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Cat. No. | Product Name | ||
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L2610 | 神经递质受体化合物库 | 1513 compounds | |
1513 种与神经递质受体相关的化合物,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0005 |
Cell Counting Kit-8 (CCK-8)
Cell Counting Kit-8 (CCK-8) |
Solution in bottle |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2204L |
CCK Octapeptide, non-sulfated acetate
CCK Octapeptide, non-sulfated acetate(25679-24-7 Free base) |
cholecystokinin | GPCR/G Protein |
CCK Octapeptide, non-sulfated acetate 是一种合成的胆囊收缩素脱硫酸肽。 | |||
TP1197 |
Sincalide
SQ19844,辛卡利特,CCK-8,Cholecystokinin octapeptide |
Others | Others |
Sincalide (CCK-8) 是一种速效的胆囊收缩素的氨基酸多肽激素类似物,可在胆囊造影术中静脉使用。它的肝胆生理作用是增加胆汁的分泌,使胆囊收缩并使 Oddi 的括约肌松弛,从而使胆汁排入十二指肠。它是一种通过注射促进胆囊收缩并帮助诊断胆囊和胰腺疾病的药物。 | |||
TP1198 |
Sincalide ammonium
SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium |
cholecystokinin | GPCR/G Protein |
Sincalide ammonium (CCK-8 ammonium) 是一种有效的氨基酸多肽激素胆囊收缩素 (CCK) 的类似物,是保留了 CCK 的大部分生物活性的活性片段。Sincalide ammonium 促进胆汁的分泌,使胆囊收缩并使 Oddi 的括约肌松弛,从而促进胆汁排入十二指肠。Sincalide ammonium 可通过注射促进胆囊收缩,常用于辅助诊断胆囊、胰腺疾病和胆囊造影术。 | |||
TP2500 |
Cholecystokinin (26-33) free acid
CCK (26-33) free acid |
cholecystokinin | GPCR/G Protein |
Cholecystokinin (26-33) free acid 是胆囊收缩素 (CCK) 的一部分, 是脊椎动物中枢神经系统中存在的 CCKB 型受体的高选择性配体,可诱导大鼠轻度味觉厌恶条件反射。 | |||
T37205 |
CCK (26-31) (sulfated)
|
||
CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-31) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 21% when used at a concentration of 0.1 mM. | |||
T37203 |
CCK (26-30) (sulfated)
|
||
CCK (26-30) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-30) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 10% when used at a concentration of 0.1 mM. | |||
T37204 |
CCK (26-31) (non-sulfated)
|
||
CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. | |||
T13260 |
Gastrin/CCK antagonist 1
|
cholecystokinin | GPCR/G Protein |
Gastrin/CCK antagonist 1 是一种有效的 gastrin/CCK 拮抗剂,可用于研究代谢系统相关疾病。 | |||
T37206 |
CCK (27-33) (non-sulfated)
|
||
CCK (27-33) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. Non-sulfated CCK (27-33) inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 uM) and inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 uM), an effect that can be reversed by naloxone. Unlike sulfated CCK (27-33), the non-sulfated form does not reduce exploratory behavior in m... | |||
T10707 |
CCK-B Receptor Antagonist 2
|
Others | Others |
CCK-B Receptor Antagonist 2 is a potent and orally active antagonist of Gastrin/CCK-B (IC50: 0.43 nM). It also inhibits gastrin/CCK-A activity (IC50: 1.82 μM). | |||
T12404 |
CCK-A receptor inhibitor 1
|
cholecystokinin | GPCR/G Protein |
CCK-A receptor inhibitor 1 是一种有效的缩胆囊素 A (CCK-A) 受体抑制剂(IC50:340 nM)。CCK-A receptor inhibitor 1 可用于研究与消化系统相关的疾病。 | |||
T13261 |
CCK-B Receptor Antagonist 1
|
Others | Others |
CCK-B Receptor Antagonist 1 is a cholecystokinin B (CCK-B) receptor agonist and has the potential of reducing the secretion of gastric acid. | |||
TP2419 |
V-9-M Cholecystokinin nonapeptide
V 9 M,Prepro CCK Fragment V-9-M,Val-pro-val-glu-ala-val-asp-pro-met,Cholecystokinin Precursor (24-32),V9M,V-9-M |
