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Search Results for " c-29 "

Targets Recommended: TLR

22

抑制剂 & 化合物

2

天然产物

14

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3502	C29	TLR	Immunology/Inflammation
	C29 是 Toll 样受体 2 抑制剂，可阻断 hTLR2/1 和 hTLR2/6 信号，IC50值分别为 19.7 和 37.6 μM。
T11539	HCV-IN-29	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	HCV-IN-29 是一种丙型肝炎病毒抑制剂。
T18622	BnOH-NH-bis-(C2-S)-propane-O-isoprene ester PROTAC Linker 29	Others	Others
	BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (PROTAC Linker 29) is an alkyl ether-based linker primarily utilized in the synthesis of PROTACs.
T17206	UPGL00004	Others; Glutaminase	Others; Proteases/Proteasome
	UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂，其 IC50为29 nM。UPGL00004 对 GAC 的 Kd 为27 nM。UPGL00004 对高度侵袭性三阴性乳腺癌细胞系的增殖具有很强的抑制作用。
T6351	MGCD-265 analog MGCD-265,Glesatinib	Apoptosis; VEGFR; c-Met/HGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	MGCD-265 analog (Glesatinib) 是一种口服生物可利用的多靶点酪氨酸激酶抑制剂，具有抗肿瘤活性，对 c-Met 和 VEGFR2 的 IC50 分别为 29 nM 和 10 nM。
T6318	AZ 628	Apoptosis; Raf	Apoptosis; MAPK
	AZ 628 是一种泛Raf 激酶抑制剂，抑制B-Raf、B-RafV600E 和c-Raf-1，IC50分别为 105、34和 29 nM。
T4426	CEP-40783 CEP 40783,RXDX-106	c-Met/HGFR; TAM Receptor	Tyrosine Kinase/Adaptors
	CEP-40783 (RXDX-106) 是一种有口服活性的，高效的，选择性的 AXL (IC50:7 nM) 和 c-Met (IC50:12 nM) 抑制剂。
T11540	HCV-IN-3	Others	Others
	HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor (IC50: 20 μM; Kd: 29 μM).
T63590	c-Met-IN-10	Others	Others
	c-Met-IN-10 是高效的 c-Met 激酶抑制剂 (IC50: 16 nM)。c-Met-IN-10 能够抑制癌细胞 A549、H460 和 HT-29 的活性，通过抑制 HT-29 细胞集落形成，进而诱导 HT-29 和 A549 细胞凋亡 apoptosis，抑制 A549 细胞移动。c-Met-IN-10 能够用于抗癌研究。
T125696	Scheffursoside C	Others	Others
	Scheffursoside C 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125696，CAS号为 160669-29-4。
TP1231	β-Amyloid (29-40) Amyloid beta-protein(29-40),β-Amyloid 29-40
	β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties related to those of fusion peptides of viral proteins. The fusion of liposomes can be induced by th
T79715	c-Met-IN-19	c-Met/HGFR	Tyrosine Kinase/Adaptors
	c-Met-IN-19（Compound 21j）作为c-Met抑制剂，呈现出对A549、HT-29、SGC-7901、MDA-MB-231细胞系的细胞毒效应，其IC50分别为0.25、0.36、0.98、0.76 μM，并具有较高的抑制活性（IC50: 1.99 nM）。
T36913	17-Epiestriol	Others	Others
	17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16α-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor α (ERα) and ERβ with relative binding affinities of 29 and 80 compared with 17β-estradiol .2 1.Brinton, L.A., Trabert, B., Anderson, G.L., et al.Serum estrogens and estrogen metabolites and endometrial cancer risk among postmenopausal womenCancer Epidemiol. Biomarkers Prev.25(7)1081-1089(2016) 2.Kuiper, G.G.J.M., Lemme...
T84977	N-desmethyl Regorafenib N-oxide	Others	Others
	N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.
T83738	SMAP 29 (ovine) TFA Sheep Myeloid Antimicrobial Peptide 29
	SMAP 29是一种抗微生物肽，同时也是绵羊防御素前体肽的C末端切割产物。在低盐和高盐条件下，对P. aeruginosa菌株PAO1具有杀菌作用，该作用在能量依赖的发光测定中表现出来（EC50s分别为0.05和0.06 µM）。它还能够以浓度依赖的方式引起绵羊红细胞的溶血。
T37922	7(Z),11(Z)-Pentacosadiene	Others	Others
	Unsaturated, long-chain hydrocarbons are found on the cuticles of insects and can act as pheromones. In mature Drosophila melanogaster, certain cuticular hydrocarbons are sexually dimorphic: males synthesize 23- and 25-C monoenes and females produce 27- and 29-C dienes. Each of these lipids plays specific roles in regulating male sexual behavior, with dienes stimulating courtship. 7(Z),11(Z)-Pentacosadiene is a 25-C hydrocarbon that is found in low abundance on cuticles of mature Drosophila fema...
T36929	Pal-KTTKS (acetate)	Others	Others
	Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS...
T36431	7,10-dihydroxy-8(E)-Octadecenoic Acid	Others	Others
	7,10-dihydroxy-8(E)-Octadecenoic acid is a hydroxy fatty acid and metabolite of oleic acid that is produced byP. aeruginosafrom vegetable oils.1It is active against the food-borne pathogenic bacteriaS. aureus,S. typhimurium,L. monocytogenes,B. subtilis, andE. coli(MIC50s = 31.3, 125, 125, 62.5, and 250 μg/ml, respectively), as well as the plant pathogenic bacteriaErwinia,R. solanacearum,C. glutamicum, andP. syringae(MIC90s = 125, 125, 250, and 500 μg/ml, respectively).2,1 1.Sohn, H.-R., Bae, J.-...
T36991	Monascuspiloin	Others	Others
	Monascuspiloin is a fungal metabolite that has been found inM. pilosusM93-fermented rice.1It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 ...
T36668	Geranylgeranoic Acid	Others	Others
	Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also...
T37632	TFM	Others	Others
	TFM is a piscicide.1It is toxic to sea lamprey (P. marinus) with LC50values ranging from 1.97 to 2.11 and 2.05 to 2.21 mg/L for sac and swim-up fry, respectively, 1.6 to 2.45 mg/L for juveniles, and 1.6 to 1.63 mg/L for adults. It is also toxic to juvenile lake sturgeon (A. fulvescens) less than 100 mm in size but not to a variety of other fish species. TFM (50 μM) uncouples oxidative phosphorylation by 22 and 28% in isolated sea lamprey and rainbow trout (O. mykiss) liver, respectively.2Formula...
T12925	Sitravatinib malate MGCD516 malate,MG-516 malate	TAM Receptor	Tyrosine Kinase/Adaptors
	Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively.) , shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

