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Search Results for " cd34 "

19

抑制剂 & 化合物

1

TargetMol 试剂盒

19

重组蛋白

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Cat. No.	Product Name	Form	Specificity Of Inhibition
C0066	Human CD34+ Cell Enrichment Kit (positive selection) 人 CD34+ 细胞富集试剂盒 (阴选)	Suspension in bottle	适用于从人脐带血单个核细胞（CBMC）或外周血单个核细胞（PBMC）中富集 <em>CD</em><em>34</em>+ 细胞。

TargetMol 试剂盒

人 CD34+ 细胞富集试剂盒 (阴选)

Cat.No: C0066

Cat. No.	Product Name	Target	Signaling Pathways
TMAZ-0023A	Anti-CD34 Monoclonal Antibody-APC
	Anti-CD34 Monoclonal Antibody-APC is a biotin-conjugated humanized rabbit antibody targeting CD34. Anti-CD34 Monoclonal Antibody-APC can be used FACS.
TMAZ-0023P	Anti-CD34 Monoclonal Antibody-PE
	Anti-CD34 Monoclonal Antibody-PE is a biotin-conjugated humanized rabbit antibody targeting CD34. Anti-CD34 Monoclonal Antibody-PE can be used FACS.
TMAZ-0023B	Anti-CD34 Monoclonal Antibody-Biotin
	Anti-CD34 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CD34. Anti-CD34 Monoclonal Antibody-Biotin can be used FACS.
TMAZ-0023A4	Anti-CD34 Monoclonal Antibody-AF488
	Anti-CD34 Monoclonal Antibody-AF488 is a biotin-conjugated humanized rabbit antibody targeting CD34. Anti-CD34 Monoclonal Antibody-AF488 can be used FACS.
TMAZ-0023A6	Anti-CD34 Monoclonal Antibody-AF647
	Anti-CD34 Monoclonal Antibody-AF647 is a biotin-conjugated humanized rabbit antibody targeting CD34. Anti-CD34 Monoclonal Antibody-AF647 can be used FACS.
TMAZ-0023A5	Anti-CD34 Monoclonal Antibody-AF555
	Anti-CD34 Monoclonal Antibody-AF555 is a biotin-conjugated humanized rabbit antibody targeting CD34. Anti-CD34 Monoclonal Antibody-AF555 can be used FACS.
T8342	BRD9876 6-叔丁基-2,3-二氰基萘	Others; Kinesin; Microtubule Associated	Cytoskeletal Signaling; Others
	BRD9876 是一种 MM1S 生长的选择性抑制剂，可将驱动蛋白 5 锁定在增强微管结合的状态，从而导致 MT 的捆绑和稳定。它特异性靶向微管结合的 Eg5，选择性抑制 CD34 细胞的骨髓瘤，有用于多发性骨髓瘤的研究潜力。
T2040	OAC1 BAS 00287861	OCT	Membrane transporter/Ion channel
	OAC1 (BAS 00287861) 是一种能够激活 Octamer 结合转录因子 4 的化合物。它提高了 iPSC 重编程效率并加速重编程过程。
T2562	Eltrombopag SB-497115,SB-497115-GR,艾曲波帕	Thrombin	Proteases/Proteasome
	Eltrombopag (SB-497115-GR) 是一种具有巨核细胞生成刺激活性的口服活性血小板生成素受体激动剂，可结合并刺激血小板血小板生成素受体，用于血小板减少的某些病症研究。
T6825	Eltrombopag Olamine Promacta Olamine,Revolade,艾曲泊帕乙醇胺盐,Eltrombopag diethanolamine salt,SB497115,艾曲波帕乙醇胺盐,SB-497115GR	Thrombin	Proteases/Proteasome
	Eltrombopag Olamine (Eltrombopag diethanolamine salt) 是 Eltrombopag 的口服活性乙醇胺盐，是一种血小板生成素(TPO)受体激动剂，用于血小板减少的某些病症研究。
T28663	Sarmustine NSC-364432,SarCNU,Sarcosinamide,NSC 364432,NSC364432	Others	Others
	Sarmustine (SarCNU) 是一种具有抗癌活性的烷化剂，通过 p53 依赖性和 p53 非依赖性途径抑制前列腺癌细胞的生长。Sarmustine 在体外介导 P140K 甲基鸟嘌呤-DNA-甲基转移酶转导的人 CD34(+)细胞的选择。
T14919	CDKI-73	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	CDKI-73 是一种具有口服活性的 CDK9抑制剂，其对 CDK9、CDK1 和 CDK2 的Ki 值分别为 4 nM、4 nM 和 3 nM。CDKI-73 可下调 RNA 聚合酶 II 的磷酸化。CDKI-73 也是一种 Rab11 的抑制剂。
T23400	StemRegenin 1 (hydrochloride) StemRegenin 1 (hydrochloride) (1227633-49-9 free base)	Others	Others
	StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells).
T69241	MEISi-1	Others	Others
	MEISi-1 is a novel MEIS inhibitor (MEISi), significantly inhibiting MEIS-luciferase reporters in vitro and inducing murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo.
T73451	BAY-364 BAY-299N	Others	Others
	BAY-364 (BAY-299N) 为TAF1第二溴结构域抑制剂。对于Kasumi-1细胞、CD34+细胞及K562细胞中的TAF1显示出抑制作用，其IC50值分别为1.0 µM、10.4 µM与10.0 µM。
T69296	PHA-680626	Others	Others
	PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases. PHA-680626 inhibits Plk1 (IC50 = 0.53 μM), Plk2 (IC50 = 0.07 μM) and Plk3 (IC50 = 1.61 μM).
T10567	BMS-214662	Raf	MAPK
	BMS-214662是一种有效的、有选择性的 farnesyl transferase 抑制剂，可诱导原始CD34+慢性髓性白血病(CML)干细胞/祖细胞的线粒体凋亡，具有选择性靶向CML 干细胞/祖细胞的能力，具有抗肿瘤活性。
T64110	Debio 0617B	Others	Others
	Debio 0617B 是一种多激酶抑制剂，能够降低原代人 AML CD34+干/祖细胞的维持和自我更新。Debio 0617B 靶向 STAT3/STAT5 信号上游关键激酶，如 JAK、ABL、SRC 和 III/V 类受体酪氨酸激酶。Debio 0617B 能够用于研究 STAT3 驱动的实体瘤。
T83763	EPI-X4 TFA Endogenous Peptide Inhibitor of CXCR4
	EPI-X4是一种源于人血清白蛋白408-423氨基酸的内源性肽段，是趋化因子(C-X-C基序)受体4 (CXCR4)的拮抗剂。在0.8至1,000µM的浓度范围内，EPI-X4能抑制表达CXCR4的HEK293细胞中由趋化因子(C-X-C基序)配体12 (CXCL12)诱发的钙离子动员和受体内化。EPI-X4还能抑制CXCL12诱导的Jurkat T细胞和人类CD34+造血干细胞的迁移。体内实验中，EPI-X4（16µmol/kg）在急性过敏性气道高嗜酸性粒细胞疾病的小鼠模型中减少了Cxcr4依赖的炎症细胞气道浸润。慢性肾脏病患者尿液中EPI-X4的水平增高，并与肾小球滤过率(GFR)成反比。

