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11

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16748	Ridinilazole SMT19969	Antibacterial	Microbiology/Virology
	Ridinilazole (SMT19969) 是一种新型的窄谱非吸收性抗生素。它显示出对艰难梭菌的有效抑制作用 (MIC90=0.125 mg/L)，并且比甲硝唑 (MIC90 = 8 mg/L) 或万古霉素 (MIC90 = 2 mg/L) 更有效。
T16071	MGB-BP-3	DNA/RNA Synthesis; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	MGB-BP-3 是一种合成抗生素，具有杀菌活性，抑制细菌 DNA 复制，可用于研究复发性艰难梭菌感染。
T10243	Ibezapolstat ACX-362E	Others	Others
	ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections (MIC50: 2 μg/mL for C. difficile).
T76806	Bezlotoxumab
	Bezlotoxumab 是一种针对 C. difficile 毒素 B 的人单克隆抗体。Bezlotoxumab 与 C. difficile 毒素 B 结合，可预防肠上皮损伤和结肠炎。
T79774	Antibacterial agent 159	Antibiotic	Microbiology/Virology
	Antibacterialagent 159 (Compound 6d) 是一款高效抗菌化合物，具备针对脓疱疮和C. difficile感染（CDI）的抗菌活性。其使用过程中未发现C. difficile复发现象，并对益生肠道菌群仅有微弱影响。
T36075	Cholic Acid anilide	Others	Others
	Cholic acid anilide is a synthetic bile acid and derivative of cholic acid that inhibits the germination of C. difficile strain R20291 spores in vitro (IC50 = 1.8 μM).1 \|1. Sharma, S.K., Yip, C., Esposito, E.X., et al. The design, synthesis, and characterizations of spore germination inhibitors effective against an epidemic strain of Clostridium difficile. J. Med. Chem. 61(15), 6759-6778 (2018).
T78897	Antibacterial agent 156	Others	Others
	Antibacterialagent 156 (Compound 57) 是针对 C. difficile 的选择性高效杀菌化合物，作用机制为目标细胞壁合成。其对101株的MIMIC50值和MIC90值分别为0.5 μg/mL与1 μg/mL。
T38259	Phenelfamycin E	Others	Others
	Phenelfamycin E is an antibiotic originally isolated from Streptomyces. It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus128 μg/ml). Phenelfamycin E (4-64 mg/kg) increases survival in a mouse model of lethal S. pyogenes infection in a dose-dependent manner. Dietary administration of phenelfamycin E increases body weight in chickens.
T61553	ATPase-IN-2	Others	Others
	ATPase-IN-2 is a compound that acts as an inhibitor of ATPase, with an IC50 value of 0.9 μM. It also inhibits the glycohydrolase activity of C. difficile toxin B (TcdB) with an AC50 value of 30.91 μM. ATPase-IN-2 is commonly utilized in ATP-related research [1].
T70798	Benastatin B	Others	Others
	Benastatin B is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities. It inhibits glutathione S-transferase (GST; Ki = 3.7 µM for the rat liver enzyme).2 Benastatin B also inhibits the transglycosylase activity of A. baumannii, C. difficile, E. coli, and S. aureus recombinant penicillin-binding proteins (PBPs; IC50s = 16, 53.3, 30.7, and 31.6 µM, respectively).3 It is active against several bacteria, including methicillin-resistant S....
T65598	Cefminox sodium	Others	Others
	Cefminox (Sodium) is a new cephamycin antibiotic possessing a D-amino acid moiety derived from D-cysteine at the C-7B side chain. Cefminox is active against a wide range of bacteria, especially Gram-negative and anaerobic bacteria. Cefminox shows excellent in vivo efficacy (ED50) which is higher than would be expected from its in vitro activity (MIC). Moreover, cefminox possesses more potent activity in suppression of bacterial regrowth than other cephems[1]. Cefminox (Sodium) was the most activ...

化合物

Cat.No: T16748

Synonym: SMT19969

Target: Antibacterial

Cat.No: T16071

Target: DNA/RNA Synthesis, Antibiotic

Cat.No: T10243

Synonym: ACX-362E

Target: Others

Cat.No: T76806

Antibacterial agent 159

Cat.No: T79774

Target: Antibiotic

Cholic Acid anilide

Cat.No: T36075

Target: Others

Antibacterial agent 156

Cat.No: T78897

Target: Others

Phenelfamycin E

Cat.No: T38259

Target: Others

Cat.No: T61553

Target: Others

Cat.No: T70798

Target: Others

Cefminox sodium

Cat.No: T65598

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1126	Penicillin V Potassium 青霉素V钾,Penicillin V potassium salt,Phenoxymethylpenicillin potassium salt	Antibacterial; Antibiotic	Microbiology/Virology
	Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) 是一种有口服活性的抗生素。它可抑制链球菌，艰难梭菌和金黄色葡萄球菌的生长，可研究中耳炎，鼻窦炎，咽炎和扁桃体炎。
T36585	Isodeoxycholic Acid isoDCA	Chloride channel; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology
	Isodeoxycholic Acid 是一种胆汁酸，由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚，这表明它的去污活性降低了，而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid（0.1%）能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发，并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中，血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。

天然产物

Penicillin V Potassium

Cat.No: T1126

Synonym: 青霉素V钾,Penicillin V potassium salt,Phenoxymethylpenicillin potassium salt

Target: Antibacterial, Antibiotic

Isodeoxycholic Acid

Cat.No: T36585

Synonym: isoDCA

Target: Chloride channel, Antibacterial

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