the ability to elicit a CD4+ T-cell response.
T39863 LCMV GP (61-80)

LCMV GP (61-80) is a peptide fragment derived from LCMV glycoprotein (GP) and corresponds to amino acids 61-80. This specific epitope, LCMV GP (61-80), has the ability to elicit CD4+ T-cell response.
T80621 Semzuvolimab

UB421

Semzuvolimab是靶向T细胞表面抗原T4/Leu-3,即p55 (CD4)的鼠IgG1κ类抗体。该CD4抗体具备中和HIV感染的能力,潜在用于抑制HAART稳定型HIV感染。
T78031 MOG peptide (35-55)

MOG peptide (35-55) 是一段特定的髓鞘少突胶质细胞糖蛋白 (MOG) 免疫原肽的35至55氨基酸序列。该肽段具有针对CD4+T细胞的特异性活性,并可用于诱导实验性自身免疫性脑脊髓炎 (EAE) 的动物模型。
TP2080 ADWX 1

Potent and selective KV1.3 channel blocker (IC50 values are 0.0019 and 0.65 nM for KV1.3 and KV1.1, respectively). Inhibits CD4+ CCR7- T cell activation. Ameliorates rat experimental autoimmune encephalomyelitis, in a model for multiple sclerosis.
T72668 PD-1/PD-L1-IN-26

PD-1/PD-L1 Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
PD-1/PD-L1-IN-26 (Compound II-14) 是一种高效的 PD-1/PD-L1 抑制剂,IC50 为 0.0380 μM。该化合物能够激活肿瘤免疫微环境,通过促进 CD4+ T 细胞向肿瘤组织的浸润。PD-1/PD-L1-IN-26 展示了在癌症治疗研究中的应用潜力。
T25109 ARN-6039

ARN 6039,ARN6039

Others Others
ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HEK 293 cells (360 nM) and in IL-17 r
T83724 TPP-1 hydrochloride

Targeting PD-L1 Peptide

TPP-1是一种针对程序化细胞死亡蛋白1(PD-1)及其配体PD-1配体(PD-L1)之间蛋白-蛋白相互作用的肽抑制剂。它在无细胞实验中结合到PD-L1(Kd = 94.67 nM)。TPP-1 (20 µM)能逆转PD-L1在抗CD3激活的人类CD4+ T细胞中所引起的干扰素γ(IFN-γ)水平的下降。在使用HL-60白血病细胞与抗CD3激活的人类CD4+ T细胞共培养并在植入前预处理时,以4 mg/kg的剂量给药,可减少小鼠异种移植模型中的肿瘤体积。
T85077 AKP-11

Others Others
AKP-11 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist with an EC50 of 0.047 μM for [35S]GTPγS binding to CHO-K1 cell membranes expressing human S1P1. It reduces S1P1 surface expression and enhances Akt and ERK phosphorylation in CHO cells with S1P1-HA at a 100 nM concentration. At doses of 1.3 and 3 mg/kg, AKP-11 lowers IFN-γ and IL-17 protein levels in the spinal cord and mitigates disease severity in a rat experimental autoimmune encephalomyelitis (EAE) model. Additionally, it decrease...
T83846 HOXB7 (8-25) TFA

Homeobox B7 (8-25)

HOXB7 (8-25) 是 homeobox B7 (HOXB7) 的肽段,是细胞增殖的主要调控因子和肿瘤基因途径的激活剂。通过 HOXB7 (8-25) 肽脉冲的树突状细胞展示抗原,这些树突状细胞来源于分离的人类外周血单核细胞(PBMCs),刺激CD4+辅助T细胞的激活和IFN-γ的产生,从而引发特异性和多向性肿瘤反应性的抗肿瘤反应。
TP1703 FliC, Serotype a (427-441), S.paratyphi A

This is amino acids 427 to 441 fragment belongs to the FliC, serotype a of the S. FliC epitope recognized by a CD4+ T cell from naturally infected C57BL/6 mice is located in a region common to a number of distinct Salmonella serovars such as the S. paraty
T73651 Forigerimod TFA