化合物

Anti-CD34 Monoclonal Antibody-APC

Cat.No: TMAZ-0023A

Anti-CD34 Monoclonal Antibody-PE

Cat.No: TMAZ-0023P

Anti-CD34 Monoclonal Antibody-Biotin

Cat.No: TMAZ-0023B

Anti-CD34 Monoclonal Antibody-AF488

Cat.No: TMAZ-0023A4

Anti-CD34 Monoclonal Antibody-AF647

Cat.No: TMAZ-0023A6

Anti-CD34 Monoclonal Antibody-AF555

Cat.No: TMAZ-0023A5

Cat.No: T8342

Synonym: 6-叔丁基-2,3-二氰基萘

Target: Others, Kinesin, Microtubule Associated

Cat.No: T2040

Synonym: BAS 00287861

Target: OCT

Cat.No: T2562

Synonym: SB-497115,SB-497115-GR,艾曲波帕

Target: Thrombin

Eltrombopag Olamine

Cat.No: T6825

Synonym: Promacta Olamine,Revolade,艾曲泊帕乙醇胺盐,Eltrombopag diethanolamine salt,SB497115,艾曲波帕乙醇胺盐,SB-497115GR

Target: Thrombin

Cat.No: T28663

Synonym: NSC-364432,SarCNU,Sarcosinamide,NSC 364432,NSC364432

Target: Others

Cat.No: T14919

Target: Apoptosis, CDK

StemRegenin 1 (hydrochloride)

