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Search Results for " ccrcc "
Targets Recommended: Gamma-secretase

5

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T3633 Crenigacestat

LY3039478

Gamma-secretase Neuroscience; Proteases/Proteasome; Stem Cells
Crenigacestat (LY3039478) 是一种口服具有活性的Notch 和γ-secretase 的抑制剂,其在多种肿瘤细胞中的IC50为 ∼1nM。
T8344 CPTH2

Apoptosis; Histone Acetyltransferase Apoptosis; Chromatin/Epigenetic
CPTH2 是一种组蛋白乙酰基转移酶抑制剂。它选择性地抑制Gcn5对组蛋白 H3 的乙酰化,通过抑制乙酰转移酶p300 (KAT3B)诱导凋亡并降低透明细胞肾癌细胞系的侵袭性。
T77810 XPW1

CDK Cell Cycle/Checkpoint
XPW1 是一种新的强效和选择性 CDK9 抑制剂,具有抗肿瘤活性,转录抑制ccRCC细胞中的DNA修复程序。XPW1 可用于研究透明细胞肾细胞癌。
T16679 Belzutifan

PT2977,MK-6482

HIF Angiogenesis; Chromatin/Epigenetic
Belzutifan (MK-6482) 是具有口服活性的 HIF-2α选择性抑制剂,IC50为 9 nM。Belzutifan 具有提高的效力和改善的药代动力学特征。Belzutifan (MK-6482) 可以抑制透明细胞肾细胞癌。
T61442 HIF-1/2α-IN-1

Others Others
HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrease HIF-1α levels. This compound is particularly valuable for research on clear cell renal cell carcinoma (ccRCC) [1].

化合物

Crenigacestat
Cat.No: T3633
Synonym: LY3039478
Target: Gamma-secretase
CPTH2
Cat.No: T8344
Synonym:
Target: Apoptosis, Histone Acetyltransferase
XPW1
Cat.No: T77810
Synonym:
Target: CDK
Belzutifan
Cat.No: T16679
Synonym: PT2977,MK-6482
Target: HIF
HIF-1/2α-IN-1
Cat.No: T61442
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPK-00935 APLP2 Protein, Human, Recombinant (His)

APPL2,YWK-II,APPH,CDEI box-binding,CDEBP

Human HEK293 Cells
Amyloid β precursor-like protein 2 (APLP2) has been determined to serve an important role in the progression of a number of cancer types. APLP2 expression was significantly associated with disease-specific survival (P<0.001). APLP2 may be used to potentially predict patient prognosis, and to guide clinical diagnosis and treatment in CCRCC.

重组蛋白

APLP2 Protein, Human, Recombinant (His)
Cat.No: TMPK-00935
Species: Human
Expression System: HEK293 Cells
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