化合物

Cat.No: T3502

Target: TLR

Cat.No: T11539

Target: HCV Protease

BnOH-NH-bis-(C2-S)-propane-O-isoprene ester

Cat.No: T18622

Synonym: PROTAC Linker 29

Target: Others

Cat.No: T17206

Target: Others, Glutaminase

MGCD-265 analog

Cat.No: T6351

Synonym: MGCD-265,Glesatinib

Target: Apoptosis, VEGFR, c-Met/HGFR

Cat.No: T6318

Target: Apoptosis, Raf

Cat.No: T4426

Synonym: CEP 40783,RXDX-106

Target: c-Met/HGFR, TAM Receptor

Cat.No: T11540

Target: Others

Cat.No: T63590

Target: Others

Scheffursoside C

Cat.No: T125696

Target: Others

β-Amyloid (29-40)

Cat.No: TP1231

Synonym: Amyloid beta-protein(29-40),β-Amyloid 29-40

Cat.No: T79715

Target: c-Met/HGFR

Cat.No: T36913

Target: Others

N-desmethyl Regorafenib N-oxide

Cat.No: T84977

Target: Others

SMAP 29 (ovine) TFA

Cat.No: T83738

Synonym: Sheep Myeloid Antimicrobial Peptide 29

7(Z),11(Z)-Pentacosadiene

Cat.No: T37922

Target: Others

Pal-KTTKS (acetate)

Cat.No: T36929

Target: Others

7,10-dihydroxy-8(E)-Octadecenoic Acid

Cat.No: T36431

Target: Others

Cat.No: T36991

Target: Others

Geranylgeranoic Acid

Cat.No: T36668

Target: Others

Cat.No: T37632

Target: Others

Sitravatinib malate

Cat.No: T12925

Synonym: MGCD516 malate,MG-516 malate

Target: TAM Receptor

Cat. No.	Product Name	Target	Signaling Pathways
TN1993	Norsanguinarine	Antifection	Microbiology/Virology
	Norsanguinarine has antifungal activity, it exhibits 100 % inhibition of A. brassicicola and C. maculans at 1000 ppm whereas. It shows significant cytotoxic activities (ED (50) values < 4 microg/ml) against P-388, KB16, A549, and HT-29 cell lines.
TN3870	Iriflophenone 2-O-Rhamnoside Dimethylmatairesinol	Others	Others
	Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung c

