11
1
10
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0005 |
Cell Counting Kit-8 (CCK-8)
Cell Counting Kit-8 (CCK-8) |
Solution in bottle |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1197 |
Sincalide
SQ19844,辛卡利特,CCK-8,Cholecystokinin octapeptide |
Others | Others |
Sincalide (CCK-8) 是一种速效的胆囊收缩素的氨基酸多肽激素类似物,可在胆囊造影术中静脉使用。它的肝胆生理作用是增加胆汁的分泌,使胆囊收缩并使 Oddi 的括约肌松弛,从而使胆汁排入十二指肠。它是一种通过注射促进胆囊收缩并帮助诊断胆囊和胰腺疾病的药物。 | |||
TP1198 |
Sincalide ammonium
SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium |
cholecystokinin | GPCR/G Protein |
Sincalide ammonium (CCK-8 ammonium) 是一种有效的氨基酸多肽激素胆囊收缩素 (CCK) 的类似物,是保留了 CCK 的大部分生物活性的活性片段。Sincalide ammonium 促进胆汁的分泌,使胆囊收缩并使 Oddi 的括约肌松弛,从而促进胆汁排入十二指肠。Sincalide ammonium 可通过注射促进胆囊收缩,常用于辅助诊断胆囊、胰腺疾病和胆囊造影术。 | |||
T9343 |
N-Cbz-DL-tryptophan
|
cholecystokinin | GPCR/G Protein |
N-Cbz-DL-tryptophan 是一种胆囊收缩素受体拮抗剂,可消除离体心脏对 CCK-8 的反应。 | |||
TP1931L1 |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base) |
cholecystokinin | GPCR/G Protein |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) 是广谱神经肽反向激动剂和拮抗剂。 ghrelin 受体的强效完全反向激动剂(EC50 = 5.2 nM);减少组成型生长素释放肽受体信号传导。它也是速激肽、缓激肽、CCK 和铃蟾肽受体的拮抗剂。在体外诱导细胞凋亡并抑制癌细胞生长。 | |||
T34669 |
Snf 8906
Snf-8906,Snf8906 |
Others | Others |
Snf 8906 is a CCK-8 analog. | |||
T25108 |
ARL 15849XX
ARL15849XX,FPL15849,FPL-15849,FPL 15849,ARL-15849XX |
Others | Others |
ARL 15849XX, a CCK-8 analog, is a novel anti-obesity agent. | |||
T25437 |
Fpl 14294
Fpl-14294,Fpl14294 |
Others | Others |
Fpl 14294 is a novel CCK-8 agonist with effective intranasal anorectic activity in the rat. | |||
T16906 |
Sograzepide
YM-220,Netazepide,YF 476 |
Others | Others |
Sograzepide is an effective and highly selective Gastrin/CCK-B antagonist (IC50: 0.1 nM), has an inhibitory effect on Gastrin/CCK-A activity (IC50: 502 nM). Sograzepide replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine, and cloned human Gastrin/CCK-B receptors (Ki: 0.068, 0.62 and 0.19 nM, respectively). | |||
T15105 |
Dexloxiglumide
|
Others | Others |
Dexloxiglumide, an active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8). It is a selective antagonist of cholecystokinin type A (CCKA) receptors. | |||
T60700 |
Butabindide
|
Others | Others |
Butabindide (UCL-1397) 是三肽肽酶II (TPP II)的选择性抑制剂,对 TPP I 和TPP II 的Ki 值分别为 10 μM 和 7 nM。Butabindide 抑制 TPP II 以保护 CCK-8 免于失活。 | |||
T36629 |
Givinostat
|
Others | Others |
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00678 |
CALCA/CGRP Protein, Mouse, Recombinant (hFc)
CGRP,Katacalcin,PDN-21,CGRP-I,CGRP1,Calcitonin 1,Calcitonin,... |
Mouse | HEK293 Cells |
Specific fragments of methylation changes in the target gene (Calca) were identified by IGV analysis. CGRP was applied to compare the effects on ASCs-T2DM morphology via phalloidin staining, proliferation through CCK-8 assay, and osteogenic differentiation with osteogenic staining, qPCR, and repair of calvarial defect. Furthermore, 5-azacytidine (5-az) was used to intervene ASCs-T2DM to verify the relationship between the methylation level of the target fragment and expression of Calca. | |||
TMPY-04123 |
CEACAM1 Protein, Human, Recombinant (His & hFc)
CEACAM‑1,carcinoembryonic antigen-related cell adhesion mole... |
Human | HEK293 Cells |
CEACAM1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 71.4 kDa and the accession number is P13688-8. | |||
TMPJ-00808 |
CD45RA Protein, Human, Recombinant (His)
PTPRC,CD45R,CD45,LCA,protein tyrosine phosphatase, receptor ... |
Human | HEK293 Cells |
CD45RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-135 KDa and the accession number is P08575-8. | |||
TMPH-01705 |
Mucin-1/MUC1 Protein, Human, Recombinant (Isoform 8, His)
Peanut-reactive urinary mucin,Isoform 8 of Mucin-1,... |
Human | E. coli |
Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8. | |||
TMPY-00717 |
CEACAM1 Protein, Human, Recombinant (His)
CEACAM‑1,BGP1,BGP,carcinoembryonic antigen-related cell adhe... |
Human | HEK293 Cells |
CEACAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.8 kDa and the accession number is P13688-8. | |||
TMPJ-00828 |
Tau-F Protein, Human, Recombinant
Neurofibrillary tangle protein,Paired helical filament-tau,M... |
Human | E. coli |
Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are def... | |||
TMPY-00668 |
APP/Protease nexin-II Protein, Human, Recombinant (hFc)
CTFγ,amyloid beta (A4) precursor protein,AAA,ABPP,CVAP,APPI,... |
Human | HEK293 Cells |
APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8. | |||
TMPY-06707 |
Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His)
ADMCKD,PEMT,KL-6,ADMCKD1,H23AG,mucin 1, cell surface associa... |
Human | HEK293 Cells |
Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.49 kDa and the accession number is P15941-8. | |||
TMPJ-01330 |
CD299 Protein, Human, Recombinant (His & Flag)
DC-SIGNR,L-SIGN,CD299,CD209L,LSIGN,C-type lectin domain fami... |
Human | HEK293 Cells |
CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysoso... | |||
TMPH-01683 |
Tau-F Protein, Human, Recombinant (HEK293, His)
Microtubule-associated protein tau,Paired helical filament-t... |
Human | HEK293 Cells |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the ... |