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TMPY-02550
|
Eotaxin/CCL11 Protein, Human, Recombinant (His)
SCYA11,chemokine (C-C mo...
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Human
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E. coli
|
|
CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small ... |
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TMPY-03650
|
BirA Protein, E. coli, Recombinant (His & MBP)
BirA,dhbB,bioR
|
E. coli
|
E. coli
|
|
The enzyme BirA is a key reagent because of its ability to biotinylate proteins at a specific residue in a recognition sequence. This enzyme is used to biotinylate the C termini of membrane proteins, allowing these proteins to be tetramerized by binding to streptavidin. Because of the specificity of the biotinylation at the C terminus, the orientation of the membrane proteins on the streptavidin is equivalent to that of the native protein on the cell surface. These tetrameric proteins can be use... |
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TMPJ-01407
|
FIS1 Protein, Human, Recombinant (His)
FIS1 Homolog,FIS1,Tetratricopeptide Repeat Protein ...
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Human
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E. coli
|
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Mitochondrial Fission 1 Protein (FIS1) is a member of the FIS1 family. FIS1 is a single-pass membrane protein and contains one TPR repeat. FIS1 is part of the mitochondrial complex that promotes mitochondrial fission. FIS1 can induce cytochrome C discharge from the mitochondrion to the cytosol, eventually leading to apoptosis. In addition, FIS1 participates in peroxisomal growth and division. The C-terminus of FIS1 is required for mitochondrial or peroxisomal localization, while the N-terminus i... |
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TMPH-03046
|
TBP1 Protein, MenB, Recombinant (His & Myc)
Transferrin-binding protein 1,Transferrin-binding protein A,...
|
MenB
|
E. coli
|
|
Neisseria acquires iron by extracting it from serum transferrin (TF) in its human host. Acts as a TF receptor and is required for TF utilization. Binds both apo- and holo-TF, via the TF C-terminus. |
|
TMPK-01095
|
MEPE Protein, Mouse, Recombinant (His)
Osteoregulin,MEPE,OF45
|
Mouse
|
HEK293 Cells
|
|
Matrix extracellular phosphoglycoprotein (MEPE) is expressed in bone and teeth where it has multiple functions. The C-terminus of MEPE contains a mineral-binding, acidic serine- and aspartate-rich motif (ASARM) that is also present in other noncollagenous proteins of mineralized tissues.MEPE-derived ASARM peptides function in phosphate homeostasis and direct inhibition of bone mineralization in a phosphorylation-dependent manner. |
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TMPJ-00467
|
Mindin Protein, Human, Recombinant (His)
Spondin-2,Differentially expressed in canc...
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Human
|
HEK293 Cells
|
|
Spondin-2, also referred to as mindin, belongs to the F-spondin family of secreted extracellular matrix proteins. Spondins are characterised by the presence of F-spondin domains 1 and 2 (FS1 and FS2) at the N-terminus and a thrombospondin-type 1 repeat (TSR1) domain at the C-terminus. Spondin-2 functions as a pattern-recognition molecule for bacterial and viral pathogens and as an integrin ligand for inflammatory cell recruitment and T cell priming. In addition to its roles in promoting neuron o... |
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TMPH-01683
|
Tau-F Protein, Human, Recombinant (HEK293, His)
Microtubule-associated protein tau,Paired ...
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Human
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HEK293 Cells
|
|
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the ... |
|
TMPJ-00827
|
Tau-D Protein, Human, Recombinant (His)
PHF-Tau,MAPTL,MAPT,Paired Helical Filament-Tau,Mi
|
Human
|
E. coli
|
|
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective,... |
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TMPY-01345
|
ACBD6 Protein, Human, Recombinant (His)
acyl-CoA binding domain containin...
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Human
|
Baculovirus Insect Cells
|
|
Human acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. In mammals, there are six members of the acyl-CoA binding domain-containing (ACBD) family, and their annotation is not uniform. All six ACBD proteins contain an ACB domain at the N terminus, but they do not share significant homology at the C-terminal region. ACBD6 is a 32 kDa protein that is predicted by sequenc... |
|
TMPJ-01032
|
SPINK7 Protein, Human, Recombinant (His)
ECG2,SPINK7,Serine protease inhibitor Kazal-type 7,...