Cat.No: T23400

Synonym: StemRegenin 1 (hydrochloride) (1227633-49-9 free base)

Target: Others

Cat.No: T69241

Target: Others

Cat.No: T73451

Synonym: BAY-299N

Target: Others

Cat.No: T69296

Target: Others

Cat.No: T10567

Target: Raf

Cat.No: T64110

Target: Others

Cat.No: T83763

Synonym: Endogenous Peptide Inhibitor of CXCR4

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00709	CD34 Protein, Human, Recombinant (His) CD34 molecule	Human	HEK293 Cells
	CD34 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29 kDa and the accession number is P28906-1.
TMPY-00708	CD34 Protein, Human, Recombinant (hFc) CD34 molecule	Human	HEK293 Cells
	CD34 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54 kDa and the accession number is P28906-1.
TMPY-03031	CD34 Protein, Rat, Recombinant (hFc) CD34 molecule	Rat	HEK293 Cells
	CD34 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.5 kDa and the accession number is B1PLB1.
TMPY-05772	CD34 Protein, Human, Recombinant (His), Biotinylated CD34 molecule	Human	HEK293 Cells
	CD34 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29 kDa and the accession number is P28906-1.
TMPY-06764	CD34 Protein, Mouse, Recombinant (hFc) CD34 molecule,AU040960	Mouse	HEK293 Cells
	CD34 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.92 kDa and the accession number is NP_001104529.1.
TMPY-05582	CD34 Protein, Human, Recombinant (hFc), Biotinylated CD34 molecule	Human	HEK293 Cells
	CD34 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54 kDa and the accession number is P28906-1.
TMPY-01652	CD34 Protein, Mouse, Recombinant (His) CD34 molecule,AU040960	Mouse	HEK293 Cells
	CD34 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the accession number is Q543Y2.
TMPY-06716	CD34 Protein, Human, Recombinant (His & Avi), Biotinylated CD34 molecule	Human	HEK293 Cells
	CD34 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 30.75 kDa and the accession number is NP_001020280.1.
TMPY-00021	PADI4 Protein, Human, Recombinant (His) PADI5,PAD4,PDI4,peptidyl arginine deiminase, type IV,PAD,PDI...	Human	Baculovirus Insect Cells
	Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres...
TMPK-01270	CD117 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) KIT,PBT,c-kit,CD117,SCFR,ckit	Cynomolgus,Rhesus	HEK293 Cells
	The c-kit proto-oncogen (CD117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and megakaryocytic cell lineages.
TMPK-00777	CD117 Protein, Mouse, Recombinant (His) ckit,PBT,SCFR,KIT,CD117,c-kit	Mouse	HEK293 Cells
	The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and megakaryocytic cell lineages. CD117 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 56.63 kDa and the accession number is P05...
TMPK-01213	PODXL2 Protein, Human, Recombinant (His) BRN1,oct-8,UNQ1861/PRO3742,brain-1,EG,Endoglycan,PODLX2,OTF8	Human	HEK293 Cells
	Transmembrane protein endoglycan (PODXL2), which belongs to the CD34-family of highly glycosylated sialomucins. Endoglycan is broadly expressed in the developing mouse brains and is proteolytically shed in vitro in mouse neurons and in vivo in mouse brains. Endoglycan shedding in primary neurons was mediated by the transmembrane protease a disintegrin and metalloprotease 10 (ADAM10), but not by its homolog ADAM17. PODXL2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells wi...
TMPK-00685	CYTL1 Protein, Mouse, Recombinant (hFc) CYTL1,C4orf4,Protein C17	Mouse	HEK293 Cells
	Cytokine-like protein 1 (Cytl1), also named Protein C17 or C4orf4 is located on human chromosome 4p15-p16 and encodes a polypeptide of 126 amino acid residues that displays characteristics of a secretory protein. Cytl1 is expressed by a sub-population of CD34 human mononuclear cells from bone marrow and cord blood, and by chondrocytes (cartilage-forming cells).
TMPY-00044	CYTL1 Protein, Human, Recombinant (mFc) C4orf4,C17,cytokine-like 1	Human	HEK293 Cells
	Cytokine-like protein 1 (CYTL1) is a small widely expressed secreted protein lacking significant primary sequence homology to any other known protein. Cytokine-like 1 (CYTL1) is a novel potential cytokine that was first identified in CD34(+) cells derived from bone marrow and cord blood, and it was also found using our immunogenomics strategy. CYTL1 expression appears to be highest in the hematopoietic system and in chondrocytes; however, maintenance of cartilage in mouse models of arthritis is ...
TMPK-00805	CD117 Protein, Human, Recombinant (His & Avi), Biotinylated CD117,EC 2.7.10,EC 2.7.10.1,c-kit,KIT,SCFR,PBT,ckit	Human	HEK293 Cells
	The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and megakaryocytic cell lineages. CD117 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 58.60 kDa and the...
TMPK-01088	PODXL2 Protein, Mouse, Recombinant (His) UNQ1861/PRO3742,oct-8,PODLX2,OTF8,Endoglycan,BRN1,EG,brain-1	Mouse	HEK293 Cells
	Transmembrane protein endoglycan (PODXL2), which belongs to the CD34-family of highly glycosylated sialomucins. Endoglycan is broadly expressed in the developing mouse brains and is proteolytically shed in vitro in mouse neurons and in vivo in mouse brains. Endoglycan shedding in primary neurons was mediated by the transmembrane protease a disintegrin and metalloprotease 10 (ADAM10), but not by its homolog ADAM17. PODXL2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells wi...
TMPJ-00895	SCF Protein, Rat, Recombinant (HEK293, His) steel factor,Mast cell growth factor,SLF,MGFSHEP7,SCFStem ce...	Rat	HEK293 Cells
	SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II...
TMPJ-00521	CHL2 Protein, Mouse, Recombinant (His) CHRDL2,chordin-like 2,chordin-like protein 2,BNF-1	Mouse	HEK293 Cells
	Mouse Chordin-Like 2, also known as CHL2, is a novel chordin family member with structural homology to CHL1 which is implicated in tumor angiogenesis. The mouse CHL2 gene encodes a 426 amino acids (aa) protein with a 25 aa signal peptide. The mature chain of CHL2 protein contains two potential N-linked glycosylation sites, one putative NLS and three 63 aa cysteine-rich von Willebrand type C repeats (CRs). CHL2 gene is weakly expressed in the liver and kidney, partly expressed in the connective ...
TMPY-01345	ACBD6 Protein, Human, Recombinant (His) acyl-CoA binding domain containing 6	Human	Baculovirus Insect Cells
	Human acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. In mammals, there are six members of the acyl-CoA binding domain-containing (ACBD) family, and their annotation is not uniform. All six ACBD proteins contain an ACB domain at the N terminus, but they do not share significant homology at the C-terminal region. ACBD6 is a 32 kDa protein that is predicted by sequenc...