天然产物

Norsanguinarine

Cat.No: TN1993

Target: Antifection

Iriflophenone 2-O-Rhamnoside

Cat.No: TN3870

Synonym: Dimethylmatairesinol

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01066	CCR6 Protein, Human, Recombinant (His & Myc) GPRCY4,Chemokine receptor-like 3,...	Human	E. coli
	CCR6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 12.9 kDa and the accession number is P51684.
TMPY-05807	PRTN3 Protein, Human, Recombinant (S203A, His) AGP7,NP-4,NP4,PR-3,CANCA,ACPA,MBT...	Human	HEK293 Cells
	PRTN3 Protein, Human, Recombinant (S203A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.57 kDa and the accession number is P24158.
TMPJ-00557	Kallikrein 8/KLK8 Protein, Human, Recombinant (aa 29-260, His) Tumor-Associated Differentially Expressed Gene 14 P...	Human	HEK293 Cells
	Kallikrein 8/KLK8 Protein, Human, Recombinant (aa 29-260, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35 KDa and the accession number is AAH40887.1.
TMPH-02287	ZRANB1 Protein, Human, Recombinant (His & Myc) TRAF-binding domain-containing protein,Zinc	Human	E. coli
	Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling. ZRANB1 Prot...
TMPK-00168	OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated IMD16,TNFRSF4,CD134,ACT-135, TXGP1L,OX40 h...	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight ...
TMPK-01018	B7-H3 Protein, Human, Recombinant (aa 29-245, His) PRO352,B7H3, UNQ309,PSEC0249,CD276,B7-H3,B...	Human	HEK293 Cells
	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 Protein, Human, Recombinant (aa 29-245, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig...
TMPK-01017	B7-H3 Protein, Human, Recombinant (aa 29-245, hFc) B7H3,B7-H3,B7 homolog 3,PSEC0249,CD276,PRO...	Human	HEK293 Cells
	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 Protein, Human, Recombinant (aa 29-245, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weig...
TMPK-00986	IL-2 R gamma/CD132 Protein, Cynomolgus, Recombinant (His) SCIDX1,IL2RG,gammaC,γC,C...	Cynomolgus	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein, Cynomolgus, Recombinant...
TMPK-00239	IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi), Biotinylated SCIDX,IMD4,IL-2 R gamma,CD132,SCI...	Human	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein, Human, Recombinant (His...
TMPK-00238	IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi) CD132,gammaC,γC,IMD4,IL2RG,SC...	Human	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein, Human, Recombinant (His...
TMPK-00987	IL-2 R gamma/CD132 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated IL-2 R γ/CD132,IL-2 R gamma,IMD4,gammaC,S<...	Cynomolgus	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein (Primary Amine Labeling)...
TMPK-01450	HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi), Biotinylated KRAS1,MHC,K-RAS4B,KRAS,CFC2,K-RAS...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01456	HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein, Human, MHC (His & Avi) KRAS2,NS,MHC,C-K-RAS,KRAS1,K-RAS2A,K-RAS2B...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01451	HLA-C 03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi) NS3,K-RAS4A,K-Ras 2,NS,KRAS1,RASK2,MHC,KI-RAS,KRAS,...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

重组蛋白

CCR6 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01066

Species: Human

Expression System: E. coli

PRTN3 Protein, Human, Recombinant (S203A, His)

Cat.No: TMPY-05807

Species: Human

Expression System: HEK293 Cells

Kallikrein 8/KLK8 Protein, Human, Recombinant (aa 29-260, His)

Cat.No: TMPJ-00557

Species: Human

Expression System: HEK293 Cells

ZRANB1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02287

Species: Human

Expression System: E. coli

OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated

Cat.No: TMPK-00168

Species: Human

Expression System: HEK293 Cells

B7-H3 Protein, Human, Recombinant (aa 29-245, His)

Cat.No: TMPK-01018

Species: Human

Expression System: HEK293 Cells

B7-H3 Protein, Human, Recombinant (aa 29-245, hFc)

Cat.No: TMPK-01017

Species: Human

Expression System: HEK293 Cells

IL-2 R gamma/CD132 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00986

Species: Cynomolgus

Expression System: HEK293 Cells

IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00239

Species: Human

Expression System: HEK293 Cells

IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00238

Species: Human

Expression System: HEK293 Cells

IL-2 R gamma/CD132 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

Cat.No: TMPK-00987

Species: Cynomolgus

Expression System: HEK293 Cells

HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01450

Species: Human

Expression System: HEK293 Cells

HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01456

Species: Human

Expression System: HEK293 Cells

HLA-C 03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01451

Species: Human

Expression System: HEK293 Cells

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