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Human
|
HEK293 Cells
|
|
Serine protease inhibitor Kazal-type 7(SPINK7) is a secreted protein, that in humans is encoded by the SPINK7 gene. SPINK7 contains 1 Kazal-like domain. SPINK7 is probably serine protease inhibitor. Recombinant human SPINK7 is a single, non-glycosylated polypeptide chain containing 74 amino acids and fused to His-tag at c-terminus. |
|
TMPJ-01372
|
Cornulin Protein, Human, Recombinant (His)
Tumor-Related Protein,58 kDa Heat Shock Protein,PDR...
|
Human
|
E. coli
|
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Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and ... |
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TMPH-00379
|
MLCK Protein, Chicken, Recombinant (His & Myc & SUMO)
Mylk,Telokin,Myosin light chain kinase, smooth mus<...
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Chicken
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E. coli
|
|
Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals. MLCK Protein, Chicken, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 52.9 kDa and the accession number is P11799. |
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TMPJ-00858
|
Ezrin Protein, Human, Recombinant
Villin-2,VIL2,EZR,p81,Ezrin,Cytovillin
|
Human
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E. coli
|
|
Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskele... |
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TMPJ-00445
|
IBSP Protein, Mouse, Recombinant (His)
BNSP,IBSP,Integrin binding sialoprotein,Cell bindin...
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Mouse
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HEK293 Cells
|
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Bone sialoprotein 2(IBSP) is a monomeric non‑collagenous member of the SIBLING family of extracellular matrix proteins. It is principally associated with the early stages of bone mineralization. Mouse IBSP is synthesized as a 324 amino acid (aa) precursor that contains a 16 aa signal sequence and a 308 aa mature region. The mature segment is divided into a basic N‑terminus (aa 17 ‑ 62), a central region (aa 63 ‑ 233), and an acidic C‑terminus (aa 234 ‑ 317). IBSP is highly glycosylated, sulfate... |
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TMPJ-01270
|
ZMYND19 Protein, Human, Recombinant (His)
MCH-R1-Interacting Zinc Finger Pr...
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Human
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E. coli
|
|
Human Zinc Finger MYND Domain-Containing Protein 19 (ZMYND19) is a protein that contains 1 MYND-Type Zinc Finger. ZMYND19 can be expressed by the brain, testis, placenta, heart, liver, skeletal muscle, kidney, and stomach. ZMYND19 interacts with GPR24/MCH-R1. It binds to the C terminus of Melanin-Concentrating Hormone Receptor-1 and the N Termini of α-Tubulin. ZMYND19 may be involved as a regulatory molecule in GPR24/MCH-R1 signaling. |
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TMPH-02285
|
USP6 Protein, Human, Recombinant (His & KSI)
Proto-oncogene TRE-2,Ubiquitin-specifi...
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Human
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E. coli
|
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Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. |
|
TMPY-01125
|
MDMX Protein, Human, Recombinant (His)
MRP1,MDM4, p53 regulator,HDMX,MDMX
|
Human
|
E. coli
|
|
MDM4 (MDM4 Regulator Of P53, also known as MDMX) is a Protein Coding gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows structural similarity to p53-binding protein MDM2. MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function. MDM4, an essential negative regulator of the P53 tumor ... |
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TMPY-03280
|
RAMP3 Protein, Human, Recombinant (hFc)
receptor (G protein-coupled) acti...
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Human
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HEK293 Cells
|
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RAMP3 belongs to the RAMP family. Members of this family are single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. They are required to transp... |
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TMPJ-01291
|
CPNE1 Protein, Human, Recombinant (His)
CPNE1,CPN1,Copine I,Copi...
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Human
|
E. coli
|
|
Copine-1(CPNE1) encodes a calcium-dependent protein which belongs to the copine family. CPNE1contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, CPNE1 does not contain a predicted signal sequence or transmembrane domains. CPNE1 may regulate molecular events at the interface of the cell membrane and cytoplasm. CPNE1 has a broad tissue distribution and it may function in membrane trafficking. |
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TMPH-01023
|
C5AR1 Protein, Human, Recombinant (Cell-Free, His)
C5a anaphylatoxin chemotactic...
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Human
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E. coli
|
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Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. C5AR1 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression syst... |
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TMPH-01022
|
C5AR1 Protein-VLP, Human, Recombinant (His)
C5a anaphylatoxin chemotactic...
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Human
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HEK293 Cells
|
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Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. C5AR1 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-... |
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TMPJ-01237
|
IL-17D Protein, Human, Recombinant
IL17D,Interleukin-17D,IL-17D
|
Human
|
E. coli
|
|
The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence ho... |
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TMPJ-01006
|
KPNA2 Protein, Human, Recombinant (His)
RCH1,SRP1-Alpha,Importin Subunit Alpha-2,Importin S...
