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Search Results for " cck receptor "

Targets Recommended: Others

31

抑制剂 & 化合物

1

化合物库

1

重组蛋白

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Cat. No.	Product Name
L2610	神经递质受体化合物库		1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；

化合物库

神经递质受体化合物库

Cat.No: L2610

Compounds: 1513

Cat. No.	Product Name	Target	Signaling Pathways
T10707	CCK-B Receptor Antagonist 2	Others	Others
	CCK-B Receptor Antagonist 2 is a potent and orally active antagonist of Gastrin/CCK-B (IC50: 0.43 nM). It also inhibits gastrin/CCK-A activity (IC50: 1.82 μM).
T13261	CCK-B Receptor Antagonist 1	Others	Others
	CCK-B Receptor Antagonist 1 is a cholecystokinin B (CCK-B) receptor agonist and has the potential of reducing the secretion of gastric acid.
T12404	CCK-A receptor inhibitor 1	cholecystokinin	GPCR/G Protein
	CCK-A receptor inhibitor 1 是一种有效的缩胆囊素 A (CCK-A) 受体抑制剂(IC50：340 nM）。CCK-A receptor inhibitor 1 可用于研究与消化系统相关的疾病。
TP1197	Sincalide SQ19844,辛卡利特,CCK-8,Cholecystokinin octapeptide	Others	Others
	Sincalide (CCK-8) 是一种速效的胆囊收缩素的氨基酸多肽激素类似物，可在胆囊造影术中静脉使用。它的肝胆生理作用是增加胆汁的分泌，使胆囊收缩并使 Oddi 的括约肌松弛，从而使胆汁排入十二指肠。它是一种通过注射促进胆囊收缩并帮助诊断胆囊和胰腺疾病的药物。
T1052	Proglumide 二丙谷酰胺	cholecystokinin	GPCR/G Protein
	Proglumide (Binoside) 是一种非肽的、口服具有活性的胆囊收缩素(CCK)-A/B 受体拮抗剂。它能够选择性阻断 CCK 在中枢神经系统中的作用。它能够抑制胃分泌，具有保护胃十二指肠粘膜的能力，并表现出抗癫痫和抗氧化活性。
TQ0062	Nastorazepide Z-360	cholecystokinin	GPCR/G Protein
	Nastorazepide 是一种选择性的、口服有效的1,5-苯并二氮杂环衍生物胃泌素/胆囊收缩素2（CCK-2）受体拮抗剂，具有抗肿瘤的潜能。
T2312	Loxiglumide CR-1505,氯谷胺	cholecystokinin	GPCR/G Protein
	Loxiglumide (CR-1505) 是一种缩胆囊素受体拮抗剂。
T4579	Pentagastrin 五肽胃泌素,ICI-50123	Others; cholecystokinin	GPCR/G Protein; Others
	Pentagastrin (ICI-50123) 是一种选择性的胆囊收缩素 B(CCKB) 受体激动剂，IC50=11 nM。它能够增强胃粘膜对酸的防御机制，并保护胃粘膜免受损伤。
T14932	Ceruletide Cerulein,Caerulein,雨蛙素,FI-6934	cholecystokinin	GPCR/G Protein
	Ceruletide (Caerulein) 是一种十肽，是一种安全有效的胆囊收缩剂，是一种胆囊收缩素受体激动剂，对胆囊肌肉和胆管有直接的痉挛性作用。
T27640	Itriglumide CR2945,CR 2945,CR-2945	cholecystokinin	GPCR/G Protein
	Itriglumide (CR-2945) 是一种胆囊收缩素（CCK）-2 受体拮抗剂，具有抗分泌和抗溃疡作用。
T9343	N-Cbz-DL-tryptophan	cholecystokinin	GPCR/G Protein
	N-Cbz-DL-tryptophan 是一种胆囊收缩素受体拮抗剂，可消除离体心脏对 CCK-8 的反应。
T14932L	Ceruletide Ammonium acetate FI-6934 Ammonium acetate,Caerulein Ammonium acetate,Ceruletide Ammonium acetate (17650-98-5 free base)	cholecystokinin	GPCR/G Protein
	Ceruletide Ammonium acetate (FI-6934 Ammonium acetate) 是一种胆囊收缩素 (CCK) 受体激动剂。它是一种安全有效的胆囊动力剂和小肠和胰腺外分泌兴奋剂。
TP1931L1	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base)	cholecystokinin	GPCR/G Protein
	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) 是广谱神经肽反向激动剂和拮抗剂。 ghrelin 受体的强效完全反向激动剂(EC50 = 5.2 nM)；减少组成型生长素释放肽受体信号传导。它也是速激肽、缓激肽、CCK 和铃蟾肽受体的拮抗剂。在体外诱导细胞凋亡并抑制癌细胞生长。
T15101	Devazepide L-364,718,地伐西匹,MK-329	Others	Others
	Devazepide is a competitive and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor (IC50s: 81 pM, 45 pM, and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively).