Forigerimod TFA (IPP-201101 TFA) 为 CD4T 细胞调节剂,属于 U1 小核核糖核蛋白 70 kDa 的 21 个氨基酸片段,并在 Ser140 位点磷酸化。它能有效抑制自噬,适用于系统性红斑狼疮 (SLE) 等自身免疫性疾病的研究。
T36034 CAY10774

Others Others
CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50= 15 nM in a homologous time-resolved fret (HTRF) assay).1It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50= 6.6 μM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4+and CD8+T cells co-cultured with aAPCs. 1.Konieczny, M., Musielak, B., Koc...
T73650 Forigerimod

Forigerimod (IPP-201101) 是一种 CD4T 细胞调节剂。Forigerimod 是 U1 小核核糖核蛋白 70 kDa 的 21 个氨基酸片段,在 Ser140 位点被磷酸化。Forigerimod 可以有效抑制自噬。Forigerimod 可用于系统性红斑狼疮 (SLE) 等自身免疫性疾病的研究。
T64280 ODN 2216

Others Others
ODN 2216 是一种 TLR9 (toll-like receptor 9) 配体或激动剂,能够诱导产生大量的 IFN-α 和 IFN-β。ODN 2216 可以利用 pDC (浆细胞样 DC) 诱导 IFN-α,以及利用 DC (树突状细胞) 产生IL-12 (p40)。ODN 2216 能够间接的、在 IFN-α/β 介导下刺激外周血单核细胞 (PBMC) 产生 IFN-γ。ODN 2216 可以激活 NK 细胞,诱导 IFN-γ 产生 TCR 触发的 CD4+T 细胞。

化合物

ML604440
Cat.No: T12079
Synonym:
Target: Proteasome
Anisperimus
Cat.No: T30077
Synonym: LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195
Target: Caspase
Tetanus Toxin (830–844)
Cat.No: T81011
Synonym:
Target:
Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl
Cat.No: T72099
Synonym:
Target:
HOXB7 8–25
Cat.No: T82179
Synonym: MDM2 32-46
Target: Others
Zanolimumab
Cat.No: T80744
Synonym: Anti-Human CD4 Recombinant Antibody
Target:
Keliximab
Cat.No: T77049
Synonym:
Target:
Influenza Matrix Protein (61-72)
Cat.No: T38687
Synonym:
Target:
LCMV GP (61-80)
Cat.No: T39863
Synonym:
Target:
Semzuvolimab
Cat.No: T80621
Synonym: UB421
Target:
MOG peptide (35-55)
Cat.No: T78031
Synonym:
Target:
ADWX 1
Cat.No: TP2080
Synonym:
Target:
PD-1/PD-L1-IN-26
Cat.No: T72668
Synonym:
Target: PD-1/PD-L1
ARN-6039
Cat.No: T25109
Synonym: ARN 6039,ARN6039
Target: Others
TPP-1 hydrochloride
Cat.No: T83724
Synonym: Targeting PD-L1 Peptide
Target:
AKP-11
Cat.No: T85077
Synonym:
Target: Others
HOXB7 (8-25) TFA
Cat.No: T83846
Synonym: Homeobox B7 (8-25)
Target:
FliC, Serotype a (427-441), S.paratyphi A
Cat.No: TP1703
Synonym:
Target:
Forigerimod TFA
Cat.No: T73651
Synonym:
Target:
CAY10774
Cat.No: T36034
Synonym:
Target: Others
Forigerimod
Cat.No: T73650
Synonym:
Target:
ODN 2216
Cat.No: T64280
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T5S0993 Kurarinone

苦参酮,苦参黄素

BCL; Others; IκB/IKK; TNF; NF-κB; JAK; STAT Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; Stem Cells
Kurarinone 是从灌木苦参中提取的黄酮类化合物,具有抗肿瘤、雌激素和抗炎活性,对免疫反应也有很强的抑制作用。

天然产物

Kurarinone
Cat.No: T5S0993
Synonym: 苦参酮,苦参黄素
Target: BCL, Others, IκB/IKK, TNF, NF-κB, JAK, STAT
Cat. No. Product Name Species Expression System
TMPY-01648 TREML2 Protein, Human, Recombinant (His)

TLT2,dJ238O23.1,triggering recep<...

Human HEK293 Cells
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune respons...
TMPJ-00451 IL-16 Protein, Human, Recombinant

Interleukin-16,IL16,Lymphocyte Chemoat...