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Human
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E. coli
|
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Karyopherin Subunit α-2 (KPNA2) belongs to the importin alpha family. KPNA2 is widely expressed in many tissues and contains an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. KPNA2 interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. KPNA2 functions in nuclear protein importantly as an adapter protein for nu... |
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TMPY-03613
|
COMMD8 Protein, Human, Recombinant (His)
COMM domain containing 8
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Human
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E. coli
|
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COMMD8 is a member of the COMMD family. Members of this family are a group of evolutionary conserved proteins that share a common COMM domain at the extreme C-terminus, which provides an interface for protein-protein interactions. Most COMMD proteins play a role in the regulation of NF˚B and, despite their similarities, seem to function in unique and non-redundant pathways. COMMD proteins may also play a role in the function of epithelial sodium channels, cell proliferation, copper homeostasis a... |
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TMPH-03593
|
Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (Avi & His)
Thiol-activated cytolysin,Pneumolysin,ply
|
Streptococcus pneumoniae
|
E. coli
|
|
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. Pneum... |
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TMPY-02399
|
TRF1 Protein, Human, Recombinant (His)
TRF,telomeric repeat binding factor (NIMA-...
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Human
|
Baculovirus Insect Cells
|
|
Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2/TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2/TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell ... |
|
TMPY-02440
|
SAP/SH2D1A Protein, Human, Recombinant (His)
XLPD,EBVS,DSHP,SAP,MTCP1,IMD5,SH2 domain c...
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Human
|
E. coli
|
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SH2domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cell... |
|
TMPH-03592
|
Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (His)
Thiol-activated cytolysin,ply,Pneumolysin
|
Streptococcus pneumoniae
|
P. pastoris (Yeast)
|
|
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. Pneum... |
|
TMPY-03504
|
CBFB Protein, Human, Recombinant (His)
core-binding factor, β subunit,co...
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Human
|
E. coli
|
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CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). CBFB is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enh... |
|
TMPJ-00060
|
IL-25/IL17E Protein, Human, Recombinant (His)
白细胞介素,IL17E,白介素,IL-17E,IL-25,IL25,Interleukin-25,Interleukin...
|
Human
|
HEK293 Cells
|
|
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammator... |
|
TMPJ-00798
|
ACYP1 Protein, Human, Recombinant (His)
ACYPE,Acylphosphate phosphohydrolase 1,ery...
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Human
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E. coli
|
|
ACYP1, also known as Acylphosphatase-1, Acylphosphatase, erythrocyte isozyme, Acylphosphatase, organ-common type isozyme, Acylphosphate phosphohydrolase 1 and ACYPE, is a small cytosolic enzyme which catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates.ACYP1 is a protein which belongs to the acylphosphatase family and contains 1 fibrinogen C-terminal domain. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of thei... |
|
TMPH-00201
|
BK polyomavirus (BKPyV) VP2 Protein (His)
Minor capsid protein VP2,Minor structural ...
|
BKPyV
|
E. coli
|
|
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA ... |
|
TMPY-03440
|
Sts1 Protein, Human, Recombinant (His)
STS-1,ubiquitin associated and SH3 domain c
|
Human
|
E. coli
|
|
UBASH3B contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. UBASH3B interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. It promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on... |
|
TMPY-01880
|
PDZD11 Protein, Human, Recombinant (His)
AIPP1,PISP,PDZ domain containing 11,PDZK11
|
Human
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E. coli
|
|
PDZ domain-containing protein 11, also known as AIPP1a, PISP, PDZD11 and PDZK11, is a cytosolic protein that contains one PDZ (DHR) domain. PDZD11 bears resemblance to members of the MALS / VELIS family of proteins. It contains but one PDZ domain that apparently interacts with the C-terminus of partner proteins. PDZD11 is ubiquitously expressed, and appears to target calcium and copper ATPases to basolateral cell membranes. PDZD11 is a transiently interacting partner of the PMCA b-splice forms t... |
|
TMPH-02365
|
JC polyomavirus (JCV) Minor capsid protein VP2 (His)
Minor capsid protein VP2,Minor structural ...
|
JCPyV
|
E. coli
|
|
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA ... |
|
TMPY-02714
|
PRC1 Protein, Human, Recombinant (His)
ASE1,protein regulator of cytokinesis 1
|
Human
|
Baculovirus Insect Cells
|
|
PRC1 (protein regulator of cytokinesis 1) is a key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. It is essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. PRC1 is required for KIF14 localization to the central spindle and midbody. It is also required to recruit PLK1 to the spindle. PRC1 stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. It is a homodi... |
|
TMPY-03750
|
CRIPT Protein, Human, Recombinant (His)
HSPC139,SSMDF,cysteine-rich PDZ-b...