Beta Amyloid | Neuroscience |
V-9-M Cholecystokinin nonapeptide (Prepro CCK Fragment V-9-M) 是胆囊收缩素(CCK)的前体化合物。胆囊收缩素(CCK)是一种刺激胆囊收缩和胰腺外分泌的脑肠肽,可从狗和猫的小肠中提取的,可以引起胆囊收缩。 | |||
T30904 |
Cholecystokinin-J
CCK-J |
Others | Others |
Cholecystokinin-J can be used in cholecystography, radiomanometry and biliary cinematography. | |||
T82732 |
Cholecystokinin (1-21)
CCK-1-21 |
||
Cholecystokinin (1-21),作为一种胆囊收缩素 (CCK) 片段,能够激活人体脂肪组织的脂肪分解作用。 | |||
TP2204 |
Cholecystokinin Octapeptide, desulfated
CCK Octapeptide, non-sulfated |
Others | Others |
Non-sulfated form of the C-terminal octapeptide of CCK | |||
T1052 |
Proglumide
二丙谷酰胺 |
cholecystokinin | GPCR/G Protein |
Proglumide (Binoside) 是一种非肽的、口服具有活性的胆囊收缩素(CCK)-A/B 受体拮抗剂。它能够选择性阻断 CCK 在中枢神经系统中的作用。它能够抑制胃分泌,具有保护胃十二指肠粘膜的能力,并表现出抗癫痫和抗氧化活性。 | |||
TP2376 |
Cholecystokinin pentapeptide
CCK-5,Gly-trp-met-asp-phe-NH2 |
||
Cholecystokinin pentapeptide is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. | |||
T32297 |
Jmv 180
Cck-jmv-180,Jmv-180,Jmv180 |
Others | Others |
Jmv 180, a CCK analog, can distinguish high-affinity cholecystokinin receptors from low-affinity cholecystokinin receptors. | |||
T82733 |
Cholecystokinin
CCK-33(human),Cholecystokinin-33(human) |
||
Cholecystokinin是一种通过抑制食物摄入并促进脂肪及蛋白质消化作用的肽类激素,常用于胃肠系统研究。 | |||
T39170 |
Cholecystokinin Octapeptide, desulfated TFA
CCK Octapeptide, desulfated TFA,Cholecystokinin Octapeptide, desulfated TFA |
||
Cholecystokinin Octapeptide, desulfated TFA, is a synthetic octapeptide derived from Cholecystokinin (CCK) that has undergone desulfation. | |||
T26197 |
Snf 8815
Snf8815,Snf-8815,28-Mephe-31-N-meile-cck (26-33) |
Others | Others |
Snf 8815 is an antagonist of cholecystokinin-B (CCK-B). | |||
T25551 |
Jmv 236
Jmv236,t-Boc(nle(28,31))-cck (26-33),Jmv-236 |
Others | Others |
Jmv 236 is a cholecystokinin antagonist. | |||
TQ0062 |
Nastorazepide
Z-360 |
cholecystokinin | GPCR/G Protein |
Nastorazepide 是一种选择性的、口服有效的1,5-苯并二氮杂环衍生物胃泌素/胆囊收缩素2(CCK-2)受体拮抗剂,具有抗肿瘤的潜能。 | |||
T2312 |
Loxiglumide
CR-1505,氯谷胺 |
cholecystokinin | GPCR/G Protein |
Loxiglumide (CR-1505) 是一种缩胆囊素受体拮抗剂。 | |||
T14932 |
Ceruletide
Cerulein,Caerulein,雨蛙素,FI-6934 |
cholecystokinin | GPCR/G Protein |
Ceruletide (Caerulein) 是一种十肽,是一种安全有效的胆囊收缩剂,是一种胆囊收缩素受体激动剂,对胆囊肌肉和胆管有直接的痉挛性作用。 | |||
T4579 |
Pentagastrin
五肽胃泌素,ICI-50123 |
Others; cholecystokinin | GPCR/G Protein; Others |
Pentagastrin (ICI-50123) 是一种选择性的胆囊收缩素 B(CCKB) 受体激动剂,IC50=11 nM。它能够增强胃粘膜对酸的防御机制,并保护胃粘膜免受损伤。 | |||
T17727 |
CCK2R Ligand-Linker Conjugates 1
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
CCK2R Ligand-Linker Conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) as ligand-linker conjugates[1]. | |||
T76113 |
Creatine kinase (OcCK)
|
Others | Others |
Creatine kinase (OcCK) 催化肌酸和 ATP 的可逆反应,形成磷酸肌酸和 ADP。Creatine kinase (OcCK) 是在快速能量周转期间维持恒定 ATP/ADP 比率的关键酶。 | |||
T26483 |
A-65186
A 65186,A65186 |
cholecystokinin | GPCR/G Protein |
A-65186 是一种选择性A型谷氨酸基胆囊收缩素 (CCK) 拮抗剂,可用于研究炎症和胃肠道损伤。 | |||
T27640 |
Itriglumide
CR2945,CR 2945,CR-2945 |
cholecystokinin | GPCR/G Protein |
Itriglumide (CR-2945) 是一种胆囊收缩素 (CCK)-2 受体拮抗剂,具有抗分泌和抗溃疡作用。 | |||
T9343 |
N-Cbz-DL-tryptophan
|
cholecystokinin | GPCR/G Protein |