Human E. coli
Interleukin-16 (IL-16) is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-...
TMPJ-00064 OX40L/TNFSF4 Protein, Human, Recombinant (His)

TNFSF4,Glycoprotein Gp34...

Human HEK293 Cells
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proli...
TMPK-01135 CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (His)

T3E,CD3-ε,FLJ18683,CD3e,IMD18,

Cynomolgus HEK293 Cells
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular...
TMPK-00095 CD3 epsilon/CD3e 1-27 peptide Protein, Human, Recombinant (hFc & Avi)

CD3-epsilon,IMD18,T3E,CD3-ε,C...

Human HEK293 Cells
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e 1-27 peptide Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The p...
TMPH-02622 DOCK8 Protein, Mouse, Recombinant (E. coli, His)

DOCK8,Dedicator of cytokinesis prot

Mouse E. coli
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing cent...
TMPY-02518 TCL1A Protein, Human, Recombinant (His)

TCL1,T-cell leukemia/lymphoma 1A

Human E. coli
T-cell leukemia/lymphoma protein 1A (abbreviated for TCL1A) is a member of the TCL1 family. TCL1 protooncogene is expressed in CD3-CD4-CD8-precursor T cells and is extinguished at the CD4+CD8+stage of thymocyte development. In B cells, TCL1 is first expressed in pro-B cells and remains high in naive mantle zone B cells of peripheral lymphoid tissues. The TCL1 protooncogene is overexpressed in many mature B cell lymphomas, especially from AIDS patients. It has been demonstrated that TCL1 is a pow...
TMPJ-00433 VSIR Protein, Cynomolgus, Recombinant (His)

Stress-induced secreted protein-1...

Cynomolgus HEK293 Cells
platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling pathway. It also regulates the CD4-pasitive, alpha-beta T cell proliferation, and T cell cytokine production negatively. However, the protein can regulate stem cell differentiation positively.
TMPK-01350 CD3 epsilon/CD3e 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi)

CD3E,T3E,FLJ18683,CD3-ε,CD

Cynomolgus HEK293 Cells
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. ...
TMPH-01207 DOCK8 Protein, Human, Recombinant (His)

DOCK8,Dedicator of cytokinesis prot

Human P. pastoris (Yeast)
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing c...
TMPK-01351 CD3 epsilon/CD3e epsilon 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated

TCRE,FLJ18683,T3E,CD3E,CD

Cynomolgus HEK293 Cells
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e epsilon 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cell...
TMPH-02623 DOCK8 Protein, Mouse, Recombinant (His)

Dedicator of cytokinesis protein ...

Mouse P. pastoris (Yeast)
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing cent...
TMPK-01385 CRTAM Protein, Canine, Recombinant (His)

CRTAM,CD355 antigen,CD35...

Canine HEK293 Cells
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Pr...
TMPK-00971 CRTAM Protein, Mouse, Recombinant (His)

CRTAM,CD355,CD355 antige...

Mouse HEK293 Cells
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Pr...
TMPK-01136 CD3 epsilon/CD3e Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

TCRE,CD3e,CD3-epsilon,FLJ18683,

Cynomolgus HEK293 Cells
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells ...
TMPJ-00226 SLAMF1 Protein, Mouse, Recombinant (His)

signaling lymphocytic activation ...

Mouse HEK293 Cells
Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, and macrophages. SLAM consists of a extracellular domain (ECD) with two Ig-like domains,transmembrane segment, and cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM). SLAM is thought to play an important role in adhesion between T cells and APCs and has been...
TMPK-01290 PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His)

B7DC,PDL2,CD273, PDCD1 ligand 2,Bt

Cynomolgus HEK293 Cells
PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals. PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 23.73 kDa and the acces...
TMPK-00515 IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His)

Interleukin-1 β,IL-1 beta,IL1B,IL1F2,IL-1B...

Cynomolgus E. coli
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The p...
TMPK-00161 IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi)

Interleukin-1 beta,IL-1 β,IL-1β,IL1F2,IL-1...

Human E. coli
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with C-His-Avi tag. ...
TMPK-00166 PD-L2 Protein, Human, Recombinant (His & Avi)

PDL2,Btdc,Butyrophilin B7-DC,PDCD...