T22666	CI-988 CI 988	Others	Others
	CCK2 (CCK-B) receptor antagonist
T28340	PD-135666 PD 135666	Others	Others
	PD-135666 is an antagonist of CCK receptor.
T27014	CI-1015 CI1015,CI 1015,PD 144598	Others	Others
	CI-1015 is a CCK-B receptor antagonist with oral activity.
T13084	Tarazepide	Others	Others
	Tarazepide is a potent and specific antagonist of CCK-A receptor.
T29502	A 70874 A-70874,A70874	Others	Others
	A70874 has high selectivity and potency for cholecystokinin (CCK) a receptor.
T23886	Cholecystokinin (27-32)-amide Cholecystokinin (27-32)-NH2	Others	Others
	Cholecystokinin (27-32)-amide is a CCK receptor antagonist.
T27900	LY 219057 LY-219057,LY219057	Others	Others
	LY 219057 is a potent, competitive, and specific antagonist of CCK receptor on the exocrine pancreas.
T28342	PD-149164 PD 149164,PD149164	Others	Others
	PD-149164 is an agonist of the CCK-A receptor.
T27774	L-740093 L 740093	Others	Others
	L-740093 is a specific antagonist of CCK-B receptor.
T25553	Jmv 332 Jmv-332,Jmv332	Others	Others
	Jmv 332 is a cyclic analog of the C-terminal hexapeptide of CCK. It is a CCK/gastrin receptor agonist.
T17274	YM022	CCR	Immunology/Inflammation; Microbiology/Virology
	YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively.
T28331	PD 136450 Cam1189,PD136450,Cam-1189,PD-136450,Cam 1189	Others	Others
	Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. Gastrin (cholecystokinin type B (CCK-B)) receptor antagonists may help to elucidate the physiological role o
T27772	L-736380 L-736,380,L 736380,L736,380,L 736,380	Others	Others
	L-736380 is a CCK-B receptor antagonist. L-736,380 dose-dependently inhibited gastric acid secretion in anesthetized rats (ID(50), 0.064 mg/kg) and ex vivo binding of [(125)I]CCK-8S in BKTO mice brain membranes (ED(50), 1.7 mg/kg).
T62039	L-365260 hemihydrate	Others	Others
	L-365260 hemihydrate 是选择性的、具有口服活性的非肽胃泌素和脑胆囊收缩素受体 (CCK-B) 拮抗剂，Kis 值分别为 1.9 nM 和 2.0 nM。L-365260 hemihydrate 以竞争性方式与豚鼠胃泌素和脑 CCK 受体相互作用。
TP1931	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
	Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. In
T68482	CE-326597	Others	Others
	CE-326597 is a potent and selective CCK1R agonist. The type 1 cholecystokinin receptor (CCK1R) has multiple physiologic roles relating to nutrient homeostasis,including mediation of postcibal satiety. The type 1 cholecystokinin (CCK) receptor (CCK1R) is a key mediator of postcibal satiety and a potential target for drugs that may be useful to prevent and/or treat obesity.
T8761	[Leu15]-Gastrin I human Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2	Others	Others
	[Leu15]-Gastrin I human (Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2) 基因编码人体内的蛋白质 [Leu15]-胃泌素 I。在人类染色体中，GAST 基因定位于 17q21.2。胃窦中的 G 细胞产生 [Leu15]-胃泌素 I 的前体前胃泌素。前胃泌素经过裂解和加工产生胃泌素，它对整个胃肠道上皮细胞具有营养作用。胃泌素对消化系统的生长至关重要，并刺激壁细胞产生胃酸。胃泌素通过称为胆囊收缩素(CCK) 或 CCK-B 受体 (CCK-BR) 的 G 蛋白偶联受体发挥其功能。胃泌素的释放受到食物的刺激，尤其是蛋白质饮食，并受到非常低的 pH 值的抑制。萎缩性胃炎、幽门螺杆菌感染和长期服用质子泵抑制剂感染可能导致胃泌素过度表达。胃腺癌显示高水平的胃泌素。