重组蛋白

CD34 Protein, Human, Recombinant (His)

Cat.No: TMPY-00709

Species: Human

Expression System: HEK293 Cells

CD34 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00708

Species: Human

Expression System: HEK293 Cells

CD34 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03031

Species: Rat

Expression System: HEK293 Cells

CD34 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05772

Species: Human

Expression System: HEK293 Cells

CD34 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-06764

Species: Mouse

Expression System: HEK293 Cells

CD34 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05582

Species: Human

Expression System: HEK293 Cells

CD34 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01652

Species: Mouse

Expression System: HEK293 Cells

CD34 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06716

Species: Human

Expression System: HEK293 Cells

PADI4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00021

Species: Human

Expression System: Baculovirus Insect Cells

CD117 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-01270

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD117 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00777

Species: Mouse

Expression System: HEK293 Cells

PODXL2 Protein, Human, Recombinant (His)

Cat.No: TMPK-01213

Species: Human

Expression System: HEK293 Cells

CYTL1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00685

Species: Mouse

Expression System: HEK293 Cells

CYTL1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00044

Species: Human

Expression System: HEK293 Cells

CD117 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00805

Species: Human

Expression System: HEK293 Cells

PODXL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01088

Species: Mouse

Expression System: HEK293 Cells

SCF Protein, Rat, Recombinant (HEK293, His)

Cat.No: TMPJ-00895

Species: Rat

Expression System: HEK293 Cells

CHL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00521

Species: Mouse

Expression System: HEK293 Cells

ACBD6 Protein, Human, Recombinant (His)

Cat.No: TMPY-01345

Species: Human

Expression System: Baculovirus Insect Cells

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