Human HEK293 Cells
PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals. PD-L2 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.3 kDa and the accession nu...
TMPJ-00145 4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)

Tumor necrosis factor receptor su...

Mouse HEK293 Cells
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells...
TMPJ-00877 IL-2 Protein, Rat, Recombinant (His)

白介素,白细胞介素,IL2,Interleukin-2,TCGF,IL-2,...

Rat HEK293 Cells
Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine...
TMPJ-01316 IL-21 Protein, Mouse, Recombinant (His)

白细胞介素,IL-21,Interleukin-21,白介素,IL21

Mouse E. coli
Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%,59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immun...
TMPK-00162 IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated

IL-1 β,IL-1β,IL-1 β/IL-1F2,IL-1 beta,IL1B,Int

Human E. coli
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with C...
TMPH-02275 Lck Protein, Human, Recombinant (His)

Proto-oncogene Lck,T cell-specifi...

Human E. coli
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules...
TMPY-02563 VSTM1 Protein, Human, Recombinant (hFc)

VSTM1,V-set and transmembrane dom...

Human HEK293 Cells
V-set and transmembrane domain containing 1 (VSTM1) is a protein containing the V-set domains. V-set domains are immunoglobulin-like domains resembling the antibody variable region. V-set domains are found in many kinds of protein families, including immunoglobulin light and heavy chains, several T-cells such as CD2, CD4, CD80, and CD86, myelin membrane adhesion molecules, junction adhesion molecules (JAM), tyrosine-protein kinase receptors, and the programmed cell death protein1. VSTM1 Protein,...
TMPJ-00250 LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated

transforming growth factor β1,

Human HEK293 Cells
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with ...
TMPJ-00359 SLAMF3 Protein, Human, Recombinant (His)

Signaling lymphocytic activation ...

Human HEK293 Cells
SLAMF3 (CD229) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature human SLAMF3 consists of a 407 amino acid (aa) extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains. The ECD of human SLAMF3 shares 57% - 59% aa sequence identity with mouse and rat SLAMF3. Within the first two Ig-like domains that are common to all SLAM proteins, human SLAMF3 shares 24% - 39% aa sequence identity with human 2B4, BLAME, CD2F-10, CD84, CRACC, ...
TMPJ-00599 TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His)

TIM3,Hepatitis A virus cell

Human HEK293 Cells
Hepatitis A virus cellular receptor 2(HAVCR2)is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T ...
TMPY-02555 VSTM1 Protein, Human, Recombinant (His)

SIRL-1,UNQ3033,MGC119161,V-set and transme...

Human HEK293 Cells
V-set and transmembrane domain containing 1 (VSTM1) is a protein containing the V-set domains. V-set domains are immunoglobulin-like domains resembling the antibody variable region. V-set domains are found in many kinds of protein families, including immunoglobulin light and heavy chains, several T-cells such as CD2, CD4, CD80, and CD86, myelin membrane adhesion molecules, junction adhesion molecules (JAM), tyrosine-protein kinase receptors, and the programmed cell death protein1. VSTM1 Protein,...
TMPJ-00456 APRIL/TNFSF13 Protein, Mouse, Recombinant (hFc)

TRDL-1,TNFSF13,CD256,TAL...

Mouse HEK293 Cells
Tumor necrosis factor ligand superfamily member 13 belongs to the tumor necrosis factor family. It is also known as APRIL, TALL2, TRDL1, and CD256. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. TNFSF13 is a Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA and plays a role in the regulation of tumor cell growth. It expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissu...
TMPJ-01056 IL-18 Protein, Mouse, Recombinant (His)

Interferon γ-inducing factor,Inte...

Mouse E. coli
Interleukin-18 (IL-18)is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins...
TMPH-02526 Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)

Arginase II,Kidney-type arginase,Type II a...

Mouse E. coli
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium....
TMPY-02214 OTUB1 Protein, Human, Recombinant (His)

OTU deubiquitinase, ubiquitin ald...

Human E. coli
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytoplasm protein that belongs to the peptidase C65 family. OTUB1 is a hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. OTUB1 is a regulator of T-cell anergy, a phenomenon that...
TMPJ-00552 LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated

Leukocyte Immunoglobulin-Like Receptor 2,M...