化合物

CCK-B Receptor Antagonist 2

Cat.No: T10707

Target: Others

CCK-B Receptor Antagonist 1

Cat.No: T13261

Target: Others

CCK-A receptor inhibitor 1

Cat.No: T12404

Target: cholecystokinin

Cat.No: TP1197

Synonym: SQ19844,辛卡利特,CCK-8,Cholecystokinin octapeptide

Target: Others

Cat.No: T1052

Synonym: 二丙谷酰胺

Target: cholecystokinin

Cat.No: TQ0062

Synonym: Z-360

Target: cholecystokinin

Cat.No: T2312

Synonym: CR-1505,氯谷胺

Target: cholecystokinin

Cat.No: T4579

Synonym: 五肽胃泌素,ICI-50123

Target: Others, cholecystokinin

Cat.No: T14932

Synonym: Cerulein,Caerulein,雨蛙素,FI-6934

Target: cholecystokinin

Cat.No: T27640

Synonym: CR2945,CR 2945,CR-2945

Target: cholecystokinin

N-Cbz-DL-tryptophan

Cat.No: T9343

Target: cholecystokinin

Ceruletide Ammonium acetate

Cat.No: T14932L

Synonym: FI-6934 Ammonium acetate,Caerulein Ammonium acetate,Ceruletide Ammonium acetate (17650-98-5 free base)

Target: cholecystokinin

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate

Cat.No: TP1931L1

Synonym: [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base)

Target: cholecystokinin

Cat.No: T15101

Synonym: L-364,718,地伐西匹,MK-329

Target: Others

Cat.No: T22666

Synonym: CI 988

Target: Others

Cat.No: T28340

Synonym: PD 135666

Target: Others

Cat.No: T27014

Synonym: CI1015,CI 1015,PD 144598

Target: Others

Cat.No: T13084

Target: Others

Cat.No: T29502

Synonym: A-70874,A70874

Target: Others

Cholecystokinin (27-32)-amide

Cat.No: T23886

Synonym: Cholecystokinin (27-32)-NH2

Target: Others

Cat.No: T27900

Synonym: LY-219057,LY219057

Target: Others

Cat.No: T28342

Synonym: PD 149164,PD149164

Target: Others

Cat.No: T27774

Synonym: L 740093

Target: Others

Cat.No: T25553

Synonym: Jmv-332,Jmv332

Target: Others

Cat.No: T17274

Target: CCR

Cat.No: T28331

Synonym: Cam1189,PD136450,Cam-1189,PD-136450,Cam 1189

Target: Others

Cat.No: T27772

Synonym: L-736,380,L 736380,L736,380,L 736,380

Target: Others

L-365260 hemihydrate

Cat.No: T62039

Target: Others

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

Cat.No: TP1931

Cat.No: T68482

Target: Others

[Leu15]-Gastrin I human

Cat.No: T8761

Synonym: Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03991	DBI Protein, Human, Recombinant (His) diazepam binding inhibitor (GABA receptor modulator...	Human	E. coli
	The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine receptor and facilitates transport of cholesterol to the inner membrane to stimulate steroid synthesis. Through this action, DBI indirectly modulates gamma-aminobutyric acid (GABA)-mediated inhibitory neurotransmission. DBI can be postulated as a candidate gene for psychiatric phenot...

重组蛋白

DBI Protein, Human, Recombinant (His)

Cat.No: TMPY-03991

Species: Human

Expression System: E. coli

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