N-Cbz-DL-tryptophan 是一种胆囊收缩素受体拮抗剂,可消除离体心脏对 CCK-8 的反应。 | |||
T9991 |
WAY-620645
|
cholecystokinin | GPCR/G Protein |
WAY-620645 是一种 CCK 拮抗剂,具有抗肿瘤和镇痛活性。 | |||
T11868 |
Lorglumide sodium salt
CR-1409 sodium salt |
cholecystokinin | GPCR/G Protein |
Lorglumide sodium salt (CR-1409 sodium salt) 是胆囊收缩素受体 (CCK) 的拮抗剂。 | |||
T14932L |
Ceruletide Ammonium acetate
FI-6934 Ammonium acetate,Caerulein Ammonium acetate,Ceruletide Ammonium acetate (17650-98-5 free base) |
cholecystokinin | GPCR/G Protein |
Ceruletide Ammonium acetate (FI-6934 Ammonium acetate) 是一种胆囊收缩素 (CCK) 受体激动剂。它是一种安全有效的胆囊动力剂和小肠和胰腺外分泌兴奋剂。 | |||
TP1931L1 |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base) |
cholecystokinin | GPCR/G Protein |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) 是广谱神经肽反向激动剂和拮抗剂。 ghrelin 受体的强效完全反向激动剂(EC50 = 5.2 nM);减少组成型生长素释放肽受体信号传导。它也是速激肽、缓激肽、CCK 和铃蟾肽受体的拮抗剂。在体外诱导细胞凋亡并抑制癌细胞生长。 | |||
T16906 |
Sograzepide
YM-220,Netazepide,YF 476 |
Others | Others |
Sograzepide is an effective and highly selective Gastrin/CCK-B antagonist (IC50: 0.1 nM), has an inhibitory effect on Gastrin/CCK-A activity (IC50: 502 nM). Sograzepide replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine, and cloned human Gastrin/CCK-B receptors (Ki: 0.068, 0.62 and 0.19 nM, respectively). | |||
T10055 |
(Iso)-FK-480
CHEMBL333994 |
cholecystokinin | GPCR/G Protein |
(Iso)-FK-480 是一种新型可口服的胆囊收缩素 A(CCK-A)拮抗剂,可用于研究治疗慢性胰腺炎。 | |||
T15101 |
Devazepide
L-364,718,地伐西匹,MK-329 |
Others | Others |
Devazepide is a competitive and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor (IC50s: 81 pM, 45 pM, and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively). | |||
T22666 |
CI-988
CI 988 |
Others | Others |
CCK2 (CCK-B) receptor antagonist | |||
T23185 |
Proglumide sodium
丙谷胺钠,Proglumide sodium salt |
Others | Others |
Non-selective cholecystokinin (CCK) antagonist | |||
T25921 |
Pbc 264
Pbc264,Pbc-264 |
Others | Others |
Pbc 264 is a CCK agonist. | |||
T24287 |
L 365031
L 365,031,L365031,L-365,031,L-365031,L365,031 |
Others | Others |
L 365031 is a CCK antagonist. | |||
T28340 |
PD-135666
PD 135666 |
Others | Others |
PD-135666 is an antagonist of CCK receptor. | |||
T25139 |
BC 197
Boc-asp-tyr(SO3H)-ahx-lys-trp-ahx-asp-phe-NH2,BC197,BC-197 |
Others | Others |
BC 197 is a selective CCK-B agonist. | |||
T27014 |
CI-1015
CI1015,CI 1015,PD 144598 |
Others | Others |
CI-1015 is a CCK-B receptor antagonist with oral activity. | |||
T26484 |
A71378
A-71378,A 71378 |
Others | Others |
A71378 is a high potency, selectivity CCK-A receptors agonist. | |||
T13084 | Tarazepide | Others | Others |
Tarazepide is a potent and specific antagonist of CCK-A receptor. | |||
T29502 |
A 70874
A-70874,A70874 |
Others | Others |
A70874 has high selectivity and potency for cholecystokinin (CCK) a receptor. | |||
T25108 |
ARL 15849XX
ARL15849XX,FPL15849,FPL-15849,FPL 15849,ARL-15849XX |
Others | Others |
ARL 15849XX, a CCK-8 analog, is a novel anti-obesity agent. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00520 |
PTK7/CCK4 Protein, Cynomolgus, Recombinant (His)
PTK7,CCK-4 |
Cynomolgus | HEK293 Cells |