Human HEK293 Cells
Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa...
TMPY-06983 IFN gamma Protein, Human, Recombinant (E. coli)

Interferon Gamma,IFN γ,IFN gamma,IFG,IFI,干扰素,In...

Human E. coli
IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activ...
TMPJ-00067 BAFFR/TNFRSF13C Protein, Human, Recombinant (His)

BR3,BAFFR,CD268,TNFRSF13C,BAFF R

Human HEK293 Cells
Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF...

重组蛋白

TREML2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01648
Species: Human
Expression System: HEK293 Cells
IL-16 Protein, Human, Recombinant
Cat.No: TMPJ-00451
Species: Human
Expression System: E. coli
OX40L/TNFSF4 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00064
Species: Human
Expression System: HEK293 Cells
CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01135
Species: Cynomolgus
Expression System: HEK293 Cells
CD3 epsilon/CD3e 1-27 peptide Protein, Human, Recombinant (hFc & Avi)
Cat.No: TMPK-00095
Species: Human
Expression System: HEK293 Cells
DOCK8 Protein, Mouse, Recombinant (E. coli, His)
Cat.No: TMPH-02622
Species: Mouse
Expression System: E. coli
TCL1A Protein, Human, Recombinant (His)
Cat.No: TMPY-02518
Species: Human
Expression System: E. coli
VSIR Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPJ-00433
Species: Cynomolgus
Expression System: HEK293 Cells
CD3 epsilon/CD3e 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi)
Cat.No: TMPK-01350
Species: Cynomolgus
Expression System: HEK293 Cells
DOCK8 Protein, Human, Recombinant (His)
Cat.No: TMPH-01207
Species: Human
Expression System: P. pastoris (Yeast)
CD3 epsilon/CD3e epsilon 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPK-01351
Species: Cynomolgus
Expression System: HEK293 Cells
DOCK8 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02623
Species: Mouse
Expression System: P. pastoris (Yeast)
CRTAM Protein, Canine, Recombinant (His)
Cat.No: TMPK-01385
Species: Canine
Expression System: HEK293 Cells
CRTAM Protein, Mouse, Recombinant (His)
Cat.No: TMPK-00971
Species: Mouse
Expression System: HEK293 Cells
CD3 epsilon/CD3e Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
Cat.No: TMPK-01136
Species: Cynomolgus
Expression System: HEK293 Cells
SLAMF1 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00226
Species: Mouse
Expression System: HEK293 Cells
PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His)
Cat.No: TMPK-01290
Species: Cynomolgus
Expression System: HEK293 Cells
IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00515
Species: Cynomolgus
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00161
Species: Human
Expression System: E. coli
PD-L2 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00166
Species: Human
Expression System: HEK293 Cells
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00145
Species: Mouse
Expression System: HEK293 Cells
IL-2 Protein, Rat, Recombinant (His)
Cat.No: TMPJ-00877
Species: Rat
Expression System: HEK293 Cells
IL-21 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01316
Species: Mouse
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00162
Species: Human
Expression System: E. coli
Lck Protein, Human, Recombinant (His)
Cat.No: TMPH-02275
Species: Human
Expression System: E. coli
VSTM1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02563
Species: Human
Expression System: HEK293 Cells
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPJ-00250
Species: Human
Expression System: HEK293 Cells
SLAMF3 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00359
Species: Human
Expression System: HEK293 Cells
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His)
Cat.No: TMPJ-00599
Species: Human
Expression System: HEK293 Cells
VSTM1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02555
Species: Human
Expression System: HEK293 Cells
APRIL/TNFSF13 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00456
Species: Mouse
Expression System: HEK293 Cells
IL-18 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01056
Species: Mouse
Expression System: E. coli
Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02526
Species: Mouse
Expression System: E. coli
OTUB1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02214
Species: Human
Expression System: E. coli
LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated
Cat.No: TMPJ-00552
Species: Human
Expression System: HEK293 Cells
IFN gamma Protein, Human, Recombinant (E. coli)
Cat.No: TMPY-06983
Species: Human
Expression System: E. coli
BAFFR/TNFRSF13C Protein, Human, Recombinant (His)
Cat.No: TMPJ-00067
Species: Human
Expression System: HEK293 Cells
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