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Human
|
E. coli
|
|
CRIPT, also known as cysteine-rich PDZ-binding protein, belongs to the CRIPT family. It interacts with TUBB1. CRIPT also interacts strongly with the PDZ3 domain of members of the DLG4 family. It is involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. CRIPT is highly conserved from mammals to plants and binds selectively to the third PDZ domain (PDZ3) of PSD-95 via its C terminus. n heterologous cells, CRIPT causes a redistribution of PSD-95 to microtubules. In brain, CRIPT colo... |
|
TMPJ-00110
|
GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)
Tnfrsf18,GITR-D,CD357,AITR,Tumor necrosis ...
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Mouse
|
HEK293 Cells
|
|
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and... |
|
TMPY-06815
|
SYAP1 Protein, Human, Recombinant (His)
PRO3113,synapse associated protein 1
|
Human
|
Baculovirus Insect Cells
|
|
Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the C-terminus. Expressed near neuronal Golgi and synaptic regions of cerebellar Purkinje cells, SYAP1 has been linked to intact sensorimotor control and general vesicular trafficking in neurons. SYAP1-deficient mice display impaired locomotor activity. In cultured adipocytes, SYAP1 ... |
|
TMPJ-01292
|
Chemerin/RARRES2 Protein, Human, Recombinant (His)
RAR-responsive protein TIG2,RARRES2,Chemerin,Tazaro...
|
Human
|
HEK293 Cells
|
|
Retinoic acid receptor responder protein 2(RARRES2) is a secreted protein that in humans is encoded by the RARRES2 gene. It is highly expressed in skin, also found in pancreas, liver, spleen, prostate, ovary, small intestine and colon. It is a chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1. RARRES2 is secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases. It is thou... |
|
TMPH-01288
|
Elongin-B Protein, Human, Recombinant (GST)
EloB,Elongin-B,TCEB2,ELOB,SIII p18
|
Human
|
E. coli
|
|
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region ... |
|
TMPH-03741
|
BoNT/F Protein, Clostridium botulinum, Recombinant (His)
Bontoxilysin-F,BoNT/F,botF,Botulinum neurotoxin type F
|
Clostridium botulinum
|
E. coli
|
|
Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell ... |
|
TMPJ-00835
|
FGF-4 Protein, Mouse, Recombinant
HSTF1,HST-1,FGF4,FGF-4,HBGF-4,Fibroblast growth fac...
|
Mouse
|
E. coli
|
|
Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2... |
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TMPY-02211
|
USP5 Protein, Human, Recombinant (His)
ISOT,ubiquitin specific peptidase 5 (isope...
|
Human
|
Baculovirus Insect Cells
|
|
Ubiquitin carboxyl-terminal hydrolase 5, also known as Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin-specific-processing protease 5, ISOT and USP5, is a member of the peptidase C19 family. USP5 contains 2 UBA domains and one UBP-type zinc finger. The UBP-type zinc finger domain interacts selectively with an unmodified C-terminus of the proximal ubiquitin. Both UBA domains are involved in polyubiquitin recognition. The UBP-type zinc finger domain crystallizes as ... |
|
TMPJ-01188
|
CORO6 Protein, Human, Recombinant (His)
Coronin-6,Clipin-E,CORO6
|
Human
|
E. coli
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Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is promin... |
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TMPH-01531
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IKBKB Protein, Human, Recombinant (His)
Serine/threonine protein kinase IKBKB,Nuclear fa
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Human
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Baculovirus Insect Cells
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Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu... |
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TMPH-01532
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IKBKB Protein, Human, Recombinant (E. coli, His)
Nuclear factor NF-kappa-B inhibitor kinase...
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Human
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E. coli
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Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu... |
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TMPK-01450
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HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
KRAS1,MHC,K-RAS4B,KRAS,CFC2,K-RAS...
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Human
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HEK293 Cells
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Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |
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TMPK-01456
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HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein, Human, MHC (His & Avi)
KRAS2,NS,MHC,C-K-RAS,KRAS1,K-RAS2A,K-RAS2B...
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Human
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HEK293 Cells
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Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |
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TMPK-01451
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HLA-C 03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi)
NS3,K-RAS4A,K-Ras 2,NS,KRAS1,RASK2,MHC,KI-RAS,KRAS,...
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Human
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HEK293 Cells
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Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |
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