Protein Tyrosine Kinase 7 (PTK7) is as a critical regulator of canonical and non-canonical Wnt-signaling during embryonic development and cancer cell formation. Disrupting PTK7 activity perturbs vertebrate nervous system development, and also promotes human cancer formation. Observations in different model systems suggest a complex cross-talk between PTK7 protein and Wnt signaling. PTK7/CCK4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predict... | |||
TMPK-01080 |
PTK7/CCK4 Protein, Mouse, Recombinant (His)
PTK7,CCK-4 |
Mouse | HEK293 Cells |
Protein Tyrosine Kinase 7 (PTK7) is as a critical regulator of canonical and non-canonical Wnt-signaling during embryonic development and cancer cell formation. Disrupting PTK7 activity perturbs vertebrate nervous system development, and also promotes human cancer formation. Observations in different model systems suggest a complex cross-talk between PTK7 protein and Wnt signaling. PTK7/CCK4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted mo... | |||
TMPY-06249 |
CCK4/PTK7 Protein, Human, Recombinant (His)
CCK4,PTK7 |
Human | HEK293 Cells |
CCK4/PTK7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 76.1 kDa and the accession number is Q13308-1. | |||
TMPY-03991 |
DBI Protein, Human, Recombinant (His)
diazepam binding inhibitor (GABA receptor modulator, acyl-Co... |
Human | E. coli |
The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine receptor and facilitates transport of cholesterol to the inner membrane to stimulate steroid synthesis. Through this action, DBI indirectly modulates gamma-aminobutyric acid (GABA)-mediated inhibitory neurotransmission. DBI can be postulated as a candidate gene for psychiatric phenot... | |||
TMPY-03728 |
CCL28 Protein, Human, Recombinant (His)
MEC,SCYA28,chemokine (C-C motif) ligand 28,CCK1 |
Human | E. coli |
CCL28 chemokine is expressed by epithelial cells of various mucosal tissues. This chemokine binds to CCR3 and CCR10 receptors and plays an essential role in the IgA antibody secreting cells (IgA-ASC) homing to mucosal surfaces and lactating mammary gland as well. Besides, CCL28 has been shown to exert a potent antimicrobial activity against both Gram-negative and Gram-positive bacteria and fungi. The potent antimicrobial function of CCL28 combined with its wide distribution in mucosal tissues an... | |||
TMPY-06250 |
CCK4/PTK7 Protein, Cynomolgus, Rhesus, Recombinant (His)
|
Cynomolgus,Rhesus | HEK293 Cells |
CCK4/PTK7 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 76.1 kDa and the accession number is XP_005552998.1&NP_001248508.1. | |||
TMPK-00678 |
CALCA/CGRP Protein, Mouse, Recombinant (hFc)
CGRP,Katacalcin,PDN-21,CGRP-I,CGRP1,Calcitonin 1,Calcitonin,... |
Mouse | HEK293 Cells |
Specific fragments of methylation changes in the target gene (Calca) were identified by IGV analysis. CGRP was applied to compare the effects on ASCs-T2DM morphology via phalloidin staining, proliferation through CCK-8 assay, and osteogenic differentiation with osteogenic staining, qPCR, and repair of calvarial defect. Furthermore, 5-azacytidine (5-az) was used to intervene ASCs-T2DM to verify the relationship between the methylation level of the target fragment and expression of Calca. |